8892 results
Cited 20 times since 2013 (1.6 per year)
source: EuropePMC
Journal of electrocardiology,
Volume 46, Issue 4, 14 2 2013, Pages 302-311
Difference vectors to describe dynamics of the ST segment and the ventricular gradient in acute ischemia.
ter Haar CC, Maan AC, Warren SG, Ringborn M, Horáček BM, Schalij MJ, Swenne CA
Background: The ECG is important in the diagnosis and triage of the acute coronary syndrome (ACS), especially in the hyperacute phase, the "golden hours," during which myocardial salvage possibilities are largest. An important triaging decision to be taken is whether or not a patient requires primary PCI, for which, as mentioned in the guidelines, the presence of an ST elevation (STE) pattern in the ECG is a major criterion. However, preexisting non-zero ST amplitudes (diagnostic, but...
Abstract
Cited 10 times since 2013 (0.8 per year)
source: EuropePMC
Circulation. Cardiovascular quality and outcomes,
Volume 6, Issue 3, 14 2 2013, Pages 360-366
Journey through cholesteryl ester transfer protein inhibition: from bench to bedside.
Karalis I, Rensen PC, Jukema JW
Abstract
Cited 32 times since 2013 (2.6 per year)
source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
Volume 26, Issue 7, 11 2 2013, Pages 691-698
Impact of valvuloarterial impedance on 2-year outcome of patients undergoing transcatheter aortic valve implantation.
Katsanos S, Yiu KH, Clavel MA, Rodés-Cabau J, Leong D, van der Kley F, Ajmone Marsan N, Bax JJ, Pibarot P, Delgado V
Background: Elderly patients with severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI) often have increased calcification and fibrosis of the aorta. Indices that account for the severity of valvular obstruction and systemic vascular impedance may better assess total left ventricular afterload. The aims of the present study were to evaluate changes in valvuloarterial impedance (Zva), systemic arterial compliance, and systemic vascular resistance after TAVI and to inves...
Abstract
Cited 16 times since 2013 (1.3 per year)
source: EuropePMC
Bioorganic & medicinal chemistry letters,
Volume 23, Issue 13, 9 2 2013, Pages 3749-3752
Improving the biological activity of the antimicrobial peptide anoplin by membrane anchoring through a lipophilic amino acid derivative.
Slootweg JC, van Schaik TB, Quarles van Ufford HL, Breukink E, Liskamp RM, Rijkers DT
The lipophilic amino acid, (S)-2-aminoundecanoic acid, was synthesized and incorporated at a number of specific positions within the peptide sequence of anoplin. These lipophilic anoplin analogs showed to be more active against Escherichia coli and Staphylococcus aureus compared to native anoplin, while the EC50-value of hemolysis was at least one order of magnitude lower than the MIC values. This was in sharp contrast to the N-acylated anoplin derivative, where a gain in activity also led to a...
Abstract
Cited 72 times since 2013 (5.8 per year)
source: EuropePMC
Circulation research,
Volume 113, Issue 2, 8 2 2013, Pages 153-166
Intracoronary infusion of allogeneic mesenchymal precursor cells directly after experimental acute myocardial infarction reduces infarct size, abrogates adverse remodeling, and improves cardiac function.
Houtgraaf JH, de Jong R, Kazemi K, de Groot D, van der Spoel TI, Arslan F, Hoefer I, Pasterkamp G, Itescu S, Zijlstra F, Geleijnse ML, Serruys PW, Duckers HJ
Rationale: Mesenchymal precursor cells (MPCs) are a specific Stro-3+ subpopulation of mesenchymal stem cells isolated from bone marrow. MPCs exert extensive cardioprotective effects, and are considered to be immune privileged. Objective: This study assessed the safety, feasibility, and efficacy of intracoronary delivery of allogeneic MPCs directly after acute myocardial infarction in sheep. Methods and results: Initially, intracoronary delivery conditions were optimized in 20 sheep. These condit...
Abstract
Cited 114 times since 2013 (9.2 per year)
source: EuropePMC
Epigenetics & chromatin,
Volume 6, Issue 1, 8 2 2013, Pages 12
Nucleosomal DNA binding drives the recognition of H3K36-methylated nucleosomes by the PSIP1-PWWP domain.
van Nuland R, van Schaik FM, Simonis M, van Heesch S, Cuppen E, Boelens R, Timmers HM, van Ingen H
Background: Recognition of histone modifications by specialized protein domains is a key step in the regulation of DNA-mediated processes like gene transcription. The structural basis of these interactions is usually studied using histone peptide models, neglecting the nucleosomal context. Here, we provide the structural and thermodynamic basis for the recognition of H3K36-methylated (H3K36me) nucleosomes by the PSIP1-PWWP domain, based on extensive mutational analysis, advanced nuclear magnetic...
Abstract
Cited 1 times since 2013 (0.1 per year)
source: EuropePMC
Nature reviews. Cardiology,
Volume 10, Issue 7, 7 1 2013, Pages 370-371
Imaging: myocardial thinning is not always transmural scarring.
Bax JJ
Abstract
Cited 30 times since 2013 (2.4 per year)
source: EuropePMC
The Journal of hand surgery,
Volume 38, Issue 6, 4 1 2013, Pages 1202-1208
How surgeons make decisions when the evidence is inconclusive.
Hageman MG, Guitton TG, Ring D, Science of Variation Group
Purpose: To address the factors that surgeons use to decide between 2 options for treatment when the evidence is inconclusive. Methods: We tested the null hypothesis that the factors surgeons use do not vary by training, demographics, and practice. A total of 337 surgeons rated the importance of 7 factors when deciding between treatment and following the natural history of the disease and 12 factors when deciding between 2 operative treatments using a 5-point Likert scale between "very impo...
Abstract
Cited 24 times since 2013 (1.9 per year)
source: EuropePMC
BMC genomics,
Volume 14, 3 1 2013, Pages 299
Functional genomic analysis of bile salt resistance in Enterococcus faecium.
Zhang X, Bierschenk D, Top J, Anastasiou I, Bonten MJ, Willems RJ, van Schaik W
Background: Enterococcus faecium is a Gram-positive commensal bacterium of the mammalian intestinal tract. In the last two decades it has also emerged as a multi-resistant nosocomial pathogen. In order to survive in and colonize the human intestinal tract E. faecium must resist the deleterious actions of bile. The molecular mechanisms exploited by this bacterium to tolerate bile are as yet unexplored. Results: In this study we used a high-throughput quantitative screening approach of transposon...
Abstract
Cited 4 times since 2013 (0.3 per year)
source: EuropePMC
International journal of cardiology,
Volume 168, Issue 4, 3 1 2013, Pages 3327-3333
Exercise-resembling effects of periodic somatosensory stimulation in heart failure.
Gademan MG, van Exel HJ, van de Vooren H, Haest JC, van Pelt J, van der Laarse A, Cannegieter SC, Lucas CM, Somer S, Verwey HF, Schalij MJ, van der Wall EE, Swenne CA
Background: The mechanism of the beneficial effects of exercise training on autonomic derangement and neurohumoral activation in chronic heart failure (CHF) is largely unexplained. In our here-presented hypothesis-generating study we propose that part of these effects is mediated by the exercise-accompanying somatosensory nerve traffic. To demonstrate this, we compared the effects of periodic electrical somatosensory stimulation in patients with CHF with the effects of exercise training and with...
Abstract
Cited 19 times since 2013 (1.5 per year)
source: EuropePMC
International journal of cardiology,
Volume 168, Issue 4, 3 1 2013, Pages 3212-3216
Complications of pacemaker therapy in adults with congenital heart disease: a multicenter study.
Opić P, van Kranenburg M, Yap SC, van Dijk AP, Budts W, Vliegen HW, van Erven L, Can A, Sahin G, Theuns DA, Witsenburg M, Roos-Hesselink JW
Background: This study aims to investigate indications and complications of permanent cardiac pacing in adults with congenital heart disease (CHD). Methods and results: Two-hundred and seventy-four CHD patients were identified who underwent permanent pacemaker implantation between 1972 and 2009. The indication for pacing was acquired sinus node or AV node conduction disease (63%), sinus node or AV node conduction disease after cardiac surgery (28%), and drug/arrhythmia-related indications (9%)....
Abstract
Cited 78 times since 2013 (6.3 per year)
source: EuropePMC
Clinical cancer research : an official journal of the American Association for Cancer Research,
Volume 19, Issue 12, 2 1 2013, Pages 3316-3324
CYP3A4*22 genotype and systemic exposure affect paclitaxel-induced neurotoxicity.
de Graan AJ, Elens L, Sprowl JA, Sparreboom A, Friberg LE, van der Holt B, de Raaf PJ, de Bruijn P, Engels FK, Eskens FA, Wiemer EA, Verweij J, Mathijssen RH, van Schaik RH
Purpose: Paclitaxel is used for the treatment of several solid tumors and displays a high interindividual variation in exposure and toxicity. Neurotoxicity is one of the most prominent side effects of paclitaxel. This study explores potential predictive pharmacokinetic and pharmacogenetic determinants for the onset and severity of neurotoxicity. Experimental design: In an exploratory cohort of patients (n = 261) treated with paclitaxel, neurotoxicity incidence, and severity, pharmacokinetic para...
Abstract
Cited 72 times since 2013 (5.8 per year)
source: EuropePMC
Journal of pain research,
Volume 6, 1 1 2013, Pages 331-353
Consequences of the 118A>G polymorphism in the OPRM1 gene: translation from bench to bedside?
Mura E, Govoni S, Racchi M, Carossa V, Ranzani GN, Allegri M, van Schaik RH
The 118A>G single nucleotide polymorphism (SNP) in the μ-opioid receptor (OPRM1) gene has been the most described variant in pharmacogenetic studies regarding opioid drugs. Despite evidence for an altered biological function encoded by this variant, this knowledge is not yet utilized clinically. The aim of the present review was to collect and discuss the available information on the 118A>G SNP in the OPRM1 gene, at the molecular level and in its clinical manifestations. In vitro biochemic...
Abstract
Cited 1 times since 2013 (0.1 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 21, Issue 5, 1 1 2013, Pages 256-261
Einthoven dissertation prizes 2012.
van der Wall EE, van Gilst WH, Schalij MJ, Umans V
Abstract
Cited 14 times since 2013 (1.1 per year)
source: EuropePMC
The bone & joint journal,
Volume 95-B, Issue 5, 1 1 2013, Pages 689-693
Risk factors for the displacement of fractures of both bones of the forearm in children.
Colaris JW, Allema JH, Reijman M, Biter LU, de Vries MR, van de Ven CP, Bloem RM, Verhaar JA
Forearm fractures in children have a tendency to displace in a cast leading to malunion with reduced functional and cosmetic results. In order to identify risk factors for displacement, a total of 247 conservatively treated fractures of the forearm in 246 children with a mean age of 7.3 years (sd 3.2; 0.9 to 14.9) were included in a prospective multicentre study. Multivariate logistic regression analyses were performed to assess risk factors for displacement of reduced or non-reduced fractures i...
Abstract
Cited 37 times since 2013 (3 per year)
source: EuropePMC
Giornale italiano di cardiologia (2006),
Volume 14, Issue 5, 1 1 2013, Pages 328-392
[European Guidelines on Cardiovascular Disease Prevention in Clinical Practice (version 2012). The Fifth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of nine societies and by invited experts)].
Perk J, De Backer G, Gohlke H, Graham I, Reiner Z, Verschuren WM, Albus C, Benlian P, Boysen G, Cifkova R, Deaton C, Ebrahim S, Fisher M, Germanò G, Hobbs R, Hoes A, Karadeniz S, Mezzani A, Prescott E, Ryden L, Scherer M, Syvanne M, Scholte Op Reimer WJ, Vrints C, Wood D, Zamorano JL, Zannad F, Comitato per Linee Guida Pratiche (CPG) dell'ESC
Abstract
Cited 21 times since 2013 (1.7 per year)
source: EuropePMC
Respiratory medicine,
Volume 107, Issue 7, 30 5 2013, Pages 959-966
CD8(+) T cells characterize early smoking-related airway pathology in patients with asthma.
Ravensberg AJ, Slats AM, van Wetering S, Janssen K, van Wijngaarden S, de Jeu R, Rabe KF, Sterk PJ, Hiemstra PS
Background: Smoking in asthma occurs frequently and is associated with increased symptom severity, an impaired response to corticosteroids, and accelerated lung function decline. Airway pathology in smoking asthmatics is characterized by neutrophilia and epithelial changes such as goblet cell hyperplasia and increased proliferation. Bronchial CD8(+) T cells are implicated in lung function decline in asthma and COPD. We hypothesized that smoking modifies airway inflammation in asthma by increasin...
Abstract
Cited 43 times since 2013 (3.4 per year)
source: EuropePMC
American heart journal,
Volume 166, Issue 1, 30 5 2013, Pages 20-29
Effect of atrioventricular and ventriculoventricular delay optimization on clinical and echocardiographic outcomes of patients treated with cardiac resynchronization therapy: a meta-analysis.
Auger D, Hoke U, Bax JJ, Boersma E, Delgado V
Background: Optimization of atrioventricular (AV) and ventriculoventricular (VV) delays of cardiac resynchronization therapy (CRT) devices maximizes left ventricular filling and stroke volume. However, the incremental value of these optimizations over empiric device programming remains unclear. The objective of this analysis was to perform a systematic review and meta-analysis of the effects of AV and VV delay optimization on clinical and echocardiographic end points of patients with heart failu...
Abstract
Cited 25 times since 2013 (2 per year)
source: EuropePMC
Journal of cardiothoracic and vascular anesthesia,
Volume 27, Issue 4, 28 4 2013, Pages 723-727
Determinants of clinical right ventricular failure after congenital heart surgery in adults.
Schuuring MJ, van Gulik EC, Koolbergen DR, Hazekamp MG, Lagrand WK, Backx AP, Mulder BJ, Bouma BJ
Objectives: Right ventricular (RV) failure after cardiac surgery is a clinical entity with high morbidity and mortality. Patients with congenital heart disease (CHD) often undergo right-sided cardiac surgery. The authors aimed to identify determinants of RV failure after cardiac surgery to differentiate patients with increased risk. Design: A retrospective chart review. Setting: University hospital. Participants: Adults with CHD operated on between January 2001 and January 2011. Interventions: C...
Abstract
Cited 7 times since 2013 (0.6 per year)
source: EuropePMC
International journal of cardiology,
Volume 168, Issue 3, 26 4 2013, Pages 3031-3032
Long term effects of intramyocardial bone marrow cell injection on anginal symptoms and quality of life in patients with chronic myocardial ischemia.
van Ramshorst J, Rodrigo SF, Beeres SL, Fibbe WE, Zwaginga JJ, Bax JJ, Schalij MJ, Atsma DE
Abstract
