Research

Publications

Below you can find a list of our published research.

6128 results

Nederlands tijdschrift voor geneeskunde, Volume 150, Issue 27, 1 1 2006, Pages 1523-1527 [Intramyocardial injection of autologous bone-marrow stem cells in a 74-year-old man with untreatable angina pectoris and demonstrated myocardial ischaemia]. Beeres SL, Bax JJ, Stokkel MP, Fibbe WE, van der Wall EE, Schalij MJ, Atsma DE

For a 74-year-old man with angina pectoris and demonstrated myocardial ischaemia, optimal medical treatment was insufficient. He was ineligible for coronary revascularization. To improve myocardial perfusion, autologous bone-marrow stem cells were injected into the ischaemic myocardium. During the months following the injection, the frequency of angina attacks decreased and myocardial perfusion and cardiac function improved. Abstract

Cited 1 times since 2006 (0.1 per year) source: EuropePMC

Clinical physiology and functional imaging, Volume 26, Issue 4, 1 1 2006, Pages 220-223 The effect of lung inflation on absolute ventricular volume measurement by conductance. Haney MF, Steendijk P, Johansson G, Biber B

Background: Conductance catheter in vivo ventricular volume measurements during lung ventilation may provide important information on left ventricular (LV) function. Breathing potentially may alter parallel conductance (V(c)), complicating interpretation of the conductance-derived volume signals. The effects of controlled positive pressure lung inflation (PPLI) on measured parallel conductance with dual-field conductance volumetry were investigated. Methods: Eight anaesthetized pigs were instrum... Abstract

Cited 17 times since 2006 (0.9 per year) source: EuropePMC

Circulation, Volume 114, Issue 3, 1 1 2006, Pages e51-2 Images in cardiovascular medicine. Epicardial radiofrequency catheter ablation of ventricular tachycardia in the vicinity of coronary arteries is facilitated by fusion of 3-dimensional electroanatomical mapping with multislice computed tomography. Zeppenfeld K, Tops LF, Bax JJ, Schalij MJ

Abstract

Cited 1 times since 2006 (0.1 per year) source: EuropePMC

Expert review of medical devices, Volume 3, Issue 4, 1 1 2006, Pages 441-451 Advances in the noninvasive evaluation of coronary artery disease with multislice computed tomography. Pundziute G, Schuijf JD, Jukema JW, de Roos A, van der Wall EE, Bax JJ

Current noninvasive detection of coronary artery disease (CAD) is based on the demonstration of ischemia using stress-rest imaging, which is an indirect way of identifying CAD by demonstration of the hemodynamic consequences, rather than direct visualization of the obstructive lesions in the coronary arteries. Multislice computed tomography (MSCT) has recently emerged as an extremely rapidly developing noninvasive imaging modality, which allows anatomical imaging of the coronary arteries or noni... Abstract

Cited 17 times since 2006 (0.9 per year) source: EuropePMC

Chest, Volume 130, Issue 1, 1 1 2006, Pages 58-65 Improvement in bronchodilation following deep inspiration after a course of high-dose oral prednisone in asthma. Slats AM, Sont JK, van Klink RH, Bel EH, Sterk PJ

Background: Bronchodilation following deep inspiration is usually impaired in patients with asthma. This might be due to changes in airway mechanics in the presence of inflammation or structural changes within the airways. Although inhaled corticosteroid treatment has been shown to improve airway responses to deep inspiration in patients with asthma, airway inflammation can persist despite inhaled corticosteroid treatment, and thus could still influence the airway mechanics during deep breaths.... Abstract

Cited 30 times since 2006 (1.6 per year) source: EuropePMC

Molecular and cellular biology, Volume 26, Issue 14, 1 1 2006, Pages 5270-5283 Differential binding of replication proteins across the human c-myc replicator. Ghosh M, Kemp M, Liu G, Ritzi M, Schepers A, Leffak M

The binding of the prereplication complex proteins Orc1, Orc2, Mcm3, Mcm7, and Cdc6 and the novel DNA unwinding element (DUE) binding protein DUE-B to the endogenous human c-myc replicator was studied by chromatin immunoprecipitation. In G(1)-arrested HeLa cells, Mcm3, Mcm7, and DUE-B were prominent near the DUE, while Orc1 and Orc2 were least abundant near the DUE and more abundant at flanking sites. Cdc6 binding mirrored that of Orc2 in G(1)-arrested cells but decreased in asynchronous or M-ph... Abstract

Cited 73 times since 2006 (3.9 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 13, Issue 4, 1 1 2006, Pages 495-506 Prognostic value of poststress left ventricular volume and ejection fraction by gated myocardial perfusion SPECT in women and men: gender-related differences in normal limits and outcomes. Sharir T, Kang X, Germano G, Bax JJ, Shaw LJ, Gransar H, Cohen I, Hayes SW, Friedman JD, Berman DS

Background: Whether there are gender differences in the prognostic application of gated myocardial perfusion single photon emission computed tomography (SPECT) has not been assessed. Methods and results: Gender-specific normal limits of poststress volume and ejection fraction (EF) were obtained in 597 women and 824 men with a low likelihood of coronary artery disease and normal perfusion and were applied in a prognostic evaluation of 6713 patients (2735 women and 3978 men). Patients underwent re... Abstract

Cited 23 times since 2006 (1.2 per year) source: EuropePMC

European heart journal, Volume 27, Issue 14, 1 1 2006, Pages 1750-1753 The future of cardiovascular imaging and non-invasive diagnosis: a joint statement from the European Association of Echocardiography, the Working Groups on Cardiovascular Magnetic Resonance, Computers in Cardiology, and Nuclear Cardiology, of the European Society of Cardiology, the European Association of Nuclear Medicine, and the Association for European Paediatric Cardiology. Fraser AG, Buser PT, Bax JJ, Dassen WR, Nihoyannopoulos P, Schwitter J, Knuuti JM, Höher M, Bengel F, Szatmári A

Advances in medical imaging now make it possible to investigate any patient with cardiovascular disease using multiple methods which vary widely in their technical requirements, benefits, limitations, and costs. The appropriate use of alternative tests requires their integration into joint clinical diagnostic services where experts in all methods collaborate. This statement summarizes the principles that should guide developments in cardiovascular diagnostic services. Abstract

Cited 70 times since 2006 (3.7 per year) source: EuropePMC

Circulation, Volume 114, Issue 1 Suppl, 1 1 2006, Pages I344-9 High-dose beta-blockers and tight heart rate control reduce myocardial ischemia and troponin T release in vascular surgery patients. Feringa HH, Bax JJ, Boersma E, Kertai MD, Meij SH, Galal W, Schouten O, Thomson IR, Klootwijk P, van Sambeek MR, Klein J, Poldermans D

Background: Adverse perioperative cardiac events occur frequently despite the use of beta (beta)-blockers. We examined whether higher doses of beta-blockers and tight heart rate control were associated with reduced perioperative myocardial ischemia and troponin T release and improved long-term outcome. Methods and results: In an observational cohort study, 272 vascular surgery patients were preoperatively screened for cardiac risk factors and beta-blocker dose. Beta-blocker dose was converted to... Abstract

Cited 48 times since 2006 (2.6 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 13, Issue 4, 1 1 2006, Pages 480-487 Assessment of global and regional left ventricular function and volumes with 64-slice MSCT: a comparison with 2D echocardiography. Henneman MM, Schuijf JD, Jukema JW, Holman ER, Lamb HJ, de Roos A, van der Wall EE, Bax JJ

Background: In patients with coronary artery disease (CAD), LV function and volumes are important parameters for long-term prognosis. Multislice computed tomography (MSCT) allows noninvasive assessment of the coronary arteries, but the accuracy of 64-slice MSCT for the assessment of left ventricular (LV) volumes and function is unknown. Methods and results: A head-to-head comparison between 64-slice MSCT and 2-dimensional (2D) echocardiography was performed in 40 patients with known or suspected... Abstract

Cited 5 times since 2006 (0.3 per year) source: EuropePMC

The American journal of cardiology, Volume 98, Issue 5, 30 5 2006, Pages 585-590 Prognostic value of exercise stress technetium-99m-tetrofosmin myocardial perfusion imaging in patients with normal baseline electrocardiograms. Elhendy A, Schinkel AF, van Domburg RT, Bax JJ, Valkema R, Huurman A, Feringa HH, Poldermans D

Exercise stress electrocardiography is the recommended method for cardiac evaluation of patients with normal electrocardiograms (ECGs). There are no data to indicate an independent value of myocardial perfusion imaging (MPI) in predicting mortality in these patients. This study assessed the value of exercise stress MPI in predicting mortality in patients with normal baseline ECGs. We studied 319 patients (55 +/- 10 years of age; 180 men) with normal ECGs by exercise stress technetium-99m tetrofo... Abstract

Cited 1 times since 2006 (0.1 per year) source: EuropePMC

Medical science monitor : international medical journal of experimental and clinical research, Volume 12, Issue 7, 28 4 2006, Pages CR308-14 Long-term follow-up of mitral valve repair: a single-center experience. Shahin GM, van der Heijden GJ, Kelder JC, Boulaksil M, Knaepen PJ, Six AJ

Background: Our aim was to conduct a long-term follow-up of patients after mitral valve repair for incompetence. We identified determinants for mortality and compared mortality with standardized mortality rates of the Dutch population. Material/methods: We included in this single-center retrospective study 119 patients operated from March 1976 to February 1981. Patients with previous mitral valve surgery, isolated mitral stenosis, and congenital heart disease were excluded. Routine echocardiogra... Abstract

Cited 46 times since 2006 (2.5 per year) source: EuropePMC

Heart rhythm, Volume 3, Issue 9, 15 3 2006, Pages 1092-1099 Elucidation of the spatial ventricular gradient and its link with dispersion of repolarization. Draisma HH, Schalij MJ, van der Wall EE, Swenne CA

The ventricular gradient, a notion conceived by Wilson et al during the 1930s, has contributed considerably to a better understanding of the ECG manifestations of the cardiac repolarization process. The power of the ventricular gradient is its ability to assess the primary factors that contribute to the T wave (i.e., heterogeneity of action potential morphology throughout the ventricles) in the presence of secondary factors contributing to the T wave (i.e., heterogeneity in ventricular depolariz... Abstract

Cited 181 times since 2006 (9.7 per year) source: EuropePMC

Microbes and infection, Volume 8, Issue 8, 13 2 2006, Pages 2052-2060 Human T-cell responses to 25 novel antigens encoded by genes of the dormancy regulon of Mycobacterium tuberculosis. Leyten EM, Lin MY, Franken KL, Friggen AH, Prins C, van Meijgaarden KE, Voskuil MI, Weldingh K, Andersen P, Schoolnik GK, Arend SM, Ottenhoff TH, Klein MR

The dormancy (DosR) regulon of Mycobacterium tuberculosis is expressed in vitro during hypoxia and low-dose nitric oxide stimulation. Tubercle bacilli are thought to encounter these conditions in humans during latent infection. In this study, immune responses were evaluated to 25 most strongly induced DosR-regulon-encoded proteins, referred to as latency antigens. Proliferation assays were performed using M. tuberculosis-specific T-cell lines and peripheral blood mononuclear cells (PBMC) from tu... Abstract

Cited 10 times since 2006 (0.5 per year) source: EuropePMC

European journal of nuclear medicine and molecular imaging, Volume 33, Issue 10, 9 2 2006, Pages 1157-1161 Prognostic value of stress 99mTc-tetrofosmin myocardial perfusion imaging in predicting all-cause mortality: a 6-year follow-up study. Elhendy A, Schinkel AF, van Domburg RT, Bax JJ, Valkema R, Biagini E, Poldermans D

Purpose: The aim of this study was to ascertain whether stress myocardial perfusion imaging can independently predict long-term mortality. Methods: We studied 1,386 patients with known or suspected coronary artery disease by means of stress 99mTc-tetrofosmin myocardial perfusion tomography. The end point during follow-up was death from any cause. Mortality rates were compared with that in a reference population using calculated age- and gender-specific data in the general population. Results: Me... Abstract

Cited 8 times since 2006 (0.4 per year) source: EuropePMC

The American journal of cardiology, Volume 98, Issue 3, 6 1 2006, Pages 309-313 Role of calcified spots detected by intravascular ultrasound in patients with ST-segment elevation acute myocardial infarction. van der Hoeven BL, Liem SS, Oemrawsingh PV, Dijkstra J, Jukema JW, Putter H, Atsma DE, van der Wall EE, Bax JJ, Reiber JC, Schalij MJ

Electron beam computed tomographic studies have demonstrated that the extent of intracoronary calcium is related to risk of coronary events. This study was performed to gain further insight into the distribution of focal calcifications and their relation to the site of plaque rupture within the culprit artery in consecutive patients (n = 60) with acute myocardial infarction (AMI) using intravascular ultrasound imaging. Calcifications in the culprit lesion and adjacent segments were classified an... Abstract

Cited 582 times since 2006 (31 per year) source: EuropePMC

Circulation, Volume 113, Issue 23, 5 1 2006, Pages 2744-2753 Atherosclerotic lesion size and vulnerability are determined by patterns of fluid shear stress. Cheng C, Tempel D, van Haperen R, van der Baan A, Grosveld F, Daemen MJ, Krams R, de Crom R

Background: Atherosclerotic lesions are predominantly observed in curved arteries and near side branches, where low or oscillatory shear stress patterns occur, suggesting a causal connection. However, the effect of shear stress on plaque vulnerability is unknown because the lack of an appropriate in vivo model precludes cause-effect studies. Methods and results: We developed a perivascular shear stress modifier that induces regions of lowered, increased, and lowered/oscillatory (ie, with vortice... Abstract

Cited 10 times since 2006 (0.5 per year) source: EuropePMC

The American journal of cardiology, Volume 98, Issue 2, 5 1 2006, Pages 262-266 Pregnancy after biventricular repair for pulmonary atresia with ventricular septal defect. Drenthen W, Pieper PG, Zoon N, Roos-Hesselink JW, Voors AA, Mulder BJ, van Dijk AP, Sollie KM, Vliegen HW, Ebels T, van Veldhuisen DJ, ZAHARA Investigators

Information on pregnancy and delivery in women with biventricular repair for isolated noncomplex pulmonary atresia with a ventricular septal defect (PAVSD) is limited. Using a nationwide congenital heart disease registry (CONgenital CORvitia [CONCOR]), 9 women with biventricular repair for PAVSD (aged 21 to 38 years) were identified. Ten pregnancies were observed in 5 different women with PAVSD, including 3 spontaneous miscarriages. Clinically significant (non)cardiac complications were document... Abstract

Cited 4 times since 2006 (0.2 per year) source: EuropePMC

The American journal of cardiology, Volume 98, Issue 2, 5 1 2006, Pages 259-261 Fertility, pregnancy, and delivery after biventricular repair for pulmonary atresia with an intact ventricular septum. Drenthen W, Pieper PG, Roos-Hesselink JW, Zoon N, Voors AA, Mulder BJ, van Dijk AP, Vliegen HW, Sollie KM, Ebels T, van Veldhuisen DJ, ZAHARA Investigators

The objective of the present study to investigate fertility, pregnancy, and delivery in women with biventricular repair for pulmonary atresia with an intact ventricular septum (PAIVS). Using a nationwide registry (CONCOR), 37 patients with pulmonary atresia were identified, 6 of whom (aged 21 to 34 years) had biventricular repair for PAIVS. Three PAIVS patients had a total of 5 pregnancies, including 1 abortion and 1 ectopic pregnancy. Besides minor noncardiac complications, the 3 live-birth pre... Abstract

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 14, Issue 6, 1 1 2006, Pages 207-208 Pulmonary arterial hypertension associated with congenital heart disease: the efficacy of drug treatment in symptomatic patients. Henkens IR, Vliegen HW

Abstract