8892 results
Cited 23 times since 2013 (1.8 per year)
source: EuropePMC
Frontiers in neuroscience,
Volume 7, 13 2 2013, Pages 14
An FPGA Implementation of a Polychronous Spiking Neural Network with Delay Adaptation.
Wang R, Cohen G, Stiefel KM, Hamilton TJ, Tapson J, van Schaik A
We present an FPGA implementation of a re-configurable, polychronous spiking neural network with a large capacity for spatial-temporal patterns. The proposed neural network generates delay paths de novo, so that only connections that actually appear in the training patterns will be created. This allows the proposed network to use all the axons (variables) to store information. Spike Timing Dependent Delay Plasticity is used to fine-tune and add dynamics to the network. We use a time multiplexing...
Abstract
Cited 7 times since 2013 (0.6 per year)
source: EuropePMC
ISRN obesity,
Volume 2013, 12 2 2013, Pages 342802
Plasma Levels of Acylation-Stimulating Protein Are Strongly Predicted by Waist/Hip Ratio and Correlate with Decreased LDL Size in Men.
Saleh J, Wahab RA, Farhan H, Al-Amri I, Cianflone K
The association of abdominal obesity with cardiovascular risk is often linked to altered secretion of adipose-derived factors and an abnormal lipid profile including formation of atherogenic small dense low density lipoprotein particles (sdLDL). Acylation-stimulating protein (ASP) is an adipose-derived hormone that exhibits potent lipogenic effects. Plasma ASP levels increase in obesity; however, the association of ASP levels with body fat distribution is not yet established, and no study to dat...
Abstract
Cited 48 times since 2013 (3.8 per year)
source: EuropePMC
Journal of lipid research,
Volume 54, Issue 5, 10 2 2013, Pages 1265-1274
Lysophosphatidic acid triggers mast cell-driven atherosclerotic plaque destabilization by increasing vascular inflammation.
Bot M, de Jager SC, MacAleese L, Lagraauw HM, van Berkel TJ, Quax PH, Kuiper J, Heeren RM, Biessen EA, Bot I
Lysophosphatidic acid (LPA), a bioactive lysophospholipid, accumulates in the atherosclerotic plaque. It has the capacity to activate mast cells, which potentially exacerbates plaque progression. In this study, we thus aimed to investigate whether LPA contributes to plaque destabilization by modulating mast cell function. We here show by an imaging mass spectrometry approach that several LPA species are present in atherosclerotic plaques. Subsequently, we demonstrate that LPA is a potent mast ce...
Abstract
Cited 59 times since 2013 (4.6 per year)
source: EuropePMC
Clinical research in cardiology : official journal of the German Cardiac Society,
Volume 102, Issue 5, 8 2 2013, Pages 329-336
Discussing sexual function in the cardiology practice.
Nicolai MP, Both S, Liem SS, Pelger RC, Putter H, Schalij MJ, Elzevier HW
Background: In patients with cardiovascular disease, sexual dysfunction is frequently encountered. Erectile dysfunction shares the same modifiable risk factors as coronary artery disease and the fear of triggering cardiovascular events can create stress and anxiety impacting the sexual lives of patients and their partners. To optimise healthcare, knowledge of cardiologists' attitude and practice patterns regarding the discussion about sexual function is essential. Methods: A 31-itemed anony...
Abstract
Cited 173 times since 2013 (13.6 per year)
source: EuropePMC
PLoS genetics,
Volume 9, Issue 2, 7 1 2013, Pages e1003266
A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.
Porcu E, Medici M, Pistis G, Volpato CB, Wilson SG, Cappola AR, Bos SD, Deelen J, den Heijer M, Freathy RM, Lahti J, Liu C, Lopez LM, Nolte IM, O'Connell JR, Tanaka T, Trompet S, Arnold A, Bandinelli S, Beekman M, Böhringer S, Brown SJ, Buckley BM, Camaschella C, de Craen AJ, Davies G, de Visser MC, Ford I, Forsen T, Frayling TM, Fugazzola L, Gögele M, Hattersley AT, Hermus AR, Hofman A, Houwing-Duistermaat JJ, Jensen RA, Kajantie E, Kloppenburg M, Lim EM, Masciullo C, Mariotti S, Minelli C, Mitchell BD, Nagaraja R, Netea-Maier RT, Palotie A, Persani L, Piras MG, Psaty BM, Räikkönen K, Richards JB, Rivadeneira F, Sala C, Sabra MM, Sattar N, Shields BM, Soranzo N, Starr JM, Stott DJ, Sweep FC, Usala G, van der Klauw MM, van Heemst D, van Mullem A, Vermeulen SH, Visser WE, Walsh JP, Westendorp RG, Widen E, Zhai G, Cucca F, Deary IJ, Eriksson JG, Ferrucci L, Fox CS, Jukema JW, Kiemeney LA, Pramstaller PP, Schlessinger D, Shuldiner AR, Slagboom EP, Uitterlinden AG, Vaidya B, Visser TJ, Wolffenbuttel BH, Meulenbel
Thyroid hormone is essential for normal metabolism and development, and overt abnormalities in thyroid function lead to common endocrine disorders affecting approximately 10% of individuals over their life span. In addition, even mild alterations in thyroid function are associated with weight changes, atrial fibrillation, osteoporosis, and psychiatric disorders. To identify novel variants underlying thyroid function, we performed a large meta-analysis of genome-wide association studies for serum...
Abstract
Cardiovascular research,
Volume 98, Issue 1, 7 1 2013, Pages 156-157
Prolongation of minimal action potential duration in sustained fibrillation decreases complexity by transient destabilization: reply.
Bingen BO, Askar SF, Schalij MJ, de Vries AA, Pijnappels DA
Abstract
Cited 2 times since 2013 (0.2 per year)
source: EuropePMC
European heart journal,
Volume 34, Issue 17, 7 1 2013, Pages 1278
The invisible made visible: multi-modality imaging in the evaluation of cardiac sarcoidosis.
Joyce E, Delgado V, Ninaber MK, Marsan NA
Abstract
Cited 4 times since 2013 (0.3 per year)
source: EuropePMC
Cytometry. Part B, Clinical cytometry,
Volume 84, Issue 4, 7 1 2013, Pages 218-221
Effector memory and late memory T cells accumulate in the blood of CMV-carrying individuals but not in their cerebrospinal fluid.
de Jongste AH, de Graaf MT, van den Broek PD, Kraan J, Sillevis Smitt PA, Gratama JW
Cytomegalovirus (CMV)-carrying individuals have significantly higher levels of effector memory and late memory T lymphocytes in their blood than non-carriers. To date, it is well recognized that the central nervous system is subjected to active immunosurveillance, as evidenced by the presence of central memory T cells in cerebrospinal fluid (CSF) of healthy individuals. In order to investigate whether levels of effector memory and late memory T cells were also increased in the CSF of CMV-carryin...
Abstract
Cited 7 times since 2013 (0.6 per year)
source: EuropePMC
Early human development,
Volume 89, Issue 8, 5 1 2013, Pages 547-553
Parental psychological distress during pregnancy and childhood cardiovascular development. The Generation R Study.
Taal HR, de Jonge LL, Tiemeier H, van Osch-Gevers L, Hofman A, Verhulst FC, Helbing WA, van der Heijden AJ, Jaddoe VW
Background: Maternal psychological distress during pregnancy might lead to higher fetal cortisol exposure, which subsequently leads to fetal cardiovascular developmental adaptations and cardiovascular dysfunction in later life. Aims: We examined whether maternal and paternal psychological distress was associated with the cardiovascular outcome measurements in school age children. Study design and subjects: In a population-based prospective cohort study among 4831 children, we assessed maternal a...
Abstract
Cited 4 times since 2013 (0.3 per year)
source: EuropePMC
BioData mining,
Volume 6, Issue 1, 4 1 2013, Pages 2
Identification of new biomarker candidates for glucocorticoid induced insulin resistance using literature mining.
Fleuren WW, Toonen EJ, Verhoeven S, Frijters R, Hulsen T, Rullmann T, van Schaik R, de Vlieg J, Alkema W
Unlabelled: Background: Glucocorticoids are potent anti-inflammatory agents used for the treatment of diseases such as rheumatoid arthritis, asthma, inflammatory bowel disease and psoriasis. Unfortunately, usage is limited because of metabolic side-effects, e.g. insulin resistance, glucose intolerance and diabetes. To gain more insight into the mechanisms behind glucocorticoid induced insulin resistance, it is important to understand which genes play a role in the development of insulin resista...
Abstract
Cited 5 times since 2013 (0.4 per year)
source: EuropePMC
The American journal of emergency medicine,
Volume 31, Issue 3, 4 1 2013, Pages 634.e5
Angioedema after the first dose of metformin.
Atik D, Büyükcam F, Yılmaz D, Işık B, Demir OF
Abstract
Cited 7 times since 2013 (0.6 per year)
source: EuropePMC
The Journal of cardiovascular surgery,
Volume 54, Issue 1 Suppl 1, 1 1 2013, Pages 47-53
Ruptured AAA: state of the art management.
Eefting D, Ultee KH, Von Meijenfeldt GC, Hoeks SE, ten Raa S, Hendriks JM, Bastos Goncalves F, Verhagen HJ
Since its introduction more than two decades ago, endovascular aneurysm repair (EVAR) has become the primary choice for elective treatment of abdominal aortic aneurysms (AAA) in many medical centers. The (dis)advantages, including 30-day mortality and long-term survival, of both open and endovascular elective AAA repair have been studied extensively, including four randomized trials. On the contrary, the survival benefit of EVAR for ruptured AAAs is not as well established as in elective situati...
Abstract
Cited 1 times since 2013 (0.1 per year)
source: EuropePMC
International journal of nursing practice,
Volume 19, Issue 1, 1 1 2013, Pages 65-73
Determination of the use of traditional practices to ease labour among Turkish women.
Yılmaz D, Kısa S, Zeyneloğlu S, Güner T
The purpose of this study was to determine the use of traditional practices to ease labour among Turkish women. Face-to-face interviews were conducted with 809 women by using an investigator-designed questionnaire. The mean age of the women was 28.9 ± 8.33 years (min = 15, max = 74), 49.4% were between 20-29 years of age and more than half (56.2%) of the women had had one to two pregnancies. The results showed that traditional practices were known and applied mostly by the women who were at an a...
Abstract
Cited 39 times since 2013 (3.1 per year)
source: EuropePMC
Journal of lipid research,
Volume 54, Issue 2, 1 1 2013, Pages 561-566
PCSK9 SNP rs11591147 is associated with low cholesterol levels but not with cognitive performance or noncardiovascular clinical events in an elderly population.
Postmus I, Trompet S, de Craen AJ, Buckley BM, Ford I, Stott DJ, Sattar N, Slagboom PE, Westendorp RG, Jukema JW
Proprotein convertase subtilisin-like/kexin type 9 (PCSK9) is a protein involved in LDL-cholesterol metabolism. The single-nucleotide polymorphism (SNP) rs11591147 has been associated with lower LDL-cholesterol and a lower risk of coronary heart disease. Because PCSK9 has high affinity to the LDL receptor, inhibiting PCSK9 is a testable therapeutic target for lipid-lowering therapy. Currently, several approaches to inhibit PCSK9 are under development, but it is unknown what the effects of those...
Abstract
Cited 4 times since 2013 (0.3 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 21, Issue 2, 1 1 2013, Pages 101-105
Ten-year mortality risk of patients undergoing elective PCI: long-term follow-up of the GENetic Determinants of Restenosis (GENDER) study : No increased mortality risk by restenosis, only by coronary artery disease itself.
Verschuren JJ, Trompet S, Tio RA, de Winter RJ, Doevendans PA, Jukema JW
Abstract
Cited 4 times since 2013 (0.3 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 99, Issue 4, 1 1 2013, Pages 279-284
Thrombus management in the catheterisation laboratory in the setting of primary percutaneous coronary intervention: what is the current evidence?
Dharma S, Kedev S, Jukema JW
Abstract
Cited 25 times since 2013 (2 per year)
source: EuropePMC
Differentiation; research in biological diversity,
Volume 85, Issue 3, 1 1 2013, Pages 101-109
Polycistronic lentivirus induced pluripotent stem cells from skin biopsies after long term storage, blood outgrowth endothelial cells and cells from milk teeth.
Dambrot C, van de Pas S, van Zijl L, Brändl B, Wang JW, Schalij MJ, Hoeben RC, Atsma DE, Mikkers HM, Mummery CL, Freund C
The generation of human induced pluripotent stem cells (hiPSCs) requires the collection of donor tissue, but clinical circumstances in which the interests of patients have highest priority may compromise the quality and availability of cells that are eventually used for reprogramming. Here we compared (i) skin biopsies stored in standard physiological salt solution for up to two weeks (ii) blood outgrowth endothelial cells (BOECs) isolated from fresh peripheral blood and (iii) children's mi...
Abstract
Cited 11 times since 2013 (0.9 per year)
source: EuropePMC
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology,
Volume 8, Issue 10, 1 1 2013, Pages 1199-1206
Long-term outcome of second-generation everolimus-eluting stents and Endeavor zotarolimus-eluting stents in a prospective registry of ST-elevation myocardial infarction patients.
Velders MA, Boden H, van der Hoeven BL, Liem SS, Atary JZ, van der Wall EE, Jukema JW, Schalij MJ
Aims: The optimal drug-eluting stent (DES) in ST-elevation myocardial infarction (STEMI) patients remains unclear. We sought to compare the long-term performance of everolimus-eluting stents (EES) and Endeavor zotarolimus-eluting stents (E-ZES) in STEMI. Methods and results: The current analysis of a prospective registry included consecutive patients treated with EES or E-ZES for STEMI. Adjustment for measured confounders was done using Cox regression. In total, 931 patients met the inclusion cr...
Abstract
Cited 69 times since 2013 (5.4 per year)
source: EuropePMC
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer,
Volume 8, Issue 2, 1 1 2013, Pages 214-221
A randomized controlled trial of postthoracotomy pulmonary rehabilitation in patients with resectable lung cancer.
Stigt JA, Uil SM, van Riesen SJ, Simons FJ, Denekamp M, Shahin GM, Groen HJ
Introduction: Little is known about the effects of rehabilitation for patients with lung cancer after thoracotomy. The primary objective of this study was to evaluate the effect of a multidisciplinary rehabilitation program on quality of life (QOL) and secondary objectives were to determine its effects on pain and exercise capacity and the feasibility of combining rehabilitation with adjuvant chemotherapy. Methods: Patients who had undergone a thoracotomy for lung cancer were randomized between...
Abstract
Cited 10 times since 2013 (0.8 per year)
source: EuropePMC
Annals of plastic surgery,
Volume 70, Issue 2, 1 1 2013, Pages 149-153
Quantitative assessment of nipple perfusion with near-infrared fluorescence imaging.
Ashitate Y, Lee BT, Ngo LH, Laurence RG, Hutteman M, Oketokoun R, Lunsford E, Soo Choi H, Frangioni JV
Preserving the nipple-areolar complex with a nipple-sparing mastectomy improves cosmesis compared with skin-sparing mastectomy. However, complications such as necrosis of the nipple-areolar complex significantly affect cosmetic outcome. Many factors influence nipple-areolar perfusion, and no consensus currently exists on optimal incisional choice. This study evaluates 2 nipple-sparing mastectomy incision models using near-infrared fluorescence to assess perfusion quantitatively. The periareolar...
Abstract
