9618 results
Cited 17 times since 2014 (1.5 per year)
source: EuropePMC
Pharmacogenomics,
Volume 15, Issue 9, 1 1 2014, Pages 1243-1251
Calcineurin inhibitors and hypertension: a role for pharmacogenetics?
Moes AD, Hesselink DA, Zietse R, van Schaik RH, van Gelder T, Hoorn EJ
Hypertension is a common side effect of calcineurin inhibitors (CNIs), which are drugs used to prevent rejection after transplantation. Hypertension after kidney transplantation has been associated with earlier graft failure and higher cardiovascular mortality in the recipient. Recent data indicate that enzymes and transporters involved in CNI pharmacokinetics and pharmacodynamics, including CYP3A5, ABCB1, WNK4 and SPAK, are also associated with salt-sensitive hypertension. These insights raise...
Abstract
Cited 69 times since 2014 (6.1 per year)
source: EuropePMC
Pharmacogenomics,
Volume 15, Issue 9, 1 1 2014, Pages 1223-1234
Personalized pharmacogenomics profiling using whole-genome sequencing.
Mizzi C, Peters B, Mitropoulou C, Mitropoulos K, Katsila T, Agarwal MR, van Schaik RH, Drmanac R, Borg J, Patrinos GP
Aim: Pharmacogenomics holds promise to rationalize drug use by minimizing drug toxicity and at the same time increase drug efficacy. There are currently several assays to screen for known pharmacogenomic biomarkers for the most commonly prescribed drugs. However, these genetic screening assays cannot account for other known or novel pharmacogenomic markers. Materials & methods: We analyzed whole-genome sequences of 482 unrelated individuals of various ethnic backgrounds to obtain their perso...
Abstract
Cited 5 times since 2014 (0.4 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 22, Issue 6, 1 1 2014, Pages 309
Obstruction of distal left anterior descending artery by the right ventricular lead of an implantable cardiac defibrillator.
Karalis I, Bleeker GB, Schalij MJ
Abstract
Cited 1 times since 2014 (0.1 per year)
source: EuropePMC
JAMA,
Volume 311, Issue 22, 1 1 2014, Pages 2335
Left atrial fibrosis and recurrent arrhythmia.
Tops LF, Schalij MJ
Abstract
Cited 31 times since 2014 (2.8 per year)
source: EuropePMC
American journal of physiology. Heart and circulatory physiology,
Volume 307, Issue 3, 30 5 2014, Pages H361-9
Sildenafil treatment in established right ventricular dysfunction improves diastolic function and attenuates interstitial fibrosis independent from afterload.
Borgdorff MA, Bartelds B, Dickinson MG, van Wiechen MP, Steendijk P, de Vroomen M, Berger RM
Right ventricular (RV) function is an important determinant of prognosis in congenital heart diseases, pulmonary hypertension, and heart failure. Preventive sildenafil treatment has been shown to enhance systolic RV function and improve exercise capacity in a model of fixed RV pressure load. However, it is unknown whether sildenafil has beneficial effects when treatment is started in established RV dysfunction, which is clinically more relevant. Our aim was to assess the effects of sildenafil tr...
Abstract
Cited 16 times since 2014 (1.4 per year)
source: EuropePMC
Journal of cardiovascular electrophysiology,
Volume 25, Issue 9, 29 5 2014, Pages 998-1004
Chronic kidney disease and implantable cardioverter defibrillator related complications: 16 years of experience.
Buiten MS, DE Bie MK, VAN DER Heijden AC, Rotmans JI, Bootsma M, Marc Groeneveld JH, Wolterbeek R, Rabelink TJ, Jukema JW, Schalij MJ, VAN Erven L
Introduction: Implantable cardioverter defibrillator (ICD) implantation has become an accepted therapy for the prevention of sudden cardiac death. However, serious comorbidities such as chronic kidney disease (CKD) are influencing the beneficial effects of ICD therapy. In this study, the association between kidney function and the occurrence of ICD related complications was assessed. Methods: All patients receiving an ICD or cardiac resynchronization therapy-defibrillator between 1996 and 2012 w...
Abstract
Cited 37 times since 2014 (3.3 per year)
source: EuropePMC
Human molecular genetics,
Volume 23, Issue 20, 26 4 2014, Pages 5545-5557
Genome-wide association study yields variants at 20p12.2 that associate with urinary bladder cancer.
Rafnar T, Sulem P, Thorleifsson G, Vermeulen SH, Helgason H, Saemundsdottir J, Gudjonsson SA, Sigurdsson A, Stacey SN, Gudmundsson J, Johannsdottir H, Alexiusdottir K, Petursdottir V, Nikulasson S, Geirsson G, Jonsson T, Aben KK, Grotenhuis AJ, Verhaegh GW, Dudek AM, Witjes JA, van der Heijden AG, Vrieling A, Galesloot TE, De Juan A, Panadero A, Rivera F, Hurst C, Bishop DT, Sak SC, Choudhury A, Teo MT, Arici C, Carta A, Toninelli E, de Verdier P, Rudnai P, Gurzau E, Koppova K, van der Keur KA, Lurkin I, Goossens M, Kellen E, Guarrera S, Russo A, Critelli R, Sacerdote C, Vineis P, Krucker C, Zeegers MP, Gerullis H, Ovsiannikov D, Volkert F, Hengstler JG, Selinski S, Magnusson OT, Masson G, Kong A, Gudbjartsson D, Lindblom A, Zwarthoff E, Porru S, Golka K, Buntinx F, Matullo G, Kumar R, Mayordomo JI, Steineck DG, Kiltie AE, Jonsson E, Radvanyi F, Knowles MA, Thorsteinsdottir U, Kiemeney LA, Stefansson K
Genome-wide association studies (GWAS) of urinary bladder cancer (UBC) have yielded common variants at 12 loci that associate with risk of the disease. We report here the results of a GWAS of UBC including 1670 UBC cases and 90 180 controls, followed by replication analysis in additional 5266 UBC cases and 10 456 controls. We tested a dataset containing 34.2 million variants, generated by imputation based on whole-genome sequencing of 2230 Icelanders. Several correlated variants at 20p12, repres...
Abstract
Cited 21 times since 2014 (1.9 per year)
source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 21, Issue 5, 24 4 2014, Pages 913-920
I-123 mIBG and Tc-99m myocardial SPECT imaging to predict inducibility of ventricular arrhythmia on electrophysiology testing: a retrospective analysis.
Zhou Y, Zhou W, Folks RD, Manatunga DN, Jacobson AF, Bax JJ, Garcia EV, Chen J
Objectives: The purpose of this study is to assess mIBG uptake in scar border zone and its relation with ventricular arrhythmia (VA) inducibility on electrophysiology (EP) testing using I-123 mIBG SPECT and resting Tc-99m SPECT myocardial perfusion imaging (MPI). Methods: Forty-seven patients from a previous clinical trial were retrospectively analyzed. These patients underwent I-123 mIBG and resting Tc-99m tetrofosmin SPECT, and EP testing. Twenty-eight patients were positive (EP+) and 19 patie...
Abstract
Cited 440 times since 2014 (39.1 per year)
source: EuropePMC
Lab on a chip,
Volume 14, Issue 13, 23 4 2014, Pages 2202-2211
Hydrogel bioprinted microchannel networks for vascularization of tissue engineering constructs.
Bertassoni LE, Cecconi M, Manoharan V, Nikkhah M, Hjortnaes J, Cristino AL, Barabaschi G, Demarchi D, Dokmeci MR, Yang Y, Khademhosseini A
Vascularization remains a critical challenge in tissue engineering. The development of vascular networks within densely populated and metabolically functional tissues facilitate transport of nutrients and removal of waste products, thus preserving cellular viability over a long period of time. Despite tremendous progress in fabricating complex tissue constructs in the past few years, approaches for controlled vascularization within hydrogel based engineered tissue constructs have remained limite...
Abstract
Cited 5 times since 2014 (0.4 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 101, Issue 4, 22 4 2014, Pages 311-319
Diagnosis and treatment of pulmonary hypertension.
Haeck ML, Vliegen HW
Abstract
Cited 4 times since 2014 (0.4 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 15, Issue 10, 22 4 2014, Pages 1183
Helical flow pattern in the right pulmonary artery after Fontan palliation.
Houtzager JH, Westenberg JJ, de Koning PJ, Hazekamp MG, Roest AA
Abstract
Cited 122 times since 2014 (10.8 per year)
source: EuropePMC
Annals of the rheumatic diseases,
Volume 74, Issue 10, 20 3 2014, Pages 1842-1847
The relative contribution of mechanical stress and systemic processes in different types of osteoarthritis: the NEO study.
Visser AW, de Mutsert R, le Cessie S, den Heijer M, Rosendaal FR, Kloppenburg M, NEO Study Group
Objective: To study the relative contribution of surrogates for mechanical stress and systemic processes with osteoarthritis (OA) in weight-bearing and non-weight-bearing joints. Methods: The Netherlands Epidemiology of Obesity study is a population-based cohort including 6673 participants (range 45-65 years, 56% women, median body mass index 26 kg/m(2)). Weight (kg) and fat mass (kg) were measured, fat-free mass (kg) was calculated. The metabolic syndrome was defined following the Adult Treatme...
Abstract
Cited 16 times since 2014 (1.4 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 100, Issue 17, 16 3 2014, Pages 1360-1365
Persistent neo-aortic growth during adulthood in patients after an arterial switch operation.
van der Bom T, van der Palen RL, Bouma BJ, van Veldhuisen SL, Vliegen HW, Konings TC, Zwinderman AH, Blom NA, Koolbergen DR, Hazekamp MG, Mulder BJ
Objective: After the arterial switch operation (ASO), disproportional neo-aortic growth during childhood has been reported. Even though it has been suggested neo-aortic dilation will stabilise in adulthood, data are lacking. The aim of this study was to assess the change in neo-aortic dimensions, prevalence of neo-aortic dilation >40 mm and long-term outcome in adults who underwent ASO in childhood. Methods: All 116 ASO patients operated in a tertiary referral centre and born before 1995 were...
Abstract
American heart journal,
Volume 168, Issue 1, 14 2 2014, Pages e5
Response to the letter to the editor by Ariza-Solé et al.
Velders MA, James SK, Libungan B, Sarno G, Fröbert O, Carlsson J, Schalij MJ, Albertsson P, Lagerqvist B
Abstract
Cited 13 times since 2014 (1.2 per year)
source: EuropePMC
Experimental cell research,
Volume 327, Issue 2, 13 2 2014, Pages 297-306
Strategies for rapidly mapping proviral integration sites and assessing cardiogenic potential of nascent human induced pluripotent stem cell clones.
Dambrot C, Buermans HP, Varga E, Kosmidis G, Langenberg K, Casini S, Elliott DA, Dinnyes A, Atsma DE, Mummery CL, Braam SR, Davis RP
Recent methodological advances have improved the ease and efficiency of generating human induced pluripotent stem cells (hiPSCs), but this now typically results in a greater number of hiPSC clones being derived than can be wholly characterized. It is therefore imperative that methods are developed which facilitate rapid selection of hiPSC clones most suited for the downstream research aims. Here we describe a combination of procedures enabling the simultaneous screening of multiple clones to det...
Abstract
Cited 12 times since 2014 (1.1 per year)
source: EuropePMC
Circulation. Cardiovascular quality and outcomes,
Volume 7, Issue 3, 13 2 2014, Pages 437-444
Left ventricular reverse remodeling, device-related adverse events, and long-term outcome after cardiac resynchronization therapy in the elderly.
Höke U, Putter H, Van Der Velde ET, Schalij MJ, Delgado V, Bax JJ, Marsan NA
Background: Limited data are available on efficacy, safety, and long-term prognosis after cardiac resynchronization therapy (CRT) in elderly patients. We aimed at evaluating the effect of CRT, device-related adverse events, and long-term outcome after CRT among elderly patients. Methods and results: A total of 798 CRT recipients (208 elderly: age, ≥75 years; 590 nonelderly: age,
Abstract
Cited 8 times since 2014 (0.7 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 30, Issue 6, 10 2 2014, Pages 1151-1159
Associations of atherosclerosis in the descending thoracic aorta on CTA with arterial stiffness and chronic kidney disease in asymptomatic patients with diabetes mellitus.
Roos CJ, Delgado V, de Koning EJ, Rabelink TJ, Jukema JW, Bax JJ, Scholte AJ
The relation between atherosclerosis in the descending thoracic aortic (DTA), arterial stiffness and chronic kidney disease (CKD) in patients with diabetes mellitus (DM) remains unclear. The current aim was to evaluate associations of DTA atherosclerosis with arterial stiffness and parameters of CKD in asymptomatic patients with DM. A total of 213 asymptomatic patients with diabetes (mean age 52 years, 56% men) underwent cardiovascular risk assessment including multi-slice computed tomography (f...
Abstract
Cited 24 times since 2014 (2.1 per year)
source: EuropePMC
Preventive veterinary medicine,
Volume 116, Issue 4, 9 2 2014, Pages 412-422
Schmallenberg virus epidemic: impact on milk production, reproductive performance and mortality in dairy cattle in the Netherlands and Kleve district, Germany.
Veldhuis AM, Santman-Berends IM, Gethmann JM, Mars MH, van Wuyckhuise L, Vellema P, Holsteg M, Höreth-Böntgen D, Conraths FJ, van Schaik G
Schmallenberg virus (SBV), a novel orthobunyavirus that rapidly spread throughout north-western Europe in 2011, caused congenital malformations in lambs and goat kids (Van den Brom et al., 2012) and newborn calves (Hoffmann et al., 2012). The impact of the SBV epidemic seemed limited however, in terms of the number of affected herds with malformed offspring (European Food Safety Authority, 2012b). Nevertheless, little is known with regard to the overall within-herd impact of SBV infection. The o...
Abstract
Cited 1 times since 2014 (0.1 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 101, Issue 3, 9 2 2014, Pages 230-239
Cardiac resynchronisation therapy in populations underrepresented in randomised controlled trials.
Höke U, Delgado V, Marsan NA, Bax JJ
Abstract
Cited 21 times since 2014 (1.9 per year)
source: EuropePMC
Journal of the American Society of Nephrology : JASN,
Volume 25, Issue 11, 8 2 2014, Pages 2616-2624
Childhood kidney outcomes in relation to fetal blood flow and kidney size.
Kooijman MN, Bakker H, van der Heijden AJ, Hofman A, Franco OH, Steegers EA, Taal HR, Jaddoe VW
Impaired fetal abdominal blood flow may lead to smaller kidneys and subsequent impaired kidney function in later life. In a prospective cohort study among 923 pregnant women and their children, we measured fetal growth, kidney volumes, and umbilical and cerebral artery blood flow (median gestational age of 30.3 weeks; 95% range, 28.5-32.7 weeks). We used a higher umbilical/cerebral artery pulsatility index ratio as an indicator of preferential fetal blood flow to the upper body parts at the expe...
Abstract
