9618 results
Cited 26 times since 2014 (2.2 per year)
source: EuropePMC
Pharmacology, biochemistry, and behavior,
Volume 121, 15 3 2014, Pages 184-188
The 5-HT₁A receptor C(1019)G polymorphism influences the intravaginal ejaculation latency time in Dutch Caucasian men with lifelong premature ejaculation.
Janssen PK, van Schaik R, Zwinderman AH, Olivier B, Waldinger MD
Introduction: Lifelong premature ejaculation (LPE) is characterized by persistent intravaginal ejaculation latency times (IELTs) of less than 1 min, and has been postulated as a neurobiological dysfunction related to diminished serotonergic neurotransmission with 5-HT₁A receptor hyperfunction and 5-HT₂C hypofunction. Aim: To investigate the relationship between 5-HT₁A receptor gene (HTR₁A)-C(1019)G promoter polymorphism and IELT in men with LPE. This polymorphism is known to increase 5-HT1A rece...
Abstract
Cited 75 times since 2014 (6.5 per year)
source: EuropePMC
International journal of epidemiology,
Volume 43, Issue 3, 14 2 2014, Pages 878-886
Leukocyte telomere length associates with prospective mortality independent of immune-related parameters and known genetic markers.
Deelen J, Beekman M, Codd V, Trompet S, Broer L, Hägg S, Fischer K, Thijssen PE, Suchiman HE, Postmus I, Uitterlinden AG, Hofman A, de Craen AJ, Metspalu A, Pedersen NL, van Duijn CM, Jukema JW, Houwing-Duistermaat JJ, Samani NJ, Slagboom PE
Background: Human leukocyte telomere length (LTL) decreases with age and shorter LTL has previously been associated with increased prospective mortality. However, it is not clear whether LTL merely marks the health status of an individual by its association with parameters of immune function, for example, or whether telomere shortening also contributes causally to lifespan variation in humans. Methods: We measured LTL in 870 nonagenarian siblings (mean age 93 years), 1580 of their offspring and...
Abstract
Cited 14 times since 2014 (1.2 per year)
source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
Volume 27, Issue 3, 13 2 2014, Pages 239-248
Association between multilayer left ventricular rotational mechanics and the development of left ventricular remodeling after acute myocardial infarction.
Abate E, Hoogslag GE, Leong DP, Bertini M, Antoni ML, Nucifora G, Joyce E, Holman ER, Siebelink HM, Schalij MJ, Bax JJ, Delgado V, Ajmone Marsan N
Background: The identification of patients at risk for developing left ventricular (LV) remodeling after acute myocardial infarction (AMI) has crucial prognostic implications. The aims of this study were (1) to investigate the relationship between peak subepicardial and subendocardial twist and infarct transmurality, as assessed using contrast-enhanced magnetic resonance imaging, and (2) to evaluate the association between peak subepicardial and subendocardial twist and LV remodeling 6 months af...
Abstract
Cited 6 times since 2014 (0.5 per year)
source: EuropePMC
Journal of vascular surgery,
Volume 59, Issue 5, 11 2 2014, Pages 1315-22.e1
National variation in the utilization of alternative imaging in peripheral arterial disease.
de Vos MS, Hawkins AT, Hevelone ND, Hamming JF, Nguyen LL
Objective: The value and cost-effectiveness of less invasive alternative imaging (AI) modalities (duplex ultrasound scanning, computed tomography angiography, and magnetic resonance angiography) in the care of peripheral arterial disease (PAD) has been reported; however, there is no consensus on their role. We hypothesized that AI utilization is low compared with angiography in the United States and that patient and hospital characteristics are both associated with AI utilization. Methods: The N...
Abstract
Cited 15 times since 2014 (1.3 per year)
source: EuropePMC
BMC genomics,
Volume 15, 10 2 2014, Pages 16
Generation of SNP datasets for orangutan population genomics using improved reduced-representation sequencing and direct comparisons of SNP calling algorithms.
Greminger MP, Stölting KN, Nater A, Goossens B, Arora N, Bruggmann R, Patrignani A, Nussberger B, Sharma R, Kraus RH, Ambu LN, Singleton I, Chikhi L, van Schaik CP, Krützen M
Background: High-throughput sequencing has opened up exciting possibilities in population and conservation genetics by enabling the assessment of genetic variation at genome-wide scales. One approach to reduce genome complexity, i.e. investigating only parts of the genome, is reduced-representation library (RRL) sequencing. Like similar approaches, RRL sequencing reduces ascertainment bias due to simultaneous discovery and genotyping of single-nucleotide polymorphisms (SNPs) and does not require...
Abstract
Cited 6 times since 2014 (0.5 per year)
source: EuropePMC
Public health,
Volume 128, Issue 2, 10 2 2014, Pages 195-201
Democratizing the world health organization.
van de Pas R, van Schaik LG
A progressive erosion of the democratic space appears as one of the emerging challenges in global health today. Such delimitation of the political interplay has a particularly evident impact on the unique public interest function of the World Health Organization (WHO). This paper aims to identify some obstacles for a truly democratic functioning of the UN specialized agency for health. The development of civil society's engagement with the WHO, including in the current reform proposals, is...
Abstract
Cited 35 times since 2014 (3 per year)
source: EuropePMC
Journal of internal medicine,
Volume 275, Issue 6, 9 2 2014, Pages 621-630
The cardiokine secreted Frizzled-related protein 3, a modulator of Wnt signalling, in clinical and experimental heart failure.
Askevold ET, Aukrust P, Nymo SH, Lunde IG, Kaasbøll OJ, Aakhus S, Florholmen G, Ohm IK, Strand ME, Attramadal H, Fiane A, Dahl CP, Finsen AV, Vinge LE, Christensen G, Yndestad A, Gullestad L, Latini R, Masson S, Tavazzi L, GISSI-HF Investigators, Ueland T
Objectives: Experimental studies have shown involvement of Wnt signalling in heart failure (HF). We hypothesized that secreted frizzled-related protein 3 (sFRP3), a modulator of Wnt signalling, is related to the progression of HF. Design: Circulating sFRP3 was measured in 153 HF patients and compared with 25 healthy controls. The association of sFRP3 with mortality was evaluated in 1202 patients (GISSI-HF trial). sFRP3 mRNA expression was assessed in failing human and murine left ventricles (LV)...
Abstract
Cited 14 times since 2014 (1.2 per year)
source: EuropePMC
Arteriosclerosis, thrombosis, and vascular biology,
Volume 34, Issue 3, 9 2 2014, Pages 594-602
Absence of chemokine (C-x-C motif) ligand 10 diminishes perfusion recovery after local arterial occlusion in mice.
van den Borne P, Haverslag RT, Brandt MM, Cheng C, Duckers HJ, Quax PH, Hoefer IE, Pasterkamp G, de Kleijn DP
Objective: In arteriogenesis, pre-existing anastomoses undergo enlargement to restore blood flow in ischemic tissues. Chemokine (C-X-C motif) ligand 10 (CXCL10) is secreted after Toll-like receptor activation. Toll-like receptors are involved in arteriogenesis; however, the role of CXCL10 is still unclear. In this study, we investigated the role for CXCL10 in a murine hindlimb ischemia model. Approach and results: Unilateral femoral artery ligation was performed in wild-type (WT) and CXCL10(-/-)...
Abstract
Revista espanola de cardiologia (English ed.),
Volume 67, Issue 2, 8 2 2014, Pages 157
Appropriate use criteria for cardiopulmonary exercise testing in patients with cardiac resynchronization devices. Response.
de Riva-Silva M, López-Gil M, Fontenla-Cerezuela A, Arribas-Ynsaurriaga F
Abstract
Cited 25 times since 2014 (2.2 per year)
source: EuropePMC
Human gene therapy,
Volume 25, Issue 1, 7 1 2014, Pages 41-49
Short hairpin RNA gene silencing of prolyl hydroxylase-2 with a minicircle vector improves neovascularization of hindlimb ischemia.
Lijkwan MA, Hellingman AA, Bos EJ, van der Bogt KE, Huang M, Kooreman NG, de Vries MR, Peters HA, Robbins RC, Hamming JF, Quax PH, Wu JC
In this study, we target the hypoxia inducible factor-1 alpha (HIF-1-alpha) pathway by short hairpin RNA interference therapy targeting prolyl hydroxylase-2 (shPHD2). We use the minicircle (MC) vector technology as an alternative for conventional nonviral plasmid (PL) vectors in order to improve neovascularization after unilateral hindlimb ischemia in a murine model. Gene expression and transfection efficiency of MC and PL, both in vitro and in vivo, were assessed using bioluminescence imaging (...
Abstract
Cited 3 times since 2014 (0.3 per year)
source: EuropePMC
International journal of cardiology,
Volume 172, Issue 1, 4 1 2014, Pages e3-5
Confounding factors in the relation between high sensitivity cardiac troponin T levels in serum and infarct size of patients with first ST-elevation myocardial infarction.
Cobbaert CM, Bootsma M, Boden H, Ahmed TA, Hoogslag GE, Romijn FP, Ballieux BE, Wolterbeek R, Hermens WT, Schalij MJ, van der Laarse A
Abstract
Cited 11 times since 2014 (0.9 per year)
source: EuropePMC
Preventive veterinary medicine,
Volume 113, Issue 4, 2 1 2014, Pages 484-491
Use of monthly collected milk yields for the detection of the emergence of the 2007 French BTV epizootic.
Madouasse A, Marceau A, Lehébel A, Brouwer-Middelesch H, van Schaik G, Van der Stede Y, Fourichon C
Two culicoides-borne diseases, Bluetongue (BTV) and Schmallenberg, have emerged in the European cattle population since 2006. Other diseases transmitted by these vectors could emerge. This justifies the development of syndromic surveillance programs whereby one or several indicators would be routinely monitored for the early detection of emerging diseases. The aim of this study was to evaluate milk yield from milk recording in dairy cattle as an indicator to be included in an emerging disease su...
Abstract
Cited 41 times since 2014 (3.5 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 22, Issue 1, 1 1 2014, Pages 3-10
Heart disease in the Netherlands: a quantitative update.
Leening MJ, Siregar S, Vaartjes I, Bots ML, Versteegh MI, van Geuns RJ, Koolen JJ, Deckers JW
In this review we discuss cardiovascular mortality, incidence and prevalence of heart disease, and cardiac interventions and surgery in the Netherlands. We combined most recently available data from various Dutch cardiovascular registries, Dutch Hospital Data (LMR), Statistics Netherlands (CBS), and population-based cohort studies, to provide a broad quantitative update. The absolute number of people dying from cardiovascular diseases is declining and cardiovascular conditions are no longer the...
Abstract
Cited 12 times since 2014 (1 per year)
source: EuropePMC
Diabetes care,
Volume 37, Issue 1, 1 1 2014, Pages e1-2
Very-low-calorie diet increases myocardial triglyceride content and decreases diastolic left ventricular function in type 2 diabetes with cardiac complications.
Jonker JT, Djaberi R, van Schinkel LD, Hammer S, Bus MT, Kerpershoek G, Kharagjitsingh AV, Romijn JA, Bax JJ, Jukema JW, de Roos A, Smit JW, Lamb HJ
Abstract
Cited 2 times since 2014 (0.2 per year)
source: EuropePMC
Journal of cardiovascular pharmacology,
Volume 63, Issue 1, 1 1 2014, Pages 16-22
Toll-like receptor 4 inhibitor TAK-242 treatment does not influence perfusion recovery in tissue ischemia.
van den Borne P, Bastiaansen AJ, de Vries MR, Quax PH, Hoefer IE, Pasterkamp G
Toll-like receptors (TLRs) are important in innate immune responses, which are crucial in collateral artery formation (arteriogenesis). TLR4⁻/⁻ mice undergoing hind limb ischemia show decreased perfusion recovery accompanied by an impaired infiltration of inflammatory cells. TLR antagonists are currently developed and tested with the objective to inhibit acute exacerbation of organ damaging immune responses. However, systemic inhibition of innate immune responses may negatively influence arterio...
Abstract
Cited 208 times since 2014 (17.9 per year)
source: EuropePMC
JAMA,
Volume 311, Issue 3, 1 1 2014, Pages 252-262
Varespladib and cardiovascular events in patients with an acute coronary syndrome: the VISTA-16 randomized clinical trial.
Nicholls SJ, Kastelein JJ, Schwartz GG, Bash D, Rosenson RS, Cavender MA, Brennan DM, Koenig W, Jukema JW, Nambi V, Wright RS, Menon V, Lincoff AM, Nissen SE, VISTA-16 Investigators
Importance: Secretory phospholipase A2 (sPLA2) generates bioactive phospholipid products implicated in atherosclerosis. The sPLA2 inhibitor varespladib has favorable effects on lipid and inflammatory markers; however, its effect on cardiovascular outcomes is unknown. Objective: To determine the effects of sPLA2 inhibition with varespladib on cardiovascular outcomes. Design, setting, and participants: A double-blind, randomized, multicenter trial at 362 academic and community hospitals in Europe,...
Abstract
Cited 31 times since 2014 (2.7 per year)
source: EuropePMC
Revista espanola de cardiologia (English ed.),
Volume 67, Issue 1, 1 1 2014, Pages 58
2013 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy.
TheTask Force on cardiac pacing and resynchronization therapy of the European Society of Cardiology (ESC) Developed in collaboration with the European Heart Rhythm Association (EHRA), Brignole M, Auricchio A, Baron-Esquivias G, Bordachar P, Boriani G, Breithardt OA, Cleland J, Deharo JC, Delgado V, Elliott PM, Gorenek B, Israel CW, Leclercq C, Linde C, Mont L, Padeletti L, Sutton R, Vardas PE
Abstract
Cited 39 times since 2014 (3.4 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 22, Issue 1, 1 1 2014, Pages 11-19
A review of the positive and negative effects of cardiovascular drugs on sexual function: a proposed table for use in clinical practice.
Nicolai MP, Liem SS, Both S, Pelger RC, Putter H, Schalij MJ, Elzevier HW
Several antihypertensive drugs, such as diuretics and β-blockers, can negatively affect sexual function, leading to diminished quality of life and often to noncompliance with the therapy. Other drug classes, however, such as angiotensin II receptor blockers (ARBs) are able to improve patients' sexual function. Sufficient knowledge about the effects of these widely used antihypertensive drugs will make it possible for cardiologists and general practitioners to spare and even improve patients...
Abstract
Cited 1 times since 2014 (0.1 per year)
source: EuropePMC
Turk patoloji dergisi,
Volume 30, Issue 2, 1 1 2014, Pages 118-123
A study on distribution of cancer cases diagnosed in Çorum.
Baş Y, Uzbay P, Güney G, Erenler BH, Yilmaz D, Ozdemır C
Objective: In order to help obtain accurate knowledge and to contribute to the establishment of data for regional tumor statistics, we aimed to determine the frequency distribution of cancer cases that was diagnosed in Çorum province. Material and method: In this descriptive study, we retrospectively reviewed the archive records of the pathology departments' of one university hospital and two private hospitals serving in the province of Çorum. A total of 138,973 recorded pathology reports w...
Abstract
Cited 29 times since 2014 (2.5 per year)
source: EuropePMC
Acta cirurgica brasileira,
Volume 29, Issue 1, 1 1 2014, Pages 59-65
Effect of platelet rich fibrin and beta tricalcium phosphate on bone healing. A histological study in pigs.
Yilmaz D, Dogan N, Ozkan A, Sencimen M, Ora BE, Mutlu I
Purpose: To investigate the effect of platelet rich fibrin (PRF) and beta tricalcium phosphate (β-TCP), alone or in combination, on bone regeneration in pig tibial defects. Methods: Four standardized defects were prepared in both tibias of three adult male pigs. The first defect was left unfilled as a control; the others were grafted with either PRF, β-TCP or PRF mixed with β-TCP. All animals were sacrificed on the 12th postoperative week and the tibial bones were removed, histologic sections we...
Abstract
