9618 results
Cited 4 times since 2013 (0.3 per year)
source: EuropePMC
The American journal of cardiology,
Volume 113, Issue 5, 12 2 2013, Pages 772-778
Prognostic value of aortic and mitral valve calcium detected by contrast cardiac computed tomography angiography in patients with suspicion of coronary artery disease.
Kamperidis V, de Graaf MA, Broersen A, Ahmed W, Sianos G, Delgado V, Dijkstra J, Bax JJ, Scholte AJ
Aortic valve calcium (VC) detected on noncontrast cardiac computed tomography angiography (CCTA) is known to be associated with all-cause mortality in asymptomatic and primary prevention population. However, the clinical significance of aortic and mitral VC remains unknown in symptomatic patients with suspected coronary artery disease (CAD). The aim of the present study was to assess whether aortic and mitral VC is independently associated with cardiac events and all-cause mortality in symptomat...
Abstract
Cited 4 times since 2013 (0.3 per year)
source: EuropePMC
Journal of biomolecular screening,
Volume 19, Issue 2, 11 2 2013, Pages 287-296
A novel microscopy-based high-throughput screening method to identify proteins that regulate global histone modification levels.
Baas R, Lelieveld D, van Teeffelen H, Lijnzaad P, Castelijns B, van Schaik FM, Vermeulen M, Egan DA, Timmers HT, de Graaf P
Posttranslational modifications of histones play an important role in the regulation of gene expression and chromatin structure in eukaryotes. The balance between chromatin factors depositing (writers) and removing (erasers) histone marks regulates the steady-state levels of chromatin modifications. Here we describe a novel microscopy-based screening method to identify proteins that regulate histone modification levels in a high-throughput fashion. We named our method CROSS, for Chromatin Regula...
Abstract
Cited 8 times since 2013 (0.7 per year)
source: EuropePMC
Urology,
Volume 83, Issue 2, 9 2 2013, Pages 508.e7-12
The effect of intracavernosal avanafil, a newer phosphodiesterase-5 inhibitor, on neonatal type 2 diabetic rats with erectile dysfunction.
Yilmaz D, Bayatli N, Un O, Kadowitz PJ, Sikka SC, Gur S
Objective: To determine the effect of avanafil, a novel phosphodiesterase-5 inhibitor, on the treatment of erectile dysfunction associated with type 2 diabetes mellitus (T2DM). Methods: In 2-day-old rats, T2DM was induced by single intraperitoneal injection of 90 mg/kg of streptozotocin (STZ; i.p.). Erectile responses were evaluated after 10 weeks on intracavernosal injection of avanafil (1 μM) to anesthetized rats and data expressed as intracavernosal pressure (ICP)/mean arterial pressure and t...
Abstract
Cited 2 times since 2013 (0.2 per year)
source: EuropePMC
Neural computation,
Volume 26, Issue 3, 9 2 2013, Pages 472-496
Approximate, computationally efficient online learning in Bayesian spiking neurons.
Kuhlmann L, Hauser-Raspe M, Manton JH, Grayden DB, Tapson J, van Schaik A
Bayesian spiking neurons (BSNs) provide a probabilistic interpretation of how neurons perform inference and learning. Online learning in BSNs typically involves parameter estimation based on maximum-likelihood expectation-maximization (ML-EM) which is computationally slow and limits the potential of studying networks of BSNs. An online learning algorithm, fast learning (FL), is presented that is more computationally efficient than the benchmark ML-EM for a fixed number of time steps as the numbe...
Abstract
Cited 18 times since 2013 (1.5 per year)
source: EuropePMC
BMC nephrology,
Volume 14, 9 2 2013, Pages 273
Time of injury affects urinary biomarker predictive values for acute kidney injury in critically ill, non-septic patients.
de Geus HR, Fortrie G, Betjes MG, van Schaik RH, Groeneveld AB
Background: The predictive value of acute kidney injury (AKI) urinary biomarkers may depend on the time interval following tubular injury, thereby explaining in part the heterogeneous performance of these markers that has been reported in the literature. We studied the influence of timing on the predictive values of tubular proteins, measured before the rise of serum creatinine (SCr) in critically ill, non-septic patients. Methods: Seven hundred adult critically ill patients were prospectively i...
Abstract
Cited 6 times since 2013 (0.5 per year)
source: EuropePMC
European journal of trauma and emergency surgery : official publication of the European Trauma Society,
Volume 40, Issue 3, 4 1 2013, Pages 373-378
The prognostic value of plasma Δ-copeptin levels in patients with isolated traumatic brain injury.
Cavus UY, Yildirim S, Gurer B, Dibek K, Yilmaz D, Ozturk G, Buyukcam F, Sonmez E
Purpose: Traumatic brain injury (TBI) is one of the most common causes of death among trauma patients. Earlier prediction of possible poor neurological outcomes, even upon admission to the emergency department, may help to guide treatment. The aim of this prospective study was to assess the predictive value of plasma copeptin levels for early morbidity and mortality in patients with isolated TBI. Methods: This prospective study comprised 53 patients who were admitted to the emergency department...
Abstract
Cited 1 times since 2013 (0.1 per year)
source: EuropePMC
Revista espanola de cardiologia (English ed.),
Volume 67, Issue 1, 3 1 2013, Pages 1-2
Abstracts, articles, citations.
Bax JJ, Delgado V
Abstract
Cited 14 times since 2013 (1.2 per year)
source: EuropePMC
PloS one,
Volume 8, Issue 12, 2 1 2013, Pages e80619
Calf-level factors associated with bovine neonatal pancytopenia--a multi-country case-control study.
Jones BA, Sauter-Louis C, Henning J, Stoll A, Nielen M, Van Schaik G, Smolenaars A, Schouten M, den Uijl I, Fourichon C, Guatteo R, Madouasse A, Nusinovici S, Deprez P, De Vliegher S, Laureyns J, Booth R, Cardwell JM, Pfeiffer DU
Bovine neonatal pancytopenia (BNP), a high fatality condition causing haemorrhages in calves aged less than 4 weeks, was first reported in 2007 in Germany and subsequently observed at low incidence in other European countries and New Zealand. A multi-country matched case-control study was conducted in 2011 to identify calf-level risk factors for BNP. 405 BNP cases were recruited from 330 farms in Belgium, France, Germany and the Netherlands by laboratory confirmation of farmer-reported cases. Up...
Abstract
Cited 34 times since 2013 (2.9 per year)
source: EuropePMC
Journal of dairy science,
Volume 97, Issue 2, 2 1 2013, Pages 715-730
Exploring the value of routinely collected herd data for estimating dairy cattle welfare.
de Vries M, Bokkers EA, van Schaik G, Engel B, Dijkstra T, de Boer IJ
Routine on-farm assessment of dairy cattle welfare is time consuming and, therefore, expensive. A promising strategy to assess dairy cattle welfare more efficiently is to estimate the level of animal welfare based on herd data available in national databases. Our aim was to explore the value of routine herd data (RHD) for estimating dairy cattle welfare at the herd level. From November 2009 through March 2010, 7 trained observers collected data for 41 welfare indicators in a selected sample of 1...
Abstract
Cited 4 times since 2013 (0.3 per year)
source: EuropePMC
The International journal of angiology : official publication of the International College of Angiology, Inc,
Volume 22, Issue 4, 1 1 2013, Pages 213-222
The Use of Intra-aortic Balloon Pump in a Real-World Setting: A Comparison between Survivors and Nonsurvivors from Acute Coronary Syndrome Treated with IABP. The Jakarta Acute Coronary Syndrome Registry.
Dharma S, Dakota I, Firdaus I, Wardeh AJ, Jukema JW
Real-world data on acute coronary syndrome (ACS) patients who received intra-aortic balloon pump (IABP) support are limited. The objective of this study was to evaluate the characteristics of ACS patients who received IABP support from a real-world ACS registry. Patients with ACS (N = 121) who received IABP support were enrolled. Characteristics of survivors and nonsurvivors were compared at 30 days. Mortality rate of patients with ACS who received IABP was 47%. The survivors (N = 64) had less o...
Abstract
Cited 135 times since 2013 (11.5 per year)
source: EuropePMC
Annals of internal medicine,
Volume 159, Issue 12, 1 1 2013, Pages 815-823
Doxycycline for stabilization of abdominal aortic aneurysms: a randomized trial.
Meijer CA, Stijnen T, Wasser MN, Hamming JF, van Bockel JH, Lindeman JH, Pharmaceutical Aneurysm Stabilisation Trial Study Group
Background: Doxycycline inhibits formation and progression of abdominal aortic aneurysms (AAAs) in preclinical models of the disease, but it is unclear whether and how this observation translates to humans. Objective: To test whether doxycycline inhibits AAA progression in humans. Design: Randomized, placebo-controlled, double-blind trial. (Dutch Trial Registry: NTR 1345) SETTING: 14 Dutch hospitals. Patients: 286 patients with small AAAs between October 2008 and June 2011. Intervention: Daily d...
Abstract
Cited 26 times since 2013 (2.2 per year)
source: Scopus
International journal of behavioral medicine,
Volume 20, Issue 4, 1 1 2013, Pages 582-589
Changes in illness perceptions and quality of life during participation in cardiac rehabilitation.
Janssen V, De Gucht V, van Exel H, Maes S
Background: The beliefs patients hold about their disease and corresponding treatment have been shown to predict recovery in cardiac patients. Purpose: However, it is not known to what extent these beliefs change during participation in cardiac rehabilitation and whether this is related to psychological indicators of outcome. Method: Illness perceptions and health-related quality of life (HRQOL) were measured upon entry to (T0) and completion of (T1) a 3-month outpatient cardiac rehabilitation p...
Abstract
Cited 12 times since 2013 (1 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 21, Issue 12, 1 1 2013, Pages 540-544
What do cardiologists know about the effects of cardiovascular agents on sexual function? A survey among Dutch cardiologists. Part I.
Nicolai MP, Liem SS, Both S, Pelger RC, Putter H, Schalij MJ, Elzevier HW
Introduction: Several cardiovascular agents, such as diuretics and β-blockers, can negatively affect sexual function, leading to noncompliance with therapy. Others such as angiotensin II receptor blockers (ARBs) can improve patients' sexual function. Aims: We aimed to gain insight into cardiologists' knowledge about the effects of cardiovascular drugs on sexual function and whether they take this knowledge into account when prescribing drugs. Methods: An anonymous questionnaire was mai...
Abstract
Cited 5 times since 2013 (0.4 per year)
source: EuropePMC
European journal of emergency medicine : official journal of the European Society for Emergency Medicine,
Volume 20, Issue 6, 1 1 2013, Pages 402-407
EEG as a part of the decision-making process in the emergency department.
Yigit O, Eray O, Mihci E, Yilmaz D, Eray B, Özkaynak S
Study objective: Although electroencephalography (EEG) is a useful diagnostic tool for patients with a suspected seizure, its value in informing the acute care of patients in the emergency department (ED) remains unclear. The aim of this study is to determine the effects of EEG results on subsequent patient management in or from the ED. Materials and methods: This prospective observational study was carried out in the ED of a tertiary-care university hospital. All patients presenting to the ED w...
Abstract
Cited 24 times since 2013 (2 per year)
source: EuropePMC
Pharmacogenetics and genomics,
Volume 23, Issue 12, 1 1 2013, Pages 649-657
Single-nucleotide polymorphisms in P450 oxidoreductase and peroxisome proliferator-activated receptor-α are associated with the development of new-onset diabetes after transplantation in kidney transplant recipients treated with tacrolimus.
Elens L, Sombogaard F, Hesselink DA, van Schaik RH, van Gelder T
Background: New-onset diabetes after transplantation (NODAT) is an important complication after kidney transplantation. The etiology of the malady is multifactorial and includes both environmental and genetic factors. NODAT is a polygenic disease and many single-nucleotide polymorphisms could constitute potential risk factors. Peroxisome proliferator-activated receptor α (PPARα) and P450 oxidoreductase (POR) play a central role in the control of energy metabolism in humans. Some recent data high...
Abstract
Cited 23 times since 2013 (2 per year)
source: EuropePMC
Critical care medicine,
Volume 41, Issue 12, 1 1 2013, Pages e401-10
Mild hypothermia attenuates circulatory and pulmonary dysfunction during experimental endotoxemia.
Schwarzl M, Seiler S, Wallner M, von Lewinski D, Huber S, Maechler H, Steendijk P, Zelzer S, Truschnig-Wilders M, Obermayer-Pietsch B, Lueger A, Pieske BM, Post H
Objective: We tested whether mild hypothermia impacts on circulatory and respiratory dysfunction during experimental endotoxemia. Design: Randomized controlled prospective experimental study. Setting: Large animal facility, Medical University of Graz, Austria. Subjects: Thirteen anesthetized and mechanically ventilated pigs. Interventions: Lipopolysaccharide was administered for 4 hours. With the beginning of lipopolysaccharide infusion, animals were assigned to either normothermia (38°C, n = 7)...
Abstract
Cited 89 times since 2013 (7.6 per year)
source: EuropePMC
Mediators of inflammation,
Volume 2013, 30 5 2013, Pages 206039
Danger signals in the initiation of the inflammatory response after myocardial infarction.
de Haan JJ, Smeets MB, Pasterkamp G, Arslan F
During myocardial infarction, sterile inflammation occurs. The danger model is a solid theoretic framework that explains this inflammation as danger associated molecular patterns activate the immune system. The innate immune system can sense danger signals through different pathogen recognition receptors (PRR) such as toll-like receptors, nod-like receptors and receptors for advanced glycation endproducts. Activation of a PRR results in the production of cytokines and the recruitment of leukocyt...
Abstract
Cited 15 times since 2013 (1.3 per year)
source: EuropePMC
Arrhythmia & electrophysiology review,
Volume 2, Issue 2, 29 5 2013, Pages 128-134
Imaging-guided Ventricular Tachycardia Ablation.
Piers SR, Zeppenfeld K
Over the past decades important advances have been made in the field of ventricular tachycardia (VT) ablation, and as a result, VT ablation is now more widely being performed. The identification of ablation target sites still relies on electroanatomical substrate mapping, which is time-consuming, hampered by the intramural location of some scars and limited by epicardial fat. The potential of various imaging modalities to overcome these limitations have stimulated clinical electrophysiologists t...
Abstract
Cited 24 times since 2013 (2 per year)
source: EuropePMC
Veterinary microbiology,
Volume 168, Issue 2-4, 28 4 2013, Pages 281-293
Schmallenberg virus in Dutch dairy herds: potential risk factors for high within-herd seroprevalence and malformations in calves, and its impact on productivity.
Veldhuis AM, Carp-van Dijken S, van Wuijckhuise L, Witteveen G, van Schaik G
In November 2011, the new orthobunyavirus Schmallenberg virus (SBV) was identified in dairy cows that had induced fever, drop in milk production and diarrhoea in the Netherlands (Muskens et al., 2012. Tijdschrift voor Diergeneeskunde 137, 112-115) and a drop in milk production in cows in Northwestern Germany (Hoffmann et al., 2012. Emerging Infectious Diseases 18 (3), 469-472), in August/September 2011. This study aimed at quantifying risk factors for high within-herd prevalence of SBV and SBV-i...
Abstract
Cited 16 times since 2013 (1.4 per year)
source: EuropePMC
Journal of electrocardiology,
Volume 47, Issue 2, 27 4 2013, Pages 183-190
Acute coronary syndrome with a totally occluded culprit artery: relation of the ST injury vector with ST-elevation and non-ST elevation ECGs.
Man S, Rahmattulla C, Maan AC, van der Putten NH, Dijk WA, van Zwet EW, van der Wall EE, Schalij MJ, Gorgels AP, Swenne CA
Background: In acute coronary syndrome (ACS), ST-segment elevation (STE), often associated with a completely occluded culprit artery, is an important ECG criterion for primary percutaneous coronary intervention (PCI). However, several studies showed that in ACS a completely occluded culprit artery can also occur with a non-ST-elevation (NSTE) ECG. In order to elucidate reasons for this discrepancy we examined ST injury vector orientation and magnitude in ACS patients with and without STE, all ad...
Abstract
