9618 results
Bratislavske lekarske listy,
Volume 115, Issue 7, 1 1 2014, Pages 400-404
Investigation of the effects of propofol and vitamin C administration on erythrocyte deformability in rats with streptozotocin-induced diabetes mellitis.
Comu FM, Ozturk L, Alkan M, Pampal K, Arslan M, Isik B, Atac MS, Yilmaz D
Purpose: In the current study we aim to investigate the effects of vitamin C and profol on red blood cell deformability in diabetic rats. Materials and methods: Twenty- eight Wistar Albino rats were included in the study after streptozocin (60 mg/kg) treatment for 4 weeks of observation for diabetes presence. Twenty-eight rats were allocated to 4 groups. In group DP (n = 7) 150 mg.kg-1 of propofol was injected intraperitoneally. In group DP-vit C (n = 7) rats 100 mg/kg of vitamin C (Ascorbic aci...
Abstract
Cited 30 times since 2014 (2.6 per year)
source: EuropePMC
Personalized medicine,
Volume 11, Issue 1, 1 1 2014, Pages 15-26
Critical appraisal of the views of healthcare professionals with respect to pharmacogenomics and personalized medicine in Greece.
Mai Y, Mitropoulou C, Papadopoulou XE, Vozikis A, Cooper DN, van Schaik RH, Patrinos GP
Aim: In the postgenomic era, in many European countries, very little is known regarding the level of awareness of healthcare professionals with respect to pharmacogenomics and personalized medicine. Methods: Here, we report the findings of an in-depth study, involving 86 pharmacists and 208 physicians, to assess their level of awareness of pharmacogenomics and personalized medicine. Results: Our findings indicate that approximately 60% of pharmacists consider their level of knowledge of personal...
Abstract
Cited 23 times since 2014 (2 per year)
source: EuropePMC
Pharmacogenomics,
Volume 15, Issue 12, 1 1 2014, Pages 1589-1597
Effect of UGT2B7 -900G>A (-842G>A; rs7438135) on morphine glucuronidation in preterm newborns: results from a pilot cohort.
Matic M, Norman E, Rane A, Beck O, Andersson M, Elens L, Tibboel D, Fellman V, van Schaik RH
Aim: Assess association between UGT2B7 polymorphism -900G>A (rs7438135, also known as -842G>A) with morphine kinetics in preterm newborns undergoing mechanical ventilation. Materials & methods: Thirty-four infants were enrolled in a randomized clinical trial and allocated to rapid sequence intubation with remifentanil (1 µg/kg) or morphine (0.3 mg/kg). The latter group was included in our study. Results: Morphine plasma concentrations at 20 min post intubation were associated with post...
Abstract
Cited 22 times since 2014 (1.9 per year)
source: EuropePMC
NeuroRehabilitation,
Volume 34, Issue 3, 1 1 2014, Pages 401-407
Safety and feasibility of post-stroke care and exercise after minor ischemic stroke or transient ischemic attack: MotiveS & MoveIT.
Boss HM, Van Schaik SM, Deijle IA, de Melker EC, van den Berg BT, Scherder EJ, Bosboom WM, Weinstein HC, Van den Berg-Vos RM
Background: Despite the beneficial effect of cardiac rehabilitation after myocardial infarction, a rehabilitation program to improve cardiorespiratory fitness and influence secondary prevention has not been implemented for ischemic stroke and transient ischemic attack (TIA). Objective: To investigate the safety and feasibility of a post-stroke care including an exercise program after minor ischemic stroke or TIA. Methods: In a randomised controlled trial, 20 patients with a recent minor stroke o...
Abstract
Cited 67 times since 2013 (5.8 per year)
source: EuropePMC
The Cochrane database of systematic reviews,
Issue 12, 30 5 2014, Pages CD001797
Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy.
Eftimov F, Winer JB, Vermeulen M, de Haan R, van Schaik IN
Background: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) causes progressive or relapsing weakness and numbness of the limbs, developing over at least two months. Uncontrolled studies suggest that intravenous immunoglobulin (IVIg) helps. This review was first published in 2002 and has since been updated, most recently in 2013. Objectives: To review systematically the evidence from randomised controlled trials (RCTs) concerning the efficacy and safety of IVIg in CIDP. Search me...
Abstract
Cited 37 times since 2013 (3.2 per year)
source: EuropePMC
European heart journal,
Volume 35, Issue 10, 29 5 2014, Pages 633-638
Risks and benefits of cardiac imaging: an analysis of risks related to imaging for coronary artery disease.
Knuuti J, Bengel F, Bax JJ, Kaufmann PA, Le Guludec D, Perrone Filardi P, Marcassa C, Ajmone Marsan N, Achenbach S, Kitsiou A, Flotats A, Eeckhout E, Minn H, Hesse B
Abstract
Cited 14 times since 2013 (1.2 per year)
source: EuropePMC
BMC cancer,
Volume 13, 28 4 2013, Pages 612
Hot flashes are not predictive for serum concentrations of tamoxifen and its metabolites.
Jager NG, Koornstra RH, Vincent AD, van Schaik RH, Huitema AD, Korse TM, Schellens JH, Linn SC, Beijnen JH
Background: Tamoxifen has dramatically reduced the recurrence and mortality rate of estrogen receptor positive breast cancer. However, the efficacy of tamoxifen varies between individuals and 40% of patients will have a recurrence despite adjuvant tamoxifen treatment. Factors that predict tamoxifen efficacy would be helpful for optimizing treatment. Serum concentrations of the active metabolite, endoxifen, may be positively related to treatment outcome. In addition, hot flashes are suggested to...
Abstract
Cited 116 times since 2013 (10 per year)
source: EuropePMC
Journal of virology,
Volume 88, Issue 5, 26 4 2013, Pages 2844-2857
Genomewide analysis of reassortment and evolution of human influenza A(H3N2) viruses circulating between 1968 and 2011.
Westgeest KB, Russell CA, Lin X, Spronken MI, Bestebroer TM, Bahl J, van Beek R, Skepner E, Halpin RA, de Jong JC, Rimmelzwaan GF, Osterhaus AD, Smith DJ, Wentworth DE, Fouchier RA, de Graaf M
Unlabelled: Influenza A(H3N2) viruses became widespread in humans during the 1968 H3N2 virus pandemic and have been a major cause of influenza epidemics ever since. These viruses evolve continuously by reassortment and genomic evolution. Antigenic drift is the cause for the need to update influenza vaccines frequently. Using two data sets that span the entire period of circulation of human influenza A(H3N2) viruses, it was shown that influenza A(H3N2) virus evolution can be mapped to 13 antigeni...
Abstract
Cited 2 times since 2013 (0.2 per year)
source: EuropePMC
The American journal of cardiology,
Volume 113, Issue 6, 25 4 2013, Pages 982-987
Effect of cardiac resynchronization therapy on the sequence of mechanical activation assessed by two-dimensional radial strain imaging.
Auger D, Hoke U, Thijssen J, Abate E, Yiu KH, Ewe SH, Witkowski TG, Leong DP, Holman ER, Ajmone Marsan N, Schalij MJ, Bax JJ, Delgado V
Cardiac resynchronization therapy (CRT) induces left ventricular (LV) reverse remodeling by synchronizing LV mechanical activation. We evaluated changes in segmental LV activation after CRT and related them to CRT response. A total of 292 patients with heart failure (65 ± 10 years, 77% men) treated with CRT underwent baseline echocardiographic assessment of LV volumes and ejection fraction. Time-to-peak radial strain was measured for 6 midventricular LV segments with speckle-tracking strain imag...
Abstract
Cited 4 times since 2013 (0.3 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 30, Issue 2, 19 3 2013, Pages 313-322
Left ventricular twist during dobutamine stress echocardiography after acute myocardial infarction: association with reverse remodeling.
Joyce E, Leong DP, Hoogslag GE, van Herck PL, Debonnaire P, Abate E, Holman ER, Schalij MJ, Bax JJ, Delgado V, Marsan NA
Left ventricular (LV) twist is emerging as a marker of global LV contractility after acute myocardial infarction (AMI). This study aimed to describe stress-induced changes in LV twist during dobutamine stress echocardiography (DSE) after AMI and investigate their association with LV reverse remodeling at 6 months follow-up. In 82 consecutive first AMI patients (61 ± 12 years, 85 % male) treated with primary percutaneous coronary intervention, DSE was performed at 3 months follow-up. Two-dimensio...
Abstract
Cited 3 times since 2013 (0.3 per year)
source: EuropePMC
Cardiovascular and interventional radiology,
Volume 38, Issue 2, 19 3 2013, Pages 498-500
Endovascular salvage of a false aneurysm of the posterior tibial artery caused by a stab from a stingray.
van Helden EJ, Eefting D, Florie J, Verhagen HJ, Moelker A
Abstract
Cited 14 times since 2013 (1.2 per year)
source: EuropePMC
JMIR research protocols,
Volume 2, Issue 2, 17 3 2013, Pages e54
Evaluation of the Compliance, Acceptance, and Usability of a Web-Based eHealth Intervention for Parents of Children With Infantile Hemangiomas: Usability Study.
de Graaf M, Totte J, Breugem C, van Os-Medendorp H, Pasmans S
Background: Infantile hemangiomas (IH) are common benign vascular tumors in children. Recognition and timely referral of high risk IH to specialized centers is important. This might be achieved by involving parents in the care for IH by means of an eHealth intervention. Objective: The objective of our study was to evaluate parent compliance, acceptance, and usability of an open access, Web-based eHealth intervention (including e-learning and e-consult) designed to increase parents' knowledg...
Abstract
Cited 57 times since 2013 (4.9 per year)
source: EuropePMC
Drug discovery today,
Volume 19, Issue 7, 17 3 2013, Pages 859-868
Data-driven medicinal chemistry in the era of big data.
Lusher SJ, McGuire R, van Schaik RC, Nicholson CD, de Vlieg J
Science, and the way we undertake research, is changing. The increasing rate of data generation across all scientific disciplines is providing incredible opportunities for data-driven research, with the potential to transform our current practices. The exploitation of so-called 'big data' will enable us to undertake research projects never previously possible but should also stimulate a re-evaluation of all our data practices. Data-driven medicinal chemistry approaches have the potenti...
Abstract
Cited 21 times since 2013 (1.8 per year)
source: EuropePMC
Journal of medical genetics,
Volume 51, Issue 2, 16 3 2013, Pages 122-131
A genome-wide copy number association study of osteoporotic fractures points to the 6p25.1 locus.
Oei L, Hsu YH, Styrkarsdottir U, Eussen BH, de Klein A, Peters MJ, Halldorsson B, Liu CT, Alonso N, Kaptoge SK, Thorleifsson G, Hallmans G, Hocking LJ, Husted LB, Jameson KA, Kruk M, Lewis JR, Patel MS, Scollen S, Svensson O, Trompet S, van Schoor NM, Zhu K, Buckley BM, Cooper C, Ford I, Goltzman D, González-Macías J, Langdahl BL, Leslie WD, Lips P, Lorenc RS, Olmos JM, Pettersson-Kymmer U, Reid DM, Riancho JA, Slagboom PE, Garcia-Ibarbia C, Ingvarsson T, Johannsdottir H, Luben R, Medina-Gómez C, Arp P, Nandakumar K, Palsson ST, Sigurdsson G, van Meurs JB, Zhou Y, Hofman A, Jukema JW, Pols HA, Prince RL, Cupples LA, Marshall CR, Pinto D, Sato D, Scherer SW, Reeve J, Thorsteinsdottir U, Karasik D, Richards JB, Stefansson K, Uitterlinden AG, Ralston SH, Ioannidis JP, Kiel DP, Rivadeneira F, Estrada K
Background: Osteoporosis is a systemic skeletal disease characterised by reduced bone mineral density and increased susceptibility to fracture; these traits are highly heritable. Both common and rare copy number variants (CNVs) potentially affect the function of genes and may influence disease risk. Aim: To identify CNVs associated with osteoporotic bone fracture risk. Method: We performed a genome-wide CNV association study in 5178 individuals from a prospective cohort in the Netherlands, inclu...
Abstract
Cited 177 times since 2013 (15.2 per year)
source: EuropePMC
EMBO reports,
Volume 15, Issue 1, 15 3 2013, Pages 62-69
Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion.
Snippert HJ, Schepers AG, van Es JH, Simons BD, Clevers H
The concept of 'field cancerization' describes the clonal expansion of genetically altered, but morphologically normal cells that predisposes a tissue to cancer development. Here, we demonstrate that biased stem cell competition in the mouse small intestine can initiate the expansion of such clones. We quantitatively analyze how the activation of oncogenic K-ras in individual Lgr5(+) stem cells accelerates their cell division rate and creates a biased drift towards crypt clonality. K-r...
Abstract
Cited 18 times since 2013 (1.5 per year)
source: EuropePMC
The Journal of infectious diseases,
Volume 209, Issue 11, 13 2 2013, Pages 1781-1791
Streptococcus pneumoniae arginine synthesis genes promote growth and virulence in pneumococcal meningitis.
Piet JR, Geldhoff M, van Schaik BD, Brouwer MC, Valls Seron M, Jakobs ME, Schipper K, Pannekoek Y, Zwinderman AH, van der Poll T, van Kampen AH, Baas F, van der Ende A, van de Beek D
Streptococcus pneumoniae (pneumococcus) is a major human pathogen causing pneumonia, sepsis and bacterial meningitis. Using a clinical phenotype based approach with bacterial whole-genome sequencing we identified pneumococcal arginine biosynthesis genes to be associated with outcome in patients with pneumococcal meningitis. Pneumococci harboring these genes show increased growth in human blood and cerebrospinal fluid (CSF). Mouse models of meningitis and pneumonia showed that pneumococcal strain...
Abstract
Cited 12 times since 2013 (1 per year)
source: EuropePMC
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
Volume 55, Issue 1, 12 2 2013, Pages 50-57
Additional diagnostic value of integrated analysis of cardiac CTA and SPECT MPI using the SMARTVis system in patients with suspected coronary artery disease.
Kirişli HA, Gupta V, Shahzad R, Al Younis I, Dharampal A, Geuns RJ, Scholte AJ, de Graaf MA, Joemai RM, Nieman K, van Vliet L, van Walsum T, Lelieveldt B, Niessen WJ
Unlabelled: CT angiography (CTA) and SPECT myocardial perfusion imaging (MPI) are complementary imaging techniques to assess coronary artery disease (CAD). Spatial integration and combined visualization of SPECT MPI and CTA data may facilitate correlation of myocardial perfusion defects and subtending coronary arteries and thus offer additional diagnostic value over either stand-alone or side-by-side interpretation of the respective datasets from the 2 modalities. In this study, we investigated...
Abstract
Cited 47 times since 2013 (4 per year)
source: EuropePMC
Osteoarthritis and cartilage,
Volume 22, Issue 2, 12 2 2013, Pages 197-202
The role of fat mass and skeletal muscle mass in knee osteoarthritis is different for men and women: the NEO study.
Visser AW, de Mutsert R, Loef M, le Cessie S, den Heijer M, Bloem JL, Reijnierse M, Rosendaal FR, Kloppenburg M, NEO Study Group
Objective: To investigate if the amount of fat mass (FM) or skeletal muscle mass (SMM) is more strongly associated with knee osteoarthritis (OA), in both men and women. Methods: The Netherlands Epidemiology of Obesity (NEO) study is a population-based cohort aged 45-65 years, including 5313 participants (53% female, median body mass index (BMI) 29.9 kg/m(2)). FM (kg), fat percentage, SMM (kg) and skeletal muscle (SM) percentage were estimated using bioelectrical impedance analysis (BIA). Clinica...
Abstract
Cited 643 times since 2013 (55 per year)
source: EuropePMC
European urology,
Volume 65, Issue 4, 12 2 2013, Pages 778-792
EAU guidelines on muscle-invasive and metastatic bladder cancer: summary of the 2013 guidelines.
Witjes JA, Compérat E, Cowan NC, De Santis M, Gakis G, Lebret T, Ribal MJ, Van der Heijden AG, Sherif A, European Association of Urology
Context: The European Association of Urology (EAU) guidelines panel on Muscle-invasive and Metastatic bladder cancer (BCa) updates its guidelines yearly. This updated summary provides a synthesis of the 2013 guidelines document, with emphasis on the latest developments. Objective: To provide graded recommendations on the diagnosis and treatment of patients with muscle-invasive BCa (MIBC), linked to a level of evidence. Evidence acquisition: For each section of the guidelines, comprehensive liter...
Abstract
Cited 59 times since 2013 (5 per year)
source: EuropePMC
International journal of cancer,
Volume 134, Issue 11, 12 2 2013, Pages 2663-2673
Intraoperative fluorescence delineation of head and neck cancer with a fluorescent anti-epidermal growth factor receptor nanobody.
van Driel PB, van der Vorst JR, Verbeek FP, Oliveira S, Snoeks TJ, Keereweer S, Chan B, Boonstra MC, Frangioni JV, van Bergen en Henegouwen PM, Vahrmeijer AL, Lowik CW
Intraoperative near-infrared (NIR) fluorescence imaging is a technology with high potential to provide the surgeon with real-time visualization of tumors during surgery. Our study explores the feasibility for clinical translation of an epidermal growth factor receptor (EGFR)-targeting nanobody for intraoperative imaging and resection of orthotopic tongue tumors and cervical lymph node metastases. The anti-EGFR nanobody 7D12 and the negative control nanobody R2 were conjugated to the NIR fluoroph...
Abstract
