Research

Publications

Below you can find a list of our published research.

9618 results

Cited 1 times since 2025 (2.1 per year) source: EuropePMC

Molecular oncology, Volume 19, Issue 8, 22 4 2025, Pages 2348-2365 Adverse prognosis gene expression patterns in metastatic castration-resistant prostate cancer. Sharifi MN, Feng E, Rydzewski NR, Taylor AK, Sperger JM, Shi Y, Helzer KT, Bootsma ML, Carreno V, Chang AH, Nunamaker LA, Blitzer GC, Shang TA, Subramanian A, Bjartell A, Josefsson A, Wikström P, Feng E, Kohli M, Yang R, Dehm SM, Small EJ, Aggarwal R, Quigley DA, Lang JM, Zhao SG, Sjöström M

Metastatic castration-resistant prostate cancer (mCRPC) is a heterogeneous disease. Several studies have identified transcriptional subtypes of mCRPC, but comprehensive analysis of prognostic gene expression pathways has been limited. Therefore, we aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression-based pathways with clinical outcomes and intrapatient and intratumor heterogeneity. Survival data were obtained for 272 patients. P... Abstract

Journal of cardiothoracic and vascular anesthesia, Volume 39, Issue 6, 21 3 2025, Pages 1451-1463 Vasoplegia in Cardiac Surgery: A Systematic Review and Meta-analysis of Current Definitions and Their Influence on Clinical Outcomes. Papazisi O, van der Schoot MM, Berendsen RR, Arbous SM, le Cessie S, Dekkers OM, Klautz RJM, Marczin N, Palmen M, de Waal EEC

Objectives: To identify differences in the reported vasoplegia incidence, intensive care unit (ICU) length of stay (LOS), and 30-day mortality rates as influenced by different vasoplegia definitions used in cardiac surgery studies. Design: A systematic review was performed covering the period 1977 to 2023 using PubMed/MEDLINE, Embase, Web of Science, Cochrane Library, and Emcare and a meta-analysis (PROSPERO: CRD42021258328) was performed. Setting and participants: One hundred studies defining v... Abstract

Gynecologic oncology, Volume 194, 20 3 2025, Pages 86-90 Predicting lymph node metastases in three different vulvar squamous cell carcinoma subgroups. van Velzen AF, Tulling AJ, van Poelgeest MIE, Bosse T, van Doorn HC, Kortekaas KE, Nooij LS

Objective: This study aimed to analyze the risk of lymph node metastases (LNM) in three different VSCC subgroups (HPV-positive (HPVpos), HPV-negative p53 wildtype (HPVneg/p53wt) and HPV-negative p53 abnormal (HPVneg/p53abn)), and develop a predictive model for clinical use. Methods: A retrospective cohort study was performed, collecting data from all surgically treated VSCC patients between 2000 and 2022 from two oncology clinics. The primary outcome was the risk of groin LNM at diagnosis. Progn... Abstract

Circulation. Arrhythmia and electrophysiology, Volume 18, Issue 3, 20 3 2025, Pages e013099 Characteristics of Patients With the Arrhythmogenic Mitral Valve Prolapse Syndrome and Sudden Cardiac Arrest and Sustained Ventricular Arrhythmias. Chakrabarti A, Giudicessi JR, Ezzeddine FM, Delling FN, Dixit S, Lee YJ, Muser D, Magnani S, Van Wijngaarden A, Ajmone Marsan N, Miller MA, Gandhi J, Trivieri MG, Font J, Martins R, McCaffrey JA, Santangeli P, Marchlinski FE, Chapagain H, Mathew D, Kancharla K, Syed FF, Abid A, Cerbin L, Tzou WS, Garg L, Della Rocca DG, Natale A, Mohanty S, Sheldon SH, Kuo L, Haugaa KH, Aabel EW, Enriquez A, Maeda S, Deshmukh A, Ghannam M, Bogun F, Ackerman MJ, Liang JJ

Background: Patients with arrhythmogenic mitral valve prolapse syndrome are at increased risk for life-threatening ventricular arrhythmias, but studies have been limited by small sample sizes. We sought to assemble an international arrhythmogenic mitral valve prolapse syndrome registry to delineate the clinical, imaging, and treatment characteristics of patients with arrhythmogenic mitral valve prolapse syndrome who survived sudden cardiac arrest (SCA) or had sustained ventricular tachycardia (V... Abstract

Journal of cardiovascular development and disease, Volume 12, Issue 2, 18 3 2025, Pages 78 Beyond Survival: Assessing Quality of Life, Activity Level, and Ethnic Diversity in Aortic Dissection Survivors. Bacour N, van Erp O, Grewal S, Tirpan AU, Eberl S, Yeung KK, Balm R, Verwoert GC, Driessen AHG, Klautz RJM, Grewal N

Background: An acute aortic dissection (AAD) is a highly lethal condition that demands immediate medical intervention. Survivors often face significant long-term challenges. While immediate survival remains a critical focus in acute care settings, little is known about long-term results, especially with regard to activity levels, post-operative quality of life, and the impact of cultural and ethnic characteristics on recovery. Using data from the Dutch National Aortic Dissection Survivor's... Abstract

Journal of imaging, Volume 11, Issue 2, 18 3 2025, Pages 65 Impact of Data Capture Methods on 3D Reconstruction with Gaussian Splatting. Rangelov D, Waanders S, Waanders K, Keulen MV, Miltchev R

This study examines how different filming techniques can enhance the quality of 3D reconstructions with a particular focus on their use in indoor crime scene investigations. Using Neural Radiance Fields (NeRF) and Gaussian Splatting, we explored how factors like camera orientation, filming speed, data layering, and scanning path affect the detail and clarity of 3D reconstructions. Through experiments in a mock crime scene apartment, we identified optimal filming methods that reduce noise and art... Abstract

International archives of allergy and immunology, 18 3 2025, Pages 1-9 A Growing Cause of Food Allergies in Children: Sesame. Aytekin Güvenir F, Yörüsün G, Geniş C, Yılmaz D, Selmanoğlu A, Şengül Emeksiz Z, Dibek Mısırlıoğlu E

Introduction: Sesame allergy has been seen with increasing frequency in recent years and is one of the important causes of food anaphylaxis. The aim of our study was to examine the clinical and laboratory features of patients with sesame allergy and to evaluate the characteristics of sesame-related anaphylaxis. Methods: Patients diagnosed with sesame allergy at Ankara Bilkent City Hospital between January 2017 and June 2024 were included in the study. Demographic, clinical, and laboratory data o... Abstract

Cited 1 times since 2025 (2 per year) source: EuropePMC

The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland, Volume 23, Issue 2, 18 3 2025, Pages 78-86 Surgeon personality diversity across generations and subspecialties. Sier VQ, Schmitz RF, Wertenbroek RWAM, Schepers A, van der Vorst JR, SUPER Collaborators

Background: Traditional exploration of surgical professionals' personality traits focuses on general characteristics at the domain-level of the five-factor model. Personality has been related to clinically-relevant areas such as clinical decision-making and team effectiveness, yet there is limited insight in the personality of surgeons at the facet-level of the Big Five. Here, we performed a large-scale study examining domain- and facet-variations of personality in four surgical generations... Abstract

Structural heart : the journal of the Heart Team, Volume 9, Issue 5, 17 3 2025, Pages 100428 Conduction Disorders After Transcatheter Aortic Valve Implantation: Evolution Over Time and Association With Long-Term Outcomes. Chua AP, Myagmardorj R, Nabeta T, Kuneman JH, van der Kley F, Bax JJ, Ajmone Marsan N

Background: Expanding indications for transcatheter aortic valve implantation (TAVI) highlighted the importance of complications such as new left bundle branch block (LBBB) or permanent pacemaker (PPM) implantation. However, studies on the long-term outcomes of these conduction abnormalities (CA) are limited. This study aims to examine the progression of CA within the first year after TAVI and their long-term prognostic value. Methods: TAVI patients were divided into 1) PPM implantation within t... Abstract

The Journal of thoracic and cardiovascular surgery, 17 3 2025, Pages S0022-5223(25)00120-5 Valve-sparing aortic root replacement in bicuspid aortic valves-the reimplantation technique: A multicenter study. Arabkhani B, Boodhwani M, De Paulis R, Chen EP, Koolbergen D, Mastrobuoni S, Aphram G, Salica A, Jahanyar J, El Khoury G, de Kerchove L

Objective: Reported outcomes in patients with bicuspid aortic valves (BAVs) undergoing valve-sparing aortic root replacement (VSRR) are scarce. This study aims to evaluate outcomes in patients with BAV using the reimplantation (David) technique. Methods: Consecutive adult patients with BAV, aortic root aneurysm, and/or aortic valve insufficiency (AI) undergoing VSRR (reimplantation) were included from 5 centers experienced in reimplantation procedures. Patients were subcategorized into 2 groups... Abstract

Open heart, Volume 12, Issue 1, 17 3 2025, Pages e002846 Clinical use and impact of mechanical circulatory support for myocardial infarction-related cardiogenic shock in the Netherlands: a registry-based propensity-matched analysis. Bogerd M, Griffioen AM, Bunge JJH, Peters EJ, Ten Berg S, Timmermans MJC, Kraaijeveld AO, Lipsic E, Otterspoor LC, Bleeker G, Montero-Cabezas JM, Sjauw KD, Meuwissen M, Dubois EA, van Geuns RM, Henriques JPS, PCI Registration Committee of the Netherlands Heart Registration

Background: Despite limited beneficial evidence, mechanical circulatory support (MCS) is commonly used in patients with acute myocardial infarction-related cardiogenic shock (AMI-CS). In this Dutch registry, we investigated MCS usage, associated patient characteristics and clinical outcomes. Methods: This real-world, multicentre registry included CS patients undergoing percutaneous coronary intervention between 2017 and 2021 in 14 Dutch hospitals. The impact on clinical outcomes was analysed aft... Abstract

Cited 1 times since 2025 (2 per year) source: EuropePMC

Neural networks : the official journal of the International Neural Network Society, Volume 186, 14 2 2025, Pages 107256 Spiking neural networks on FPGA: A survey of methodologies and recent advancements. Karamimanesh M, Abiri E, Shahsavari M, Hassanli K, van Schaik A, Eshraghian J

The mimicry of the biological brain's structure in information processing enables spiking neural networks (SNNs) to exhibit significantly reduced power consumption compared to conventional systems. Consequently, these networks have garnered heightened attention and spurred extensive research endeavors in recent years, proposing various structures to achieve low power consumption, high speed, and improved recognition ability. However, researchers are still in the early stages of developing m... Abstract

Cell biochemistry and biophysics, 14 2 2025 Juglone Encapsulation in PLGA Nanoparticles Improves Solubility and Enhances Apoptosis in HeLa Cells. Yilmaz DE, Gumus B, Demirci H

The anticancer potential of juglone, a naphthoquinone derived from walnut trees, has been extensively studied; however, its hydrophobicity and toxicity obstruct its therapeutic applications. This study aimed to overcome these challenges by encapsulating juglone into poly (lactic-co-glycolic acid) (PLGA) nanoparticles and evaluating their antiproliferative and apoptotic effects on HeLa cells. Juglone nanoparticles (JNP) were obtained by single emulsion solvent evaporation method. Its key physicoc... Abstract

Journal of comparative psychology (Washington, D.C. : 1983), Volume 139, Issue 3, 13 2 2025, Pages 178-191 Sensitivity to immature skill deficits. Food sharing experiments in squirrel monkeys (Saimiri boliviensis) and common marmosets (Callithrix jacchus). Sehner S, Willems EP, Baumeyer A, Davis L, van Schaik CP, Burkart JM

Sharing food with immature individuals is costly and should therefore only occur when the benefits outweigh the costs. Accordingly, sharing typically decreases when immature individuals get older and become more proficient independent foragers. Providers would gain more if they could adjust food sharing not only to immature age but also to their skill level. Such sensitivity to others' skill deficits is expected to be rare, but may be found in species with high prosociality and other-regard... Abstract

The American journal of cardiology, Volume 243, 13 2 2025, Pages 45-49 Survival After Endocarditis Surgery Needing Venoarterial Extracorporeal Membrane Oxygenation Support: Results from the Netherlands Heart Registration. Heinen FJ, Akin S, van den Brink FS, Ayan K, Hermanns H, van der Stoel MD, Post MC, Klautz RJM, Tanis W, Cardiothoracic Surgery Registration Committee of the Netherlands Heart Registration

The incidence of venoarterial extracorporeal membrane oxygenation (VA-ECMO) support after cardiac surgery ranges from 0.4% to 3.7%, with in-hospital mortality rates reported at 60%. While the incidence of VA-ECMO after endocarditis (IE) surgery is unknown, these patients may face an even greater mortality risk due to additional IE-related complications. The primary objective of this study is to investigate the incidence and mortality rates of postoperative VA-ECMO following endocarditis surgery.... Abstract

Applied and environmental microbiology, Volume 91, Issue 3, 12 2 2025, Pages e0179424 Microfluidic droplets with amended culture media cultivate a greater diversity of soil microorganisms. Dai J, Ouyang Y, Gupte R, Liu XJA, Li Y, Yang F, Chen S, Provin T, Van Schaik E, Samuel JE, Jayaraman A, Zhou A, de Figueiredo P, Zhou J, Han A

Uncultivated but abundant soil microorganisms have untapped potential for producing broad ranges of natural products, as well as for bioremediation. However, cultivating soil microorganisms while maintaining a broad microorganism diversity to enable phenotyping and functional analysis of as diverse individual isolates as possible remains challenging. In this study, we developed and tested the ability of several culture media formulations that contain defined soil metabolites or soil extracts to... Abstract

Cited 2 times since 2025 (3.9 per year) source: EuropePMC

Lupus science & medicine, Volume 12, Issue 1, 12 2 2025, Pages e001424 Long-term safety and efficacy of the combination of belimumab and rituximab in the treatment of severe and refractory SLE: a preliminary report. van Schaik M, Arends EJ, Wetzels MJAL, Kraaij T, Verbruggen SH, van der Kooij SW, Kamerling SWA, Huizinga T, Goekoop RJ, van Kooten C, Rabelink T, Teng YKO

Objective: Combination therapy with rituximab and belimumab is a novel treatment strategy for severe SLE and lupus nephritis. Phase II studies have shown promising results, although long-term data are currently lacking. To address this, we analysed outcomes of patients with severe treatment-refractory SLE who previously participated in the phase II Synbiose Study, with a particular focus on immunological parameters. Methods: Eight patients continued belimumab treatment beyond the 2-year duration... Abstract

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, Volume 46, Issue 6, 12 2 2025, Pages 2819-2828 Phenotypic diversity in NAXE mutations. Solmaz I, Yalnızoğlu D, Dursun A, Çıkı K, Akar HT, Özgül RK, Koşukçu C, Sezer A, Çağdaş D, Esenboğa S, Özbek B, Aygün D, Yılmaz DY, Parlak Ş, Göçmen R, Oğuz KK, Anlar B

Background/aim: NAD(P)HX epimerase (NAXE) gene mutations have been associated with early onset progressive encephalopathy. We present three patients with NAXE gene mutations and different initial manifestations. Cases: Patient(P)1 was a 30 month-old boy whose neurological regression started after an infection and progressed, ultimately leading to death one year later. His brain magnetic resonance imaging (MRI) findings were suggesting metabolic stroke. P2, nine year-old sister of P1, had mild de... Abstract

Cited 4 times since 2025 (7.7 per year) source: EuropePMC

Nature communications, Volume 16, Issue 1, 11 2 2025, Pages 1545 The neurobench framework for benchmarking neuromorphic computing algorithms and systems. Yik J, Van den Berghe K, den Blanken D, Bouhadjar Y, Fabre M, Hueber P, Ke W, Khoei MA, Kleyko D, Pacik-Nelson N, Pierro A, Stratmann P, Sun PV, Tang G, Wang S, Zhou B, Ahmed SH, Vathakkattil Joseph G, Leto B, Micheli A, Mishra AK, Lenz G, Sun T, Ahmed Z, Akl M, Anderson B, Andreou AG, Bartolozzi C, Basu A, Bogdan P, Bohte S, Buckley S, Cauwenberghs G, Chicca E, Corradi F, de Croon G, Danielescu A, Daram A, Davies M, Demirag Y, Eshraghian J, Fischer T, Forest J, Fra V, Furber S, Furlong PM, Gilpin W, Gilra A, Gonzalez HA, Indiveri G, Joshi S, Karia V, Khacef L, Knight JC, Kriener L, Kubendran R, Kudithipudi D, Liu SC, Liu YH, Ma H, Manohar R, Margarit-Taulé JM, Mayr C, Michmizos K, Muir DR, Neftci E, Nowotny T, Ottati F, Ozcelikkale A, Panda P, Park J, Payvand M, Pehle C, Petrovici MA, Posch C, Renner A, Sandamirskaya Y, Schaefer CJS, van Schaik A, Schemmel J, Schmidgall S, Schuman C, Seo JS, Sheik S, Shrestha SB, Sifalakis M, Sironi A, Stewart K, Stewart M, Stewart TC, Timcheck J, Tömen N, Urgese G, Verhelst

Neuromorphic computing shows promise for advancing computing efficiency and capabilities of AI applications using brain-inspired principles. However, the neuromorphic research field currently lacks standardized benchmarks, making it difficult to accurately measure technological advancements, compare performance with conventional methods, and identify promising future research directions. This article presents NeuroBench, a benchmark framework for neuromorphic algorithms and systems, which is col... Abstract

BMC public health, Volume 25, Issue 1, 10 2 2025, Pages 551 The relationship between environmental literacy, ecological footprint awareness, and environmental behavior in adults. Yildirim MS, Elkoca A, Gökçay G, Yilmaz DA, Yıldız M

Background: Environmental literacy and ecological footprint awareness encouraging them to consume less energy, reduce waste and use natural resources more sustainably. Aim: In this study, the aim was to determine and compare the relationship between environmental literacy, ecological footprint awareness, and environmental behaviors of adults. Methods: The research was conducted in a descriptive and cross-sectional type. The universe of the research was individuals aged 18 and over in a province... Abstract