8684 results
Nuclear medicine communications,
Volume 37, Issue 11, 1 1 2016, Pages 1125-1135
Comparison between a count-based and geometrical approach for the assessment of left ventricular dyssynchrony using myocardial perfusion scintigraphy.
Nguyên UC, Al Younis I, Ajmone-Marsan N, Dibbets-Schneider P, Blokland JA, de Wit-van der Veen BJ
Objective: There are two distinct approaches for the assessment of left ventricular (LV) dyssynchrony by myocardial perfusion scintigraphy (MPS). The aim of this study was to compare the performance of the count-based and geometrical approach in clinical data using gated single photon emission computed tomography MPS. Material and methods: Group 1 consisted of 113 patients (49 men, 64 women) with normal perfusion [summed rest score (SRS)≤3], normal LV ejection fraction (≥55%), and normal QRS dur...
Abstract
Cited 23 times since 2016 (2.7 per year)
source: EuropePMC
Journal of human evolution,
Volume 100, 1 1 2016, Pages 25-34
Being fat and smart: A comparative analysis of the fat-brain trade-off in mammals.
Heldstab SA, van Schaik CP, Isler K
Humans stand out among non-aquatic mammals by having both an extremely large brain and a relatively large amount of body fat. To understand the evolution of this human peculiarity we report a phylogenetic comparative study of 120 mammalian species, including 30 primates, using seasonal variation in adult body mass as a proxy of the tendency to store fat. Species that rely on storing fat to survive lean periods are expected to be less active because of higher costs of locomotion and have increase...
Abstract
Cited 5 times since 2016 (0.6 per year)
source: EuropePMC
Anesthesia and analgesia,
Volume 123, Issue 5, 1 1 2016, Pages 1109-1115
Implication of UGT2B15 Genotype Polymorphism on Postoperative Anxiety Levels in Patients Receiving Lorazepam Premedication.
Mijderwijk H, Klimek M, van Beek S, van Schaik RH, Duivenvoorden HJ, Stolker RJ
Background: Lorazepam is used as premedication for its anxiolytic properties. The UGT2B15 genotype is of importance for the metabolism of lorazepam. The clinical effect of genetic polymorphisms in UGT2B15 genotype on the treatment of anxiety levels in same-day surgery patients receiving lorazepam, however, is unknown. Methods: Three hundred ninety-eight same-day surgery patients of mixed sex (from a previous double-blinded randomized controlled trial who were assigned to either lorazepam [n = 19...
Abstract
Cited 11 times since 2016 (1.3 per year)
source: EuropePMC
Pain,
Volume 157, Issue 11, 1 1 2016, Pages 2476-2482
Genetic variants associated with thermal pain sensitivity in a paediatric population.
Matic M, van den Bosch GE, de Wildt SN, Tibboel D, van Schaik RHN
Pain sensitivity is an inherited factor that varies strongly between individuals. We investigated whether genetic polymorphisms in the candidate genes COMT, OPRM1, OPRD1, TAOK3, TRPA1, TRPV1, and SCN9A are contributing to experimental pain variability between children. Our study included 136 children and adolescents (8-18 years). Cold and heat pain thresholds were determined with a Thermal Sensory Analyzer. Women and young children were significantly more sensitive to pain (P < 0.05). After c...
Abstract
Cited 40 times since 2016 (4.7 per year)
source: EuropePMC
Proceedings. Biological sciences,
Volume 283, Issue 1843, 1 1 2016, Pages 20161817
Female monkeys use both the carrot and the stick to promote male participation in intergroup fights.
Arseneau-Robar TJ, Taucher AL, Müller E, van Schaik C, Bshary R, Willems EP
Group-level cooperation often poses a social dilemma in which joint action may be difficult to achieve. Theoretical models and experimental work on humans show that social incentives, such as punishment of defectors and rewarding of cooperators, can promote cooperation in groups of unrelated individuals. Here, we demonstrate that these processes can operate in a non-human animal species, and be used to effectively promote the production of a public good. We took advantage of the fact that interg...
Abstract
Cited 11 times since 2016 (1.3 per year)
source: EuropePMC
Physiology (Bethesda, Md.),
Volume 31, Issue 6, 1 1 2016, Pages 392-397
Evolutionary Medicine: The Ongoing Evolution of Human Physiology and Metabolism.
Rühli F, van Schaik K, Henneberg M
The field of evolutionary medicine uses evolutionary principles to understand changes in human anatomy and physiology that have occurred over time in response to environmental changes. Through this evolutionary-based approach, we can understand disease as a consequence of anatomical and physiological "trade-offs" that develop to facilitate survival and reproduction. We demonstrate how diachronic study of human anatomy and physiology is fundamental for an increased understanding of huma...
Abstract
European journal of cancer (Oxford, England : 1990),
Volume 68, 30 5 2016, Pages 198
Reply to letter commenting on: A five-gene expression signature to predict progression in T1G3 bladder cancer.
van der Heijden AG, Mengual L
Abstract
Cited 74 times since 2016 (8.6 per year)
source: EuropePMC
Circulation,
Volume 135, Issue 14, 28 4 2016, Pages 1311-1320
Genetic Risk Prediction of Atrial Fibrillation.
Lubitz SA, Yin X, Lin HJ, Kolek M, Smith JG, Trompet S, Rienstra M, Rost NS, Teixeira PL, Almgren P, Anderson CD, Chen LY, Engström G, Ford I, Furie KL, Guo X, Larson MG, Lunetta KL, Macfarlane PW, Psaty BM, Soliman EZ, Sotoodehnia N, Stott DJ, Taylor KD, Weng LC, Yao J, Geelhoed B, Verweij N, Siland JE, Kathiresan S, Roselli C, Roden DM, van der Harst P, Darbar D, Jukema JW, Melander O, Rosand J, Rotter JI, Heckbert SR, Ellinor PT, Alonso A, Benjamin EJ, AFGen Consortium
Background: Atrial fibrillation (AF) has a substantial genetic basis. Identification of individuals at greatest AF risk could minimize the incidence of cardioembolic stroke. Methods: To determine whether genetic data can stratify risk for development of AF, we examined associations between AF genetic risk scores and incident AF in 5 prospective studies comprising 18 919 individuals of European ancestry. We examined associations between AF genetic risk scores and ischemic stroke in a separate stu...
Abstract
Cited 1 times since 2016 (0.1 per year)
source: EuropePMC
Journal of electrocardiology,
Volume 50, Issue 1, 28 4 2016, Pages 82-89
Position of ST-deviation measurements relative to the J-point: Impact for ischemia detection.
Man S, Ter Haar CC, de Jongh MC, Maan AC, Schalij MJ, Swenne CA
Background: There is no consensus about the time instant relative to the J point where ST deviation has to be measured for detection of acute ischemia in the ECG. Methods: We analyzed 53 ECGs, recorded preceding emergency catheterization of acute coronary syndrome patients with a completely occluded culprit artery (cases), and 88 control ECGs recorded in the cardiology outpatient clinic. ECG-amplitude measurements were made every 10 ms, between 20 ms before till 80 ms after the J point. STEMI-de...
Abstract
Cited 9 times since 2016 (1 per year)
source: Scopus
Journal of cardiovascular computed tomography,
Volume 11, Issue 1, 25 4 2016, Pages 1-7
Prognostic implications of descending thoracic aorta dilation after surgery for aortic dissection.
Regeer MV, Martina B, Versteegh MI, de Weger A, Klautz RJ, Schalij MJ, Bax JJ, Marsan NA, Delgado V
Background: The present study assessed whether descending thoracic aorta growth can be measured reliably by volumetric analysis using multi-detector row computed tomography (MDCT) and whether growth influences the need for future aortic interventions in survivors of acute type A aortic dissection. Methods: A total of 51 patients (58 ± 11 years, 61% male) who underwent surgery for type A aortic dissection with ≥2 postoperative MDCT scans ≥5 months apart were included. Volumetric analysis of the d...
Abstract
Cited 5 times since 2016 (0.6 per year)
source: EuropePMC
Scientific reports,
Volume 6, 24 4 2016, Pages 35800
Male food defence as a by-product of intersexual cooperation in a non-human primate.
Arseneau-Robar TJ, Müller E, Taucher AL, van Schaik CP, Willems EP
Males in a number of group-living species fight in intergroup conflicts to defend access to food resources, a seemingly paradoxical behaviour, given that this resource does not usually limit male fitness directly. We investigated the mechanism(s) driving apparent male food defence in wild vervet monkeys (Chlorocebus aethiops pygerythrus) by testing the effect that female resource access, and female audience size and activity had on the response of focal males during simulated intergroup encounte...
Abstract
Cited 9 times since 2016 (1 per year)
source: EuropePMC
Primates; journal of primatology,
Volume 58, Issue 2, 22 4 2016, Pages 285-294
Validation of a field-friendly extraction and storage method to monitor fecal steroid metabolites in wild orangutans.
Nugraha TP, Heistermann M, Agil M, Purwantara B, Supriatna I, Gholib G, van Schaik CP, Weingrill T
Measuring hormone metabolites from feces is the most often used method to assess hormonal status in wildlife. Although immediate freezing of fecal samples collected in the field is the best method to minimize the risk of degradation of hormones over time, this is often not possible in remote field sites. Therefore, alternative storage and preservation methods for fecal samples are required in these conditions. We conducted an experiment to investigate if fecal glucocorticoid (FGCM) and progester...
Abstract
Cited 9 times since 2016 (1 per year)
source: EuropePMC
Pharmacogenomics,
Volume 17, Issue 16, 21 3 2016, Pages 1775-1784
Economic analysis of pharmacogenomic-guided clopidogrel treatment in Serbian patients with myocardial infarction undergoing primary percutaneous coronary intervention.
Mitropoulou C, Fragoulakis V, Rakicevic LB, Novkovic MM, Vozikis A, Matic DM, Antonijevic NM, Radojkovic DP, van Schaik RH, Patrinos GP
Introduction: Clopidogrel, which is activated by the CYP2C19 enzyme, is among the drugs for which all major regulatory agencies recommend genetic testing to be performed to identify a patient's CYP2C19 genotype in order to determine the optimal antiplatelet therapeutic scheme. The CYP2C19*2 and CYP2C19*3 variants are loss-of-function alleles, leading to abolished CYP2C19 function and thus have the risk of thrombotic events for carriers of these alleles on standard dosages, while the CYP2C19...
Abstract
Cited 57 times since 2016 (6.6 per year)
source: EuropePMC
Antimicrobial agents and chemotherapy,
Volume 60, Issue 11, 21 3 2016, Pages 6837-6843
Genomic Characterization of Colistin Heteroresistance in Klebsiella pneumoniae during a Nosocomial Outbreak.
Halaby T, Kucukkose E, Janssen AB, Rogers MR, Doorduijn DJ, van der Zanden AG, Al Naiemi N, Vandenbroucke-Grauls CM, van Schaik W
Klebsiella pneumoniae is emerging as an important nosocomial pathogen due to its rapidly increasing multidrug resistance, which has led to a renewed interest in polymyxin antibiotics, such as colistin, as antibiotics of last resort. However, heteroresistance (i.e., the presence of a subpopulation of resistant bacteria in an otherwise susceptible culture) may hamper the effectiveness of colistin treatment in patients. In a previous study, we showed that colistin resistance among extended-spectrum...
Abstract
Cited 243 times since 2016 (28.1 per year)
source: EuropePMC
The Lancet. Infectious diseases,
Volume 17, Issue 1, 14 2 2016, Pages 78-85
Import and spread of extended-spectrum β-lactamase-producing Enterobacteriaceae by international travellers (COMBAT study): a prospective, multicentre cohort study.
Arcilla MS, van Hattem JM, Haverkate MR, Bootsma MCJ, van Genderen PJJ, Goorhuis A, Grobusch MP, Lashof AMO, Molhoek N, Schultsz C, Stobberingh EE, Verbrugh HA, de Jong MD, Melles DC, Penders J
Background: International travel contributes to the dissemination of antimicrobial resistance. We investigated the acquisition of extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) during international travel, with a focus on predictive factors for acquisition, duration of colonisation, and probability of onward transmission. Methods: Within the prospective, multicentre COMBAT study, 2001 Dutch travellers and 215 non-travelling household members were enrolled. Faecal samples and...
Abstract
JACC. Cardiovascular imaging,
Volume 10, Issue 5, 12 2 2016, Pages 523-525
Implementing Quality Control of LV Longitudinal Strain Measurement.
Delgado V, Ajmone Marsan N
Abstract
Cited 168 times since 2016 (19.4 per year)
source: EuropePMC
European urology,
Volume 71, Issue 4, 10 2 2016, Pages 680-687
The Detection of Androgen Receptor Splice Variant 7 in Plasma-derived Exosomal RNA Strongly Predicts Resistance to Hormonal Therapy in Metastatic Prostate Cancer Patients.
Del Re M, Biasco E, Crucitta S, Derosa L, Rofi E, Orlandini C, Miccoli M, Galli L, Falcone A, Jenster GW, van Schaik RH, Danesi R
Background: The androgen receptor splice variant 7 (AR-V7) is associated with resistance to hormonal therapy in castration-resistant prostate cancer (CRPC). Due to limitations of the methods available for AR-V7 analysis, the identification of a reliable detection method may facilitate the use of this biomarker in clinical practice. Objective: To confirm AR-V7 as a predictor of resistance to hormonal therapy and develop a new approach to assess AR-V7 by highly sensitive digital droplet polymerase...
Abstract
Cited 1 times since 2016 (0.1 per year)
source: EuropePMC
Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG,
Volume 33, Issue 3, 7 1 2016, Pages 253-257
GSTT1 and GSTM1 gene polymorphisims in sarcoidosis.
Coskun F, Karkucak M, Yilmaz D, Yakut T, Uzaslan E
Introduction: Sarcoidosis is a granulomatous disease of unknown cause, which affects all systems, especially the lungs and the lymphatic system. Genetic and environmental factors are held accountable for the etiology. Based on the general opinion, sarcoidosis develops after exposure to a specific environmental agent by genetically susceptible individuals. The present study aimed to evaluate the disease susceptibility of the GSTT1 and GSTM1 gene polymorphisms in the patients with sarcoidosis. Me...
Abstract
Cited 24 times since 2016 (2.8 per year)
source: EuropePMC
Preventive veterinary medicine,
Volume 134, 6 1 2016, Pages 103-112
Surveillance of cattle health in the Netherlands: Monitoring trends and developments using routinely collected cattle census data.
Santman-Berends IMGA, Brouwer-Middelesch H, Van Wuijckhuise L, de Bont-Smolenaars AJG, Van Schaik G
Since 2002, a national cattle health surveillance system (CHSS) is in place that consists of several surveillance components. The CHSS combines enhanced passive reporting, diagnostic and post-mortem examinations, random surveys for prevalence estimation of endemic diseases and quarterly data analysis. The aim of the data-analysis component, which is called the Trend Analysis Surveillance Component (TASC), is to monitor trends and developments in cattle health using routine census data. The chall...
Abstract
Cited 78 times since 2016 (9 per year)
source: EuropePMC
Nature communications,
Volume 7, 6 1 2016, Pages 12989
A high-quality human reference panel reveals the complexity and distribution of genomic structural variants.
Hehir-Kwa JY, Marschall T, Kloosterman WP, Francioli LC, Baaijens JA, Dijkstra LJ, Abdellaoui A, Koval V, Thung DT, Wardenaar R, Renkens I, Coe BP, Deelen P, de Ligt J, Lameijer EW, van Dijk F, Hormozdiari F, Genome of the Netherlands Consortium, Uitterlinden AG, van Duijn CM, Eichler EE, de Bakker PI, Swertz MA, Wijmenga C, van Ommen GB, Slagboom PE, Boomsma DI, Schönhuth A, Ye K, Guryev V
Structural variation (SV) represents a major source of differences between individual human genomes and has been linked to disease phenotypes. However, the majority of studies provide neither a global view of the full spectrum of these variants nor integrate them into reference panels of genetic variation. Here, we analyse whole genome sequencing data of 769 individuals from 250 Dutch families, and provide a haplotype-resolved map of 1.9 million genome variants across 9 different variant classes...
Abstract
