9400 results
Cited 6 times since 2019 (1.1 per year)
source: EuropePMC
The Journal of infectious diseases,
Volume 220, Issue 4, 1 1 2019, Pages 624-634
Chemokine Receptor 7 Is Essential for Coxiella burnetii Whole-Cell Vaccine-Induced Cellular Immunity but Dispensable for Vaccine-Mediated Protective Immunity.
Chen C, van Schaik EJ, Gregory AE, Vigil A, Felgner PL, Hendrix LR, Faris R, Samuel JE
Background: Protective immunity against Coxiella burnetii infection is conferred by vaccination with virulent (PI-WCV), but not avirulent (PII-WCV) whole-cell inactivated bacterium. The only well-characterized antigenic difference between virulent and avirulent C. burnetii is they have smooth and rough lipopolysaccharide (LPS), respectively. Methods: Mice were vaccinated with PI-WCV and PII-WCV. Humoral and cellular responses were evaluated using protein chip microarrays and ELISpots, respective...
Abstract
Cited 13 times since 2019 (2.3 per year)
source: EuropePMC
Academic medicine : journal of the Association of American Medical Colleges,
Volume 94, Issue 7, 1 1 2019, Pages 975-982
Exemplary Learning Environments for the Health Professions: A Vision.
van Schaik SM, Reeves SA, Headrick LA
In this article, the authors propose a vision for exemplary learning environments in which everyone involved in health professions education and health care collaborates toward optimal health for individuals, populations, and communities. Learning environments in the health professions can be conceptualized as complex adaptive systems, defined as a collection of individual agents whose actions are interconnected and follow a set of shared "simple rules." Using principles from complex a...
Abstract
Cited 5 times since 2019 (0.9 per year)
source: EuropePMC
The American journal of cardiology,
Volume 124, Issue 6, 1 1 2019, Pages 892-898
Defining Subclinical Myocardial Dysfunction and Implications for Patients With Diabetes Mellitus and Preserved Ejection Fraction.
Ng ACT, Bertini M, Ewe SH, van der Velde ET, Leung DY, Delgado V, Bax JJ
Left ventricular (LV) global longitudinal strain (GLS) can detect subclinical myocardial systolic dysfunction in individuals with diabetes. The present study investigates the clinical usefulness and incremental net benefit of identifying subclinical myocardial systolic dysfunction in individuals with diabetes. A cohort of 397 type 2 diabetic individuals was followed up for the occurrence of all-cause mortality. Clinical and echocardiographic data of diabetic patients were assessed retrospectivel...
Abstract
Cited 2 times since 2019 (0.4 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 56, Issue 1, 1 1 2019, Pages 210-212
Management of incidentally diagnosed pulmonary artery dissection in patients with pulmonary arterial hypertension.
Nuche J, Montero Cabezas JM, Alonso Charterina S, Escribano Subías P
Pulmonary artery dissection is a rare entity, usually discovered post-mortem. In recent years, reported cases of living patients with a pulmonary artery dissection are growing and represent a challenging situation for clinicians.
Abstract
Cited 1 times since 2019 (0.2 per year)
source: EuropePMC
European heart journal,
Volume 40, Issue 27, 1 1 2019, Pages 2203-2205
Characterizing mitral regurgitation in a contemporary population: prognostic implications.
Delgado V, Ajmone Marsan N, Bax JJ
Abstract
Cited 25 times since 2019 (4.4 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 74, Issue 4, 1 1 2019, Pages 538-549
Staging Cardiac Damage in Patients With Symptomatic Aortic Valve Stenosis.
Vollema EM, Amanullah MR, Ng ACT, van der Bijl P, Prevedello F, Sin YK, Prihadi EA, Marsan NA, Ding ZP, Généreux P, Pibarot P, Leon MB, Narula J, Ewe SH, Delgado V, Bax JJ
Background: In severe aortic stenosis (AS), patients often show extra-aortic valvular injury. Recently, a new staging system for severe AS has been proposed on the basis of the extent of cardiac damage. Objectives: The present study evaluated the prevalence and prognostic impact of these different stages of cardiac damage in a large, real-world, multicenter cohort of symptomatic severe AS patients. Methods: From the ongoing registries from 2 academic institutions, a total of 1,189 symptomatic se...
Abstract
Cited 38 times since 2019 (6.7 per year)
source: EuropePMC
JAMA cardiology,
Volume 4, Issue 7, 1 1 2019, Pages 613-619
Effect of the PCSK9 Inhibitor Evolocumab on Total Cardiovascular Events in Patients With Cardiovascular Disease: A Prespecified Analysis From the FOURIER Trial.
Murphy SA, Pedersen TR, Gaciong ZA, Ceska R, Ezhov MV, Connolly DL, Jukema JW, Toth K, Tikkanen MJ, Im K, Wiviott SD, Kurtz CE, Honarpour N, Giugliano RP, Keech AC, Sever PS, Sabatine MS
Importance: The PCSK9 inhibitor evolocumab reduced low-density lipoprotein cholesterol and first cardiovascular events in the Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk (FOURIER) trial, but patients remain at high risk of recurrent cardiovascular events. Objective: To evaluate the effect of evolocumab on total cardiovascular events, given the importance of total number of cardiovascular events to patients, clinicians, and health economists. Desi...
Abstract
Cited 15 times since 2019 (2.6 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 20, Issue 7, 1 1 2019, Pages 740-748
Determinants and prognostic implications of left ventricular mechanical dispersion in aortic stenosis.
Prihadi EA, Vollema EM, Ng ACT, Ajmone Marsan N, Bax JJ, Delgado V
Aims: The present study aimed at investigating the association between left ventricular (LV) mechanical dispersion measured with speckle tracking echocardiography and severity of aortic stenosis (AS) and its impact on prognosis. Methods and results: This retrospective study included 630 patients [age 72 (62-78) years, 61.4% men] with various grades of AS (mild AS, 19.8%; moderate AS, 37.0%; severe AS, 43.2%). LV mechanical dispersion (defined as standard deviation of time from Q/R on electrocard...
Abstract
Cited 113 times since 2019 (19.8 per year)
source: EuropePMC
The lancet. Diabetes & endocrinology,
Volume 7, Issue 8, 1 1 2019, Pages 618-628
Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial.
Ray KK, Colhoun HM, Szarek M, Baccara-Dinet M, Bhatt DL, Bittner VA, Budaj AJ, Diaz R, Goodman SG, Hanotin C, Harrington RA, Jukema JW, Loizeau V, Lopes RD, Moryusef A, Murin J, Pordy R, Ristic AD, Roe MT, Tuñón J, White HD, Zeiher AM, Schwartz GG, Steg PG, ODYSSEY OUTCOMES Committees and Investigators
Background: After acute coronary syndrome, diabetes conveys an excess risk of ischaemic cardiovascular events. A reduction in mean LDL cholesterol to 1·4-1·8 mmol/L with ezetimibe or statins reduces cardiovascular events in patients with an acute coronary syndrome and diabetes. However, the efficacy and safety of further reduction in LDL cholesterol with an inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) after acute coronary syndrome is unknown. We aimed to explore this issue...
Abstract
Cited 3 times since 2019 (0.5 per year)
source: EuropePMC
Nature genetics,
Volume 51, Issue 7, 1 1 2019, Pages 1191-1192
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.
Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T, Giri A, Graff M, Guo X, Hendricks AE, Karaderi T, Lempradl A, Locke AE, Mahajan A, Marouli E, Sivapalaratnam S, Young KL, Alfred T, Feitosa MF, Masca NGD, Manning AK, Medina-Gomez C, Mudgal P, Ng MCY, Reiner AP, Vedantam S, Willems SM, Winkler TW, Abecasis G, Aben KK, Alam DS, Alharthi SE, Allison M, Amouyel P, Asselbergs FW, Auer PL, Balkau B, Bang LE, Barroso I, Bastarache L, Benn M, Bergmann S, Bielak LF, Blüher M, Boehnke M, Boeing H, Boerwinkle E, Böger CA, Bork-Jensen J, Bots ML, Bottinger EP, Bowden DW, Brandslund I, Breen G, Brilliant MH, Broer L, Brumat M, Burt AA, Butterworth AS, Campbell PT, Cappellani S, Carey DJ, Catamo E, Caulfield MJ, Chambers JC, Chasman DI, Chen YI, Chowdhury R, Christensen C, Chu AY, Cocca M, Collins FS, Cook JP, Corley J, Galbany JC, Cox AJ, Crosslin DS, Cuellar-Partida G, D'Eustacchio A, Danesh J, Davies G, Bakker PIW, Groot MCH, Mutsert R, Deary IJ, Dedoussis G, Demerath EW, Heijer M, Hol
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Abstract
Cited 11 times since 2019 (1.9 per year)
source: EuropePMC
Journal of vascular surgery,
Volume 70, Issue 1, 1 1 2019, Pages 286-297.e1
A systematic review of the use of near-infrared fluorescence imaging in patients with peripheral artery disease.
van den Hoven P, Ooms S, van Manen L, van der Bogt KEA, van Schaik J, Hamming JF, Vahrmeijer AL, van der Vorst JR, Mieog JSD
Objective: In the diagnosis of peripheral artery disease (PAD), the ankle-brachial index plays an important role. However, results of the ankle-brachial index are unreliable in patients with severe media sclerosis. Near-infrared (NIR) fluorescence imaging using indocyanine green (ICG) can provide information about tissue perfusion and has already been studied in oncologic, reconstructive, and cardiac surgery. For patients with PAD, this technique might give insight into skin perfusion and thereb...
Abstract
Cited 16 times since 2019 (2.8 per year)
source: EuropePMC
BMC medical genetics,
Volume 20, Issue 1, 1 1 2019, Pages 117
Overexpression of MicroRNA-148b-3p stimulates osteogenesis of human bone marrow-derived mesenchymal stem cells: the role of MicroRNA-148b-3p in osteogenesis.
Mollazadeh S, Fazly Bazzaz BS, Neshati V, de Vries AAF, Naderi-Meshkin H, Mojarad M, Mirahmadi M, Neshati Z, Kerachian MA
Background: Mesenchymal stem cells (MSCs) are attractive choices in regenerative medicine and can be genetically modified to obtain better results in therapeutics. Bone development and metabolism are controlled by various factors including microRNAs (miRs) interference, which are small non-coding endogenous RNAs. Methods: In the current study, the effects of forced miR-148b expression was evaluated on osteogenic activity. Human bone marrow-derived mesenchymal stem cells (BM-MSCs) were transduced...
Abstract
Cited 23 times since 2019 (4 per year)
source: EuropePMC
Biological reviews of the Cambridge Philosophical Society,
Volume 94, Issue 5, 27 4 2019, Pages 1809-1829
Multimodal communication and language origins: integrating gestures and vocalizations.
Fröhlich M, Sievers C, Townsend SW, Gruber T, van Schaik CP
The presence of divergent and independent research traditions in the gestural and vocal domains of primate communication has resulted in major discrepancies in the definition and operationalization of cognitive concepts. However, in recent years, accumulating evidence from behavioural and neurobiological research has shown that both human and non-human primate communication is inherently multimodal. It is therefore timely to integrate the study of gestural and vocal communication. Herein, we rev...
Abstract
Cited 18 times since 2019 (3.1 per year)
source: EuropePMC
Injury,
Volume 50, Issue 8, 25 4 2019, Pages 1440-1447
Older polytrauma: Mortality and complications.
de Vries R, Reininga IHF, de Graaf MW, Heineman E, El Moumni M, Wendt KW
Introduction: Older adults enduring a polytrauma have an increased mortality risk. Apart from age, the role of other predisposing factors on mortality are mainly described for the total polytrauma population. This study aimed to describe the mortality pattern of older polytrauma patients, its associated risk factors, and the role and etiology of in-hospital complications. Methods: An eight-year retrospective cohort was constructed from 380 polytrauma patients aged ≥65 in a Dutch level 1 trauma c...
Abstract
Cited 2 times since 2019 (0.3 per year)
source: EuropePMC
Veterinary sciences,
Volume 6, Issue 2, 22 4 2019, Pages E58
<i>Mycobacterium avium</i> subsp. <i>paratuberculosis</i> ELISA Responses in Milk Samples from Vaccinated and Nonvaccinated Dairy Goat Herds in The Netherlands.
Luttikholt S, Lievaart-Peterson K, Gonggrijp M, Aalberts M, van Schaik G, Vellema P
The aims of our study were to calculate the most appropriate cut-off value for milk samples in a serum-validated Mycobacterium avium subsp. paratuberculosis (MAP) ELISA and to analyze MAP ELISA responses in milk samples from vaccinated and nonvaccinated dairy goats in the Netherlands. Analyzed herds were representative for location and herd size of dairy goat herds in the Netherlands. A significantly higher proportion of the analyzed 49 herds were organic as compared with the total Dutch dairy g...
Abstract
Cited 34 times since 2019 (5.9 per year)
source: EuropePMC
APL bioengineering,
Volume 3, Issue 2, 21 3 2019, Pages 026105
Scalable microphysiological system to model three-dimensional blood vessels.
de Graaf MNS, Cochrane A, van den Hil FE, Buijsman W, van der Meer AD, van den Berg A, Mummery CL, Orlova VV
Blood vessel models are increasingly recognized to have value in understanding disease and drug discovery. However, continued improvements are required to more accurately reflect human vessel physiology. Realistic three-dimensional (3D) in vitro cultures of human vascular cells inside microfluidic chips, or vessels-on-chips (VoC), could contribute to this since they can recapitulate aspects of the in vivo microenvironment by including mechanical stimuli such as shear stress. Here, we used human...
Abstract
Cited 4 times since 2019 (0.7 per year)
source: EuropePMC
European radiology experimental,
Volume 3, Issue 1, 20 3 2019, Pages 24
The effects of age at correction of aortic coarctation and recurrent obstruction on adolescent patients: MRI evaluation of wall shear stress and pulse wave velocity.
Juffermans JF, Nederend I, van den Boogaard PJ, Ten Harkel ADJ, Hazekamp MG, Lamb HJ, Roest AAW, Westenberg JJM
Background: Coarctation patients before curative reconstruction are exposed to abnormal flow patterns which potentially could cause wall deterioration. This study evaluated the effect of age at correction on the pulse wave velocity (PWV) and peak wall shear stress (WSS) in adolescent patients with corrected coarctation. Effects of valve morphology and presence of reobstruction were also evaluated. Methods: Twenty-one patients aged 13.7 ± 2.6 years (mean ± standard deviation) were included (bicus...
Abstract
Cited 5 times since 2019 (0.9 per year)
source: EuropePMC
Healthcare (Basel, Switzerland),
Volume 7, Issue 2, 20 3 2019, Pages E78
The Information Needs of Adolescent Idiopathic Scoliosis Patients and Their Parents in the UK: An Online Survey.
Wellburn S, van Schaik P, Bettany-Saltikov J
Patients' involvement in decision-making regarding their own health care is considered to be of great importance. However, their information needs are frequently reported to be unfulfilled. Few studies have investigated the knowledge, information and support needs of adolescent idiopathic scoliosis (AIS) patients and their families. Furthermore, previous studies have predominantly focussed on information needs relating to surgery. No previous studies have been conducted to specifically iden...
Abstract
Cited 3 times since 2019 (0.5 per year)
source: EuropePMC
Seminars in thoracic and cardiovascular surgery,
Volume 31, Issue 4, 20 3 2019, Pages 643-649
Aortic Valve Surgery in Nonelderly Patients: Insights Gained From AVIATOR.
Lansac E, Youssefi P, de Heer F, Bavaria J, De Kerchove L, El-Hamamsy I, Elkhoury G, Enriquez-Sarano M, Jondeau LG, Kluin J, Pibarot P, Schäfers HJ, Vanoverschelde JL, Takkenberg JJM, Aortic Valve Repair Research Network Investigators from the Heart Valve Society, Collaborators
Aortic valve surgery in non-elderly patients represents a very challenging patient population. The younger the patient is at the point of aortic valve intervention, the longer their anticipated life expectancy will be, with longer exposure to valve-related complications and risk for re-operation. Although the latest international guidelines recommend aortic valve repair in patients with aortic valve insufficiency, what we see in the real world is that the vast majority of these aortic valves are...
Abstract
Cited 3 times since 2019 (0.5 per year)
source: EuropePMC
The American journal of medicine,
Volume 132, Issue 12, 20 3 2019, Pages 1466-1474.e4
Cognitive Function in Dementia-Free Subjects and Survival in Old Age: The PROSPER Study.
Rostamian S, de Haan S, van der Grond J, van Buchem MA, Ford I, Jukema JW, Sabayan B
Background: Impairment in domain-specific cognitive function is associated with the increased risk of mortality. We prospectively evaluated the association of executive function and memory with the risk of long-term mortality in dementia-free older subjects. Moreover, we investigated the role of structural brain abnormalities in this association. Methods: We included 547 dementia-free participants (mean age 78 years, 56.5% male) from the nested magnetic resonance imaging sub-study of the PROspec...
Abstract
