Research

Publications

Below you can find a list of our published research.

9618 results

Cited 12 times since 2014 (1 per year) source: EuropePMC

European journal of endocrinology, Volume 170, Issue 2, 1 1 2014, Pages 181-191 Cushing's disease and hypertension: in vivo and in vitro study of the role of the renin-angiotensin-aldosterone system and effects of medical therapy. van der Pas R, van Esch JH, de Bruin C, Danser AH, Pereira AM, Zelissen PM, Netea-Maier R, Sprij-Mooij DM, van den Berg-Garrelds IM, van Schaik RH, Lamberts SW, van den Meiracker AH, Hofland LJ, Feelders RA

Objective/methods: Cushing's disease (CD) is often accompanied by hypertension. CD can be treated surgically and, given the expression of somatostatin subtype 5 and dopamine 2 receptors by corticotroph pituitary adenomas, pharmacologically. Indeed, we recently observed that stepwise medical combination therapy with the somatostatin-analog pasireotide, the dopamine-agonist cabergoline, and ketoconazole (which directly suppresses steroidogenesis) biochemically controlled CD patients and lower... Abstract

Cited 63 times since 2014 (5.5 per year) source: EuropePMC

Therapeutic drug monitoring, Volume 36, Issue 1, 1 1 2014, Pages 71-79 Impact of POR*28 on the pharmacokinetics of tacrolimus and cyclosporine A in renal transplant patients. Elens L, Hesselink DA, Bouamar R, Budde K, de Fijter JW, De Meyer M, Mourad M, Kuypers DR, Haufroid V, van Gelder T, van Schaik RH

Background: The P450 oxidoreductase (POR)*28 variant allele has been associated with altered cytochrome P450 3A enzyme activities. Both CYP3A5 and CYP3A4 are involved in the metabolism of calcineurin inhibitors and recent data show that POR*28 may explain part of the variability observed in tacrolimus (Tac) pharmacokinetics. The aim of this study was to investigate the impact of the POR*28 allele on Tac and cyclosporine A (CsA) immunosuppressive therapies. Methods: Kidney transplant recipients r... Abstract

Cited 141 times since 2014 (12.2 per year) source: EuropePMC

European heart journal, Volume 35, Issue 22, 31 5 2014, Pages 1466-1478 The atrial fibrillation ablation pilot study: a European Survey on Methodology and results of catheter ablation for atrial fibrillation conducted by the European Heart Rhythm Association. Arbelo E, Brugada J, Hindricks G, Maggioni AP, Tavazzi L, Vardas P, Laroche C, Anselme F, Inama G, Jais P, Kalarus Z, Kautzner J, Lewalter T, Mairesse GH, Perez-Villacastin J, Riahi S, Taborsky M, Theodorakis G, Trines SA, Atrial Fibrillation Ablation Pilot Study Investigators

Aims: The Atrial Fibrillation Ablation Pilot Study is a prospective registry designed to describe the clinical epidemiology of patients undergoing an atrial fibrillation (AFib) ablation, and the diagnostic/therapeutic processes applied across Europe. The aims of the 1-year follow-up were to analyse how centres assess in routine clinical practice the success of the procedure and to evaluate the success rate and long-term safety/complications. Methods and results: Seventy-two centres in 10 Europea... Abstract

Cited 5 times since 2014 (0.4 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 30, Issue 3, 31 5 2014, Pages 583-589 Effect of intramyocardial bone marrow-derived mononuclear cell injection on cardiac sympathetic innervation in patients with chronic myocardial ischemia. van Ramshorst J, Beeres SL, Rodrigo SF, Dibbets-Schneider P, Scholte AJ, Fibbe WE, Zwaginga JJ, Schalij MJ, Bax JJ, Atsma DE

Intramyocardial bone marrow cell injection has been associated with improvements in myocardial perfusion and left ventricular function. The current substudy of a randomized, placebo-controlled, double-blinded study, investigated the effect of intramyocardial bone marrow cell injection on myocardial sympathetic innervation in patients with chronic myocardial ischemia. In a total of 16 patients (64 ± 8 years, 13 men), early and late iodine-123 metaiodobenzylguanidine (MIBG) imaging was performed b... Abstract

Cited 18 times since 2014 (1.6 per year) source: EuropePMC

BMC evolutionary biology, Volume 14, 30 5 2014, Pages 18 The effect of host social system on parasite population genetic structure: comparative population genetics of two ectoparasitic mites and their bat hosts. van Schaik J, Kerth G, Bruyndonckx N, Christe P

Background: The population genetic structure of a parasite, and consequently its ability to adapt to a given host, is strongly linked to its own life history as well as the life history of its host. While the effects of parasite life history on their population genetic structure have received some attention, the effect of host social system has remained largely unstudied. In this study, we investigated the population genetic structure of two closely related parasitic mite species (Spinturnix myo... Abstract

Cited 103 times since 2014 (8.9 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 63, Issue 12, 30 5 2014, Pages 1200-1210 Novel genetic markers associate with atrial fibrillation risk in Europeans and Japanese. Lubitz SA, Lunetta KL, Lin H, Arking DE, Trompet S, Li G, Krijthe BP, Chasman DI, Barnard J, Kleber ME, Dörr M, Ozaki K, Smith AV, Müller-Nurasyid M, Walter S, Agarwal SK, Bis JC, Brody JA, Chen LY, Everett BM, Ford I, Franco OH, Harris TB, Hofman A, Kääb S, Mahida S, Kathiresan S, Kubo M, Launer LJ, MacFarlane PW, Magnani JW, McKnight B, McManus DD, Peters A, Psaty BM, Rose LM, Rotter JI, Silbernagel G, Smith JD, Sotoodehnia N, Stott DJ, Taylor KD, Tomaschitz A, Tsunoda T, Uitterlinden AG, Van Wagoner DR, Völker U, Völzke H, Murabito JM, Sinner MF, Gudnason V, Felix SB, März W, Chung M, Albert CM, Stricker BH, Tanaka T, Heckbert SR, Jukema JW, Alonso A, Benjamin EJ, Ellinor PT

Objectives: This study sought to identify nonredundant atrial fibrillation (AF) genetic susceptibility signals and examine their cumulative relations with AF risk. Background: AF-associated loci span broad genomic regions that may contain multiple susceptibility signals. Whether multiple signals exist at AF loci has not been systematically explored. Methods: We performed association testing conditioned on the most significant, independently associated genetic markers at 9 established AF loci usi... Abstract

Cited 16 times since 2014 (1.4 per year) source: EuropePMC

Journal of virology, Volume 88, Issue 8, 29 5 2014, Pages 4595-4599 Novel avian-origin influenza A (H7N9) virus attachment to the respiratory tract of five animal models. Siegers JY, Short KR, Leijten LM, de Graaf M, Spronken MI, Schrauwen EJ, Marshall N, Lowen AC, Gabriel G, Osterhaus AD, Kuiken T, van Riel D

We determined the pattern of attachment of the avian-origin H7N9 influenza viruses A/Anhui/1/2013 and A/Shanghai/1/2013 to the respiratory tract in ferrets, macaques, mice, pigs, and guinea pigs and compared it to that in humans. The H7N9 attachment pattern in macaques, mice, and to a lesser extent pigs and guinea pigs resembled that in humans more closely than the attachment pattern in ferrets. This information contributes to our knowledge of the different animal models for influenza. Abstract

Cited 9 times since 2014 (0.8 per year) source: EuropePMC

PloS one, Volume 9, Issue 1, 27 4 2014, Pages e86522 Leukotriene B4 levels in human atherosclerotic plaques and abdominal aortic aneurysms. van den Borne P, van der Laan SW, Bovens SM, Koole D, Kowala MC, Michael LF, Schoneveld AH, van de Weg SM, Velema E, de Vries JP, de Borst GJ, Moll FL, de Kleijn DP, Quax PH, Hoefer IE, Pasterkamp G

Background: Leukotriene B4 (LTB4) has been associated with the initiation and progression of atherosclerosis and abdominal aortic aneurysm (AAA) formation. However, associations of LTB4 levels with tissue characteristics and adverse clinical outcome of advanced atherosclerosis and AAA are scarcely studied. We hypothesized that LTB4 levels are associated with a vulnerable plaque phenotype and adverse clinical outcome. Furthermore, that LTB4 levels are associated with inflammatory AAA and adverse... Abstract

Cited 57 times since 2014 (4.9 per year) source: EuropePMC

The Journal of thoracic and cardiovascular surgery, Volume 148, Issue 4, 25 4 2014, Pages 1583-1590 Ascending aorta dilation in association with bicuspid aortic valve: a maturation defect of the aortic wall. Grewal N, Gittenberger-de Groot AC, Poelmann RE, Klautz RJ, Lindeman JH, Goumans MJ, Palmen M, Mohamed SA, Sievers HH, Bogers AJ, DeRuiter MC

Objective: Patients with a bicuspid aortic valve have increased susceptibility to the development of ascending aortic dilation and dissection compared with persons with a tricuspid valve. To unravel a possible different mechanism underlying dilation in bicuspidy and tricuspidy, a comparison of the structure of the aortic wall was made. Methods: Ascending aortic wall biopsies were divided into 4 groups: bicuspid (n=36) and tricuspid (n=23) without and with dilation. The expression of vascular smo... Abstract

Cited 19 times since 2014 (1.6 per year) source: EuropePMC

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, Volume 122, Issue 1, 24 4 2014, Pages 60-63 CYP2C9*2 allele increases risk for hypoglycemia in POR*1/*1 type 2 diabetic patients treated with sulfonylureas. Ragia G, Tavridou A, Elens L, Van Schaik RH, Manolopoulos VG

It is previously shown that carriers of the defective allele CYP2C9*3 that leads to impaired sulfonylurea metabolism are at increased sulfonylurea-induced hypoglycemia risk due to diminished drug metabolism, whereas no effect of CYP2C9*2 allele was found. Recently, a polymorphism in P450 oxidoreductase (POR) gene, assigned as POR*28 allele, was associated with increased CYP2C9 activity. The aim of this study was to assess i) the effect of POR*28 allele on sulfonylurea-induced hypoglycemia risk a... Abstract

Cited 92 times since 2014 (7.9 per year) source: EuropePMC

Lung cancer (Amsterdam, Netherlands), Volume 84, Issue 1, 23 4 2014, Pages 86-91 EGFR mutated non-small cell lung cancer patients: more prone to development of bone and brain metastases? Hendriks LE, Smit EF, Vosse BA, Mellema WW, Heideman DA, Bootsma GP, Westenend M, Pitz C, de Vries GJ, Houben R, Grünberg K, Bendek M, Speel EJ, Dingemans AM

Objectives: Both bone and brain are frequent sites of metastasis in non-small cell lung cancer (NSCLC). Conflicting data exist whether EGFR mutant (+) patients are more prone to develop brain metastases or have a better outcome with brain metastases compared to EGFR/KRAS wildtype (WT) or KRAS+ patients. For bone metastases this has not been studied. Methods: In this retrospective case-control study all EGFR+ (exons 19 and 21) patients diagnosed at two pathology departments were selected (2004/20... Abstract

Cited 65 times since 2014 (5.6 per year) source: EuropePMC

Arthritis research & therapy, Volume 16, Issue 1, 22 4 2014, Pages R19 Adiposity and hand osteoarthritis: the Netherlands Epidemiology of Obesity study. Visser AW, Ioan-Facsinay A, de Mutsert R, Widya RL, Loef M, de Roos A, le Cessie S, den Heijer M, Rosendaal FR, Kloppenburg M, NEO Study Group

Introduction: Obesity, usually characterized by the body mass index (BMI), is a risk factor for hand osteoarthritis (OA). We investigated whether adipose tissue and abdominal fat distribution are associated with hand OA. Methods: The Netherlands Epidemiology of Obesity (NEO) study is a population-based cohort aged 45 to 65 years, including 5315 participants (53% women, median BMI 29.9 kg/m²). Fat percentage and fat mass (FM) (kg) were estimated using bioelectrical impedance analysis. The waist-t... Abstract

Cited 44 times since 2014 (3.8 per year) source: EuropePMC

Environmental science & technology, Volume 48, Issue 3, 22 4 2014, Pages 1753-1761 Chromium(III) complexation to natural organic matter: mechanisms and modeling. Gustafsson JP, Persson I, Oromieh AG, van Schaik JW, Sjöstedt C, Kleja DB

Chromium is a common soil contaminant, and it often exists as chromium(III). However, limited information exists on the coordination chemistry and stability of chromium(III) complexes with natural organic matter (NOM). Here, the complexation of chromium(III) to mor layer material and to Suwannee River Fulvic Acid (SRFA) was investigated using EXAFS spectroscopy and batch experiments. The EXAFS results showed a predominance of monomeric chromium(III)-NOM complexes at low pH ( 5 there were polynuc... Abstract

Cited 50 times since 2014 (4.3 per year) source: EuropePMC

PloS one, Volume 9, Issue 1, 22 4 2014, Pages e85197 Mobile HIV screening in Cape Town, South Africa: clinical impact, cost and cost-effectiveness. Bassett IV, Govindasamy D, Erlwanger AS, Hyle EP, Kranzer K, van Schaik N, Noubary F, Paltiel AD, Wood R, Walensky RP, Losina E, Bekker LG, Freedberg KA

Background: Mobile HIV screening may facilitate early HIV diagnosis. Our objective was to examine the cost-effectiveness of adding a mobile screening unit to current medical facility-based HIV testing in Cape Town, South Africa. Methods and findings: We used the Cost Effectiveness of Preventing AIDS Complications International (CEPAC-I) computer simulation model to evaluate two HIV screening strategies in Cape Town: 1) medical facility-based testing (the current standard of care) and 2) addition... Abstract

Cited 36 times since 2014 (3.1 per year) source: EuropePMC

Advances in health sciences education : theory and practice, Volume 19, Issue 4, 22 4 2014, Pages 565-580 Interpretation of radiological images: towards a framework of knowledge and skills. van der Gijp A, van der Schaaf MF, van der Schaaf IC, Huige JC, Ravesloot CJ, van Schaik JP, Ten Cate TJ

The knowledge and skills that are required for radiological image interpretation are not well documented, even though medical imaging is gaining importance. This study aims to develop a comprehensive framework of knowledge and skills, required for two-dimensional and multiplanar image interpretation in radiology. A mixed-method study approach was applied. First, a literature search was performed to identify knowledge and skills that are important for image interpretation. Three databases, PubMed... Abstract

Cited 24 times since 2014 (2.1 per year) source: EuropePMC

Heart rhythm, Volume 11, Issue 5, 22 4 2014, Pages 806-813 QRS fusion complex analysis using wave interference to predict reverse remodeling during cardiac resynchronization therapy. Sweeney MO, Hellkamp AS, van Bommel RJ, Schalij MJ, Borleffs CJ, Bax JJ

Background: Biventricular (BV) electrical wavefront fusion can induce improvement in left ventricular (LV) size and function during cardiac resynchronization therapy (CRT). Changes in BV wave propagation sequence and duration register in the QRS complex on the standard electrocardiogram. We developed a wave interference method for the characterization of BV fusion to predict LV reverse remodeling. Objective: To develop a simple electrocardiographic method for predicting reverse remodeling during... Abstract

Cited 110 times since 2014 (9.5 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 100, Issue 12, 21 3 2014, Pages 960-968 Significant lead-induced tricuspid regurgitation is associated with poor prognosis at long-term follow-up. Höke U, Auger D, Thijssen J, Wolterbeek R, van der Velde ET, Holman ER, Schalij MJ, Bax JJ, Delgado V, Marsan NA

Background: Although the presence of an RV lead is a potential cause of tricuspid regurgitation (TR), the clinical impact of significant lead-induced TR is unknown. Objective: To evaluate the effect of significant lead-induced TR on cardiac performance and long-term outcome after cardioverter-defibrillator (ICD) or pacemaker implantation. Methods: A retrospective cohort of 239 ICD (n=191) or pacemaker (n=48) recipients (age 60±14 years, 77% male) from a tertiary care university hospital, with an... Abstract

Cited 18 times since 2014 (1.6 per year) source: EuropePMC

Critical care (London, England), Volume 18, Issue 1, 20 3 2014, Pages R18 Neurofilaments as a plasma biomarker for ICU-acquired weakness: an observational pilot study. Wieske L, Witteveen E, Petzold A, Verhamme C, Schultz MJ, van Schaik IN, Horn J

Introduction: Early diagnosis of intensive care unit - acquired weakness (ICU-AW) using the current reference standard, that is, assessment of muscle strength, is often hampered due to impaired consciousness. Biological markers could solve this problem but have been scarcely investigated. We hypothesized that plasma levels of neurofilaments are elevated in ICU-AW and can diagnose ICU-AW before muscle strength assessment is possible. Methods: For this prospective observational cohort study, neuro... Abstract

Cited 22 times since 2014 (1.9 per year) source: EuropePMC

Kidney international, Volume 85, Issue 6, 15 3 2014, Pages 1444-1453 Genetic and in vivo determinants of glucocorticoid sensitivity in relation to clinical outcome of childhood nephrotic syndrome. Teeninga N, Kist-van Holthe JE, van den Akker EL, Kersten MC, Boersma E, Krabbe HG, Knoers NV, van der Heijden AJ, Koper JW, Nauta J

Following initial glucocorticoid treatment, the clinical course in children with nephrotic syndrome is highly variable. Intrinsic sensitivity to glucocorticoids might be a determinant of this variability. Functional polymorphisms of the glucocorticoid receptor gene NR3C1 have been associated with either relatively impaired (GR-9β) or increased (BclI) glucocorticoid sensitivity. Here, in a prospective, well-defined cohort of children with nephrotic syndrome, we evaluated both carriage of GR-9β+Tt... Abstract

Cited 30 times since 2014 (2.6 per year) source: EuropePMC

The Journal of thoracic and cardiovascular surgery, Volume 148, Issue 4, 15 3 2014, Pages 1490-1497 Exercise capacity in children after total cavopulmonary connection: lateral tunnel versus extracardiac conduit technique. Bossers SS, Helbing WA, Duppen N, Kuipers IM, Schokking M, Hazekamp MG, Bogers AJ, Ten Harkel AD, Takken T

Objectives: In patients with univentricular heart disease, the total cavopulmonary connection (TCPC) is the preferred treatment. TCPC can be performed using the intra-atrial lateral tunnel (ILT) or extracardiac conduit (ECC) technique. The purpose of the present study was to evaluate exercise capacity in contemporary TCPC patients and compare the results between the 2 techniques. Methods: A total of 101 TCPC patients (ILT, n=42; ECC, n=59; age, 12.2±2.6 years; age at TCPC completion, 3.2±1.1 yea... Abstract