Research

Publications

Below you can find a list of our published research.

9618 results

Cited 12 times since 2020 (2.2 per year) source: EuropePMC

Chemosphere, Volume 254, 11 2 2020, Pages 126604 Ecological risks of imidacloprid to aquatic species in the Netherlands: Measured and estimated concentrations compared to species sensitivity distributions. Thunnissen NW, Lautz LS, van Schaik TWG, Hendriks AJ

Recent declines of insects' biomass have been a major point of interest. While several causes, including use of neonicotinoids like imidacloprid, have been suggested, scientific underpinning is limited. The aim of our study was to assess the potential risk of imidacloprid for freshwater fauna in the Netherlands and to validate the SimpleBox model to allow application elsewhere. To this end, we compared imidacloprid concentrations estimated from emissions using the SimpleBox model to measure... Abstract

Cited 8 times since 2020 (1.5 per year) source: EuropePMC

Journal of cardiovascular computed tomography, Volume 14, Issue 6, 11 2 2020, Pages 520-523 4D MDCT in the assessment of the tricuspid valve and its spatial relationship with the right coronary artery: A customized tool based on computed tomography for the planning of percutaneous procedures. Pappalardo OA, Votta E, Selmi M, Luciani GB, Redaelli A, Delgado V, Bax JJ, Ajmone Marsan N

Multidetector computed tomography (MDCT) is currently the imaging technique of choice for the assessment of tricuspid valve (TV) annulus geometry and relationship with the right coronary artery (RCA). However, standardized protocols with a full 3D analysis are still lacking to plan percutaneous procedures for functional tricuspid regurgitation (FTR). A novel customized 4-dimensional tool based on MDCT data was developed and provided accurate information on TV annulus morphology (3D-perimeter, 2D... Abstract

Cited 23 times since 2020 (4.3 per year) source: EuropePMC

Journal of medical genetics, Volume 57, Issue 12, 10 2 2020, Pages 843-850 Identification of known and unknown genes associated with mitral valve prolapse using an exome slice methodology. van Wijngaarden AL, Hiemstra YL, Koopmann TT, Ruivenkamp CAL, Aten E, Schalij MJ, Bax JJ, Delgado V, Barge-Schaapveld DQCM, Ajmone Marsan N

Purpose: Although a familial distribution has been documented, the genetic aetiology of mitral valve prolapse (MVP) is largely unknown, with only four genes identified so far: FLNA, DCHS1, DZIP1 and PLD1. The aim of this study was to evaluate the genetic yield in known causative genes and to identify possible novel genes associated with MVP using a heart gene panel based on exome sequencing. Methods: Patients with MVP were referred for genetic counselling when a positive family history for MVP w... Abstract

Cited 1 times since 2020 (0.2 per year) source: EuropePMC

Stem cell research, Volume 45, 8 2 2020, Pages 101764 Generation of two human induced pluripotent stem cell lines, LUMCi020-A and LUMCi021-A, from two patients with Catecholaminergic Polymorphic Ventricular Tachycardia carrying heterozygous mutations in the RYR2 gene. Meraviglia V, Arendzen CH, Freund C, Atsma DE, Mummery CL, Bellin M

Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) is a malignant channelopathy associated with exercise- and stress-induced cardiac sudden death. The autosomal dominant form of CPVT is due to mutations in the ryanodine receptor 2 (RYR2) gene. We generated induced pluripotent stem cells (hiPSCs) from skin fibroblasts of two patients carrying the c.12441 G>T and c.14885 A>G RYR2 missense mutations, respectively, using non-integrating Sendai virus. These lines show the typical morp... Abstract

Cited 3 times since 2020 (0.6 per year) source: EuropePMC

JMIR human factors, Volume 7, Issue 2, 8 2 2020, Pages e17131 Teamwork and Safety Attitudes in Complex Aortic Surgery at a Dutch Hospital: Cross-Sectional Survey Study. Hilt AD, Kaptein AA, Schalij MJ, van Schaik J

Background: Improving teamwork in surgery is a complex goal and difficult to achieve. Human factors questionnaires, such as the Safety Attitudes Questionnaire (SAQ), can help us understand medical teamwork and may assist in achieving this goal. Objective: This paper aimed to assess local team and safety culture in a cardiovascular surgery setting to understand how purposeful teamwork improvements can be reached. Methods: Two cardiovascular surgical teams performing complex aortic treatments were... Abstract

Cited 11 times since 2020 (2.1 per year) source: EuropePMC

Journal of molecular and cellular cardiology, Volume 143, 8 2 2020, Pages 26-37 Human epicardium-derived cells reinforce cardiac sympathetic innervation. Ge Y, Smits AM, van Munsteren JC, Gittenberger-de Groot AC, Poelmann RE, van Brakel TJ, Schalij MJ, Goumans MJ, DeRuiter MC, Jongbloed MRM

Rationale: After cardiac damage, excessive neurite outgrowth (sympathetic hyperinnervation) can occur, which is related to ventricular arrhythmias/sudden cardiac death. Post-damage reactivation of epicardium causes epicardium-derived cells (EPDCs) to acquire a mesenchymal character, contributing to cardiac regeneration. Whether EPDCs also contribute to cardiac re/hyperinnervation, is unknown. Aim: To investigate whether mesenchymal EPDCs influence cardiac sympathetic innervation. Methods and res... Abstract

Cited 29 times since 2020 (5.4 per year) source: EuropePMC

Atherosclerosis, Volume 301, 6 1 2020, Pages 37-43 The relation between healthy lifestyle changes and decrease in systemic inflammation in patients with stable cardiovascular disease. van 't Klooster CC, van der Graaf Y, Ridker PM, Westerink J, Hjortnaes J, Sluijs I, Asselbergs FW, Bots ML, Kappelle LJ, Visseren FLJ, UCC-SMART study group

Background and aims: Pharmacological lowering of inflammation has proven effective in reducing recurrent cardiovascular event rates. Aim of the current study is to evaluate lifestyle changes (smoking cessation, weight loss, physical activity level increase, alcohol moderation, and a summary lifestyle improvement score) in relation to change in plasma C-reactive protein (CRP) concentration in patients with established cardiovascular disease. Methods: In total, 1794 patients from the UCC-SMART coh... Abstract

Cited 36 times since 2020 (6.7 per year) source: EuropePMC

Circulation research, Volume 127, Issue 2, 6 1 2020, Pages 229-243 Identification of Functional Variant Enhancers Associated With Atrial Fibrillation. van Ouwerkerk AF, Bosada FM, Liu J, Zhang J, van Duijvenboden K, Chaffin M, Tucker NR, Pijnappels D, Ellinor PT, Barnett P, de Vries AAF, Christoffels VM

Rationale: Genome-wide association studies have identified a large number of common variants (single-nucleotide polymorphisms) associated with atrial fibrillation (AF). These variants are located mainly in noncoding regions of the genome and likely include variants that modulate the function of transcriptional regulatory elements (REs) such as enhancers. However, the actual REs modulated by variants and the target genes of such REs remain to be identified. Thus, the biological mechanisms by whic... Abstract

Cited 1 times since 2020 (0.2 per year) source: EuropePMC

Heart and vessels, Volume 35, Issue 9, 4 1 2020, Pages 1290-1298 Influence of long-standing pulmonary arterial hypertension and its severity on pulmonary artery aneurysm development. Nuche J, Montero-Cabezas JM, Lareo A, Huertas S, Jiménez López-Guarch C, Velázquez Martín M, Alonso Charterina S, Revilla Ostolaza Y, Delgado JF, Arribas Ynsaurriaga F, Escribano Subías P

Pulmonary artery aneurysm (PAA) is a common finding in patients with long-term pulmonary arterial hypertension (PAH). The influence of PAH severity in the development of PAA remains unclear. We sought to determine whether PAA development is related to PAH severity and whether treatment optimization based on risk profile estimation is effective to stop pulmonary artery (PA) enlargement. This is a retrospective study of 125 PAH patients who underwent an imaging test (computed tomography or magneti... Abstract

Cited 4 times since 2020 (0.7 per year) source: EuropePMC

Journal of cardiology, Volume 76, Issue 3, 4 1 2020, Pages 287-294 Blood biomarkers in patients with bicuspid aortic valve disease. Bons LR, Geenen LW, van den Hoven AT, Dik WA, van den Bosch AE, Duijnhouwer AL, Siebelink HJ, Budde RPJ, Boersma E, Wessels MW, van de Laar IMBH, DeRuiter MC, Goumans MJ, Loeys BL, Roos-Hesselink JW

Background: Patients with a bicuspid aortic valve (BAV) are at risk of developing valve deterioration and aortic dilatation. We aimed to investigate whether blood biomarkers are associated with disease stage in patients with BAV. Methods: Serum levels of high sensitivity C-reactive protein (hsCRP), high sensitivity troponin T (hsTnT), N-terminal pro-B-type natriuretic peptide (NT-proBNP), and total transforming growth factor-beta 1 (TGF-ß1) were measured in adult BAV patients with valve dysfunct... Abstract

Cited 6 times since 2020 (1.1 per year) source: EuropePMC

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, Volume 29, Issue 8, 4 1 2020, Pages 2231-2239 Minimal important change in physical function in trauma patients: a study using the short musculoskeletal function assessment. de Graaf MW, Reininga IHF, Heineman E, El Moumni M

Purpose: The Short Musculoskeletal Function Assessment (SMFA) questionnaire can be used to evaluate physical functioning in patients with traumatic injuries. It is not known what change in score reflects a meaningful change to patients. The aim was to determine minimal important change (MIC) values of the subscales (0-100) of the Dutch SMFA-NL in a sample of patients with a broad range of injuries. Methods: Patients between 18 and 65 years of age completed the SMFA-NL and the Global Rating of Ef... Abstract

Cited 23 times since 2020 (4.3 per year) source: EuropePMC

Diabetologia, Volume 63, Issue 6, 3 1 2020, Pages 1110-1119 Prediction models for development of retinopathy in people with type 2 diabetes: systematic review and external validation in a Dutch primary care setting. van der Heijden AA, Nijpels G, Badloe F, Lovejoy HL, Peelen LM, Feenstra TL, Moons KGM, Slieker RC, Herings RMC, Elders PJM, Beulens JW

Aims/hypothesis: The aims of this study were to identify all published prognostic models predicting retinopathy risk applicable to people with type 2 diabetes, to assess their quality and accuracy, and to validate their predictive accuracy in a head-to-head comparison using an independent type 2 diabetes cohort. Methods: A systematic search was performed in PubMed and Embase in December 2019. Studies that met the following criteria were included: (1) the model was applicable in type 2 diabetes;... Abstract

Cited 13 times since 2020 (2.4 per year) source: EuropePMC

Japan journal of nursing science : JJNS, Volume 17, Issue 4, 2 1 2020, Pages e12338 Effects of three different methods used during heel lance procedures on pain level in term neonates. Yilmaz D, Inal S

Aim: This study aims to experimentally determine effects of three different methods (swaddling; swaddling and holding; swaddling, holding and breastfeeding) used during heel lancing on pain levels in healthy term neonates. Methods: This study was a prospective, randomized controlled trial. The sample of newborns (n = 160) were allocated to the groups (group 1, control; group 2, swaddling; group 3, swaddling and holding; group 4, swaddling, holding and breastfeeding) by blocked randomization. The... Abstract

Cited 33 times since 2020 (6.1 per year) source: EuropePMC

JAMA internal medicine, Volume 180, Issue 4, 1 1 2020, Pages 533-541 Effect of No Prehydration vs Sodium Bicarbonate Prehydration Prior to Contrast-Enhanced Computed Tomography in the Prevention of Postcontrast Acute Kidney Injury in Adults With Chronic Kidney Disease: The Kompas Randomized Clinical Trial. Timal RJ, Kooiman J, Sijpkens YWJ, de Vries JPM, Verberk-Jonkers IJAM, Brulez HFH, van Buren M, van der Molen AJ, Cannegieter SC, Putter H, van den Hout WB, Jukema JW, Rabelink TJ, Huisman MV

Importance: Prevention of postcontrast acute kidney injury in patients with stage 3 chronic kidney disease (CKD) by means of prehydration has been standard care for years. However, evidence for the need for prehydration in this group is limited. Objective: To assess the renal safety of omitting prophylactic prehydration prior to iodine-based contrast media administration in patients with stage 3 CKD. Design, setting, and participants: The Kompas trial was a multicenter, noninferiority, randomize... Abstract

Cited 3 times since 2020 (0.6 per year) source: EuropePMC

World journal of surgery, Volume 44, Issue 4, 1 1 2020, Pages 1309-1315 Is Ischemia-Modified Albumin a Reliable Marker in Accurate Diagnosis of Appendicitis in Children? Ulusoy E, Çitlenbik H, Akgül F, Öztürk A, Şık N, Ulusoy O, Küme T, Yılmaz D, Duman M

Background: Acute appendicitis is one of the most common abdominal emergencies. Despite all improvements in diagnostic techniques, there are still ongoing problems as proper diagnosis, misdiagnosis and perforated appendicitis. The aim of this study is to demonstrate the clinical value of IMA in patients with appendicitis and to determine the accurate diagnosis of appendicitis in clinically suspected patients. Methods: Pediatric patients with acute abdominal pain who had the Pediatric Appendiciti... Abstract

Cited 4 times since 2020 (0.7 per year) source: EuropePMC

Medicine, Volume 99, Issue 17, 1 1 2020, Pages e19851 Pain acceptance levels of patients with chronic pain. Çinar HG, Yilmaz D, Akin E

This study was conducted with the aim of determining pain acceptance levels in patients with chronic pain attending an algology outpatients' department.The research was conducted as a descriptive and cross-sectional study. The population of the study consisted of 97 patients with chronic pain who attended the Algology Outpatients' Department of the Health Implementation and Research Center of Bursa Uludağ University. A Patient Description Form and a Chronic Pain Acceptance Questionnair... Abstract

Cited 16 times since 2020 (3 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 21, Issue 4, 1 1 2020, Pages 357-362 The evaluation of aortic stenosis, how the new guidelines are implemented across Europe: a survey by EACVI. Michalski B, Dweck MR, Marsan NA, Cameli M, D'Andrea A, Carvalho RF, Holte E, Podlesnikar T, Manka R, Haugaa KH

Aortic stenosis (AS) is the most prevalent valvular disease in developed countries, with a prevalence that is set to expand further with an ageing population. The most recent guidelines on valvular heart disease published by the European Society of Cardiology and the European Association for Cardio-Thoracic Surgery, aim to standardize the diagnosis and management of valvular heart diseases. The imaging criteria of the current guidelines are mostly based on EACVI Recommendations, with an appropri... Abstract

Cited 47 times since 2020 (8.7 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 75, Issue 16, 1 1 2020, Pages 1869-1877 Age-Related Variations in Takotsubo Syndrome. Cammann VL, Szawan KA, Stähli BE, Kato K, Budnik M, Wischnewsky M, Dreiding S, Levinson RA, Di Vece D, Gili S, Citro R, Bossone E, Neuhaus M, Franke J, Meder B, Jaguszewski M, Noutsias M, Knorr M, Heiner S, D'Ascenzo F, Dichtl W, Burgdorf C, Kherad B, Tschöpe C, Sarcon A, Shinbane J, Rajan L, Michels G, Pfister R, Cuneo A, Jacobshagen C, Karakas M, Koenig W, Pott A, Meyer P, Roffi M, Banning A, Wolfrum M, Cuculi F, Kobza R, Fischer TA, Vasankari T, Airaksinen KEJ, Napp LC, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Chan C, Bridgman P, Beug D, Delmas C, Lairez O, Gilyarova E, Shilova A, Gilyarov M, El-Battrawy I, Akin I, Poledniková K, Toušek P, Winchester DE, Galuszka J, Ukena C, Poglajen G, Carrilho-Ferreira P, Hauck C, Paolini C, Bilato C, Kobayashi Y, Shoji T, Ishibashi I, Takahara M, Himi T, Din J, Al-Shammari A, Prasad A, Rihal CS, Liu K, Schulze PC, Bianco M, Jörg L, Rickli H, Pestana G, Nguyen TH, Böhm M, Maier LS, Pinto FJ, Widimský P, Felix SB, Braun-Dullaeus RC, Rottbauer W, Hasenfu

Background: Takotsubo syndrome (TTS) occurs predominantly in post-menopausal women but is also found in younger patients. Objectives: This study aimed to investigate age-related differences in TTS. Methods: Patients diagnosed with TTS and enrolled in the International Takotsubo Registry between January 2011 and February 2017 were included in this analysis and were stratified by age (younger: ≤50 years, middle-age: 51 to 74 years, elderly: ≥75 years). Baseline characteristics, hospital course, as... Abstract

Cited 28 times since 2020 (5.2 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 21, Issue 4, 1 1 2020, Pages 363-374 Increased long-term mortality in women with high left ventricular ejection fraction: data from the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter) long-term registry. Gebhard C, Maredziak M, Messerli M, Buechel RR, Lin F, Gransar H, Achenbach S, Al-Mallah MH, Andreini D, Bax JJ, Berman DS, Budoff MJ, Cademartiri F, Callister TQ, Chang HJ, Chinnaiyan K, Chow BJW, Cury RC, DeLago A, Feuchtner G, Hadamitzky M, Hausleiter J, Kim YJ, Leipsic J, Maffei E, Marques H, Gonçalves PA, Pontone G, Raff GL, Rubinshtein R, Shaw LJ, Villines TC, Lu Y, Jones EC, Peña JM, Min JK, Kaufmann PA

Aims: There are significant sex-specific differences in left ventricular ejection fraction (LVEF), with a higher LVEF being observed in women. We sought to assess the clinical relevance of an increased LVEF in women and men. Methods and results: A total of 4632 patients from the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter) registry (44.8% women; mean age 58.7 ± 13.2 years in men and 59.5 ± 13.3 years in women, P = 0.05), in whom LVEF was measur... Abstract

JACC. Cardiovascular imaging, Volume 13, Issue 4, 1 1 2020, Pages 1099 The Authors Reply: Computed Tomography Angiography-Based Risk Discrimination: An Established Bright Future for Prognostication. van Rosendael AR, Min JK, Shaw LJ, Bax JJ

Abstract