6263 results
Cited 45 times since 2014 (4 per year)
source: EuropePMC
Future virology,
Volume 9, Issue 5, 1 1 2014, Pages 513-524
Avian influenza A viruses: from zoonosis to pandemic.
Richard M, de Graaf M, Herfst S
Zoonotic influenza A viruses originating from the animal reservoir pose a threat for humans, as they have the ability to trigger pandemics upon adaptation to and invasion of an immunologically naive population. Of particular concern are the H5N1 viruses that continue to circulate in poultry in numerous countries in Europe, Asia and Africa, and the recently emerged H7N9 viruses in China, due to their relatively high number of human fatalities and pandemic potential. To start a pandemic, zoonotic...
Abstract
Cited 7 times since 2014 (0.6 per year)
source: EuropePMC
Atherosclerosis,
Volume 235, Issue 1, 26 4 2014, Pages 58-64
In search for genetic determinants of clinically meaningful differential cardiovascular event reduction by pravastatin in the PHArmacogenetic study of Statins in the Elderly at risk (PHASE)/PROSPER study.
Postmus I, Johnson PC, Trompet S, de Craen AJ, Slagboom PE, Devlin JJ, Shiffman D, Sacks FM, Kearney PM, Stott DJ, Buckley BM, Sattar N, Ford I, Westendorp RG, Jukema JW
Background: Statin therapy is widely used in the prevention and treatment of cardiovascular events and is associated with significant risk reductions. However, there is considerable variation in response to statin therapy both in terms of LDL cholesterol reduction and clinical outcomes. It has been hypothesized that genetic variation contributes importantly to this individual drug response. Methods and results: We investigated the interaction between genetic variants and pravastatin or placebo t...
Abstract
Cited 4 times since 2014 (0.4 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 101, Issue 1, 23 4 2014, Pages 72-81
Advanced techniques in dobutamine stress echocardiography: focus on myocardial deformation analysis.
Joyce E, Delgado V, Bax JJ, Marsan NA
Abstract
Cited 98 times since 2014 (8.7 per year)
source: EuropePMC
BioMed research international,
Volume 2014, 23 4 2014, Pages 893106
The multifaceted functions of CXCL10 in cardiovascular disease.
van den Borne P, Quax PH, Hoefer IE, Pasterkamp G
C-X-C motif ligand 10 (CXCL10), or interferon-inducible protein-10, is a small chemokine belonging to the CXC chemokine family. Its members are responsible for leukocyte trafficking and act on tissue cells, like endothelial and vascular smooth muscle cells. CXCL10 is secreted by leukocytes and tissue cells and functions as a chemoattractant, mainly for lymphocytes. After binding to its receptor CXCR3, CXCL10 evokes a range of inflammatory responses: key features in cardiovascular disease (CVD)....
Abstract
Cited 12 times since 2014 (1.1 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 47, Issue 2, 17 3 2014, Pages 348-54; discussion 354
Valve-sparing aortic root replacement†.
Koolbergen DR, Manshanden JS, Bouma BJ, Blom NA, Mulder BJ, de Mol BA, Hazekamp MG
Objectives: To evaluate our results of valve-sparing aortic root replacement and associated (multiple) valve repair. Methods: From September 2003 to September 2013, 97 patients had valve-sparing aortic root replacement procedures. Patient records and preoperative, postoperative and recent echocardiograms were reviewed. Median age was 40.3 (range: 13.4-68.6) years and 67 (69.1%) were male. Seven (7.2%) patients were younger than 18 years, the youngest being 13.4 years. Fifty-four (55.7%) had Marf...
Abstract
Expert review of cardiovascular therapy,
Volume 12, Issue 7, 16 3 2014, Pages 787-789
Primary prevention implantable cardioverter-defibrillator implantation in elderly patients: is it justified to withhold treatment?
van der Heijden AC, van Erven L, Schalij MJ, Borleffs CJ
Implementation of primary prevention implantable cardioverter-defibrillator (ICD) treatment in the current clinical guidelines led to a significant increase in patients that may benefit from implantation of an ICD. Currently non-guideline-guided patient selection takes place by physicians whereby patients at higher age are more frequently excluded for ICD implantation. This editorial focuses on ICD treatment in the elderly and aims to clarify whether it is justified to withhold ICD treatment in...
Abstract
Cited 19 times since 2014 (1.7 per year)
source: EuropePMC
European journal of trauma and emergency surgery : official publication of the European Trauma Society,
Volume 40, Issue 4, 15 3 2014, Pages 421-428
Challenges in the training of military surgeons: experiences from Dutch combat operations in southern Afghanistan.
Hoencamp R, Tan EC, Idenburg F, Ramasamy A, van Egmond T, Leenen LP, Hamming JF
Background: To improve care for battle casualties, we analyzed the surgical workload during the Dutch deployment to Uruzgan, Afghanistan. This surgical workload was compared with the resident surgical training and the pre-deployment medical specialist program. Methods: Patient data from the trauma registry (2006-2010) at the Dutch Role 2 Medical Treatment Facility (MTF) were analyzed. The case logs of chief residents (n = 15) from the general surgery training program in the Netherlands were used...
Abstract
Cited 4 times since 2014 (0.4 per year)
source: EuropePMC
Mediators of inflammation,
Volume 2014, 6 1 2014, Pages 395278
Danger signals in cardiovascular disease.
Frantz S, Monaco C, Arslan F
Abstract
Cited 55 times since 2014 (4.9 per year)
source: EuropePMC
American heart journal,
Volume 168, Issue 1, 4 1 2014, Pages 45-52.e7
A metabolomic profile is associated with the risk of incident coronary heart disease.
Vaarhorst AA, Verhoeven A, Weller CM, Böhringer S, Göraler S, Meissner A, Deelder AM, Henneman P, Gorgels AP, van den Brandt PA, Schouten LJ, van Greevenbroek MM, Merry AH, Verschuren WM, van den Maagdenberg AM, van Dijk KW, Isaacs A, Boomsma D, Oostra BA, van Duijn CM, Jukema JW, Boer JM, Feskens E, Heijmans BT, Slagboom PE
Background: Metabolomics, defined as the comprehensive identification and quantification of low-molecular-weight metabolites to be found in a biological sample, has been put forward as a potential tool for classifying individuals according to their risk of coronary heart disease (CHD). Here, we investigated whether a single-point blood measurement of the metabolome is associated with and predictive for the risk of CHD. Methods and results: We obtained proton nuclear magnetic resonance spectra in...
Abstract
Cited 3 times since 2014 (0.3 per year)
source: EuropePMC
Heart, lung & circulation,
Volume 23, Issue 8, 2 1 2014, Pages e169-71
Transcatheter mitral valve repair in osteogenesis imperfecta associated mitral valve regurgitation.
van der Kley F, Delgado V, Ajmone Marsan N, Schalij MJ
Objectives: Osteogenesis imperfecta is associated with increased prevalence of significant mitral valve regurgitation. Surgical mitral valve repair and replacement are feasible but are associated with increased risk of bleeding and dehiscence of implanted valves may occur more frequently. The present case report describes the outcomes of transcatheter mitral valve repair in a patient with osteogenesis imperfecta. Patients/methods: A 60 year-old patient with osteogenesis imperfecta and associated...
Abstract
Cited 2 times since 2014 (0.2 per year)
source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 21, Issue 2, 1 1 2014, Pages 245-247
The importance of heart rate response during myocardial perfusion imaging.
Bax JJ, Delgado V
Abstract
Cited 30 times since 2014 (2.6 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 16 Suppl 1, 1 1 2014, Pages i1-78
Statistics on the use of cardiac electronic devices and electrophysiological procedures in 55 ESC countries: 2013 report from the European Heart Rhythm Association (EHRA).
Arribas F, Auricchio A, Boriani G, Brugada J, Deharo JC, Hindriks G, Kuck KH, Merino JL, Vardas P, Wolpert C, Zeppenfeld K
Abstract
Cited 21 times since 2014 (1.9 per year)
source: EuropePMC
The American journal of cardiology,
Volume 113, Issue 12, 1 1 2014, Pages 1947-1955
Feasibility of an automated quantitative computed tomography angiography-derived risk score for risk stratification of patients with suspected coronary artery disease.
de Graaf MA, Broersen A, Ahmed W, Kitslaar PH, Dijkstra J, Kroft LJ, Delgado V, Bax JJ, Reiber JH, Scholte AJ
Coronary computed tomography angiography (CTA) has important prognostic value. Additionally, quantitative CTA (QCT) provides a more detailed accurate assessment of coronary artery disease (CAD) on CTA. Potentially, a risk score incorporating all quantitative stenosis parameters allows accurate risk stratification. Therefore, the purpose of this study was to determine if an automatic quantitative assessment of CAD using QCT combined into a CTA risk score allows risk stratification of patients. In...
Abstract
Cited 95 times since 2014 (8.4 per year)
source: EuropePMC
Surgical endoscopy,
Volume 28, Issue 4, 1 1 2014, Pages 1076-1082
Optimization of near-infrared fluorescence cholangiography for open and laparoscopic surgery.
Verbeek FP, Schaafsma BE, Tummers QR, van der Vorst JR, van der Made WJ, Baeten CI, Bonsing BA, Frangioni JV, van de Velde CJ, Vahrmeijer AL, Swijnenburg RJ
Background: During laparoscopic cholecystectomy, common bile duct (CBD) injury is a rare but severe complication. To reduce the risk of injury, near-infrared (NIR) fluorescent cholangiography using indocyanine green (ICG) has recently been introduced as a novel method of visualizing the biliary system during surgery. To date, several studies have shown feasibility of this technique; however, liver background fluorescence remains a major problem during fluorescent cholangiography. The aim of the...
Abstract
Cited 13 times since 2014 (1.1 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 22, Issue 4, 1 1 2014, Pages 186-189
Using genetic variation for establishing causality of cardiovascular risk factors: overcoming confounding and reverse causality.
Smit RA, Trompet S, de Craen AJ, Jukema JW
Cardiovascular disease (CVD) remains the leading cause of death in developed countries, despite the decline of CVD mortality over the last two decades. From observational, predictive research, efforts have been made to find causal risk factors for CVD. However, in recent years, some of these findings have been shown to be mistaken. Possible explanations for the discrepant findings are confounding and reverse causation. Genetic epidemiology has tried to address these problems through the use of M...
Abstract
Cited 221 times since 2014 (19.5 per year)
source: EuropePMC
Cell,
Volume 157, Issue 2, 1 1 2014, Pages 329-339
Identification, characterization, and natural selection of mutations driving airborne transmission of A/H5N1 virus.
Linster M, van Boheemen S, de Graaf M, Schrauwen EJA, Lexmond P, Mänz B, Bestebroer TM, Baumann J, van Riel D, Rimmelzwaan GF, Osterhaus ADME, Matrosovich M, Fouchier RAM, Herfst S
Recently, A/H5N1 influenza viruses were shown to acquire airborne transmissibility between ferrets upon targeted mutagenesis and virus passage. The critical genetic changes in airborne A/Indonesia/5/05 were not yet identified. Here, five substitutions proved to be sufficient to determine this airborne transmission phenotype. Substitutions in PB1 and PB2 collectively caused enhanced transcription and virus replication. One substitution increased HA thermostability and lowered the pH of membrane f...
Abstract
Cited 36 times since 2014 (3.2 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 22, Issue 4, 1 1 2014, Pages 160-166
Left cardiac sympathetic denervation in the Netherlands for the treatment of inherited arrhythmia syndromes.
Olde Nordkamp LR, Driessen AH, Odero A, Blom NA, Koolbergen DR, Schwartz PJ, Wilde AA
Introduction: Treating therapy-resistant patients with inherited arrhythmia syndromes can be difficult and left cardiac sympathetic denervation (LCSD) might be a viable alternative treatment option. We provide an overview of the indications and outcomes of LCSD in patients with inherited arrhythmia syndromes in the only tertiary referral centre in the Netherlands where LCSD is conducted in these patients. Methods: This was a retrospective study, including all patients with inherited arrhythmia s...
Abstract
Cited 27 times since 2014 (2.4 per year)
source: EuropePMC
Annals of oncology : official journal of the European Society for Medical Oncology,
Volume 25, Issue 6, 31 5 2014, Pages 1198-1203
Screening for coronary artery disease after mediastinal irradiation in Hodgkin lymphoma survivors: phase II study of indication and acceptance†.
Daniëls LA, Krol AD, de Graaf MA, Scholte AJ, Van't Veer MB, Putter H, de Roos A, Schalij MJ, Creutzberg CL
Background: Cardiovascular diseases are the most common nonmalignant cause of death in Hodgkin lymphoma (HL) survivors, especially after mediastinal irradiation. We investigated the role of computed tomographic coronary angiography (CTA) as a screening tool for coronary artery disease (CAD) in asymptomatic HL survivors, and related CTA findings to exercise testing and subsequent interventions. Patients and methods: Patients were eligible for this phase II study if at least 10 years disease-free...
Abstract
Cited 180 times since 2014 (15.9 per year)
source: EuropePMC
Human molecular genetics,
Volume 23, Issue 16, 31 5 2014, Pages 4420-4432
Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.
Deelen J, Beekman M, Uh HW, Broer L, Ayers KL, Tan Q, Kamatani Y, Bennet AM, Tamm R, Trompet S, Guðbjartsson DF, Flachsbart F, Rose G, Viktorin A, Fischer K, Nygaard M, Cordell HJ, Crocco P, van den Akker EB, Böhringer S, Helmer Q, Nelson CP, Saunders GI, Alver M, Andersen-Ranberg K, Breen ME, van der Breggen R, Caliebe A, Capri M, Cevenini E, Collerton JC, Dato S, Davies K, Ford I, Gampe J, Garagnani P, de Geus EJ, Harrow J, van Heemst D, Heijmans BT, Heinsen FA, Hottenga JJ, Hofman A, Jeune B, Jonsson PV, Lathrop M, Lechner D, Martin-Ruiz C, Mcnerlan SE, Mihailov E, Montesanto A, Mooijaart SP, Murphy A, Nohr EA, Paternoster L, Postmus I, Rivadeneira F, Ross OA, Salvioli S, Sattar N, Schreiber S, Stefánsson H, Stott DJ, Tiemeier H, Uitterlinden AG, Westendorp RG, Willemsen G, Samani NJ, Galan P, Sørensen TI, Boomsma DI, Jukema JW, Rea IM, Passarino G, de Craen AJ, Christensen K, Nebel A, Stefánsson K, Metspalu A, Magnusson P, Blanché H, Christiansen L, Kirkwood TB, van Duijn CM, Franceschi C, Houwing-Duister
The genetic contribution to the variation in human lifespan is ∼ 25%. Despite the large number of identified disease-susceptibility loci, it is not known which loci influence population mortality. We performed a genome-wide association meta-analysis of 7729 long-lived individuals of European descent (≥ 85 years) and 16 121 younger controls (
Abstract
Cited 6 times since 2014 (0.5 per year)
source: EuropePMC
Journal of electrocardiology,
Volume 47, Issue 4, 30 5 2014, Pages 500-504
Directionality and proportionality of the ST and ventricular gradient difference vectors during acute ischemia.
ter Haar CC, Maan AC, Schalij MJ, Swenne CA
Background: The ECG is important in diagnosis and triage in the initial phase of the acute coronary syndrome (ACS). The primary goal of making an ECG at first medical contact should be the reliable detection of cardiac ischemia, thus facilitating a correct triage by corroborating the diagnosis of ACS. Ischemia detection by ST amplitude analysis is limited to situations in which there is an identifiable J point. The ventricular gradient (VG) is independent of conduction and might be an alternativ...
Abstract
