Research

Publications

Below you can find a list of our published research.

9618 results

Cited 18 times since 2020 (3.2 per year) source: EuropePMC

Acta odontologica Scandinavica, Volume 78, Issue 5, 24 4 2020, Pages 327-331 Salivary human beta-defensins and cathelicidin levels in relation to periodontitis and type 2 diabetes mellitus. Yilmaz D, Topcu AO, Akcay EU, Altındis M, Gursoy UK

Objective: Type 2 diabetes mellitus (T2DM) is a well-defined risk factor of periodontitis and it can affect expression of human beta-defensins (hBDs) and cathelicidin (LL-37) as well. The aim of the present study was to evaluate the impact of periodontitis and T2DM on salivary concentrations of these antimicrobial peptides.Material and methods: Unstimulated saliva samples, together with full-mouth periodontal recordings were collected from 92 individuals with periodontitis (63 with T2DM and 21 s... Abstract

Cited 10 times since 2020 (1.8 per year) source: EuropePMC

The British journal of surgery, Volume 107, Issue 5, 24 4 2020, Pages 552-559 Safety of hospital discharge before return of bowel function after elective colorectal surgery. EuroSurg Collaborative

Background: Ileus is common after colorectal surgery and is associated with an increased risk of postoperative complications. Identifying features of normal bowel recovery and the appropriateness for hospital discharge is challenging. This study explored the safety of hospital discharge before the return of bowel function. Methods: A prospective, multicentre cohort study was undertaken across an international collaborative network. Adult patients undergoing elective colorectal resection between... Abstract

Cited 7 times since 2020 (1.3 per year) source: EuropePMC

Frontiers in oncology, Volume 9, 22 4 2020, Pages 1521 Implementation of Novel Molecular Biomarkers for Non-small Cell Lung Cancer in the Netherlands: How to Deal With Increasing Complexity. van den Broek D, Hiltermann TJN, Biesma B, Dinjens WNM, 't Hart NA, Hinrichs JWJ, Leers MPG, Monkhorst K, van Oosterhout M, Scharnhorst V, Schuuring E, Speel EM, van den Heuvel MM, van Schaik RHN, von der Thüsen J, Willems SM, de Visser L, Ligtenberg MJL

The diagnostic landscape of non-small cell lung cancer (NSCLC) is changing rapidly with the availability of novel treatments. Despite high-level healthcare in the Netherlands, not all patients with NSCLC are tested with the currently relevant predictive tumor markers that are necessary for optimal decision-making for today's available targeted or immunotherapy. An expert workshop on the molecular diagnosis of NSCLC involving pulmonary oncologists, clinical chemists, pathologists, and clinic... Abstract

Cited 6 times since 2020 (1.1 per year) source: EuropePMC

Thrombosis research, Volume 188, 21 3 2020, Pages 44-48 The association between leptin concentration and blood coagulation: Results from the NEO study. Buis DTP, Christen T, Smit RAJ, de Mutsert R, Jukema JW, Cannegieter SC, Lijfering WM, Rosendaal FR

Background: The adipocyte-derived hormone leptin has been associated with altered blood coagulation in in vitro studies. However, it is unclear whether this association is relevant in vivo and to what extent this association is influenced by total body fat. Therefore, we aimed to examine the association between serum leptin and blood coagulation while taking total body fat into account in a population-based cohort study. Methods: We performed a cross-sectional analysis with baseline measurements... Abstract

Cited 7 times since 2020 (1.3 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 110, Issue 3, 18 3 2020, Pages 956-961 Mitral Valve Replacement With the 15-mm Mechanical Valve: A 20-Year Multicenter Experience. IJsselhof RJ, Slieker MG, Hazekamp MG, Accord R, van Wetten H, Haas F, Schoof PH

Background: The aim of this study was to evaluate early and long-term outcomes (mortality and prosthetic valve replacement) after mitral valve replacement with the 15-mm St Jude Medical prosthesis (St Jude Medical, St Paul, MN). Methods: A multicenter, retrospective cohort study was performed among patients who underwent mitral valve replacement with a 15-mm St Jude Medical Masters prosthesis at 4 congenital cardiac centers in The Netherlands. Operative results were evaluated and echocardiograph... Abstract

Cited 6 times since 2020 (1.1 per year) source: EuropePMC

Ocular immunology and inflammation, Volume 28, Issue 7, 16 3 2020, Pages 1049-1055 Immunoblot and Polymerase Chain Reaction to Diagnose Ocular Syphilis and Neurosyphilis in HIV-positive and HIV-negative Patients. Smit D, De Graaf M, Meyer D, de Groot-Mijnes JDF

Purpose: To evaluate immunoblot (IB) and polymerase chain reaction (PCR) to diagnose ocular- and neurosyphilis. Methods: Prospective cross-sectional study. Aqueous humor (AH) and cerebrospinal fluid (CSF) samples were tested for treponemal DNA or antibodies to treponemal antigens. Results: Thirteen of 106 cases had positive syphilis serology of which 69.2% were HIV+ (median CD4+ = 181 cells/µL). Four cases met CDC criteria for neurosyphilis (3 confirmed, 1 probable) and 2 additional cases requir... Abstract

Cited 7 times since 2020 (1.3 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 13, Issue 5, 15 3 2020, Pages 1152-1160 Stress-Only Adenosine CMR Improves Diagnostic Yield in Stable Symptomatic Patients With Coronary Artery Calcium. Rijlaarsdam-Hermsen D, Lo-Kioeng-Shioe M, van Domburg RT, Deckers JW, Kuijpers D, van Dijkman PRM

Objectives: This study assessed whether adenosine stress-only perfusion cardiac magnetic resonance (CMR) following a positive coronary artery calcium (CAC) score improved the diagnostic yield of invasive coronary angiography (CAG) in patients with stable chest pain. The study also established the association between positive CAC scores and stress-induced myocardial ischemia. Background: The diagnostic yield of catheterization among patients with suspected coronary artery disease (CAD) is low. Im... Abstract

Cited 44 times since 2020 (7.9 per year) source: EuropePMC

Nature medicine, Volume 26, Issue 1, 13 2 2020, Pages 110-117 Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug-metabolite atlas. Liu J, Lahousse L, Nivard MG, Bot M, Chen L, van Klinken JB, Thesing CS, Beekman M, van den Akker EB, Slieker RC, Waterham E, van der Kallen CJH, de Boer I, Li-Gao R, Vojinovic D, Amin N, Radjabzadeh D, Kraaij R, Alferink LJM, Murad SD, Uitterlinden AG, Willemsen G, Pool R, Milaneschi Y, van Heemst D, Suchiman HED, Rutters F, Elders PJM, Beulens JWJ, van der Heijden AAWA, van Greevenbroek MMJ, Arts ICW, Onderwater GLJ, van den Maagdenberg AMJM, Mook-Kanamori DO, Hankemeier T, Terwindt GM, Stehouwer CDA, Geleijnse JM, 't Hart LM, Slagboom PE, van Dijk KW, Zhernakova A, Fu J, Penninx BWJH, Boomsma DI, Demirkan A, Stricker BHC, van Duijn CM

Progress in high-throughput metabolic profiling provides unprecedented opportunities to obtain insights into the effects of drugs on human metabolism. The Biobanking BioMolecular Research Infrastructure of the Netherlands has constructed an atlas of drug-metabolite associations for 87 commonly prescribed drugs and 150 clinically relevant plasma-based metabolites assessed by proton nuclear magnetic resonance. The atlas includes a meta-analysis of ten cohorts (18,873 persons) and uncovers 1,071 dr... Abstract

Cited 1 times since 2020 (0.2 per year) source: EuropePMC

EJVES vascular forum, Volume 47, 11 2 2020, Pages 87-89 Rupture of a Median Sacral Artery Aneurysm in a Patient with Vascular Ehlers Danlos Syndrome. Verhagen MJ, van der Meer RW, van Rijswijk CSP, van Schaik J

Introduction: Vascular Ehlers Danlos syndrome is a rare connective tissue disease that is associated with various arterial complications. Report: A 25 year old man with vascular Ehlers Danlos syndrome presented with acute lower back pain as a result of a ruptured aneurysm of the median sacral artery (MSA). Prior medical history included several vascular events resulting in a right iliac occlusion. The unusual location of aneurysmal disease of the MSA might be explained by extensive collateral fl... Abstract

Cited 11 times since 2020 (2 per year) source: EuropePMC

Clinical therapeutics, Volume 42, Issue 2, 11 2 2020, Pages 276-285 Pharmacokinetic, Pharmacodynamic, and Safety Profiles of Ferric Carboxymaltose in Chinese Patients with Iron-deficiency Anemia. Ding Y, Zhu X, Li X, Zhang H, Wu M, Liu J, Palmen M, Roubert B, Li C

Purpose: Iron deficiency (ID) is one of the most commonly known nutritional deficiencies and is considered the primary cause of anemia (iron-deficiency anemia). Ferric carboxymaltose (FCM), an intravenous iron preparation, has been widely used for >10 years for iron-deficiency anemia treatment worldwide because of its many advantages. Methods: This single-center, open-label, single dose escalation study in Chinese subjects was designed to assess the pharmacokinetic/pharmacodynamic parameters... Abstract

Cited 22 times since 2020 (3.9 per year) source: EuropePMC

Biotechnology progress, Volume 36, Issue 3, 9 2 2020, Pages e2947 Application of Raman spectroscopy in monoclonal antibody producing continuous systems for downstream process intensification. Yilmaz D, Mehdizadeh H, Navarro D, Shehzad A, O'Connor M, McCormick P

Monoclonal antibodies (mAbs) are biopharmaceuticals produced by mammalian cell lines in bioreactors at a variety of scales. Cell engineering, media optimization, process monitoring, and control strategies for in vitro production have become crucial subjects to meet increasing demand for these high value pharmaceuticals. Raman Spectroscopy has gained great attention in the pharmaceutical industry for process monitoring and control to maintain quality assurance. For the first time, this article de... Abstract

Cited 5 times since 2020 (0.9 per year) source: EuropePMC

The American journal of cardiology, Volume 125, Issue 7, 9 2 2020, Pages 1108-1114 Prognostic Implications of Renal Dysfunction in Patients With Aortic Stenosis. Vollema EM, Prihadi EA, Ng ACT, Gegenava T, Ajmone Marsan N, Bax JJ, Delgado V

Aortic stenosis (AS) and renal dysfunction share risk factors and often occur simultaneously. The influence of renal dysfunction on the prognosis of patients with various grades of AS has not been extensively described. The present study aimed to assess the prognostic implications of renal dysfunction in a large cohort of patients with aortic sclerosis and patients with various grades of AS. Patients diagnosed with various grades of AS by transthoracic echocardiography were assessed and divided... Abstract

Cited 535 times since 2020 (95.4 per year) source: EuropePMC

Nature communications, Volume 11, Issue 1, 9 2 2020, Pages 163 Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure. Shah S, Henry A, Roselli C, Lin H, Sveinbjörnsson G, Fatemifar G, Hedman ÅK, Wilk JB, Morley MP, Chaffin MD, Helgadottir A, Verweij N, Dehghan A, Almgren P, Andersson C, Aragam KG, Ärnlöv J, Backman JD, Biggs ML, Bloom HL, Brandimarto J, Brown MR, Buckbinder L, Carey DJ, Chasman DI, Chen X, Chen X, Chung J, Chutkow W, Cook JP, Delgado GE, Denaxas S, Doney AS, Dörr M, Dudley SC, Dunn ME, Engström G, Esko T, Felix SB, Finan C, Ford I, Ghanbari M, Ghasemi S, Giedraitis V, Giulianini F, Gottdiener JS, Gross S, Guðbjartsson DF, Gutmann R, Haggerty CM, van der Harst P, Hyde CL, Ingelsson E, Jukema JW, Kavousi M, Khaw KT, Kleber ME, Køber L, Koekemoer A, Langenberg C, Lind L, Lindgren CM, London B, Lotta LA, Lovering RC, Luan J, Magnusson P, Mahajan A, Margulies KB, März W, Melander O, Mordi IR, Morgan T, Morris AD, Morris AP, Morrison AC, Nagle MW, Nelson CP, Niessner A, Niiranen T, O'Donoghue ML, Owens AT, Palmer CNA, Parry HM, Perola M, Portilla-Fernandez E, Psaty BM, Regeneron Genetics Center, Rice KM, Ridker PM

Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report results from a GWAS meta-analysis of HF comprising 47,309 cases and 930,014 controls. Twelve independent variants at 11 genomic loci are associated with HF, all of which demonstrate one o... Abstract

Cited 5 times since 2020 (0.9 per year) source: EuropePMC

European journal of case reports in internal medicine, Volume 7, Issue 1, 9 2 2020, Pages 001351 Magnetic Resonance Direct Thrombus Imaging (MRDTI) Can Distinguish Between Old and New Thrombosis in the Abdominal Aorta: a Case Report. van Dam LF, Kroft LJ, Dronkers CE, van Schaik J, van Haren GR, Huisman MV, Klok FA

A 43-year-old man complaining of abdominal angina for several months showed a large suprarenal aneurysm of the abdominal aorta with extensive circumferential wall thrombosis, complete occlusion of the right renal artery and a critically stenosed left renal artery on CT angiography. He suffered from severe hypertension and renal failure. A percutaneous transluminal angioplasty (PTA) was planned. After the PTA procedure, which was complicated by the development of left renal artery occlusion, succ... Abstract

Cited 11 times since 2020 (2 per year) source: EuropePMC

Science advances, Volume 6, Issue 2, 8 2 2020, Pages eaaw2685 Early sociability fosters later exploratory tendency in wild immature orangutans. Schuppli C, van Noordwijk M, Atmoko SU, van Schaik C

Exploration is essential for skill acquisition and strongly facilitates cognitive performance. In humans, it is widely known that exploration and later cognitive performance are highly dependent on early social inputs. Here, we aim to shed light on the evolutionary roots of this process by studying the effects of variation in opportunities for social learning on the exploratory tendency of immature orangutans (Pongo spp.) in nature. We based our analyses on mixed cross-sectional, longitudinal da... Abstract

Cited 13 times since 2020 (2.3 per year) source: EuropePMC

Aging, Volume 12, Issue 2, 7 1 2020, Pages 1496-1511 Association of cardiovascular structure and function with cerebrovascular changes and cognitive function in older patients with end-stage renal disease. Zijlstra LE, Trompet S, Jukema JW, Kroft LJM, de Bresser J, van Osch MJP, Hammer S, Witjes MN, van Buren M, Mooijaart SP

The Dutch prospective multicenter cohort study COPE (Cognitive decline in Older Patients with End stage renal disease) aimed to investigate the association of cardiovascular structure and function with cerebrovascular changes and cognitive function in 85 older patients with chronic kidney disease stage 4 and 5, awaiting either dialysis or conservative care. MRI was performed measuring aortic stiffness (pulse wave velocity [PWV]) and cardiac systolic function (ejection fraction and cardiac index)... Abstract

Cited 73 times since 2020 (13 per year) source: EuropePMC

Nature communications, Volume 11, Issue 1, 7 1 2020, Pages 39 Heritability estimates for 361 blood metabolites across 40 genome-wide association studies. Hagenbeek FA, Pool R, van Dongen J, Draisma HHM, Jan Hottenga J, Willemsen G, Abdellaoui A, Fedko IO, den Braber A, Visser PJ, de Geus EJCN, Willems van Dijk K, Verhoeven A, Suchiman HE, Beekman M, Slagboom PE, van Duijn CM, BBMRI Metabolomics Consortium, Harms AC, Hankemeier T, Bartels M, Nivard MG, Boomsma DI

Metabolomics examines the small molecules involved in cellular metabolism. Approximately 50% of total phenotypic differences in metabolite levels is due to genetic variance, but heritability estimates differ across metabolite classes. We perform a review of all genome-wide association and (exome-) sequencing studies published between November 2008 and October 2018, and identify >800 class-specific metabolite loci associated with metabolite levels. In a twin-family cohort (N = 5117), these met... Abstract

Cited 23 times since 2020 (4.1 per year) source: EuropePMC

Journal of arrhythmia, Volume 36, Issue 1, 3 1 2020, Pages 1-58 2019 HRS/EHRA/APHRS/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias: Executive summary. Cronin EM, Bogun FM, Maury P, Peichl P, Chen M, Namboodiri N, Aguinaga L, Leite LR, Al-Khatib SM, Anter E, Berruezo A, Callans DJ, Chung MK, Cuculich P, d'Avila A, Deal BJ, Bella PD, Deneke T, Dickfeld TM, Hadid C, Haqqani HM, Kay GN, Latchamsetty R, Marchlinski F, Miller JM, Nogami A, Patel AR, Pathak RK, Saenz Morales LC, Santangeli P, Sapp JL, Sarkozy A, Soejima K, Stevenson WG, Tedrow UB, Tzou WS, Varma N, Zeppenfeld K

Ventricular arrhythmias are an important cause of morbidity and mortality and come in a variety of forms, from single premature ventricular complexes to sustained ventricular tachycardia and fibrillation. Rapid developments have taken place over the past decade in our understanding of these arrhythmias and in our ability to diagnose and treat them. The field of catheter ablation has progressed with the development of new methods and tools, and with the publication of large clinical trials. There... Abstract

Cited 122 times since 2020 (21.7 per year) source: EuropePMC

European heart journal, Volume 41, Issue 3, 1 1 2020, Pages 359-367 Machine learning of clinical variables and coronary artery calcium scoring for the prediction of obstructive coronary artery disease on coronary computed tomography angiography: analysis from the CONFIRM registry. Al'Aref SJ, Maliakal G, Singh G, van Rosendael AR, Ma X, Xu Z, Alawamlh OAH, Lee B, Pandey M, Achenbach S, Al-Mallah MH, Andreini D, Bax JJ, Berman DS, Budoff MJ, Cademartiri F, Callister TQ, Chang HJ, Chinnaiyan K, Chow BJW, Cury RC, DeLago A, Feuchtner G, Hadamitzky M, Hausleiter J, Kaufmann PA, Kim YJ, Leipsic JA, Maffei E, Marques H, Gonçalves PA, Pontone G, Raff GL, Rubinshtein R, Villines TC, Gransar H, Lu Y, Jones EC, Peña JM, Lin FY, Min JK, Shaw LJ

Aims: Symptom-based pretest probability scores that estimate the likelihood of obstructive coronary artery disease (CAD) in stable chest pain have moderate accuracy. We sought to develop a machine learning (ML) model, utilizing clinical factors and the coronary artery calcium score (CACS), to predict the presence of obstructive CAD on coronary computed tomography angiography (CCTA). Methods and results: The study screened 35 281 participants enrolled in the CONFIRM registry, who underwent ≥64 de... Abstract

Cited 3794 times since 2020 (673.8 per year) source: EuropePMC

European heart journal, Volume 41, Issue 3, 1 1 2020, Pages 407-477 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes. Knuuti J, Wijns W, Saraste A, Capodanno D, Barbato E, Funck-Brentano C, Prescott E, Storey RF, Deaton C, Cuisset T, Agewall S, Dickstein K, Edvardsen T, Escaned J, Gersh BJ, Svitil P, Gilard M, Hasdai D, Hatala R, Mahfoud F, Masip J, Muneretto C, Valgimigli M, Achenbach S, Bax JJ, ESC Scientific Document Group

Abstract