Research

Publications

Below you can find a list of our published research.

7429 results

Cited 52 times since 2011 (3.8 per year) source: EuropePMC

American journal of hypertension, Volume 24, Issue 9, 16 3 2011, Pages 999-1006 SNPs in microRNA binding sites in 3'-UTRs of RAAS genes influence arterial blood pressure and risk of myocardial infarction. Nossent AY, Hansen JL, Doggen C, Quax PH, Sheikh SP, Rosendaal FR

Background: We hypothesized that single nucleotide polymorphisms (SNPs) located in microRNA (miR) binding sites in genes of the renin angiotensin aldosterone system (RAAS) can influence blood pressure and risk of myocardial infarction. Methods: Using online databases dbSNP and TargetScan, we identified 10 SNPs in potential miR binding sites in eight RAAS-related genes, common in Caucasians. We genotyped a large case-control study on myocardial infarctions, the Study of Myocardial Infarctions LEi... Abstract

Cited 83 times since 2011 (6.1 per year) source: EuropePMC

Thrombosis and haemostasis, Volume 106, Issue 1, 14 2 2011, Pages 1-19 Stabilisation of atherosclerotic plaques. Position paper of the European Society of Cardiology (ESC) Working Group on atherosclerosis and vascular biology. Ylä-Herttuala S, Bentzon JF, Daemen M, Falk E, Garcia-Garcia HM, Herrmann J, Hoefer I, Jukema JW, Krams R, Kwak BR, Marx N, Naruszewicz M, Newby A, Pasterkamp G, Serruys PW, Waltenberger J, Weber C, Tokgözoglu L

Plaque rupture and subsequent thrombotic occlusion of the coronary artery account for as many as three quarters of myocardial infarctions. The concept of plaque stabilisation emerged about 20 years ago to explain the discrepancy between the reduction of cardiovascular events in patients receiving lipid lowering therapy and the small decrease seen in angiographic evaluation of atherosclerosis. Since then, the concept of a vulnerable plaque has received a lot of attention in basic and clinical res... Abstract

Cited 14 times since 2011 (1 per year) source: EuropePMC

American journal of medical genetics. Part A, Volume 155A, Issue 7, 10 2 2011, Pages 1661-1667 Adults with congenital heart disease: patients' knowledge and concerns about inheritance. van Engelen K, Baars MJ, van Rongen LT, van der Velde ET, Mulder BJ, Smets EM

With recent advances in medical and surgical management, most patients with congenital heart disease (CHD) survive to reproductive age. Current guidelines recommend counseling about inheritance and transmission of CHD to offspring. We evaluated whether adult CHD patients recalled having received information about the inheritance of their CHD, patients' knowledge about inheritance and their concerns in this regard. A questionnaire was sent to 486 non-syndromic CHD patients aged 20-45 years.... Abstract

Cited 18 times since 2011 (1.3 per year) source: EuropePMC

BMC musculoskeletal disorders, Volume 12, 9 2 2011, Pages 130 A hinged external fixator for complex elbow dislocations: a multicenter prospective cohort study. Schep NW, De Haan J, Iordens GI, Tuinebreijer WE, Bronkhorst MW, De Vries MR, Goslings JC, Ham SJ, Rhemrev S, Roukema GR, Schipper IB, Sintenie JB, Van der Meulen HG, Van Thiel TP, Van Vugt AB, Verleisdonk EJ, Vroemen JP, Wittich P, Patka P, Van Lieshout EM, Den Hartog D

Background: Elbow dislocations can be classified as simple or complex. Simple dislocations are characterized by the absence of fractures, while complex dislocations are associated with fractures of the radial head, olecranon, or coronoid process. The majority of patients with these complex dislocations are treated with open reduction and internal fixation (ORIF), or arthroplasty in case of a non-reconstructable radial head fracture. If the elbow joint remains unstable after fracture fixation, a... Abstract

Cited 48 times since 2011 (3.5 per year) source: EuropePMC

Cell transplantation, Volume 21, Issue 1, 7 1 2011, Pages 153-173 Myogenic properties of human mesenchymal stem cells derived from three different sources. de la Garza-Rodea AS, van der Velde-van Dijke I, Boersma H, Gonçalves MA, van Bekkum DW, de Vries AA, Knaän-Shanzer S

Mesenchymal stem cells (MSCs) of mammals have been isolated from many tissues and are characterized by their aptitude to differentiate into bone, cartilage, and fat. Differentiation into cells of other lineages like skeletal muscle, tendon/ligament, nervous tissue, and epithelium has been attained with MSCs derived from some tissues. Whether such abilities are shared by MSCs of all tissues is unknown. We therefore compared for three human donors the myogenic properties of MSCs from adipose tiss... Abstract

Cited 23 times since 2011 (1.7 per year) source: EuropePMC

European heart journal, Volume 32, Issue 21, 5 1 2011, Pages 2678-2687 Driving restrictions after implantable cardioverter defibrillator implantation: an evidence-based approach. Thijssen J, Borleffs CJ, van Rees JB, de Bie MK, van der Velde ET, van Erven L, Bax JJ, Cannegieter SC, Schalij MJ

Aims: Little evidence is available regarding restrictions from driving following implantable cardioverter defibrillator (ICD) implantation or following first appropriate or inappropriate shock. The purpose of the current analysis was to provide evidence for driving restrictions based on real-world incidences of shocks (appropriate and inappropriate). Methods and results: A total of 2786 primary and secondary prevention ICD patients were included. The occurrence of shocks was noted during a media... Abstract

Cited 27 times since 2011 (2 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 28, Issue 4, 3 1 2011, Pages 755-762 Right ventricular function declines after cardiac surgery in adult patients with congenital heart disease. Schuuring MJ, Bolmers PP, Mulder BJ, de Bruin-Bon RA, Koolbergen DR, Hazekamp MG, Lagrand WK, De Hert SG, de Beaumont EM, Bouma BJ

Right ventricular function (RVF) is often selectively declined after coronary artery bypass graft surgery. In adult patients with congenital heart disease (CHD) the incidence and persistence of declined RVF after cardiac surgery is unknown. The current study aimed to describe RVF after cardiac surgery in these patients. Adult CHD patients operated between January 2008 and December 2009 in the Academic Medical Centre in Amsterdam were studied. Clinical characteristics, laboratory tests, surgical... Abstract

Cited 39 times since 2011 (2.8 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 28, Issue 4, 3 1 2011, Pages 921-933 Automatic centerline extraction of coronary arteries in coronary computed tomographic angiography. Yang G, Kitslaar P, Frenay M, Broersen A, Boogers MJ, Bax JJ, Reiber JH, Dijkstra J

Coronary computed tomographic angiography (CCTA) is a non-invasive imaging modality for the visualization of the heart and coronary arteries. To fully exploit the potential of the CCTA datasets and apply it in clinical practice, an automated coronary artery extraction approach is needed. The purpose of this paper is to present and validate a fully automatic centerline extraction algorithm for coronary arteries in CCTA images. The algorithm is based on an improved version of Frangi's vesseln... Abstract

Cited 8 times since 2011 (0.6 per year) source: EuropePMC

Toxicology and industrial health, Volume 28, Issue 2, 2 1 2011, Pages 114-121 Influence of naringin on cadmium-induced genomic damage in human lymphocytes in vitro. Yilmaz D, Aydemir NC, Vatan O, Tüzün E, Bilaloglu R

Cadmium is an important toxic environmental heavy metal. Generally, occupational and environmental exposures to cadmium result from heavy metal mining, metallurgy and industrial use and the manufacturing of nickel-cadmium batteries, pigments and plastic stabilizers. Cadmium induces oxidative stress and alters the antioxidant system, resulting in oxidative DNA damage and lipid peroxidation. The effect of naringin, a grapefruit flavonone, on cadmium-induced genomic damage was studied by using an i... Abstract

Cited 3 times since 2011 (0.2 per year) source: EuropePMC

Interactive cardiovascular and thoracic surgery, Volume 13, Issue 3, 1 1 2011, Pages 339-340 Neo-coarctation after the arterial switch operation. Lalezari S, Gittenberger-de Groot AC, Blom NA, Hazekamp MG

Neo-coarctation following arterial switch operation (ASO) for transposition of the great arteries (TGA) is a complication that is not regularly described, but may occur. We describe five patients who developed a neo-coarctation after operation. They were diagnosed with TGA, either with or without ventricular septal defect without signs or symptoms of a coarctation. Except for one patient, all patients were reoperated for a neo-coarctation within one year after the ASO. Several explanations are d... Abstract

Cited 2 times since 2011 (0.1 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 19, Issue 6, 1 1 2011, Pages 297-300 Patent ductus arteriosus in adults - indications and possibilities for closure. van de Sandt FM, Boekholdt SM, Bouma BJ, Groenink M, Backx AP, Koolbergen DR, de Winter RJ, Mulder BJ

Patent ductus arteriosus (PDA) is a rare diagnosis in adults, since symptoms and signs usually occur in infancy and most cases are treated shortly after diagnosis. We present two patients who were first diagnosed with PDA during adulthood. The first case represents a more severe form of PDA, where the need for closure of the PDA is obvious. In the second case the sequelae of the PDA are less clear. In both patients, closure of the PDA (surgically in one case, percutaneously in the other) was suc... Abstract

Cited 11 times since 2011 (0.8 per year) source: EuropePMC

Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, Volume 15, Issue 3, 1 1 2011, Pages 256-262 Determinants and outcome of unsuccessful referral after positive screening in a large birth-cohort study of population-based vision screening. Tjiam AM, Groenewoud JH, Passchier J, Loudon SE, De Graaf M, Hoogeveen WC, Lantau VK, Juttmann RE, De Koning HJ, Simonsz HJ

Purpose: The efficacy of population-based vision screening is hampered by unsuccessful referral after a positive screening test. We studied the nature and causes of unsuccessful referral in a 7-year birth cohort study of vision screening in Rotterdam, the Netherlands. Methods: All parents of children who had been unsuccessfully referred were asked whether they recalled the referral. Reasons for noncompliance, if any, were identified using semi-structured interviews. Screening records were checke... Abstract

Cited 24 times since 2011 (1.7 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 19, Issue 6, 1 1 2011, Pages 290-296 Founder mutations in the Netherlands: familial idiopathic ventricular fibrillation and DPP6. Postema PG, Christiaans I, Hofman N, Alders M, Koopmann TT, Bezzina CR, Loh P, Zeppenfeld K, Volders PG, Wilde AA

In this part of a series on founder mutations in the Netherlands, we review familial idiopathic ventricular fibrillation linked to the DPP6 gene. Familial idiopathic ventricular fibrillation determines an intriguing subset of the inheritable arrhythmia syndromes as there is no recognisable phenotype during cardiological investigation other than ventricular arrhythmias highly associated with sudden cardiac death. Until recently, it was impossible to identify presymptomatic family members at risk... Abstract

Cited 31 times since 2011 (2.3 per year) source: EuropePMC

Arthritis care & research, Volume 63, Issue 6, 1 1 2011, Pages 909-917 Randomized comparison of a multidisciplinary team care program with usual care in patients with systemic sclerosis. Schouffoer AA, Ninaber MK, Beaart-van de Voorde LJ, van der Giesen FJ, de Jong Z, Stolk J, Voskuyl AE, Scherptong RW, van Laar JM, Schuerwegh AJ, Huizinga TW, Vlieland TP

Objective: To compare the effectiveness of a multidisciplinary team care program with usual outpatient care in patients with systemic sclerosis (SSc; scleroderma). Methods: We performed a randomized controlled trial comparing a 12-week multidisciplinary team care program (1 day per week; individual treatments, group exercises, and group education) with outpatient clinic care. Outcome measures included the Hand Mobility in Scleroderma (HAMIS) test, grip strength, maximal mouth opening (MMO), 6-mi... Abstract

Cited 3 times since 2011 (0.2 per year) source: EuropePMC

The Journal of arthroplasty, Volume 27, Issue 3, 31 5 2011, Pages 454-460 A prospective randomized clinical trial comparing tibial baseplate fixation with or without screws in total knee arthroplasty: a radiographic evaluation. Schepers A, Cullingworth L, van der Jagt DR

In a randomized prospective study, we compared the use of tibial screws with screwless tibial baseplate fixation in uncemented total knee arthroplasty and report the results of 154 prostheses at a mean follow-up of 5 years. Patients were mobilized within 24 hours and continued with partial weight-bearing for up to 6 weeks postoperatively. There were no significant differences in radiologic results and revision rates. Radiographic outcomes do not seem to be influenced by the use of screws in tibi... Abstract

Cited 19 times since 2011 (1.4 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 28, Issue 4, 26 4 2011, Pages 865-876 Performance and efficacy of 320-row computed tomography coronary angiography in patients presenting with acute chest pain: results from a clinical registry. van Velzen JE, de Graaf FR, Kroft LJ, de Roos A, Reiber JH, Bax JJ, Jukema JW, Schuijf JD, Schalij MJ, van der Wall EE

The purpose of this study was to evaluate the performance of 320-row computed tomography angiography (CTA) in the identification of significant coronary artery disease (CAD) in patients presenting with acute chest pain and to examine the relation to outcome during follow-up. A total of 106 patients with acute chest pain underwent CTA to evaluate presence of CAD. Each CTA was classified as: normal, non-significant CAD ( Abstract

Cited 48 times since 2011 (3.5 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 97, Issue 16, 25 4 2011, Pages 1332-1337 Left atrial strain is related to adverse events in patients after acute myocardial infarction treated with primary percutaneous coronary intervention. Antoni ML, ten Brinke EA, Atary JZ, Marsan NA, Holman ER, Schalij MJ, Bax JJ, Delgado V

Background: Left atrial (LA) maximal volume is of prognostic value in patients after acute myocardial infarction (AMI). Recently, LA mechanical function and LA strain have been introduced as alternative methods to assess LA performance more accurately. Objective: To evaluate the relation between LA volume, mechanical function and strain, and adverse events in patients after AMI. Methods: Patients with AMI underwent two-dimensional echocardiography within 48 h of admission. LA volume and LA perfo... Abstract

Cited 136 times since 2011 (9.9 per year) source: EuropePMC

Circulation, Volume 123, Issue 23, 23 4 2011, Pages 2690-2700 Arrhythmogenic right ventricular dysplasia/cardiomyopathy: pathogenic desmosome mutations in index-patients predict outcome of family screening: Dutch arrhythmogenic right ventricular dysplasia/cardiomyopathy genotype-phenotype follow-up study. Cox MG, van der Zwaag PA, van der Werf C, van der Smagt JJ, Noorman M, Bhuiyan ZA, Wiesfeld AC, Volders PG, van Langen IM, Atsma DE, Dooijes D, van den Wijngaard A, Houweling AC, Jongbloed JD, Jordaens L, Cramer MJ, Doevendans PA, de Bakker JM, Wilde AA, van Tintelen JP, Hauer RN

Background: Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is an autosomal dominant inherited disease with incomplete penetrance and variable expression. Causative mutations in genes encoding 5 desmosomal proteins are found in ≈50% of ARVD/C index patients. Previous genotype-phenotype relation studies involved mainly overt ARVD/C index patients, so follow-up data on relatives are scarce. Methods and results: One hundred forty-nine ARVD/C index patients (111 male patients; age... Abstract

Cited 94 times since 2011 (6.8 per year) source: EuropePMC

Journal of the American Academy of Dermatology, Volume 65, Issue 2, 20 3 2011, Pages 320-327 Adverse effects of propranolol when used in the treatment of hemangiomas: a case series of 28 infants. de Graaf M, Breur JMPJ, Raphaël MF, Vos M, Breugem CC, Pasmans SGMA

Background: Infantile hemangioma (IH) is a frequently encountered tumor with a potentially complicated course. Recently, propranolol was discovered to be an effective treatment option. Objective: To describe the effects and side effects of propranolol treatment in 28 children with (complicated) IH. Methods: A protocol for treatment of IH with propranolol was designed and implemented. Propranolol was administered to 28 children (21 girls and 7 boys, mean age at onset of treatment: 8.8 months). Re... Abstract

Cited 41 times since 2011 (3 per year) source: EuropePMC

Developmental dynamics : an official publication of the American Association of Anatomists, Volume 240, Issue 7, 20 3 2011, Pages 1670-1680 Tgfβ/Alk5 signaling is required for shear stress induced klf2 expression in embryonic endothelial cells. Egorova AD, Van der Heiden K, Van de Pas S, Vennemann P, Poelma C, DeRuiter MC, Goumans MJ, Gittenberger-de Groot AC, ten Dijke P, Poelmann RE, Hierck BP

Endothelial cells (EC) translate biomechanical forces into functional and phenotypic responses that play important roles in cardiac development. Specifically, EC in areas of high shear stress, i.e., in the cardiac outflow tract and atrioventricular canal, are characterized by high expression of Krüppel-like factor 2 (Klf2) and by transforming growth factor-beta (Tgfβ)-driven endothelial-to-mesenchymal transition. Extraembryonic venous obstruction (venous clip model) results in congenital heart m... Abstract