Research

Publications

Below you can find a list of our published research.

8892 results

Cited 8 times since 2024 (8.4 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 26, Issue 11, 1 1 2024, Pages euae243 2024 updated European Heart Rhythm Association core curriculum for physicians and allied professionals: a statement of the European Heart Rhythm Association of the European Society of Cardiology. Trines SA, Moore P, Burri H, Gonçalves Nunes S, Massoullié G, Merino JL, Paton MF, Porta-Sánchez A, Sommer P, Steven D, Whittaker-Axon S, Yorgun H, Arribas F, Claude Deharo J, Steffel J, Wolpert C

Heart rhythm management is a continuously evolving sub-speciality of cardiology. Every year, many physicians and allied professionals (APs) start and complete their training in cardiac implantable electronic devices (CIEDs) or electrophysiology (EP) across the European Heart Rhythm Association (EHRA) member countries. While this training ideally ends with an EHRA certification, the description of the learning pathway (what, how, when, and where) through an EHRA core curriculum is also a prerequi... Abstract

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, Volume 29, Issue 47, 1 1 2024 Agile, on-demand wastewater surveillance of virus infections to support pandemic and outbreak response in Rotterdam-Rijnmond, the Netherlands, 2020 to 2022. Besijn E, Whelan J, Bijkerk P, Sips GJ, Langeveld J, Izquierdo-Lara RW, van Baarle E, Schilperoort R, Koopmans MPG, de Graaf M, Medema G, Fanoy E

BackgroundWastewater surveillance may support early and comprehensive detection of infectious diseases' community transmission, particularly in settings where other health surveillance systems provide biased or limited information. Amid the SARS-CoV-2 pandemic, deploying passive samplers to monitor targeted populations gained importance. Evaluation of the added public health value of this approach in the field can support its broader adoption.AimWe aimed to assess the feasibility and utilit... Abstract

Communications medicine, Volume 4, Issue 1, 1 1 2024, Pages 223 Regional mechanical dyssynchrony and shortened systole are present in people with Takotsubo syndrome. Reil JC, Sequeira V, Reil GH, Steendijk P, Maack C, Fink T, Rawish E, Eitel I, Stiermaier T

Background: Takotsubo syndrome is characterized by transient regional systolic dysfunction, left ventricular (LV) dilatation, and edema, often occurring without obstructive coronary artery disease. The mechanisms underlying this stress-induced condition, especially the role of mechanical dyssynchrony in affecting systolic function, remain poorly understood. Methods: In our study, we evaluated global LV function and mechanical dyssynchrony in 24 Takotsubo patients compared to 20 controls by analy... Abstract

Cited 4 times since 2024 (4.2 per year) source: EuropePMC

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Volume 39, Issue 12, 1 1 2024, Pages 2048-2057 Long-term renal and cardiovascular risks of tacrolimus in patients with lupus nephritis. van Schaik M, Bredewold OW, Priester M, Michels WM, Rabelink TJ, Rotmans JI, Teng YKO

Background: Despite continuous advancement, treatment of lupus nephritis (LN) remains challenging. Recent guidelines now include a regimen incorporating tacrolimus as a first-line treatment option. Even though tacrolimus is effective in combination with mycophenolate and corticosteroids, concerns remain regarding long-term use, given its association with increased cardiovascular risks including nephrotoxicity, hypertension, dyslipidemia and hyperglycemia in kidney transplant recipients. However,... Abstract

Microbial genomics, Volume 10, Issue 11, 1 1 2024 Longitudinal genomic surveillance of a UK intensive care unit shows a lack of patient colonisation by multi-drug-resistant Gram-negative bacterial pathogens. Snaith AE, Moran RA, Hall RJ, Casey A, Ratcliffe L, van Schaik W, Whitehouse T, McNally A

Vulnerable patients in an intensive care unit (ICU) setting are at high risk of infection from bacteria including gut-colonising Escherichia coli and Klebsiella species. Complex ICU procedures often depend on successful antimicrobial treatment, underscoring the importance of understanding the extent of patient colonisation by multi-drug-resistant organisms (MDROs) in large UK ICUs. Previous work on ICUs globally uncovered high rates of colonisation by transmission of MDROs, but the situation in... Abstract

Cited 1 times since 2024 (1 per year) source: EuropePMC

Human reproduction (Oxford, England), Volume 39, Issue 11, 1 1 2024, Pages 2423-2433 The impact of maternal vulnerability on stress biomarkers and first-trimester growth: the Rotterdam Periconceptional Cohort (Predict Study). Van Zundert SKM, Van Rossem L, Mirzaian M, Willemsen SP, Voskamp LW, Bastiaansen WAP, Nikpayam D, Griffioen PH, Schilleman WF, Koning AHJ, Van Den Berg SAA, Rousian M, Van Schaik RHN, Steegers-Theunissen RPM

Study question: Is the degree of maternal vulnerability positively associated with stress biomarkers (stress hormones, C-reactive protein, tryptophan metabolites, and one-carbon metabolites), and does long-term exposure to stress hormones reduce first-trimester growth? Summary answer: The maternal vulnerability risk score is positively associated with concentrations of hair cortisol and cortisone and negatively with tryptophan, while higher hair cortisol concentrations are associated with reduce... Abstract

Cited 21 times since 2024 (21.9 per year) source: EuropePMC

European heart journal, Volume 45, Issue 42, 1 1 2024, Pages 4512-4522 Benefit of isolated surgical valve repair or replacement for functional tricuspid regurgitation and long-term outcomes stratified by the TRI-SCORE. Dreyfus J, Juarez-Casso F, Sala A, Carnero-Alcazar M, Eixerés-Esteve A, Bohbot Y, Bazire B, Flagiello M, Riant E, Mbaki Y, Tomasi J, Senage T, Rahmouni El Idrissi K, Coisne A, Eyharts D, Doguet F, Viau F, Eggenspieler F, Heuts S, Sardari Nia P, Heitzinger G, Galloo X, Ajmone Marsan N, Benfari G, Badano L, Muraru D, Maisano F, Topilsky Y, Michelena H, Enriquez-Sarano M, Bax J, Bartko P, Selton-Suty C, Habib G, Lavie-Badie Y, Modine T, Chan V, Le Tourneau T, Donal E, Lim P, Radu C, Bernick J, Wells GA, Tribouilloy C, Iung B, Obadia JF, De Bonis M, Crestanello J, Messika-Zeitoun D

Background and aims: Severe tricuspid regurgitation is associated with increased mortality rates, but benefit of its correction and ideal timing are not clearly determined. This study aimed to identify patient subsets who might benefit from the surgery. Methods: In TRIGISTRY, an international cohort study of consecutive patients with severe isolated functional tricuspid regurgitation (33 centres, 10 countries), survival rates up to 10 years were compared between patients who underwent isolated t... Abstract

Cited 3 times since 2024 (3.1 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 66, Issue 6, 1 1 2024, Pages ezae426 Learning curve of robotic mitral repair: prospective two-centre study of proficiency and clinical outcomes. Sandoval E, Bhoera RA, Tomšič A, Morales-Rey I, García-Álvarez A, Palmen M, Pereda D

Objectives: Robotic-assisted mitral valve repair surgery has a steep learning curve, and it is not clear whether previous experience in minimally invasive mitral valve surgery (MIMVS) facilitates this process. We aimed to investigate the initial experience of 2 cardiac centres starting their robotic programmes, evaluating the impact of previous MIMVS experience. Methods: Retrospective analysis was performed for the 1st consecutive cases operated due to severe degenerative mitral valve regurgitat... Abstract

Cited 1 times since 2024 (1 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 66, Issue 6, 1 1 2024, Pages ezae440 The effect of virtual reality on postoperative anxiety and pain in patients following cardiac surgery: a randomized controlled trial. El Mathari S, Shehadeh S, Zwaan WP, Boulidam N, Kuitert L, Twisk JWR, Klautz RJM, de Lind van Wijngaarden R, Veen K, Kluin J

Objectives: The VRECOVERY investigated the impact of virtual reality (VR) distraction therapy on postoperative pain, anxiety and quality of recovery in patients undergoing coronary artery bypass grafting surgery. Methods: A single-centre randomized controlled trial was conducted involving 192 participants, allocated to either the intervention or control group. Participants in the intervention group received VR distraction therapy on postoperative days 1, 2 and 3, while the control group received... Abstract

Cited 3 times since 2024 (3.1 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 25, Issue 12, 1 1 2024, Pages 1721-1733 Association between echocardiography-derived haemodynamic force parameters and left ventricular reverse remodelling after cardiac resynchronization therapy. Laenens D, van der Bijl P, Galloo X, Rossi AC, Tonti G, Reiber JHC, Pedrizzetti G, Ajmone Marsan N, Bax JJ

Aims: Cardiac resynchronization therapy (CRT) may induce left ventricular (LV) reverse remodelling (=LV response) in patients with heart failure. Intraventricular pressure gradients can be quantified using echocardiography-derived haemodynamic forces (HDF). The aim was to evaluate the association between baseline HDF and LV response and to compare the change of HDF after CRT between LV responders and LV non-responders. Methods and results: The following HDF parameters were assessed: (i) apical-b... Abstract

Cited 2 times since 2024 (2.1 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 66, Issue 6, 1 1 2024, Pages ezae418 External validation of EuroSCORE I and II in patients with infective endocarditis: results from a nationwide prospective registry. Heinen FJ, Peijster AJL, Fu EL, Kamp O, Chamuleau SAJ, Post MC, van der Stoel MD, Keyhan-Falsafi MA, van Nieuwkoop C, Klautz RJM, Tanis W, Cardiothoracic Surgery Registration Committee of the Netherlands Heart Registration

Objectives: The primary objective was to externally validate EuroSCORE I and II in surgically treated endocarditis patients. The secondary objective was to assess the predictive performance of both models across sex, redo surgery, age, and urgency. Methods: Data were retrieved from the Netherlands Heart Registration. All patients with infective endocarditis who underwent cardiac surgery between 2013 and 2021 were included. Predictive performance was assessed by discrimination (area under the cur... Abstract

Cited 4 times since 2024 (4.2 per year) source: EuropePMC

Blood, Volume 144, Issue 21, 1 1 2024, Pages 2248-2265 Whole-genome analysis of plasma fibrinogen reveals population-differentiated genetic regulators with putative liver roles. Huffman JE, Nicholas J, Hahn J, Heath AS, Raffield LM, Yanek LR, Brody JA, Thibord F, Almasy L, Bartz TM, Bielak LF, Bowler RP, Carrasquilla GD, Chasman DI, Chen MH, Emmert DB, Ghanbari M, Haessler J, Hottenga JJ, Kleber ME, Le NQ, Lee J, Lewis JP, Li-Gao R, Luan J, Malmberg A, Mangino M, Marioni RE, Martinez-Perez A, Pankratz N, Polasek O, Richmond A, Rodriguez BAT, Rotter JI, Steri M, Suchon P, Trompet S, Weiss S, Zare M, Auer P, Cho MH, Christofidou P, Davies G, de Geus E, Deleuze JF, Delgado GE, Ekunwe L, Faraday N, Gögele M, Greinacher A, Gao H, Howard T, Joshi PK, Kilpeläinen TO, Lahti J, Linneberg A, Naitza S, Noordam R, Paüls-Vergés F, Rich SS, Rosendaal FR, Rudan I, Ryan KA, Souto JC, van Rooij FJA, Wang H, Zhao W, Becker LC, Beswick A, Brown MR, Cade BE, Campbell H, Cho K, Crapo JD, Curran JE, de Maat MPM, Doyle M, Elliott P, Floyd JS, Fuchsberger C, Grarup N, Guo X, Harris SE, Hou L, Kolcic I, Kooperberg C, Menni C, Nauck M, O'Connell JR, Orrù V, Psaty BM, Räikkönen K, Smith JA, Soria JM, Stott DJ,

Abstract: Genetic studies have identified numerous regions associated with plasma fibrinogen levels in Europeans, yet missing heritability and limited inclusion of non-Europeans necessitates further studies with improved power and sensitivity. Compared with array-based genotyping, whole-genome sequencing (WGS) data provide better coverage of the genome and better representation of non-European variants. To better understand the genetic landscape regulating plasma fibrinogen levels, we meta-analy... Abstract

Cited 2 times since 2024 (2.1 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 25, Issue 12, 1 1 2024, Pages 1638-1648 Prognostic implications and alterations in left atrial deformation following transcatheter aortic valve implantation. Butcher SC, Hirasawa K, Meucci MC, Stassen J, Kuneman JH, Pereira AR, van der Kley F, de Weger A, van Rosendael PJ, Marsan NA, Playford D, Delgado V, Bax JJ

Aims: To evaluate the prognostic implications of the left atrial reservoir strain-defined diastolic dysfunction (LARS-DD) grade in patients undergoing transcatheter aortic valve implantation (TAVI) for severe aortic stenosis (AS) and to determine whether post-TAVI LARS was more closely associated with new-onset atrial fibrillation than pre-TAVI LARS. Methods and results: Pre-TAVI LARS-DD was evaluated by speckle-tracking echocardiography and was assigned as Grade 0 to 1 (LARS ≥24%), Grade 2 (LAR... Abstract

Journal of cell science, Volume 137, Issue 20, 31 5 2024, Pages jcs262041 Cell-cell junctions in focus - imaging junctional architectures and dynamics at high resolution. Janssen V, Huveneers S

Studies utilizing electron microscopy and live fluorescence microscopy have significantly enhanced our understanding of the molecular mechanisms that regulate junctional dynamics during homeostasis, development and disease. To fully grasp the enormous complexity of cell-cell adhesions, it is crucial to study the nanoscale architectures of tight junctions, adherens junctions and desmosomes. It is important to integrate these junctional architectures with the membrane morphology and cellular topog... Abstract

Cited 4 times since 2024 (4.2 per year) source: EuropePMC

Journal of clinical medicine, Volume 13, Issue 21, 31 5 2024, Pages 6567 Evaluating Virtual Reality Patient Education in Cardiac Surgery: Impact on Preoperative Anxiety and Postoperative Patient Satisfaction. El Mathari S, Kuitert L, Boulidam N, Shehadeh S, Klautz RJM, de Lind van Wijngaarden R, Kluin J

Background/Objectives: Preoperative anxiety in cardiac surgery patients can adversely affect mental well-being and postoperative outcomes. Virtual reality (VR) patient education has been proposed as a novel method to enhance patient education and potentially reduce preoperative anxiety. The VR Patient Journey Trial aimed to evaluate the impact of VR patient education on preoperative anxiety and patient satisfaction compared to traditional education methods. Methods: This randomized controlled tr... Abstract

Microorganisms, Volume 12, Issue 11, 31 5 2024, Pages 2216 Evaluation of the Antimicrobial Effects of Olive Mill Wastewater Extract Against Food Spoiling/Poisoning, Fish-Pathogenic and Non-Pathogenic Microorganisms. Yılmaz DK, Kesbiç FI, Çelik EŞ, Odabaşı DA, Yilmaz S, Abdel-Latif HMR

Although antibiotics are the main therapy for bacterial infections, the reports showed that the overuse (or misuse) of antibiotics will results in several problems such as the development of antibiotic-resistant strains, persistence of drug residues, and numerous environmental concerns. Therefore, finding antibiotic alternatives is considered of vital importance. Investigation of the antimicrobial properties of several plant substances and extracts is of great value to replace antibiotics. With... Abstract

Cited 4 times since 2024 (4.2 per year) source: EuropePMC

JACC. Basic to translational science, Volume 10, Issue 3, 30 5 2024, Pages 383-395 EPA Induces an Anti-Inflammatory Transcriptome in T Cells, Implicating a Triglyceride-Independent Pathway in Cardiovascular Risk Reduction. Reilly NA, Dekkers KF, Molenaar J, Arumugam S, Kuipers TB, Ariyurek Y, Hoeksema MA, Jukema JW, Heijmans BT

Twice-daily intake of purified eicosapentaenoic acid (EPA) reduces atherosclerotic cardiovascular disease risk in patients with high triglycerides, but its exact mechanism remains unclear. We exposed non-activated CD4+ T cells to 100μM EPA, oleic acid, palmitic acid, or control, and conducted RNA and ATAC-sequencing after 48 hours. EPA exposure downregulated immune response-related genes like HLA-DRA, CD69, and IL2RA, and upregulated oxidative stress prevention genes like NQO1. Transcription fac... Abstract

Cited 1 times since 2024 (1 per year) source: EuropePMC

Scientific reports, Volume 14, Issue 1, 29 5 2024, Pages 26018 Accessible viral metagenomics for public health and clinical domains with Jovian. Schmitz D, Zwagemaker F, Nooij S, Janssens TKS, Cremer J, Verhagen R, Vennema H, Kroneman A, Koopmans MPG, Laros JFJ, de Graaf M

The integration of next-generation sequencing into clinical diagnostics and surveillance initiatives is impeded by the lack of data analysis pipelines that align with privacy legislation and laboratory certification protocols. To address these challenges, we developed Jovian, an open-source, virus-focused, metagenomic analysis workflow for Illumina data. Jovian generates scaffolds enriched with pertinent annotations, including taxonomic classification, combined with metrics needed for quality as... Abstract

Cited 22 times since 2024 (22.7 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 85, Issue 9, 28 4 2024, Pages 878-890 Transcatheter Aortic Valve Replacement in Patients With Systolic Heart Failure and Moderate Aortic Stenosis: TAVR UNLOAD. Van Mieghem NM, Elmariah S, Spitzer E, Pibarot P, Nazif TM, Bax JJ, Hahn RT, Popma A, Ben-Yehuda O, Kallel F, Redfors B, Chuang ML, Alu MC, Lindeboom W, Kolte D, Zahr FE, Kodali SK, Strote JA, Hermanides RS, Cohen DJ, Tijssen JGP, Leon MB

Background: Neurohormonal modulation and afterload reduction are key for treatment of heart failure with reduced ejection fraction (HFrEF). In HFrEF patients with concomitant moderate aortic stenosis (AS), treatment with transcatheter aortic valve replacement (TAVR) may be complementary to guideline-directed medical therapy (GDMT). Objectives: This study sought to determine whether TAVR for moderate AS provides clinical benefit in patients with HFrEF on top of GDMT. Methods: We performed an inve... Abstract

Translational lung cancer research, Volume 13, Issue 10, 28 4 2024, Pages 2813-2827 What do we know about the role of neoadjuvant targeted therapy in early-stage <i>EGFR</i>-mutant and <i>ALK</i>-fused non-small cell lung cancer?-a narrative review of the current literature. Kemper M, Elges S, Kies P, Wiebe K, Lenz G, Bleckmann A, Evers G

Background and objective: The standard first-line treatment for patients with advanced non-small cell lung cancer (NSCLC) harbouring epidermal growth factor receptor (EGFR) mutations or anaplastic lymphoma kinase (ALK) fusions is targeted therapy using tyrosine kinase inhibitors (TKIs). However, data are still lacking on the use of TKIs as a neoadjuvant or induction approach. Therefore, this narrative review aims to summarize the current knowledge on resectable EGFR-mutant and ALK-fused NSCLC re... Abstract