Research

Publications

Below you can find a list of our published research.

9618 results

Cited 5 times since 2019 (0.9 per year) source: EuropePMC

Experimental parasitology, Volume 208, 22 4 2019, Pages 107808 Risk-based surveillance for meat-borne parasites. Alban L, Häsler B, van Schaik G, Ruegg S

There is a plethora of meat-borne hazards - including parasites - for which there may be a need for surveillance. However, veterinary services worldwide need to decide how to use their scarce resources and prioritise among the perceived hazards. Moreover, to remain competitive, food business operators - irrespective of whether they are farmers or abattoir operators - are preoccupied with maintaining a profit and minimizing costs. Still, customers and trade partners expect that meat products plac... Abstract

Journal of cardiothoracic surgery, Volume 14, Issue 1, 21 3 2019, Pages 200 Vasoresponsiveness in patients with heart failure (VASOR): protocol for a prospective observational study. van Vessem ME, Beeres SLMA, de Wilde RBP, de Vries R, Berendsen RR, de Jonge E, Danser AHJ, Klautz RJM, Schalij MJ, Palmen M

Background: Vasoplegia is a severe complication which may occur after cardiac surgery, particularly in patients with heart failure. It is a result of activation of vasodilator pathways, inactivation of vasoconstrictor pathways and the resistance to vasopressors. However, the precise etiology remains unclear. The aim of the Vasoresponsiveness in patients with heart failure (VASOR) study is to objectify and characterize the altered vasoresponsiveness in patients with heart failure, before, during... Abstract

Cited 126 times since 2019 (21.9 per year) source: EuropePMC

European journal of human genetics : EJHG, Volume 28, Issue 4, 19 3 2019, Pages 508-517 Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction of DPYD and fluoropyrimidines. Lunenburg CATC, van der Wouden CH, Nijenhuis M, Crommentuijn-van Rhenen MH, de Boer-Veger NJ, Buunk AM, Houwink EJF, Mulder H, Rongen GA, van Schaik RHN, van der Weide J, Wilffert B, Deneer VHM, Swen JJ, Guchelaar HJ

Despite advances in the field of pharmacogenetics (PGx), clinical acceptance has remained limited. The Dutch Pharmacogenetics Working Group (DPWG) aims to facilitate PGx implementation by developing evidence-based pharmacogenetics guidelines to optimize pharmacotherapy. This guideline describes the starting dose optimization of three anti-cancer drugs (fluoropyrimidines: 5-fluorouracil, capecitabine and tegafur) to decrease the risk of severe, potentially fatal, toxicity (such as diarrhoea, hand... Abstract

Cited 116 times since 2019 (20.2 per year) source: EuropePMC

European urology, Volume 77, Issue 2, 19 3 2019, Pages 223-250 EAU-ESMO Consensus Statements on the Management of Advanced and Variant Bladder Cancer-An International Collaborative Multistakeholder Effort<sup>†</sup>: Under the Auspices of the EAU-ESMO Guidelines Committees. Witjes JA, Babjuk M, Bellmunt J, Bruins HM, De Reijke TM, De Santis M, Gillessen S, James N, Maclennan S, Palou J, Powles T, Ribal MJ, Shariat SF, Der Kwast TV, Xylinas E, Agarwal N, Arends T, Bamias A, Birtle A, Black PC, Bochner BH, Bolla M, Boormans JL, Bossi A, Briganti A, Brummelhuis I, Burger M, Castellano D, Cathomas R, Chiti A, Choudhury A, Compérat E, Crabb S, Culine S, De Bari B, De Blok W, J L De Visschere P, Decaestecker K, Dimitropoulos K, Dominguez-Escrig JL, Fanti S, Fonteyne V, Frydenberg M, Futterer JJ, Gakis G, Geavlete B, Gontero P, Grubmüller B, Hafeez S, Hansel DE, Hartmann A, Hayne D, Henry AM, Hernandez V, Herr H, Herrmann K, Hoskin P, Huguet J, Jereczek-Fossa BA, Jones R, Kamat AM, Khoo V, Kiltie AE, Krege S, Ladoire S, Lara PC, Leliveld A, Linares-Espinós E, Løgager V, Lorch A, Loriot Y, Meijer R, Mir MC, Moschini M, Mostafid H, Müller AC, Müller CR, N'Dow J, Necchi A, Neuzillet Y, Oddens JR, Oldenburg J, Osanto S, J G Oyen W, Pacheco-Figueiredo L, Pappot H, Patel MI, Pieters BR, Plas

Background: Although guidelines exist for advanced and variant bladder cancer management, evidence is limited/conflicting in some areas and the optimal approach remains controversial. Objective: To bring together a large multidisciplinary group of experts to develop consensus statements on controversial topics in bladder cancer management. Design: A steering committee compiled proposed statements regarding advanced and variant bladder cancer management which were assessed by 113 experts in a Del... Abstract

Cited 25 times since 2019 (4.4 per year) source: EuropePMC

Radiology, Volume 294, Issue 1, 19 3 2019, Pages 61-73 Ischemia and No Obstructive Stenosis (INOCA) at CT Angiography, CT Myocardial Perfusion, Invasive Coronary Angiography, and SPECT: The CORE320 Study. Schuijf JD, Matheson MB, Ostovaneh MR, Arbab-Zadeh A, Kofoed KF, Scholte AJHA, Dewey M, Steveson C, Rochitte CE, Yoshioka K, Cox C, Di Carli MF, Lima JAC

Background CT allows evaluation of atherosclerosis, coronary stenosis, and myocardial ischemia. Data on the characterization of ischemia and no obstructive stenosis (INOCA) at CT remain limited. Purpose This was an observational study to describe the prevalence of INOCA defined at coronary CT angiography with CT perfusion imaging and associated clinical and atherosclerotic characteristics. The analysis was also performed for the combination of invasive coronary angiography (ICA) and SPECT as a s... Abstract

Cited 36 times since 2019 (6.3 per year) source: EuropePMC

JMIR mental health, Volume 6, Issue 11, 18 3 2019, Pages e12814 Wearable Technology for High-Frequency Cognitive and Mood Assessment in Major Depressive Disorder: Longitudinal Observational Study. Cormack F, McCue M, Taptiklis N, Skirrow C, Glazer E, Panagopoulos E, van Schaik TA, Fehnert B, King J, Barnett JH

Background: Cognitive symptoms are common in major depressive disorder and may help to identify patients who need treatment or who are not experiencing adequate treatment response. Digital tools providing real-time data assessing cognitive function could help support patient treatment and remediation of cognitive and mood symptoms. Objective: The aim of this study was to examine feasibility and validity of a wearable high-frequency cognitive and mood assessment app over 6 weeks, corresponding to... Abstract

Cited 21 times since 2019 (3.7 per year) source: EuropePMC

Infection and immunity, Volume 87, Issue 12, 18 3 2019, Pages e00178-19 Coxiella burnetii Intratracheal Aerosol Infection Model in Mice, Guinea Pigs, and Nonhuman Primates. Gregory AE, van Schaik EJ, Russell-Lodrigue KE, Fratzke AP, Samuel JE

Coxiella burnetii, the etiological agent of Q fever, is a Gram-negative bacterium transmitted to humans by inhalation of contaminated aerosols. Acute Q fever is often self-limiting, presenting as a febrile illness that can result in atypical pneumonia. In some cases, Q fever becomes chronic, leading to endocarditis that can be life threatening. The formalin-inactivated whole-cell vaccine (WCV) confers long-term protection but has significant side effects when administered to presensitized indivi... Abstract

Cited 3 times since 2019 (0.5 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 27, Issue 1, 18 3 2019, Pages 53-61 Multimodality imaging: Bird's eye view from the European Society of Cardiology Congress 2019 Paris, August 31st-September 4th, 2019. Delgado V, Saraste A, Dweck M, Bucciarelli-Ducci C, Bax JJ

At the European Society of Cardiology (ESC) congress of this year 2019, held in Paris from August 31st to September 4th, 4509 abstracts were presented. Of those, 414 (9%) belonged to an imaging category. Experts in echocardiography (VD), nuclear imaging (AS), cardiac computed tomography (CT) (MD) and cardiovascular magnetic resonance (CMR) (CBD), have selected the abstracts in their areas of expertise that were of most interest to them and are summarized in this bird's eye view from this ES... Abstract

Cited 3 times since 2019 (0.5 per year) source: EuropePMC

International journal of cardiology, Volume 306, 16 3 2019, Pages 152-157 Doppler gradients, valve area and ventricular function in pregnant women with aortic or pulmonary valve disease: Left versus right. Siegmund AS, Pieper PG, Mulder BJM, Sieswerda GT, van Dijk APJ, Roos-Hesselink JW, Jongbloed MRM, Konings TC, Bouma BJ, Groen H, Sollie-Szarynska KM, Kampman MAM, Bilardo CM, van Veldhuisen DJ, Aalberts JJJ

Objective: Little is known about the course of echocardiographic parameters used for the evaluation of valvular heart disease (VHD) during pregnancy, hampering interpretation of possible changes (physiological vs. pathophysiological). Therefore we studied the course of these parameters and ventricular function in pregnant women with aortic and pulmonary VHD. Methods: The cohort comprised 66 pregnant women enrolled in the prospective ZAHARA studies or evaluated by an identical protocol who had pu... Abstract

Cited 1 times since 2019 (0.2 per year) source: EuropePMC

PloS one, Volume 14, Issue 11, 14 2 2019, Pages e0225493 Correction: The modulation of facial mimicry by attachment tendencies and their underlying affiliation motives in 3-year-olds: An EMG study. Vacaru SV, van Schaik JE, Hunnius S

[This corrects the article DOI: 10.1371/journal.pone.0218676.]. Abstract

Cited 15 times since 2019 (2.6 per year) source: EuropePMC

Science advances, Volume 5, Issue 11, 13 2 2019, Pages eaax6656 Role of climate in the rise and fall of the Neo-Assyrian Empire. Sinha A, Kathayat G, Weiss H, Li H, Cheng H, Reuter J, Schneider AW, Berkelhammer M, Adalı SF, Stott LD, Edwards RL

Northern Iraq was the political and economic center of the Neo-Assyrian Empire (c. 912 to 609 BCE)-the largest and most powerful empire of its time. After more than two centuries of regional dominance, the Neo-Assyrian state plummeted from its zenith (c. 670 BCE) to complete political collapse (c. 615 to 609 BCE). Earlier explanations for the Assyrian collapse focused on the roles of internal politico-economic conflicts, territorial overextension, and military defeat. Here, we present a high-res... Abstract

JACC. Cardiovascular imaging, Volume 13, Issue 2 Pt 1, 13 2 2019, Pages 526-528 Out of Focus: Increase of the Excess Longitudinal Range in Coronary Computed Tomographic Angiography. Stocker TJ, Heckner M, Leipsic J, Hadamitzky M, Deseive S, Achenbach S, Chen MY, Rubinshtein R, Bax JJ, Bittencourt MS, Jadhav UM, Schlosser T, Ramanathan S, Yu JH, Massberg S, Hausleiter J

Abstract

Cited 43 times since 2019 (7.5 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 13, Issue 6, 13 2 2019, Pages 1409-1417 Differences in Progression to Obstructive Lesions per High-Risk Plaque Features and Plaque Volumes With CCTA. Lee SE, Sung JM, Andreini D, Al-Mallah MH, Budoff MJ, Cademartiri F, Chinnaiyan K, Choi JH, Chun EJ, Conte E, Gottlieb I, Hadamitzky M, Kim YJ, Lee BK, Leipsic JA, Maffei E, Marques H, de Araújo Gonçalves P, Pontone G, Raff GL, Shin S, Stone PH, Samady H, Virmani R, Narula J, Berman DS, Shaw LJ, Bax JJ, Lin FY, Min JK, Chang HJ

Objectives: This study explored whether the pattern of nonobstructive lesion progression into obstructive lesions would differ according to the presence of high-risk plaque (HRP). Background: It is still debatable whether HRP simply represents a certain phase during the natural history of coronary atherosclerotic plaques or if disease progression would differ according to the presence of HRP. Methods: Patients with nonobstructive coronary artery disease, defined as percent diameter stenosis (%DS... Abstract

Cited 45 times since 2019 (7.8 per year) source: EuropePMC

European journal of heart failure, Volume 22, Issue 7, 11 2 2019, Pages 1147-1155 Concentric vs. eccentric remodelling in heart failure with reduced ejection fraction: clinical characteristics, pathophysiology and response to treatment. Nauta JF, Hummel YM, Tromp J, Ouwerkerk W, van der Meer P, Jin X, Lam CSP, Bax JJ, Metra M, Samani NJ, Ponikowski P, Dickstein K, Anker SD, Lang CC, Ng LL, Zannad F, Filippatos GS, van Veldhuisen DJ, van Melle JP, Voors AA

Aims: Heart failure is traditionally classified by left ventricular ejection fraction (LVEF), rather than by left ventricular (LV) geometry, with guideline-recommended therapies in heart failure with reduced ejection fraction (HFrEF) but not heart failure with preserved ejection fraction (HFpEF). Most patients with HFrEF have eccentric LV hypertrophy, but some have concentric LV hypertrophy. We aimed to compare clinical characteristics, biomarker patterns, and response to treatment of patients w... Abstract

Cited 72 times since 2019 (12.5 per year) source: EuropePMC

Circulation, Volume 140, Issue 25, 11 2 2019, Pages 2054-2062 Effect of Alirocumab on Stroke in ODYSSEY OUTCOMES. Jukema JW, Zijlstra LE, Bhatt DL, Bittner VA, Diaz R, Drexel H, Goodman SG, Kim YU, Pordy R, Reiner Ž, Roe MT, Tse HF, Montenegro Valdovinos PC, White HD, Zeiher AM, Szarek M, Schwartz GG, Steg PG, ODYSSEY OUTCOMES Investigators

Background: Lowering of atherogenic lipoproteins, including low-density lipoprotein cholesterol (LDL-C), reduces the risk of ischemic stroke. However, concerns have been raised about very low LDL-C levels and a potential increased risk of hemorrhagic stroke. ODYSSEY OUTCOMES compared the PCSK9 inhibitor alirocumab with placebo in 18 924 patients with recent acute coronary syndrome and elevated atherogenic lipoproteins, despite intensive statin therapy, targeting LDL-C levels of 25 to 50 mg/dL an... Abstract

Cited 145 times since 2019 (25.1 per year) source: EuropePMC

Neurology, Volume 93, Issue 24, 11 2 2019, Pages e2257-e2271 Profile of and risk factors for poststroke cognitive impairment in diverse ethnoregional groups. Lo JW, Crawford JD, Desmond DW, Godefroy O, Jokinen H, Mahinrad S, Bae HJ, Lim JS, Köhler S, Douven E, Staals J, Chen C, Xu X, Chong EJ, Akinyemi RO, Kalaria RN, Ogunniyi A, Barbay M, Roussel M, Lee BC, Srikanth VK, Moran C, Kandiah N, Chander RJ, Sabayan B, Jukema JW, Melkas S, Erkinjuntti T, Brodaty H, Bordet R, Bombois S, Hénon H, Lipnicki DM, Kochan NA, Sachdev PS, Stroke and Cognition (STROKOG) Collaboration

Objective: To address the variability in prevalence estimates and inconsistencies in potential risk factors for poststroke cognitive impairment (PSCI) using a standardized approach and individual participant data (IPD) from international cohorts in the Stroke and Cognition Consortium (STROKOG) consortium. Methods: We harmonized data from 13 studies based in 8 countries. Neuropsychological test scores 2 to 6 months after stroke or TIA and appropriate normative data were used to calculate standard... Abstract

Cited 12 times since 2019 (2.1 per year) source: EuropePMC

Circulation. Cardiovascular quality and outcomes, Volume 12, Issue 11, 11 2 2019, Pages e005858 Alirocumab Reduces Total Hospitalizations and Increases Days Alive and Out of Hospital in the ODYSSEY OUTCOMES Trial. Szarek M, Steg PG, DiCenso D, Bhatt DL, Bittner VA, Budaj A, Diaz R, Goodman SG, Gotcheva N, Jukema JW, Pordy R, Roe MT, Sourdille T, White HD, Xavier D, Zeiher AM, Schwartz GG

Background: In ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab), alirocumab was compared with placebo, added to high-intensity or maximum tolerated statin treatment after acute coronary syndrome in 18 924 patients. Alirocumab reduced first occurrence of the primary composite end point-coronary heart disease death, nonfatal myocardial infarction, fatal or nonfatal ischemic stroke, or hospitalization for unstable angina-as w... Abstract

Cited 4 times since 2019 (0.7 per year) source: EuropePMC

Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, Volume 25, Issue 3, 10 2 2019, Pages e12722 An initial exploration of subtraction electrocardiography to detect myocardial ischemia in the prehospital setting. Ter Haar CC, Peters RJG, Bosch J, Sbrollini A, Gripenstedt S, Adams R, Bleijenberg E, Kirchhof CJHJ, Alizadeh Dehnavi R, Burattini L, de Winter RJ, Macfarlane PW, Postema PG, Man S, Scherptong RWC, Schalij MJ, Maan AC, Swenne CA

Background: In the prehospital triage of patients presenting with symptoms suggestive of acute myocardial ischemia, reliable myocardial ischemia detection in the electrocardiogram (ECG) is pivotal. Due to large interindividual variability and overlap between ischemic and nonischemic ECG-patterns, incorporation of a previous elective (reference) ECG may improve accuracy. The aim of the current study was to explore the potential value of serial ECG analysis using subtraction electrocardiography. M... Abstract

Cited 7 times since 2019 (1.2 per year) source: EuropePMC

European journal of neurology, Volume 27, Issue 3, 7 1 2019, Pages 506-513 Combined intravenous immunoglobulin and methylprednisolone as induction treatment in chronic inflammatory demyelinating polyneuropathy (OPTIC protocol): a prospective pilot study. Adrichem ME, Bus SR, Wieske L, Mohammed H, Verhamme C, Hadden R, van Schaik IN, Eftimov F

Background and purpose: We hypothesized that combining intravenous immunoglobulin (IVIg) and intravenous methylprednisolone (IVMP) leads to more frequent remission compared with IVIg alone while maintaining the fast efficacy of IVIg. In this uncontrolled pilot study, we evaluated remission, rate of improvement and safety in patients with chronic inflammatory demyelinating polyradiculoneuropathy receiving induction treatment with combined IVIg and IVMP. Methods: Consecutive treatment-naive patien... Abstract

Cancer treatment reviews, Volume 81, 6 1 2019, Pages 101913 Corrigendum to "Drug-drug interactions in breast cancer patients treated with CDK4/6 inhibitors" [Cancer Treatm. Rev. 74 (2019) 21-28]. Fogli S, Del Re M, Curigliano G, van Schaik RH, Lancellotti P, Danesi R

Abstract