7971 results
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
Volume 62, Issue 11, 5 1 2016, Pages 1470
Reply to Leenders.
Hetem DJ, Bootsma MC, Bonten MJ
Abstract
Cited 136 times since 2016 (14.8 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 67, Issue 19, 2 1 2016, Pages 2263-2288
Natural History, Diagnostic Approaches, and Therapeutic Strategies for Patients With Asymptomatic Severe Aortic Stenosis.
Généreux P, Stone GW, O'Gara PT, Marquis-Gravel G, Redfors B, Giustino G, Pibarot P, Bax JJ, Bonow RO, Leon MB
Aortic stenosis (AS) is one of the most common valvular diseases encountered in clinical practice. Current guidelines recommend aortic valve replacement (AVR) when the aortic valve is severely stenotic and the patient is symptomatic; however, a substantial proportion of patients with severe AS are asymptomatic at the time of first diagnosis. Although specific morphological valve features, exercise testing, stress imaging, and biomarkers can help to identify patients with asymptomatic severe AS w...
Abstract
Cited 1 times since 2016 (0.1 per year)
source: EuropePMC
Pancreas,
Volume 45, Issue 4, 1 1 2016, Pages 541-545
A Common CCK-B Receptor Intronic Variant in Pancreatic Adenocarcinoma in a Hungarian Cohort.
Balázs A, Németh BC, Ördög B, Hegyi E, Hritz I, Czakó L, Czimmer J, Gódi S, Csiszkó A, Rakonczay Z, Párniczky A, Izbéki F, Halász A, Kahán Z, Hegyi P, Sahin-Tóth M, Hungarian Pancreatic Study Group
Objectives: Variant c.811+32C>A in intron 4 of the cholecystokinin-B receptor gene (CCKBR) was reported to correlate with higher pancreatic cancer risk and poorer survival. The variant was suggested to induce retention of intron 4, resulting in a new splice form with enhanced receptor activity. Our objective was to validate the c.811+32C>A variant as an emerging biomarker for pancreatic cancer risk and prognosis. Methods: We genotyped variant c.811+32C>A in 122 pancreatic adenocarcinoma...
Abstract
Cited 5 times since 2016 (0.5 per year)
source: EuropePMC
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology,
Volume 11, Issue 13, 1 1 2016, Pages 1554-1561
Acute effect of MitraClip implantation on mitral valve geometry in patients with functional mitral regurgitation: insights from three-dimensional transoesophageal echocardiography.
Al Amri I, Debonnaire P, van der Kley F, Schalij MJ, Bax JJ, Marsan NA, Delgado V
Aims: Our aim was to evaluate the acute effects of transcatheter edge-to-edge mitral valve repair using the MitraClip device on mitral valve geometry in patients with functional mitral regurgitation (FMR). Methods and results: Forty-two patients (age 73 years [IQ range 66.1-78.0], 55% men, 62% ischaemic FMR) with moderate-to-severe and severe FMR treated with the MitraClip were included. Three-dimensional transoesophageal echocardiography was performed prior to and immediately after MitraClip im...
Abstract
Cited 9 times since 2016 (1 per year)
source: EuropePMC
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology,
Volume 11, Issue 13, 1 1 2016, Pages 1554-1561
Acute effect of MitraClip implantation on mitral valve geometry in patients with functional mitral regurgitation: insights from three-dimensional transoesophageal echocardiography.
Al Amri I, Debonnaire P, van der Kley F, Schalij MJ, Bax JJ, Marsan NA, Delgado V
Aims: Our aim was to evaluate the acute effects of transcatheter edge-to-edge mitral valve repair using the MitraClip device on mitral valve geometry in patients with functional mitral regurgitation (FMR). Methods and results: Forty-two patients (age 73 years [IQ range 66.1-78.0], 55% men, 62% ischaemic FMR) with moderate-to-severe and severe FMR treated with the MitraClip were included. Three-dimensional transoesophageal echocardiography was performed prior to and immediately after MitraClip im...
Abstract
Cited 29 times since 2016 (3.2 per year)
source: EuropePMC
Journal of medical genetics,
Volume 53, Issue 7, 1 1 2016, Pages 441-449
Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels.
van Leeuwen EM, Sabo A, Bis JC, Huffman JE, Manichaikul A, Smith AV, Feitosa MF, Demissie S, Joshi PK, Duan Q, Marten J, van Klinken JB, Surakka I, Nolte IM, Zhang W, Mbarek H, Li-Gao R, Trompet S, Verweij N, Evangelou E, Lyytikäinen LP, Tayo BO, Deelen J, van der Most PJ, van der Laan SW, Arking DE, Morrison A, Dehghan A, Franco OH, Hofman A, Rivadeneira F, Sijbrands EJ, Uitterlinden AG, Mychaleckyj JC, Campbell A, Hocking LJ, Padmanabhan S, Brody JA, Rice KM, White CC, Harris T, Isaacs A, Campbell H, Lange LA, Rudan I, Kolcic I, Navarro P, Zemunik T, Salomaa V, LifeLines Cohort Study, Kooner AS, Kooner JS, Lehne B, Scott WR, Tan ST, de Geus EJ, Milaneschi Y, Penninx BW, Willemsen G, de Mutsert R, Ford I, Gansevoort RT, Segura-Lepe MP, Raitakari OT, Viikari JS, Nikus K, Forrester T, McKenzie CA, de Craen AJ, de Ruijter HM, CHARGE Lipids Working Group, Pasterkamp G, Snieder H, Oldehinkel AJ, Slagboom PE, Cooper RS, Kähönen M, Lehtimäki T, Elliott P, van der Harst P, Jukema JW, Mook-Kanamori DO, Boomsma DI, Ch
Background: So far, more than 170 loci have been associated with circulating lipid levels through genome-wide association studies (GWAS). These associations are largely driven by common variants, their function is often not known, and many are likely to be markers for the causal variants. In this study we aimed to identify more new rare and low-frequency functional variants associated with circulating lipid levels. Methods: We used the 1000 Genomes Project as a reference panel for the imputation...
Abstract
Cited 31 times since 2016 (3.4 per year)
source: EuropePMC
Circulation research,
Volume 118, Issue 8, 1 1 2016, Pages 1254-1263
Meta-Analyses of Human Cell-Based Cardiac Regeneration Therapies: Controversies in Meta-Analyses Results on Cardiac Cell-Based Regenerative Studies.
Gyöngyösi M, Wojakowski W, Navarese EP, Moye LÀ, ACCRUE Investigators
In contrast to multiple publication-based meta-analyses involving clinical cardiac regeneration therapy in patients with recent myocardial infarction, a recently published meta-analysis based on individual patient data reported no effect of cell therapy on left ventricular function or clinical outcome. A comprehensive review of the data collection, statistics, and the overall principles of meta-analyses provides further clarification and explanation for this controversy. The advantages and pitfa...
Abstract
Cited 16 times since 2016 (1.7 per year)
source: EuropePMC
Circulation. Arrhythmia and electrophysiology,
Volume 9, Issue 4, 1 1 2016, Pages e003439
Allosteric Modulation of Kv11.1 (hERG) Channels Protects Against Drug-Induced Ventricular Arrhythmias.
Yu Z, Liu J, van Veldhoven JP, IJzerman AP, Schalij MJ, Pijnappels DA, Heitman LH, de Vries AA
Background: Ventricular arrhythmias as a result of unintentional blockade of the Kv11.1 (hERG [human ether-à-go-go-related gene]) channel are a major safety concern in drug development. In past years, several highly prescribed drugs have been withdrawn for their ability to cause such proarrhythmia. Here, we investigated whether the proarrhythmic risk of existing drugs could be reduced by Kv11.1 allosteric modulators. Methods and results: Using [(3)H]dofetilide-binding assays with membranes of hu...
Abstract
Cited 81 times since 2016 (8.8 per year)
source: EuropePMC
Nature communications,
Volume 7, 31 5 2016, Pages 10846
Quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expression.
de Bruin RG, Shiue L, Prins J, de Boer HC, Singh A, Fagg WS, van Gils JM, Duijs JM, Katzman S, Kraaijeveld AO, Böhringer S, Leung WY, Kielbasa SM, Donahue JP, van der Zande PH, Sijbom R, van Alem CM, Bot I, van Kooten C, Jukema JW, Van Esch H, Rabelink TJ, Kazan H, Biessen EA, Ares M, van Zonneveld AJ, van der Veer EP
A hallmark of inflammatory diseases is the excessive recruitment and influx of monocytes to sites of tissue damage and their ensuing differentiation into macrophages. Numerous stimuli are known to induce transcriptional changes associated with macrophage phenotype, but posttranscriptional control of human macrophage differentiation is less well understood. Here we show that expression levels of the RNA-binding protein Quaking (QKI) are low in monocytes and early human atherosclerotic lesions, bu...
Abstract
Revista espanola de cardiologia (English ed.),
Volume 69, Issue 5, 30 5 2016, Pages 533
Evidence From Pacing in Obstructive Hypertrophic Cardiomyopathy. Response.
Jurado Román A, Montero Cabezas JM, Tascón Pérez JC
Abstract
Cited 18 times since 2016 (2 per year)
source: EuropePMC
Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc,
Volume 21, Issue 5, 28 4 2016, Pages 526-528
De Winter Electrocardiographic Pattern Related with a Non-Left Anterior Descending Coronary Artery Occlusion.
Montero Cabezas JM, Karalis I, Schalij MJ
The electrocardiographic pattern consisting of ST-segment depression and hyperacute T waves in patients with acute chest pain, known as "De Winter pattern," has been related with the occlusion of the proximal left anterior descending artery (LAD). The association of these findings with the involvement of a different coronary artery has not been described. We present a 53-year-old patient with an occlusion of the first diagonal branch and an electrocardiogram showing a "De Winter p...
Abstract
Cited 6 times since 2016 (0.7 per year)
source: EuropePMC
Diabetic medicine : a journal of the British Diabetic Association,
Volume 33, Issue 6, 25 4 2016, Pages 794-802
Effectiveness of insulin therapy in people with Type 2 diabetes in the Hoorn Diabetes Care System.
Mast MR, Walraven I, Hoekstra T, Jansen AP, van der Heijden AA, Elders PJ, Heine RJ, Dekker JM, Nijpels G, Hugtenburg JG
Aims: To identify HbA1c trajectories after the start of insulin treatment and to identify clinically applicable predictors of the response to insulin therapy. Methods: The study population comprised 1203 people with Type 2 diabetes included in the Hoorn Diabetes Care System (n = 9849). Inclusion criteria were: age ≥ 40 years; initiation of insulin during follow-up after failure to reach HbA1c levels ≤ 53 mmol/mol (7%) with oral glucose-lowering agents; and a follow up ≥ 2 years after initiating...
Abstract
Cited 12 times since 2016 (1.3 per year)
source: EuropePMC
Langenbeck's archives of surgery,
Volume 401, Issue 3, 24 4 2016, Pages 365-373
Characteristics of contralateral carcinomas in patients with differentiated thyroid cancer larger than 1 cm.
Lodewijk L, Kluijfhout WP, Kist JW, Stegeman I, Plukker JT, Nieveen van Dijkum EJ, Bonjer HJ, Bouvy ND, Schepers A, de Wilt JH, Netea-Maier RT, van der Hage JA, Burger JW, Ho G, Lee WS, Shen WT, Aronova A, Zarnegar R, Benay C, Mitmaker EJ, Sywak MS, Aniss AM, Kruijff S, James B, Grogan RH, Brunaud L, Hoch G, Pandolfi C, Ruan DT, Jones MD, Guerrero MA, Valk GD, Borel Rinkes IH, Vriens MR
Purpose: Traditionally, total thyroidectomy has been advocated for patients with tumors larger than 1 cm. However, according to the ATA and NCCN guidelines (2015, USA), patients with tumors up to 4 cm are now eligible for lobectomy. A rationale for adhering to total thyroidectomy might be the presence of contralateral carcinomas. The purpose of this study was to describe the characteristics of contralateral carcinomas in patients with differentiated thyroid cancer (DTC) larger than 1 cm. Methods...
Abstract
Cited 6 times since 2016 (0.7 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 18, Issue 2, 24 4 2016, Pages 203-211
The influence of clinical and acquisition parameters on the interpretability of adenosine stress myocardial computed tomography perfusion.
van Rosendael AR, de Graaf MA, Dimitriu-Leen AC, van Zwet EW, van den Hoogen IJ, Kharbanda RK, Bax JJ, Kroft LJ, Scholte AJ
Aims: The interpretation of adenosine stress myocardial computed tomography perfusion (CTP) is often hampered by image artefacts caused by cardiac motion, beam hardening, and cone beam. The aim of the present analysis was to assess the influence of the heart-rate response during adenosine infusion, patient characteristics, and medication use on the interpretability of stress myocardial CTP examinations. Methods and results: Interpretability of stress myocardial CTP examinations was evaluated in...
Abstract
Cited 5 times since 2016 (0.5 per year)
source: EuropePMC
Journal of vascular surgery,
Volume 63, Issue 6, 19 3 2016, Pages 1428-1433.e1
Predicting reinterventions after open and endovascular aneurysm repair using the St George's Vascular Institute score.
de Bruin JL, Karthikesalingam A, Holt PJ, Prinssen M, Thompson MM, Blankensteijn JD, Dutch Randomised Endovascular Aneurysm Management (DREAM) Study Group
Background: Identifying patients at risk for aneurysm rupture and sac expansion after open and endovascular abdominal aortic aneurysm (AAA) repair (EVAR) may help to attenuate this risk by intensifying follow-up and early detection of problems. The goal of this study was to validate the St George's Vascular Institute (SGVI) score to identify patients at risk for a secondary intervention after elective aneurysm repair. Methods: A post hoc on-treatment analysis of a randomized trial comparing...
Abstract
Cited 1 times since 2016 (0.1 per year)
source: EuropePMC
The Canadian journal of cardiology,
Volume 32, Issue 12, 19 3 2016, Pages 1576.e7-1576.e9
Prosthesis Dislocation After Transapical Valve-In-Valve Mitral Valve Implantation.
Tomšič A, Palmen M, Versteegh MI, van der Kley F, Siebelink HJ, Berendsen RR, Schalij MJ
Transapical valve-in-valve mitral valve implantation (TA-MVI) has been described as an alternative treatment option in patients with degenerated bioprostheses in the mitral position. We report the first case of prosthesis dislocation and migration into the left atrium after TA-MVI. A new prosthesis was implanted using the same approach. The dislocated prosthesis was successfully removed through the left atrial appendage through an extended anterolateral thoracotomy without the use of cardiopulmo...
Abstract
Cited 12 times since 2016 (1.3 per year)
source: EuropePMC
European journal of nuclear medicine and molecular imaging,
Volume 43, Issue 8, 18 3 2016, Pages 1522-1529
Segmental quantitative myocardial perfusion with PET for the detection of significant coronary artery disease in patients with stable angina.
Berti V, Sciagrà R, Neglia D, Pietilä M, Scholte AJ, Nekolla S, Rouzet F, Pupi A, Knuuti J
Purpose: The goal of this study is to determine the technical accuracy of segmental perfusion parameters assessed with quantitative cardiac PET imaging in the evaluation of coronary artery disease (CAD) in patients with stable angina. Methods: A cohort of patients who participated in the EVINCI protocol underwent an evaluation of coronary anatomy by invasive coronary angiography (ICA) and/or coronary computed tomography angiography (CCTA) and PET myocardial perfusion imaging with H2 (15)O, (13)N...
Abstract
Cited 52 times since 2016 (5.6 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 17, Issue 9, 18 3 2016, Pages 951-960
Multicentre multi-device hybrid imaging study of coronary artery disease: results from the EValuation of INtegrated Cardiac Imaging for the Detection and Characterization of Ischaemic Heart Disease (EVINCI) hybrid imaging population.
Liga R, Vontobel J, Rovai D, Marinelli M, Caselli C, Pietila M, Teresinska A, Aguadé-Bruix S, Pizzi MN, Todiere G, Gimelli A, Chiappino D, Marraccini P, Schroeder S, Drosch T, Poddighe R, Casolo G, Anagnostopoulos C, Pugliese F, Rouzet F, Le Guludec D, Cappelli F, Valente S, Gensini GF, Zawaideh C, Capitanio S, Sambuceti G, Marsico F, Filardi PP, Fernández-Golfín C, Rincón LM, Graner FP, de Graaf MA, Stehli J, Reyes E, Nkomo S, Mäki M, Lorenzoni V, Turchetti G, Carpeggiani C, Puzzuoli S, Mangione M, Marcheschi P, Giannessi D, Nekolla S, Lombardi M, Sicari R, Scholte AJ, Zamorano JL, Underwood SR, Knuuti J, Kaufmann PA, Neglia D, Gaemperli O, EVINCI Study Investigators
Aims: Hybrid imaging provides a non-invasive assessment of coronary anatomy and myocardial perfusion. We sought to evaluate the added clinical value of hybrid imaging in a multi-centre multi-vendor setting. Methods and results: Fourteen centres enrolled 252 patients with stable angina and intermediate (20-90%) pre-test likelihood of coronary artery disease (CAD) who underwent myocardial perfusion scintigraphy (MPS), CT coronary angiography (CTCA), and quantitative coronary angiography (QCA) with...
Abstract
Cited 55 times since 2016 (6 per year)
source: EuropePMC
Journal of molecular and cellular cardiology,
Volume 94, 17 3 2016, Pages 13-20
Simulation of early calcific aortic valve disease in a 3D platform: A role for myofibroblast differentiation.
Hjortnaes J, Goettsch C, Hutcheson JD, Camci-Unal G, Lax L, Scherer K, Body S, Schoen FJ, Kluin J, Khademhosseini A, Khademhosseini A, Aikawa E
Purpose: Calcific aortic valve disease (CAVD) is the most prevalent valve disease in the Western world. Recent difficulty in translating experimental results on statins to beneficial clinical effects warrants the need for understanding the role of valvular interstitial cells (VICs) in CAVD. In two-dimensional culture conditions, VICs undergo spontaneous activation similar to pathological differentiation, which intrinsically limits the use of in vitro models to study CAVD. Here, we hypothesized t...
Abstract
Cited 33 times since 2016 (3.6 per year)
source: EuropePMC
BMJ open,
Volume 6, Issue 3, 17 3 2016, Pages e009971
Epidemic potential of Escherichia coli ST131 and Klebsiella pneumoniae ST258: a systematic review and meta-analysis.
Dautzenberg MJ, Haverkate MR, Bonten MJ, Bootsma MC
Objectives: Observational studies have suggested that Escherichia coli sequence type (ST) 131 and Klebsiella pneumoniae ST258 have hyperendemic properties. This would be obvious from continuously high incidence and/or prevalence of carriage or infection with these bacteria in specific patient populations. Hyperendemicity could result from increased transmissibility, longer duration of infectiousness, and/or higher pathogenic potential as compared with other lineages of the same species. The aim...
Abstract
