9618 results
Cited 174 times since 2014 (15.6 per year)
source: EuropePMC
ACS chemical biology,
Volume 9, Issue 8, 17 3 2014, Pages 1788-1798
Phytochemicals perturb membranes and promiscuously alter protein function.
Ingólfsson HI, Thakur P, Herold KF, Hobart EA, Ramsey NB, Periole X, de Jong DH, Zwama M, Yilmaz D, Hall K, Maretzky T, Hemmings HC, Blobel C, Marrink SJ, Koçer A, Sack JT, Andersen OS
A wide variety of phytochemicals are consumed for their perceived health benefits. Many of these phytochemicals have been found to alter numerous cell functions, but the mechanisms underlying their biological activity tend to be poorly understood. Phenolic phytochemicals are particularly promiscuous modifiers of membrane protein function, suggesting that some of their actions may be due to a common, membrane bilayer-mediated mechanism. To test whether bilayer perturbation may underlie this diver...
Abstract
Cited 13 times since 2014 (1.2 per year)
source: EuropePMC
PloS one,
Volume 9, Issue 6, 17 3 2014, Pages e100135
Risk factors for malformations and impact on reproductive performance and mortality rates of Schmallenberg virus in sheep flocks in the Netherlands.
Luttikholt S, Veldhuis A, van den Brom R, Moll L, Lievaart-Peterson K, Peperkamp K, van Schaik G, Vellema P
In Northwestern Europe, an epizootic outbreak of congenital malformations in newborn lambs due to infection with Schmallenberg virus (SBV) started at the end of 2011. The objectives of this study were to describe clinical symptoms of SBV infection, the effect of infection on mortality rates, and reproductive performance in sheep, as well as to identify and quantify flock level risk factors for SBV infections resulting in malformations in newborn lambs. A case-control study design was used, with...
Abstract
Cited 56 times since 2014 (5 per year)
source: EuropePMC
Scientific reports,
Volume 4, 16 3 2014, Pages 5309
Extending the viability of acute brain slices.
Buskila Y, Breen PP, Tapson J, van Schaik A, Barton M, Morley JW
The lifespan of an acute brain slice is approximately 6-12 hours, limiting potential experimentation time. We have designed a new recovery incubation system capable of extending their lifespan to more than 36 hours. This system controls the temperature of the incubated artificial cerebral spinal fluid (aCSF) while continuously passing the fluid through a UVC filtration system and simultaneously monitoring temperature and pH. The combination of controlled temperature and UVC filtering maintains b...
Abstract
Cited 83 times since 2014 (7.4 per year)
source: EuropePMC
Biomaterials,
Volume 35, Issue 27, 16 3 2014, Pages 7774-7785
Tri-layered elastomeric scaffolds for engineering heart valve leaflets.
Masoumi N, Annabi N, Assmann A, Larson BL, Hjortnaes J, Alemdar N, Kharaziha M, Manning KB, Mayer JE, Khademhosseini A
Tissue engineered heart valves (TEHVs) that can grow and remodel have the potential to serve as permanent replacements of the current non-viable prosthetic valves particularly for pediatric patients. A major challenge in designing functional TEHVs is to mimic both structural and anisotropic mechanical characteristics of the native valve leaflets. To establish a more biomimetic model of TEHV, we fabricated tri-layered scaffolds by combining electrospinning and microfabrication techniques. These c...
Abstract
Cited 4 times since 2014 (0.4 per year)
source: EuropePMC
Revista espanola de cardiologia (English ed.),
Volume 67, Issue 8, 14 2 2014, Pages 674-675
Delayed positive response to a flecainide test in a patient with suspected Brugada syndrome: a worrisome finding.
de-Riva-Silva M, Montero-Cabezas JM, Fontenla-Cerezuela A, Salguero-Bodes R, López-Gil M, Arribas-Ynsaurriaga F
Abstract
Cited 25 times since 2014 (2.2 per year)
source: EuropePMC
European heart journal,
Volume 36, Issue 17, 13 2 2014, Pages 1023-1030
Influence of coronary vessel dominance on short- and long-term outcome in patients after ST-segment elevation myocardial infarction.
Veltman CE, van der Hoeven BL, Hoogslag GE, Boden H, Kharbanda RK, de Graaf MA, Delgado V, van Zwet EW, Schalij MJ, Bax JJ, Scholte AJ
Aims: Prognostic importance of coronary vessel dominance in patients with ST-elevation myocardial infarction (STEMI) remains uncertain. The aim of this study was to assess influence of coronary vessel dominance on the short- and long-term outcome after STEMI. Methods and results: Coronary angiographic images of consecutive patients presenting with first STEMI were retrospectively reviewed to assess coronary vessel dominance. Patients were followed after STEMI during a median period of 48 (IQR38-...
Abstract
Cited 7 times since 2014 (0.6 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 101, Issue 5, 12 2 2014, Pages 397-407
Potential role of fibrosis imaging in severe valvular heart disease.
Debonnaire P, Delgado V, Bax JJ
Abstract
Cited 13 times since 2014 (1.2 per year)
source: EuropePMC
Mutation research. Genetic toxicology and environmental mutagenesis,
Volume 770, 6 1 2014, Pages 72-79
Radio-protective effect of cinnamic acid, a phenolic phytochemical, on genomic instability induced by X-rays in human blood lymphocytes in vitro.
Cinkilic N, Tüzün E, Çetintaş SK, Vatan Ö, Yılmaz D, Çavaş T, Tunç S, Özkan L, Bilaloğlu R
The present study was designed to determine the protective activity of cinnamic acid against induction by X-rays of genomic instability in normal human blood lymphocytes. This radio-protective activity was assessed by use of the cytokinesis-block micronucleus test and the alkaline comet assay, with human blood lymphocytes isolated from two healthy donors. A Siemens Mevatron MD2 (Siemens AG, USA, 1994) linear accelerator was used for the irradiation with 1 or 2 Gy. Treatment of the lymphocytes wi...
Abstract
Cited 5 times since 2014 (0.4 per year)
source: EuropePMC
The aging male : the official journal of the International Society for the Study of the Aging Male,
Volume 17, Issue 4, 5 1 2014, Pages 248-255
L-arginine and tetrahydrobiopterin, but not sodium nitrite partially restored erectile dysfunction in aged rats.
Un O, Yilmaz D, Bayatli N, Kaya E, Gur S
Aging is associated with erectile dysfunction (ED), in which nitric oxide synthase (NOS) activity and NO bioavailability are reduced due to deficiencies of NOS cofactor (tetrahydrobiopterin, BH(4)) and substrate (L-arginine). We determined whether the prolonged treatment with sodium nitrite (NaNO(2)) as a storage form of NO ameliorates ED in aged rats. Male Sprague-Dawley rats were divided: younger, aged and NaNO(2)-treated (20 mg/kg per day) aged groups. The erectile (intracavernosal pressure [...
Abstract
Cited 81 times since 2014 (7.2 per year)
source: EuropePMC
European journal of human genetics : EJHG,
Volume 22, Issue 11, 4 1 2014, Pages 1321-1326
Improved imputation quality of low-frequency and rare variants in European samples using the 'Genome of The Netherlands'.
Deelen P, Menelaou A, van Leeuwen EM, Kanterakis A, van Dijk F, Medina-Gomez C, Francioli LC, Hottenga JJ, Karssen LC, Estrada K, Kreiner-Møller E, Rivadeneira F, van Setten J, Gutierrez-Achury J, Westra HJ, Franke L, van Enckevort D, Dijkstra M, Byelas H, van Duijn CM, Genome of Netherlands Consortium, de Bakker PI, Wijmenga C, Swertz MA
Although genome-wide association studies (GWAS) have identified many common variants associated with complex traits, low-frequency and rare variants have not been interrogated in a comprehensive manner. Imputation from dense reference panels, such as the 1000 Genomes Project (1000G), enables testing of ungenotyped variants for association. Here we present the results of imputation using a large, new population-specific panel: the Genome of The Netherlands (GoNL). We benchmarked the performance o...
Abstract
Cited 2 times since 2014 (0.2 per year)
source: EuropePMC
PloS one,
Volume 9, Issue 6, 4 1 2014, Pages e98820
The CD200-CD200 receptor inhibitory axis controls arteriogenesis and local T lymphocyte influx.
van den Borne P, Rygiel TP, Hoogendoorn A, Westerlaken GH, Boon L, Quax PH, Pasterkamp G, Hoefer IE, Meyaard L
The role of the CD200 ligand-CD200 receptor (CD200-CD200R) inhibitory axis is highly important in controlling myeloid cell function. Since the activation of myeloid cells is crucial in arteriogenesis, we hypothesized that disruption of the CD200-CD200R axis promotes arteriogenesis in a murine hindlimb ischemia model. Female Cd200-/- and wildtype (C57Bl/6J) mice underwent unilateral femoral artery ligation. Perfusion recovery was monitored over 7 days using Laser-Doppler analysis and was increase...
Abstract
Cited 7 times since 2014 (0.6 per year)
source: EuropePMC
Fetal diagnosis and therapy,
Volume 36, Issue 1, 4 1 2014, Pages 59-68
Bicuspid aortic valve morphology and associated cardiovascular abnormalities in fetal Turner syndrome: a pathomorphological study.
van Engelen K, Bartelings MM, Gittenberger-de Groot AC, Baars MJ, Postma AV, Bijlsma EK, Mulder BJ, Jongbloed MR
Introduction: Bicuspid aortic valve (BAV) is common in Turner syndrome (TS). In adult TS, 82-95% of BAVs have fusion of the right and left coronary leaflets. Data in fetal stages are scarce. The purpose of this study was to gain insight into aortic valve morphology and associated cardiovascular abnormalities in a fetal TS cohort with adverse outcome early in development. Material and methods: We studied post-mortem heart specimens of 36 TS fetuses and 1 TS newborn. Results: BAV was present in 28...
Abstract
Cited 13 times since 2014 (1.2 per year)
source: EuropePMC
Clinical transplantation,
Volume 28, Issue 6, 3 1 2014, Pages 649-655
Genetic polymorphisms in IL-2, IL-10, TGF-β1, and IL-2RB and acute rejection in renal transplant patients.
Chen Z, Bouamar R, Van Schaik RH, De Fijter JW, Hartmann A, Zeier M, Budde K, Kuypers DR, Weimar W, Hesselink DA, Van Gelder T
Acute rejection (AR) remains a concern for kidney transplantation. Cytokines are key mediators in the induction and effector phases of all immune and inflammatory responses. Single nucleotide polymorphisms (SNPs) in cytokines and their receptors may relate to AR. We investigated the relation between AR and SNPs in the genes encoding for IL-2(-330G>T), IL-10(-592C>A and -1082G>A), TGF-β1(915G>C), and IL-2RB(rs228942 C>A and rs228953 C>T) in 325 renal transplant patients during t...
Abstract
Cited 38 times since 2014 (3.4 per year)
source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
Volume 27, Issue 8, 3 1 2014, Pages 817-825
Left ventricular functional recovery and remodeling in low-flow low-gradient severe aortic stenosis after transcatheter aortic valve implantation.
Kamperidis V, Joyce E, Debonnaire P, Katsanos S, van Rosendael PJ, van der Kley F, Sianos G, Bax JJ, Ajmone Marsan N, Delgado V
Background: Speckle-tracking-derived global longitudinal strain (GLS) is a more sensitive method of detecting left ventricular (LV) functional recovery after transcatheter aortic valve implantation (TAVI) in patients with severe aortic stenosis. However, it remains unknown whether LV function improves in patients with low-flow, low-gradient severe aortic stenosis (LFLGSAS) after TAVI. The aim of the present was to evaluate LV functional recovery and remodeling after TAVI in patients with LFLGSAS...
Abstract
Cited 19 times since 2014 (1.7 per year)
source: EuropePMC
American journal of physical anthropology,
Volume 154, Issue 4, 3 1 2014, Pages 628-632
Brief Communication: Seasonality of diet composition is related to brain size in New World Monkeys.
van Woerden JT, van Schaik CP, Isler K
New World monkeys exhibit a more pronounced variability in encephalization than other primate taxa. In this comparative study, we tested two current hypotheses on brain size evolution, the Expensive Brain hypothesis and the Cognitive Buffer hypothesis, in a sample of 21 platyrrhine species. A high degree of habitat seasonality may impose an energetic constraint on brain size evolution if it leads to a high variation in caloric intake over time, as predicted by the Expensive Brain Hypothesis. How...
Abstract
Cited 31 times since 2014 (2.8 per year)
source: EuropePMC
Stem cells (Dayton, Ohio),
Volume 32, Issue 6, 1 1 2014, Pages 1493-1502
Insulin-like growth factor promotes cardiac lineage induction in vitro by selective expansion of early mesoderm.
Engels MC, Rajarajan K, Feistritzer R, Sharma A, Nielsen UB, Schalij MJ, de Vries AA, Pijnappels DA, Wu SM
A thorough understanding of the developmental signals that direct pluripotent stem cells (PSCs) toward a cardiac fate is essential for translational applications in disease modeling and therapy. We screened a panel of 44 cytokines/signaling molecules for their ability to enhance Nkx2.5(+) cardiac progenitor cell (CPC) formation during in vitro embryonic stem cell (ESC) differentiation. Treatment of murine ESCs with insulin or insulin-like growth factors (IGF1/2) during early differentiation incr...
Abstract
Cited 11 times since 2014 (1 per year)
source: EuropePMC
American journal of physical anthropology,
Volume 154, Issue 2, 1 1 2014, Pages 215-221
Health Is not always written in bone: using a modern comorbidity index to assess disease load in paleopathology.
van Schaik K, Vinichenko D, Rühli F
Paleopathology has revealed much about disease in the past but is usually limited to conditions with osteological manifestations; this often excludes acute soft tissue infections and causes of death for most individuals in the past and present. Our understanding of the evolution of disease is essential for contextualizing and predicting the epidemiological shifts that are happening in modern society, as high rates of infectious disease coexist alongside high rates of chronic disease in rates unl...
Abstract
Cited 9 times since 2014 (0.8 per year)
source: EuropePMC
Molecular diagnosis & therapy,
Volume 18, Issue 3, 1 1 2014, Pages 323-331
Lack of association of the p450 oxidoreductase *28 single nucleotide polymorphism with the lipid-lowering effect of statins in hypercholesterolemic patients.
Ragia G, Kolovou V, Tavridou A, Elens L, Tselepis AD, Elisaf M, Van Schaik RH, Kolovou G, Manolopoulos VG
Background and objective: Inter-individual variability exists in the statin (HMG-CoA reductase inhibitor) lipid-lowering response, which is partially attributed to genetic factors. The polymorphic enzyme P450 oxidoreductase (POR) transfers electrons from nicotinamide adenine dinucleotide phosphate (NADPH) to cytochrome P450 (CYP) 3A enzymes, which metabolize atorvastatin and simvastatin. The POR*28 allele is associated with increased activity of CYP3A enzymes. We analyzed the association of the...
Abstract
The International journal of angiology : official publication of the International College of Angiology, Inc,
Volume 23, Issue 2, 1 1 2014, Pages 93-100
A Randomized Comparison between Everolimus-Eluting Stent and Cobalt Chromium Stent in Patients with Acute ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention Using Routine Intravenous Eptifibatide: The X-MAN (Xience vs. Multi-Link Stent in Acute Myocardial Infarction) Trial, A Pilot Study.
Dharma S, Wardeh AJ, Soerianata S, Firdaus I, Jukema JW
The objective of this study is to determine the efficacy and safety of an everolimus-eluting stent (EES/Xience; Abbott Vascular, Santa Clara, CA) compared with a cobalt chromium stent (CoCr/Multi-Link Vision; Abbott Vascular) in patients with acute ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) with routine administration of eptifibatide infusion. This is a prospective, single center, randomized trial comparing EES (n = 75) and CoCr stent (...
Abstract
Cited 33 times since 2014 (2.9 per year)
source: EuropePMC
Medical education,
Volume 48, Issue 6, 1 1 2014, Pages 583-592
Perceptions of interprofessional teamwork in low-acuity settings: a qualitative analysis.
van Schaik SM, O'Brien BC, Almeida SA, Adler SR
Context: Working effectively in interprofessional teams is a core competency for all health care professionals, yet there is a paucity of instruments with which to assess the associated skills. Published medical teamwork skills assessment tools focus primarily on high-acuity situations, such as cardiopulmonary arrests and crisis events in operating rooms, and may not generalise to non-high-acuity environments, such as in-patient wards and out-patient clinics. Objective: We undertook the current...
Abstract
