Research

Publications

Below you can find a list of our published research.

6196 results

Cited 88 times since 2007 (5 per year) source: EuropePMC

Radiology, Volume 245, Issue 1, 1 1 2007, Pages 251-257 Metabolic imaging of myocardial triglyceride content: reproducibility of 1H MR spectroscopy with respiratory navigator gating in volunteers. van der Meer RW, Doornbos J, Kozerke S, Schär M, Bax JJ, Hammer S, Smit JW, Romijn JA, Diamant M, Rijzewijk LJ, de Roos A, Lamb HJ

Institutional review board approval and informed consent were obtained. The purpose of the study was to prospectively compare spectral resolution and reproducibility of hydrogen 1 (1H) magnetic resonance (MR) spectroscopy, with and without respiratory motion compensation based on navigator echoes, in the assessment of myocardial triglyceride content in the human heart. In 20 volunteers (14 men, six women; mean age+/-standard error, 31 years+/-2.8 [range, 19-60 years]; body mass index, 19-30 kg/m... Abstract

Cited 34 times since 2007 (1.9 per year) source: EuropePMC

The Journal of general virology, Volume 88, Issue Pt 10, 1 1 2007, Pages 2702-2709 Immunization of Syrian golden hamsters with F subunit vaccine of human metapneumovirus induces protection against challenge with homologous or heterologous strains. Herfst S, de Graaf M, Schrauwen EJA, Ulbrandt ND, Barnes AS, Senthil K, Osterhaus ADME, Fouchier RAM, van den Hoogen BG

Human metapneumovirus (hMPV), a newly discovered paramyxovirus, is associated with acute respiratory-tract illness, primarily in young children, individuals with underlying disease and the elderly. Two genetic lineages of hMPV circulate around the world, and viruses from these two lineages demonstrate antigenic differences. The clinical impact of hMPV warrants the development of vaccines. Recombinant soluble fusion (F) proteins of prototype viruses of the two main lineages of hMPV that can be pr... Abstract

Cited 1 times since 2007 (0.1 per year) source: EuropePMC

Revista espanola de cardiologia, Volume 60, Issue 10, 1 1 2007, Pages 1083-1091 [Coronary risk assessment in the management of patients undergoing noncardiac vascular surgery]. Schouten O, Bax JJ, Poldermans D

Patients scheduled for noncardiac vascular surgery are at significant risk of cardiovascular morbidity and mortality due to underlying symptomatic or asymptomatic coronary artery disease. This review will give an overview of current preoperative cardiac risk assessment strategies for patients undergoing noncardiac vascular surgery. Clinical cardiac risk scores are useful tools for the simple identification of patients with an increased perioperative cardiac risk. These risk scores include factor... Abstract

Cited 19 times since 2007 (1.1 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 50, Issue 17, 1 1 2007, Pages 1649-1656 Intensity of statin therapy in relation to myocardial ischemia, troponin T release, and clinical cardiac outcome in patients undergoing major vascular surgery. Feringa HH, Schouten O, Karagiannis SE, Brugts J, Elhendy A, Boersma E, Vidakovic R, van Sambeek MR, Noordzij PG, Bax JJ, Poldermans D

Objectives: This study sought to examine whether higher statin doses and lower low-density lipoprotein (LDL) cholesterol are associated with improved cardiac outcome in vascular surgery patients. Background: Statins may have cardioprotective effects during major vascular surgery. Methods: In a prospective study of 359 vascular surgery patients, statin dose and cholesterol levels were recorded preoperatively. Myocardial ischemia and heart rate variability were assessed by 72-h 12-lead electrocard... Abstract

Cited 96 times since 2007 (5.5 per year) source: EuropePMC

Circulation, Volume 116, Issue 17, 1 1 2007, Pages 1931-1941 CC chemokine ligand-5 (CCL5/RANTES) and CC chemokine ligand-18 (CCL18/PARC) are specific markers of refractory unstable angina pectoris and are transiently raised during severe ischemic symptoms. Kraaijeveld AO, de Jager SC, de Jager WJ, Prakken BJ, McColl SR, Haspels I, Putter H, van Berkel TJ, Nagelkerken L, Jukema JW, Biessen EA

Background: Chemokines play an important role in atherogenesis and in ischemic injury and repair; however, prospective data on individual chemokines in unstable angina pectoris (UAP) are scarce. Therefore, we assessed chemokine patterns in a prospective cohort of patients with UAP. Methods and results: Plasma samples of 54 patients with Braunwald class IIIB UAP were examined at baseline for 11 chemokines and 5 inflammatory mediators via multiplex analysis. Levels of CC chemokine ligand (CCL)-5 (... Abstract

Cited 76 times since 2007 (4.3 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 50, Issue 16, 1 1 2007, Pages 1532-1540 Left ventricular dyssynchrony acutely after myocardial infarction predicts left ventricular remodeling. Mollema SA, Liem SS, Suffoletto MS, Bleeker GB, van der Hoeven BL, van de Veire NR, Boersma E, Holman ER, van der Wall EE, Schalij MJ, Gorcsan J, Bax JJ

Objectives: We sought to identify predictors of left ventricular (LV) remodeling after acute myocardial infarction. Background: Left ventricular remodeling after myocardial infarction is associated with an adverse long-term prognosis. Early identification of patients prone to LV remodeling is needed to optimize therapeutic management. Methods: A total of 178 consecutive patients presenting with acute myocardial infarction who underwent primary percutaneous coronary intervention were included. Wi... Abstract

Cited 64 times since 2007 (3.6 per year) source: EuropePMC

Journal of internal medicine, Volume 262, Issue 6, 1 1 2007, Pages 678-689 Differential leucocyte count and the risk of future coronary artery disease in healthy men and women: the EPIC-Norfolk Prospective Population Study. Rana JS, Boekholdt SM, Ridker PM, Jukema JW, Luben R, Bingham SA, Day NE, Wareham NJ, Kastelein JJ, Khaw KT

Background: We examined the relationship between granulocyte, lymphocyte and monocyte counts and risk of coronary heart disease (CHD) and cardiovascular disease (CVD) in men and women. There is paucity of data on the differential leucocyte count and its relationship with the risk of CHD and CVD. Methods: This prospective study comprised 7073 men and 9035 women who were 45-79 years of age and were residents of Norfolk. United Kingdom. Results: During an average of 8 years of follow-up we identifi... Abstract

Cited 19 times since 2007 (1.1 per year) source: EuropePMC

The FEBS journal, Volume 274, Issue 20, 26 4 2007, Pages 5425-5437 Aplysia temptin - the 'glue' in the water-borne attractin pheromone complex. Cummins SF, Xie F, de Vries MR, Annangudi SP, Misra M, Degnan BM, Sweedler JV, Nagle GT, Schein CH

Temptin, a component of the complex of water-borne protein pheromones that stimulate attraction and mating behavior in the marine mollusk Aplysia, has sequence homology to the epidermal growth factor (EGF)-like domains of higher organisms that mediate protein-cell surface contact during fertilization and blood coagulation. In this work, recombinant temptin for structural and functional studies was produced in Escherichia coli using a cold shock promoter and purified by RP-HPLC. CD spectra confir... Abstract

Cited 185 times since 2007 (10.5 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 50, Issue 15, 24 4 2007, Pages 1476-1483 Combined longitudinal and radial dyssynchrony predicts ventricular response after resynchronization therapy. Gorcsan J, Tanabe M, Bleeker GB, Suffoletto MS, Thomas NC, Saba S, Tops LF, Schalij MJ, Bax JJ

Objectives: The purpose of this study was to test the hypothesis that a combined echocardiographic assessment of longitudinal dyssynchrony by tissue Doppler imaging (TDI) and radial dyssynchrony by speckle-tracking strain may predict left ventricular (LV) functional response to cardiac resynchronization therapy (CRT). Background: Mechanical LV dyssynchrony is associated with response to CRT; however, complex patterns may exist. Methods: We studied 190 heart failure patients (ejection fraction [E... Abstract

Cited 42 times since 2007 (2.4 per year) source: EuropePMC

Radiology, Volume 245, Issue 2, 21 3 2007, Pages 416-423 Evaluation of patients with previous coronary stent implantation with 64-section CT. Schuijf JD, Pundziute G, Jukema JW, Lamb HJ, Tuinenburg JC, van der Hoeven BL, de Roos A, Reiber JH, van der Wall EE, Schalij MJ, Bax JJ

Purpose: To prospectively evaluate the diagnostic accuracy of 64-section computed tomography (CT) for the assessment of in-stent or peristent restenosis, with conventional coronary angiography as the reference standard. Materials and methods: The study was approved by the medical ethics committee, and informed consent was obtained in all 50 enrolled patients (40 men, 10 women; mean age, 60 years +/- 11 [standard deviation]). In addition to conventional coronary angiography with quantitative coro... Abstract

Cited 60 times since 2007 (3.4 per year) source: EuropePMC

Atherosclerosis, Volume 197, Issue 1, 14 2 2007, Pages 57-63 Atorvastatin increases HDL cholesterol by reducing CETP expression in cholesterol-fed APOE*3-Leiden.CETP mice. de Haan W, van der Hoogt CC, Westerterp M, Hoekstra M, Dallinga-Thie GM, Princen HM, Romijn JA, Jukema JW, Havekes LM, Rensen PC

Objective: In addition to lowering low-density lipoprotein (LDL)-cholesterol, statins modestly increase high-density lipoprotein (HDL)-cholesterol in humans and decrease cholesteryl ester transfer protein (CETP) mass and activity. Our aim was to determine whether the increase in HDL depends on CETP expression. Methods and results: APOE*3-Leiden (E3L) mice, with a human-like lipoprotein profile and a human-like responsiveness to statin treatment, were crossbred with mice expressing human CETP und... Abstract

Cited 58 times since 2007 (3.3 per year) source: EuropePMC

American heart journal, Volume 154, Issue 6, 14 2 2007, Pages 1160-1165 Myocardial contractile reserve predicts improvement in left ventricular function after cardiac resynchronization therapy. Ypenburg C, Sieders A, Bleeker GB, Holman ER, van der Wall EE, Schalij MJ, Bax JJ

Background: Myocardial contractile reserve has been shown to provide important prognostic information in patients with heart failure. We hypothesized that myocardial contractile reserve would predict left ventricular (LV) reverse remodeling after cardiac resynchronization therapy (CRT). Methods: Thirty-one consecutive patients with heart failure (LV ejection fraction [LVEF] 26% +/- 7%, 35% nonischemic cardiomyopathy) underwent echocardiography during low-dose dobutamine infusion before CRT impla... Abstract

Cited 51 times since 2007 (2.9 per year) source: EuropePMC

European journal of nuclear medicine and molecular imaging, Volume 35, Issue 1, 12 2 2007, Pages 166-173 Left ventricular dyssynchrony assessed by two three-dimensional imaging modalities: phase analysis of gated myocardial perfusion SPECT and tri-plane tissue Doppler imaging. Marsan NA, Henneman MM, Chen J, Ypenburg C, Dibbets P, Ghio S, Bleeker GB, Stokkel MP, van der Wall EE, Tavazzi L, Garcia EV, Bax JJ

Purpose: To compare left ventricular (LV) dyssynchrony assessment by phase analysis from gated myocardial perfusion SPECT (GMPS) with LV dyssynchrony assessment by tri-plane tissue Doppler imaging (TDI). Baseline LV dyssynchrony assessed with standard deviation (SD) of time-to-peak systolic velocity of 12 LV segments (Ts-SD) with TDI has proven to be a powerful predictor of response to CRT. Information on LV dyssynchrony can also be provided by GMPS with phase analysis of regional LV maximal cou... Abstract

Cited 109 times since 2007 (6.2 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 50, Issue 12, 4 1 2007, Pages 1180-1188 Speckle-tracking radial strain reveals left ventricular dyssynchrony in patients with permanent right ventricular pacing. Tops LF, Suffoletto MS, Bleeker GB, Boersma E, van der Wall EE, Gorcsan J, Schalij MJ, Bax JJ

Objectives: Speckle-tracking strain analysis was used to assess the effects of permanent right ventricular (RV) pacing on the heterogeneity in timing of regional wall strain and left ventricular (LV) dyssynchrony. Background: Recent studies have shown detrimental effects of RV pacing, possibly related to the induction of LV dyssynchrony. Methods: Fifty-eight patients treated with His bundle ablation and pacemaker implantation were studied. To assess the effect of RV pacing on time-to-peak radial... Abstract

Cited 141 times since 2007 (8 per year) source: EuropePMC

Circulation, Volume 116, Issue 13, 4 1 2007, Pages 1440-1448 Left ventricular resynchronization is mandatory for response to cardiac resynchronization therapy: analysis in patients with echocardiographic evidence of left ventricular dyssynchrony at baseline. Bleeker GB, Mollema SA, Holman ER, Van de Veire N, Ypenburg C, Boersma E, van der Wall EE, Schalij MJ, Bax JJ

Background: Recent studies have demonstrated that a positive response to cardiac resynchronization therapy (CRT) is related to the presence of preimplantation left ventricular (LV) dyssynchrony. The time course and the extent of LV resynchronization after CRT implantation and their relationship to response are currently unknown. Methods and results: One hundred consecutive patients scheduled for implantation of a CRT device were prospectively included if they met the following criteria: New York... Abstract

Cited 8 times since 2007 (0.5 per year) source: EuropePMC

Journal of child neurology, Volume 22, Issue 9, 1 1 2007, Pages 1143-1146 Devic's neuromyelitis optica in an infant case. Yuksel D, Senbil N, Yilmaz D, Yavuz Gurer YK

Devic's neuromyelitis optica was orginally described as an acute severe monophasic syndrome characterised by myelitis and optic neuritis. The mean age at onset was reported to be around 40 years, with a wide range. However, Devic's neuromyelitis optica has also been seen in children. Prognosis of the syndrome was poor, and no satisfactory treatment was known. This article reports a 23-month-old boy with acute myelitis and optic neuritis who was diagnosed with Devic's neuromyelitis... Abstract

Cited 14 times since 2007 (0.8 per year) source: EuropePMC

Human gene therapy, Volume 18, Issue 9, 1 1 2007, Pages 861-869 Prolonged in vivo gene silencing by electroporation-mediated plasmid delivery of small interfering RNA. Eefting D, Grimbergen JM, de Vries MR, van Weel V, Kaijzel EL, Que I, Moon RT, Löwik CW, van Bockel JH, Quax PH

For the successful application of RNA interference in vivo, it is desired to achieve (local) delivery of small interfering RNAs (siRNAs) and long-term gene silencing. Nonviral electrodelivery is suitable to obtain local and prolonged expression of transgenes. By intramuscular electrodelivery of a plasmid in which two opposing human polymerase III promoters (H1 and U6) drive the expression of siRNA constructs that form functional double-stranded siRNAs, in combination with in vivo bioluminescence... Abstract

Cited 13 times since 2007 (0.7 per year) source: EuropePMC

Journal of pediatric surgery, Volume 42, Issue 9, 1 1 2007, Pages E23-5 Anorectal impalement in a pediatric patient with transanal evisceration of small bowel. Bronkhorst MW, Wilde JC, Hamming JF, Heij HA

Rectal injuries in the pediatric population are most often attributed to accidental falls on offending objects, sexual abuse, or blunt trauma. Anorectal impalement is a rare injury, and as a result, specific knowledge or experience on the treatment of this type of injury in children is sparse. The extent of injury is often difficult to assess. Mostly, therapeutical decisions are based on general knowledge in adults. We present a case of accidental anorectal impalement in a child by a fall on the... Abstract

Cited 14 times since 2007 (0.8 per year) source: EuropePMC

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, Volume 30, Issue 3, 1 1 2007, Pages 325-331 Systolic and diastolic ventricular function in the normal and extra-embryonic venous clipped chicken embryo of stage 24: a pressure-volume loop assessment. Stekelenburg-de Vos S, Steendijk P, Ursem NT, Wladimiroff JW, Poelmann RE

Objectives: Fluid mechanical forces affect cardiac development. In the chicken embryo, permanent obstruction of the right lateral vitelline vein by clipping reduces the mechanical load on the embryonic myocardium, which has been shown to induce a spectrum of outflow tract anomalies. Insight into the effects of this intervention on the mechanical function of the developing myocardium could contribute to a better understanding of the relationship between hemodynamics and cardiac morphogenesis. We... Abstract

Cited 5 times since 2007 (0.3 per year) source: EuropePMC

Coronary artery disease, Volume 18, Issue 6, 1 1 2007, Pages 483-487 Carotid artery stenting versus endarterectomy in relation to perioperative myocardial ischemia, troponin T release and major cardiac events. Feringa HH, Hendriks JM, Karagiannis S, Schouten O, Vidakovic R, van Sambeek MR, Klein J, Noordzij P, Bax JJ, Poldermans D

Background: Carotid artery stenting (CAS) is less invasive than endarterectomy. This study examined differences in perioperative myocardial ischemia, troponin T release and clinical cardiac events in patients undergoing CAS compared with endarterectomy. Methods: In an observational study, CAS was performed in 24 and carotid endarterectomy in 44 patients. Before surgery, clinical risk factors were noted and dobutamine stress echocardiography was performed for cardiac risk assessment. Perioperativ... Abstract