Research

Publications

Below you can find a list of our published research.

9618 results

Cited 108 times since 2013 (9.1 per year) source: EuropePMC

Circulation. Arrhythmia and electrophysiology, Volume 6, Issue 5, 13 2 2013, Pages 875-883 Contrast-enhanced MRI-derived scar patterns and associated ventricular tachycardias in nonischemic cardiomyopathy: implications for the ablation strategy. Piers SR, Tao Q, van Huls van Taxis CF, Schalij MJ, van der Geest RJ, Zeppenfeld K

Background: There are limited data on typical arrhythmogenic substrates and associated ventricular tachycardias (VT) in patients with nonischemic cardiomyopathy. The substrate location may have implications for the ablation strategy. Methods and results: Nineteen consecutive patients with nonischemic cardiomyopathy (age 58±14 years, 79% men, left ventricular ejection fraction 41±11%) who underwent contrast-enhanced MRI and VT ablation were included. On the basis of 3-dimensional contrast-enhance... Abstract

Cited 28 times since 2013 (2.3 per year) source: EuropePMC

Journal of the American Society of Nephrology : JASN, Volume 24, Issue 12, 12 2 2013, Pages 2105-2117 Common variants in Mendelian kidney disease genes and their association with renal function. Parsa A, Fuchsberger C, Köttgen A, O'Seaghdha CM, Pattaro C, de Andrade M, Chasman DI, Teumer A, Endlich K, Olden M, Chen MH, Tin A, Kim YJ, Taliun D, Li M, Feitosa M, Gorski M, Yang Q, Hundertmark C, Foster MC, Glazer N, Isaacs A, Rao M, Smith AV, O'Connell JR, Struchalin M, Tanaka T, Li G, Hwang SJ, Atkinson EJ, Lohman K, Cornelis MC, Johansson A, Tönjes A, Dehghan A, Couraki V, Holliday EG, Sorice R, Kutalik Z, Lehtimäki T, Esko T, Deshmukh H, Ulivi S, Chu AY, Murgia F, Trompet S, Imboden M, Kollerits B, Pistis G, Harris TB, Launer LJ, Aspelund T, Eiriksdottir G, Mitchell BD, Boerwinkle E, Schmidt H, Hofer E, Hu F, Demirkan A, Oostra BA, Turner ST, Ding J, Andrews JS, Freedman BI, Giulianini F, Koenig W, Illig T, Döring A, Wichmann HE, Zgaga L, Zemunik T, Boban M, Minelli C, Wheeler HE, Igl W, Zaboli G, Wild SH, Wright AF, Campbell H, Ellinghaus D, Nöthlings U, Jacobs G, Biffar R, Ernst F, Homuth G, Kroemer HK, Nauck M, Stracke S, Völker U, Völzke H, Kovacs P, Stumvoll M, Mägi R, Hofman A, Uitterlinden AG,

Many common genetic variants identified by genome-wide association studies for complex traits map to genes previously linked to rare inherited Mendelian disorders. A systematic analysis of common single-nucleotide polymorphisms (SNPs) in genes responsible for Mendelian diseases with kidney phenotypes has not been performed. We thus developed a comprehensive database of genes for Mendelian kidney conditions and evaluated the association between common genetic variants within these genes and kidne... Abstract

Cited 11 times since 2013 (0.9 per year) source: EuropePMC

PloS one, Volume 8, Issue 9, 12 2 2013, Pages e73726 Evaluation of a continuous indicator for syndromic surveillance through simulation. application to vector borne disease emergence detection in cattle using milk yield. Madouasse A, Marceau A, Lehébel A, Brouwer-Middelesch H, van Schaik G, Van der Stede Y, Fourichon C

Two vector borne diseases, caused by the Bluetongue and Schmallenberg viruses respectively, have emerged in the European ruminant populations since 2006. Several diseases are transmitted by the same vectors and could emerge in the future. Syndromic surveillance, which consists in the routine monitoring of indicators for the detection of adverse health events, may allow an early detection. Milk yield is routinely measured in a large proportion of dairy herds and could be incorporated as an indica... Abstract

Cited 24 times since 2013 (2 per year) source: EuropePMC

The Journal of thoracic and cardiovascular surgery, Volume 147, Issue 5, 12 2 2013, Pages 1561-1567 Left and right ventricular performance after arterial switch operation. Klitsie LM, Roest AA, Kuipers IM, Hazekamp MG, Blom NA, Ten Harkel AD

Objective: Recent descriptions of decreased exercise capacity 10 to 15 years after arterial switch operation (ASO) suggest subclinical hemodynamic restrictions. Persistent impairment of ventricular performance following ASO may add to this. We aimed to characterize the time course of changes in biventricular performance within the first year following ASO. Methods: We prospectively included 26 patients with transposition of the great arteries undergoing ASO and 20 age-matched controls. Left and... Abstract

Cited 15 times since 2013 (1.3 per year) source: EuropePMC

PloS one, Volume 8, Issue 9, 11 2 2013, Pages e73495 Multivalent engagement of TFIID to nucleosomes. van Nuland R, Schram AW, van Schaik FM, Jansen PW, Vermeulen M, Marc Timmers HT

The process of eukaryotic transcription initiation involves the assembly of basal transcription factor complexes on the gene promoter. The recruitment of TFIID is an early and important step in this process. Gene promoters contain distinct DNA sequence elements and are marked by the presence of post-translationally modified nucleosomes. The contributions of these individual features for TFIID recruitment remain to be elucidated. Here, we use immobilized reconstituted promoter nucleosomes, conven... Abstract

Cited 23 times since 2013 (1.9 per year) source: EuropePMC

PloS one, Volume 8, Issue 9, 11 2 2013, Pages e74896 Wild orangutan males plan and communicate their travel direction one day in advance. van Schaik CP, Damerius L, Isler K

The ability to plan for the future beyond immediate needs would be adaptive to many animal species, but is widely thought to be uniquely human. Although studies in captivity have shown that great apes are capable of planning for future needs, it is unknown whether and how they use this ability in the wild. Flanged male Sumatran orangutans (Pongo abelii) emit long calls, which females use to maintain earshot associations with them. We tested whether long calls serve to communicate a male's e... Abstract

Cited 43 times since 2013 (3.6 per year) source: EuropePMC

The American journal of pathology, Volume 183, Issue 4, 10 2 2013, Pages 1137-1143 Novel avian-origin influenza A (H7N9) virus attaches to epithelium in both upper and lower respiratory tract of humans. van Riel D, Leijten LME, de Graaf M, Siegers JY, Short KR, Spronken MIJ, Schrauwen EJA, Fouchier RAM, Osterhaus ADME, Kuiken T

Influenza A viruses from animal reservoirs have the capacity to adapt to humans and cause influenza pandemics. The occurrence of an influenza pandemic requires efficient virus transmission among humans, which is associated with virus attachment to the upper respiratory tract. Pandemic severity depends on virus ability to cause pneumonia, which is associated with virus attachment to the lower respiratory tract. Recently, a novel avian-origin H7N9 influenza A virus with unknown pandemic potential... Abstract

Cited 6 times since 2013 (0.5 per year) source: EuropePMC

International journal of cardiology, Volume 169, Issue 3, 10 2 2013, Pages 190-195 The wealth of nations and the dissemination of cardiovascular research. Winnik S, Speer T, Raptis DA, Walker JH, Hasun M, Clavien PA, Komajda M, Bax JJ, Tendera M, Fox K, Van de Werf F, Mundow C, Lüscher TF, Ruschitzka F, Nallamothu BK, Matter CM

Background: This study aimed at understanding whether investigators from less wealthy countries were at a disadvantage in disseminating their research, after accounting for potential differences in research quality and infrastructure. Methods and results: In this bibliometric analysis a representative random selection of 10% (n=1002 studies) of all abstracts submitted to the European Society of Cardiology (ESC) congress 2006 was followed for publication and citation from September 2006 to Decemb... Abstract

Cited 20 times since 2013 (1.7 per year) source: EuropePMC

International journal of cardiology, Volume 169, Issue 2, 8 2 2013, Pages 139-144 Postoperative arrhythmias in adults with congenital heart disease: incidence and risk factors. Koyak Z, Achterbergh RC, de Groot JR, Berger F, Koolbergen DR, Bouma BJ, Lagrand WK, Hazekamp MG, Blom NA, Mulder BJ

Background: Little is known about the clinical impact of arrhythmias after surgery for congenital heart disease (CHD) in adults. Therefore, we investigated the prevalence of in-hospital arrhythmias after CHD surgery and their impact on clinical outcome. Methods: This was a multicenter retrospective study and included adults who underwent congenital cardiac surgery between January 2009 and December 2011. Clinical events were defined as all cause mortality, heart failure (HF) requiring medical tre... Abstract

Cited 43 times since 2013 (3.6 per year) source: EuropePMC

International journal of cardiology, Volume 169, Issue 3, 7 1 2013, Pages 183-189 A cornerstone of heart failure treatment is not effective in experimental right ventricular failure. Borgdorff MA, Bartelds B, Dickinson MG, Steendijk P, Berger RM

Background: Right ventricular (RV) failure due to increased pressure load causes significant morbidity and mortality in patients with congenital heart diseases and pulmonary arterial hypertension. It is unknown whether renin-angiotensin-aldosterone-system (RAAS) inhibition (the cornerstone of left ventricular failure treatment) is effective in RV failure. We investigated the effects of combination treatment of aldosterone-blocker eplerenone+angiotensin II receptor blocker losartan (Ep/Lo) on RV... Abstract

Cited 14 times since 2013 (1.2 per year) source: EuropePMC

Journal of molecular and cellular cardiology, Volume 64, 5 1 2013, Pages 51-58 C57BL/6 NK cell gene complex is crucially involved in vascular remodeling. de Vries MR, Seghers L, van Bergen J, Peters HA, de Jong RC, Hamming JF, Toes RE, van Hinsbergh VW, Quax PH

Objective: NK cells are known to be involved in cardiovascular disease processes. One of these processes, vascular remodeling, may strongly differ between individuals and mouse strains such as the C57BL/6 and BALB/c. Moreover, C57BL/6 and BALB/c mice vary in immune responses and in the composition of their Natural Killer gene Complex (NKC). Here we study the role of NK cells, and in particular the C57BL/6 NKC in vascular remodeling and intimal hyperplasia formation. Methods and results: C57BL/6,... Abstract

Cited 17 times since 2013 (1.4 per year) source: EuropePMC

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, Volume 46, Issue 6, 4 1 2013, Pages 624-629 Results from craniocaudal carotid body tumor resection: should it be the standard surgical approach? Paridaans MP, van der Bogt KE, Jansen JC, Nyns EC, Wolterbeek R, van Baalen JM, Hamming JF

Objectives: To evaluate results after carotid body tumor (CBT) surgery using a novel dissection technique. Methods: A retrospective analysis of all operated CBT in the last 6 years was carried out and results were compared with the current literature and our previous series, which reported another 111 cases operated on until 2005. Results: Forty-five CBTs were removed in 41 (56% hereditary cases) patients (seven Shamblin I, 22 II, and 16 III). There were no cases of permanent cranial nerve injur... Abstract

Cited 35 times since 2013 (2.9 per year) source: EuropePMC

Journal of plastic, reconstructive & aesthetic surgery : JPRAS, Volume 66, Issue 12, 4 1 2013, Pages 1732-1740 Treatment of infantile haemangiomas with atenolol: comparison with a historical propranolol group. de Graaf M, Raphael MF, Breugem CC, Knol MJ, Bruijnzeel-Koomen CA, Kon M, Breur JM, Pasmans SG

Propranolol, a lipophilic non-selective beta-blocker, has proven to be effective in the treatment of infantile haemangioma (IH). However, several side effects have been reported. Atenolol, a hydrophilic selective beta-1 blocker, could be an alternative and associated with fewer side effects. Thirty consecutive patients with IH were treated with atenolol between June 2010 and May 2011. The therapeutic effect was judged by clinical assessment and quantified by using a visual analogue scale (VAS) a... Abstract

Cited 199 times since 2013 (16.6 per year) source: EuropePMC

European heart journal, Volume 34, Issue 45, 2 1 2013, Pages 3491-3500 Losartan reduces aortic dilatation rate in adults with Marfan syndrome: a randomized controlled trial. Groenink M, den Hartog AW, Franken R, Radonic T, de Waard V, Timmermans J, Scholte AJ, van den Berg MP, Spijkerboer AM, Marquering HA, Zwinderman AH, Mulder BJ

Aim: Patients with Marfan syndrome have an increased risk of life-threatening aortic complications, mostly preceded by aortic dilatation. Treatment with losartan, an angiotensin-II receptor-1 blocker, may reduce aortic dilatation rate in Marfan patients. Methods and results: In this multicentre, open-label, randomized controlled trial with blinded assessments, we compared losartan treatment with no additional treatment in operated and unoperated adults with Marfan syndrome. The primary endpoint... Abstract

Cited 13 times since 2013 (1.1 per year) source: EuropePMC

Pacing and clinical electrophysiology : PACE, Volume 37, Issue 1, 2 1 2013, Pages 25-34 Cost-effectiveness of primary prevention implantable cardioverter defibrillator treatment: data from a large clinical registry. Thijssen J, van den Akker van Marle ME, Borleffs CJ, van Rees JB, de Bie MK, van der Velde ET, van Erven L, Schalij MJ

Background: Although randomized trials have shown the beneficial effect on survival of an implantable cardioverter defibrillator (ICD) as primary prevention therapy in selected patients, data concerning the cost-effectiveness in routine clinical practice remain scarce. Accordingly, the purpose of this study was to assess the cost-effectiveness of primary prevention ICD implantation in the real world. Methods: Patients receiving primary prevention single-chamber or dual-chamber ICD implantation a... Abstract

Cited 32 times since 2013 (2.7 per year) source: EuropePMC

PloS one, Volume 8, Issue 9, 2 1 2013, Pages e72642 Long-term effects of statin treatment in elderly people: extended follow-up of the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER). Lloyd SM, Stott DJ, de Craen AJ, Kearney PM, Sattar N, Perry I, Packard CJ, Briggs A, Marchbank L, Comber H, Jukema JW, Westendorp RG, Trompet S, Buckley BM, Ford I

Background: The PROspective Study of Pravastatin in the Elderly at Risk (PROSPER), a placebo-controlled trial of pravastatin, demonstrated a 19% reduction in coronary outcomes (p=0.006) after a mean of 3.2 years, with no impact on stroke outcomes or all-cause mortality. However, there was a suggestion of increased cancer risk. Our aim is to determine the long-term benefits and safety of pravastatin treatment in older people using post-trial follow-up of the PROSPER participants. Methods: 5,804 (... Abstract

Cited 451 times since 2013 (37.7 per year) source: EuropePMC

The New England journal of medicine, Volume 369, Issue 15, 2 1 2013, Pages 1395-1405 Cardiac-resynchronization therapy in heart failure with a narrow QRS complex. Ruschitzka F, Abraham WT, Singh JP, Bax JJ, Borer JS, Brugada J, Dickstein K, Ford I, Gorcsan J, Gras D, Krum H, Sogaard P, Holzmeister J, EchoCRT Study Group

Background: Cardiac-resynchronization therapy (CRT) reduces morbidity and mortality in chronic systolic heart failure with a wide QRS complex. Mechanical dyssynchrony also occurs in patients with a narrow QRS complex, which suggests the potential usefulness of CRT in such patients. Methods: We conducted a randomized trial involving 115 centers to evaluate the effect of CRT in patients with New York Heart Association class III or IV heart failure, a left ventricular ejection fraction of 35% or le... Abstract

Cited 32 times since 2013 (2.7 per year) source: EuropePMC

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, Volume 8, Issue 9, 1 1 2013, Pages 1190-1195 KRAS mutations in advanced nonsquamous non-small-cell lung cancer patients treated with first-line platinum-based chemotherapy have no predictive value. Mellema WW, Dingemans AM, Thunnissen E, Snijders PJ, Derks J, Heideman DA, Van Suylen R, Smit EF

Background: Kirsten rat sarcoma viral oncogene homolog (KRAS) mutation is thought to be related with dismal outcome for non-small-cell lung cancer (NSCLC) patients. The role of KRAS mutation as a predictor of response to chemotherapy for patients with metastatic NSCLC is poorly understood. Methods: From a retrospective database of two university hospitals, all patients with advanced, nonsquamous NSCLC treated with first-line platinum-containing chemotherapy were selected. Mutation analysis for K... Abstract

Cited 21 times since 2013 (1.8 per year) source: EuropePMC

Evolutionary anthropology, Volume 22, Issue 5, 1 1 2013, Pages 202-212 The evolution of the patterning of human lactation: a comparative perspective. Van Noordwijk MA, Kuzawa CW, Van Schaik CP

Some four decades ago, Jeanne Altmann started her detailed field studies of baboon mothers and their infants with a focus on the behavioral ecology of maternal reproductive investment. Around the same time, Sarah Hrdy studied langur mothers and their infants, focusing on the influence of the social environment on a female's reproductive options and decisions. Their pioneering work has inspired many subsequent studies of female primate reproduction in its natural context and shaped our own w... Abstract

Evolutionary anthropology, Volume 22, Issue 5, 1 1 2013, Pages 200-201 Contributions of Sarah Blaffer Hrdy. van Schaik C, Silk JB

Abstract