9618 results
Cited 7 times since 2021 (1.6 per year)
source: EuropePMC
Pediatric pulmonology,
Volume 56, Issue 6, 22 4 2021, Pages 1666-1672
Point of care diaphragm ultrasound: An objective tool to predict the severity of pneumonia and outcomes in children.
Şık N, Çitlenbik H, Öztürk A, Yılmaz D, Duman M
Background: Pneumonia is one of the most common serious infections in children. Scoring systems have been adopted to quantify the severity of the disease, but they were based on clinical findings that can vary according to the subjective assessment of the clinician. We hypothesized that diaphragm ultrasound (DUS) parameters may be a new useful tool to objectively score the severity of the disease and predict outcomes in children with pneumonia. Methods: Children diagnosed with pneumonia, aged be...
Abstract
Cited 8 times since 2021 (1.8 per year)
source: EuropePMC
Veterinary world,
Volume 14, Issue 3, 22 4 2021, Pages 709-720
Determination of residues of pesticides, anabolic steroids, antibiotics, and antibacterial compounds in meat products in Oman by liquid chromatography/mass spectrometry and enzyme-linked immunosorbent assay.
Al-Amri I, Kadim IT, AlKindi A, Hamaed A, Al-Magbali R, Khalaf S, Al-Hosni K, Mabood F
Background and aim: Meat is a rich source of many nutrients and plays a vital role in human life however, meat safety is one of the top priorities of great concern for consumers today. More than 90% of human exposure to harmful materials is due to consumption of contaminated meat products. This study was designed to compare four valid analytical methods for the determination of organochlorine pesticides 2,4 D (2,4-dichlorophenoxyacetic acid), dichlorodiphenyldichloroethylene/dichlorodiphenyltric...
Abstract
Cited 8 times since 2021 (1.8 per year)
source: EuropePMC
Scientific reports,
Volume 11, Issue 1, 22 4 2021, Pages 6507
Reduced scan time and superior image quality with 3D flow MRI compared to 4D flow MRI for hemodynamic evaluation of the Fontan pathway.
Rijnberg FM, van Assen HC, Juffermans JF, Kroft LJM, van den Boogaard PJ, de Koning PJH, Hazekamp MG, van der Woude SFS, Warmerdam EG, Leiner T, Grotenhuis HB, Goeman JJ, Lamb HJ, Roest AAW, Westenberg JJM
Long scan times prohibit a widespread clinical applicability of 4D flow MRI in Fontan patients. As pulsatility in the Fontan pathway is minimal during the cardiac cycle, acquiring non-ECG gated 3D flow MRI may result in a reduction of scan time while accurately obtaining time-averaged clinical parameters in comparison with 2D and 4D flow MRI. Thirty-two Fontan patients prospectively underwent 2D (reference), 3D and 4D flow MRI of the Fontan pathway. Multiple clinical parameters were assessed fro...
Abstract
Cited 3 times since 2021 (0.7 per year)
source: EuropePMC
Access microbiology,
Volume 3, Issue 3, 22 4 2021, Pages 000217
<i>Bartonella quintana</i> as a cause for prosthetic valve endocarditis and post-sternotomy mediastinitis.
Plantinga NL, Vos RJ, Georgieva L, Roescher N
An otherwise healthy patient, with minimal clinical, biochemical and peroperative signs of infection, was diagnosed with Bartonella quintana prosthetic valve endocarditis by 16S PCR. The patient subsequently developed a post-sternotomy mediastinitis and Bartonella quintana was the only detected pathogen. Bartonella quintana can cause severe infections in individuals not classically at risk, and may be missed in the routine diagnostic work-up of endocarditis.
Abstract
Cited 1 times since 2021 (0.2 per year)
source: EuropePMC
Endocrine,
Volume 73, Issue 1, 20 3 2021, Pages 226-229
No association between glucocorticoid receptor polymorphisms and long-term respiratory outcome after very preterm birth.
Baas EM, Romijn M, van der Pal SM, Vrijlandt EJLE, Rotteveel J, Finken MJJ, Dutch POPS-19 Collaborative Study Group
Abstract
Cited 7 times since 2021 (1.6 per year)
source: EuropePMC
Heart rhythm O2,
Volume 2, Issue 3, 19 3 2021, Pages 290-297
Predicting early reconnection after cryoballoon ablation with procedural and biophysical parameters.
Keçe F, de Riva M, Alizadeh Dehnavi R, Wijnmaalen AP, Mertens BJ, Schalij MJ, Zeppenfeld K, Trines SA
Background: Predicting early reconnection/dormant conduction (ERC) immediately after pulmonary vein isolation (PVI) can avoid a waiting period with adenosine testing. Objective: To identify procedural and biophysical parameters predicting ERC. Methods: Consecutive atrial fibrillation (AF) patients undergoing a first cryoballoon ablation (Arctic Front Advance) between 2014 and 2017 were included. ERC was defined as manifest or dormant pulmonary vein (PV) reconnection with adenosine 30 minutes aft...
Abstract
Cited 3 times since 2021 (0.7 per year)
source: EuropePMC
Diagnostics (Basel, Switzerland),
Volume 11, Issue 3, 19 3 2021, Pages 553
Radioiodine in Differentiated Thyroid Carcinoma: Do We Need Diagnostic Pre-Ablation Iodine-123 Scintigraphy to Optimize Treatment?
de Koster EJ, Sulaiman T, Hamming JF, Schepers A, Snel M, van Velden FHP, de Geus-Oei LF, Vriens D
Changing insights regarding radioiodine (I-131) administration in differentiated thyroid carcinoma (DTC) stir up discussions on the utility of pre-ablation diagnostic scintigraphy (DxWBS). Our retrospective study qualitatively and semi-quantitatively assessed posttherapy I-131 whole-body scintigraphy (TxWBS) data for thyroid remnant size and metastasis. Findings were associated with initial treatment success after nine months, as well as clinical, histopathological, and surgical parameters. Poss...
Abstract
Cited 9 times since 2021 (2 per year)
source: EuropePMC
Cancers,
Volume 13, Issue 6, 18 3 2021, Pages 1370
Germline Variation in <i>PDCD1</i> Is Associated with Overall Survival in Patients with Metastatic Melanoma Treated with Anti-PD-1 Monotherapy.
de With M, Hurkmans DP, Oomen-de Hoop E, Lalouti A, Bins S, El Bouazzaoui S, van Brakel M, Debets R, Aerts JGJV, van Schaik RHN, Mathijssen RHJ, van der Veldt AAM
A substantial number of melanoma patients do not benefit from therapy with anti-PD-1. Therefore, we investigated the predictive value of single nucleotide polymorphisms (SNPs) in genes related to the PD-1 axis in patients with metastatic melanoma. From 119 consecutive melanoma patients who were treated with pembrolizumab or nivolumab monotherapy, blood samples were genotyped for 11 SNPs in nine genes. Associations between SNPs and OS were tested using Cox regression analysis and internally valid...
Abstract
Cited 14 times since 2021 (3.2 per year)
source: EuropePMC
BMC medicine,
Volume 19, Issue 1, 18 3 2021, Pages 69
Investigating the relationships between unfavourable habitual sleep and metabolomic traits: evidence from multi-cohort multivariable regression and Mendelian randomization analyses.
Bos MM, Goulding NJ, Lee MA, Hofman A, Bot M, Pool R, Vijfhuizen LS, Zhang X, Li C, Mustafa R, Neville MJ, Li-Gao R, Trompet S, Beekman M, Biermasz NR, Boomsma DI, de Boer I, Christodoulides C, Dehghan A, van Dijk KW, Ford I, Ghanbari M, Heijmans BT, Ikram MA, Jukema JW, Mook-Kanamori DO, Karpe F, Luik AI, Lumey LH, van den Maagdenberg AMJM, Mooijaart SP, de Mutsert R, Penninx BWJH, Rensen PCN, Richmond RC, Rosendaal FR, Sattar N, Schoevers RA, Slagboom PE, Terwindt GM, Thesing CS, Wade KH, Wijsman CA, Willemsen G, Zwinderman AH, van Heemst D, Noordam R, Lawlor DA
Background: Sleep traits are associated with cardiometabolic disease risk, with evidence from Mendelian randomization (MR) suggesting that insomnia symptoms and shorter sleep duration increase coronary artery disease risk. We combined adjusted multivariable regression (AMV) and MR analyses of phenotypes of unfavourable sleep on 113 metabolomic traits to investigate possible biochemical mechanisms linking sleep to cardiovascular disease. Methods: We used AMV (N = 17,368) combined with two-sample...
Abstract
Cited 6 times since 2021 (1.4 per year)
source: EuropePMC
Journal of molecular and cellular cardiology,
Volume 156, 18 3 2021, Pages 95-104
New calcification model for intact murine aortic valves.
Kruithof BPT, van de Pol V, Los T, Lodder K, Mousavi Gourabi B, DeRuiter MC, Goumans MJ, Ajmone Marsan N
Calcific aortic valve disease (CAVD) is a common progressive disease of the aortic valves, for which no medical treatment exists and surgery represents currently the only therapeutic solution. The development of novel pharmacological treatments for CAVD has been hampered by the lack of suitable test-systems, which require the preservation of the complex valve structure in a mechanically and biochemical controllable system. Therefore, we aimed at establishing a model which allows the study of cal...
Abstract
JACC. Cardiovascular imaging,
Volume 14, Issue 8, 17 3 2021, Pages 1581-1583
Computed Tomography to Select Patients for Transcatheter Mitral Valve Replacement: The Challenge of Standardization.
Delgado V, van Rosendael PJ
Abstract
Cited 8 times since 2021 (1.8 per year)
source: EuropePMC
Scientific reports,
Volume 11, Issue 1, 17 3 2021, Pages 6132
Differential gene expression profile between progressive and de novo muscle invasive bladder cancer and its prognostic implication.
Carrasco R, Izquierdo L, van der Heijden AG, Lozano JJ, Franco M, Ingelmo-Torres M, Roldan FL, Llorens M, Ribal MJ, Mengual L, Alcaraz A
This study aimed to ascertain gene expression profile differences between progressive muscle-invasive bladder cancer (MIBC) and de novo MIBC, and to identify prognostic biomarkers to improve patients' treatment. Retrospective multicenter study in which 212 MIBC patients who underwent radical cystectomy between 2000 and 2019 were included. Gene expression profiles were determined in 26 samples using Illumina microarrays. The expression levels of 94 genes were studied by quantitative PCR in a...
Abstract
Cited 5 times since 2021 (1.1 per year)
source: EuropePMC
Frontiers in cardiovascular medicine,
Volume 8, 16 3 2021, Pages 644193
Validation and Feasibility of Echocardiographic Assessment of Systemic Right Ventricular Function: Serial Correlation With MRI.
Zandstra TE, Jongbloed MRM, Widya RL, Ten Harkel ADJ, Holman ER, Mertens BJA, Vliegen HW, Egorova AD, Schalij MJ, Kiès P
Background: Inherent to its geometry, echocardiographic imaging of the systemic right ventricle (RV) is challenging. Therefore, echocardiographic assessment of systemic RV function may not always be feasible and/or reproducible in daily practice. Here, we aim to validate the usefulness of a comprehensive range of 32 echocardiographic measurements of systemic RV function in a longitudinal cohort by serial assessment of their correlations with cardiac magnetic resonance (CMR)-derived systemic RV e...
Abstract
Cited 12 times since 2021 (2.7 per year)
source: EuropePMC
Teaching and learning in medicine,
Volume 33, Issue 5, 15 3 2021, Pages 473-482
What Were You Thinking? Medical Students' Metacognition and Perceptions of Self-Regulated Learning.
Versteeg M, Bressers G, Wijnen-Meijer M, Ommering BWC, de Beaufort AJ, Steendijk P
Phenomenon: As a component of self-regulated learning, metacognition is gaining attention in the medical education research community. Metacognition, simply put, is thinking about one's thinking. Having a metacognitive habit of mind is essential for healthcare professionals. This study identified the metacognitive competencies of medical students as they completed a conceptual learning task, and provided insight into students' perceptions of self-regulated learning in their curriculum....
Abstract
Cited 17 times since 2021 (3.8 per year)
source: EuropePMC
Diabetes care,
Volume 44, Issue 5, 15 3 2021, Pages 1219-1227
Relation of Lipoprotein(a) Levels to Incident Type 2 Diabetes and Modification by Alirocumab Treatment.
Schwartz GG, Szarek M, Bittner VA, Bhatt DL, Diaz R, Goodman SG, Jukema JW, Loy M, Manvelian G, Pordy R, White HD, Steg PG, ODYSSEY OUTCOMES Committees and Investigators
Objective: In observational data, lower levels of lipoprotein(a) have been associated with greater prevalence of type 2 diabetes. Whether pharmacologic lowering of lipoprotein(a) influences incident type 2 diabetes is unknown. We determined the relationship of lipoprotein(a) concentration with incident type 2 diabetes and effects of treatment with alirocumab, a PCSK9 inhibitor. Research design and methods: In the ODYSSEY OUTCOMES trial alirocumab was compared with placebo in patients with acute...
Abstract
Cited 31 times since 2021 (7 per year)
source: EuropePMC
Circulation. Arrhythmia and electrophysiology,
Volume 14, Issue 4, 15 3 2021, Pages e009135
Posterior Left Atrial Adipose Tissue Attenuation Assessed by Computed Tomography and Recurrence of Atrial Fibrillation After Catheter Ablation.
El Mahdiui M, Simon J, Smit JM, Kuneman JH, van Rosendael AR, Steyerberg EW, van der Geest RJ, Száraz L, Herczeg S, Szegedi N, Gellér L, Delgado V, Merkely B, Bax JJ, Maurovich-Horvat P
[Figure: see text].
Abstract
Cited 15 times since 2021 (3.4 per year)
source: EuropePMC
ESC heart failure,
Volume 8, Issue 3, 13 2 2021, Pages 1924-1932
Prognostic impact of acute pulmonary triggers in patients with takotsubo syndrome: new insights from the International Takotsubo Registry.
Kato K, Cammann VL, Napp LC, Szawan KA, Micek J, Dreiding S, Levinson RA, Petkova V, Würdinger M, Patrascu A, Sumalinog R, Gili S, Clarenbach CF, Kohler M, Wischnewsky M, Citro R, Vecchione C, Bossone E, Neuhaus M, Franke J, Meder B, Jaguszewski M, Noutsias M, Knorr M, Heiner S, D'Ascenzo F, Dichtl W, Burgdorf C, Kherad B, Tschöpe C, Sarcon A, Shinbane J, Rajan L, Michels G, Pfister R, Cuneo A, Jacobshagen C, Karakas M, Koenig W, Pott A, Meyer P, Roffi M, Banning A, Wolfrum M, Cuculi F, Kobza R, Fischer TA, Vasankari T, Airaksinen KEJ, Budnik M, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Chan C, Bridgman P, Beug D, Delmas C, Lairez O, Gilyarova E, Shilova A, Gilyarov M, El-Battrawy I, Akin I, Kozel M, Tousek P, Winchester DE, Galuszka J, Ukena C, Poglajen G, Carrilho-Ferreira P, Hauck C, Paolini C, Bilato C, Sano M, Ishibashi I, Takahara M, Himi T, Kobayashi Y, Prasad A, Rihal CS, Liu K, Schulze PC, Bianco M, Jörg L, Rickli H, Pestana G, Nguyen TH, Böhm M, Maier LS, Pinto FJ, Widimský P, Feli
Aims: Acute pulmonary disorders are known physical triggers of takotsubo syndrome (TTS). This study aimed to investigate prevalence of acute pulmonary triggers in patients with TTS and their impact on outcomes. Methods and results: Patients with TTS were enrolled from the International Takotsubo Registry and screened for triggering factors and comorbidities. Patients were categorized into three groups (acute pulmonary trigger, chronic lung disease, and no lung disease) to compare clinical charac...
Abstract
Cited 68 times since 2021 (15.3 per year)
source: EuropePMC
Atherosclerosis,
Volume 324, 13 2 2021, Pages 46-51
Atherogenic index of plasma and the risk of rapid progression of coronary atherosclerosis beyond traditional risk factors.
Won KB, Heo R, Park HB, Lee BK, Lin FY, Hadamitzky M, Kim YJ, Sung JM, Conte E, Andreini D, Pontone G, Budoff MJ, Gottlieb I, Chun EJ, Cademartiri F, Maffei E, Marques H, de Araújo Gonçalves P, Leipsic JA, Lee SE, Shin S, Choi JH, Virmani R, Samady H, Chinnaiyan K, Berman DS, Narula J, Shaw LJ, Bax JJ, Min JK, Chang HJ
Background and aims: The atherogenic index of plasma (AIP) has been suggested as a marker of plasma atherogenicity. This study aimed to assess the association between AIP and the rapid progression of coronary atherosclerosis using serial coronary computed tomography angiography (CCTA). Methods: A total of 1488 adults (60.9 ± 9.2 years, 58.9% male) who underwent serial CCTA with a median inter-scan period of 3.4 years were included. AIP was defined as the base 10 logarithm of the ratio of the con...
Abstract
Cited 12 times since 2021 (2.7 per year)
source: EuropePMC
Atherosclerosis,
Volume 323, 13 2 2021, Pages 13-19
An elevated ankle-brachial index is not a valid proxy for peripheral medial arterial calcification.
Hoek AG, Zwakenberg SR, Elders PJM, de Jong PA, Spiering W, Bartstra JW, Doesburg T, van der Heijden AA, van der Schouw YT, Beulens JWJ, SMART Study Group
Background and aims: The ankle brachial index (ABI) is often used as a proxy for medial arterial calcification (MAC) in studies investigating MAC as a cardiovascular risk factor, but evidence supporting this hypothesis is sparse. This study aims to investigate the use of an elevated ABI as proxy for MAC, as visualized with computed tomography (CT). Methods: Cross-sectional data of 718 participants with, or at risk of cardiovascular disease was used. The ABI was calculated using cutoffs >1.4 a...
Abstract
Cited 46 times since 2021 (10.4 per year)
source: EuropePMC
Nature communications,
Volume 12, Issue 1, 12 2 2021, Pages 1614
Model-based evaluation of school- and non-school-related measures to control the COVID-19 pandemic.
Rozhnova G, van Dorp CH, Bruijning-Verhagen P, Bootsma MCJ, van de Wijgert JHHM, Bonten MJM, Kretzschmar ME
The role of school-based contacts in the epidemiology of SARS-CoV-2 is incompletely understood. We use an age-structured transmission model fitted to age-specific seroprevalence and hospital admission data to assess the effects of school-based measures at different time points during the COVID-19 pandemic in the Netherlands. Our analyses suggest that the impact of measures reducing school-based contacts depends on the remaining opportunities to reduce non-school-based contacts. If opportunities...
Abstract
