8684 results
The Pediatric infectious disease journal,
Volume 44, Issue 5, 5 1 2025, Pages e189-e190
Is Rhinovirus More Aggressive in Children This Season?
Özdem Alataş Ş, Elvan Tüz A, Kuş S, Aslan Saritaş Ü, Koçar S, Yilmaz D
Abstract
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology,
Volume 55, Issue 3, 4 1 2025, Pages 260-263
Increased Levels of Inflammatory Proteins, Including TARC/CCL17, in Skin of AD Patients During JAK Inhibitor Treatment.
Boesjes CM, van der Gang LF, Bakker DS, den Hartog Jager CF, de Graaf M, de Bruin-Weller MS, van Wijk F, Knol EF
Abstract
Frontiers in neuroscience,
Volume 19, 4 1 2025, Pages 1493623
Low-latency hierarchical routing of reconfigurable neuromorphic systems.
Perera S, Xu Y, van Schaik A, Wang R
A reconfigurable hardware accelerator implementation for spiking neural network (SNN) simulation using field-programmable gate arrays (FPGAs) is promising and attractive research because massive parallelism results in better execution speed. For large-scale SNN simulations, a large number of FPGAs are needed. However, inter-FPGA communication bottlenecks cause congestion, data losses, and latency inefficiencies. In this work, we employed a hierarchical tree-based interconnection architecture for...
Abstract
Journal of lipid research,
Volume 66, Issue 3, 3 1 2025, Pages 100753
Efficacy of a novel PCSK9 inhibitory peptide alone and with evinacumab in a mouse model of atherosclerosis.
Inia JA, van Nieuwkoop-van Straalen A, Jukema JW, Rolin B, Staarup EM, Mogensen CK, Princen HMG, van den Hoek AM
Atherosclerosis is the major cause of cardiovascular disease. This study evaluated the effect of lipid lowering using a novel peptide inhibiting proprotein convertase subtilisin/kexin type 9 (PCSK9) and a monoclonal antibody against angiopoietin-like 3 (evinacumab), either alone or in combination in APOE∗3-Leiden.CETP mice fed a Western diet. Effects on body weight, plasma lipids, atherosclerotic lesion size, severity, composition, and morphology were assessed. Treatment with PCSK9 inhibitory pe...
Abstract
Family practice,
Volume 42, Issue 2, 1 1 2025, Pages cmae045
The effect and implementation of the COVID Box, a remote patient monitoring system for patients with a COVID-19 infection in primary care: a matched cohort study.
van Hattem NE, Mijnsbergen NJ, van Os HJA, Mertens BA, Eekhof JAH, Chavannes NH, Atsma DE, Bonten TN
At the onset of the COVID-19 pandemic, the pressure on hospitals increased tremendously. To alleviate this pressure, a remote patient monitoring system called the COVID Box was developed and implemented in primary care. The aim was to assess whether the COVID Box in primary care could reduce emergency department (ED) referrals due to a COVID-19 infection. A matched cohort study was performed between December 2020 and June 2021. Patients with a COVID-19 infection in need of intensive monitoring b...
Abstract
Cited 1 times since 2025 (2.9 per year)
source: EuropePMC
European journal of endocrinology,
Volume 192, Issue 2, 1 1 2025, Pages S1-S14
The effect of first intervention on cardiac parameters in patients with acromegaly: a systematic review.
Huynh KA, Al-Gully J, Montero-Cabezas JM, Scheffers LE, Verstegen MJT, Biermasz NR, Coopmans EC
Objective: Cardiovascular disease in acromegaly patients remains a major cause of morbidity and all-cause mortality. This systematic review investigates the effect of the first growth hormone-lowering intervention on cardiac parameters. Design: Systematic review. Methods: Studies evaluating cardiac parameters following the first intervention in acromegaly published up to February, 25, 2022 were included in this systematic review. Risk of bias was assessed using a modified Newcastle-Ottawa Scale...
Abstract
Cited 1 times since 2025 (2.9 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 27, Issue 2, 1 1 2025, Pages euaf003
Evoked delayed potential ablation for post-myocardial infarction ventricular tachycardia: results from a large prospective multicentre study.
de Riva M, Evertz R, Lukac P, Dekker LRC, Blaauw Y, Ter Bekke RMA, Kimura Y, Beukema RJ, Ouss A, Mulder BA, Vernooy K, Wijnmaalen AP, Zeppenfeld K
Aims: The optimal substrate ablation approach for post-myocardial infarction (MI) ventricular tachycardia (VT) is unknown. Proposed ablation targets are prone to individual interpretation making the ablation outcome potentially operator dependent. Evoked delayed potentials (EDPs) are a well-defined target. Evoked delayed potential ablation was effective in preventing post-MI VT recurrence in a prior study. The aims of this study were to assess long-term outcomes of EDP ablation in a large multic...
Abstract
Family practice,
Volume 42, Issue 2, 1 1 2025, Pages cmae050
Patient preferences for conservative treatment of shoulder pain: a discrete choice experiment.
Versloot AHC, Veldwijk J, Ottenheijm RPG, de Graaf M, van der Windt DA, Koes BW, Runhaar J, Schiphof D
Background: Shoulder pain is common amongst adults, but little is known about patients' preferences. Objective: The aim of this study was to determine patients' preferences for treatment options offered for shoulder pain in primary care. Methods: A discrete choice experiment was used to investigate these preferences. Adults with shoulder pain were asked to make 12 choices between two treatment options, or to opt-out. The attributes of the 12 treatment options were presented as varying...
Abstract
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology,
Volume 36, Issue 2, 1 1 2025, Pages e70040
Ocular surface disease in pediatric patients with moderate-to-severe atopic dermatitis.
van der Rijst LP, Veldhuis N, van der Kamp S, Achten RE, van Luijk CM, Voskuil-Kerkhof ESM, Haeck IM, de Bruin-Weller MS, de Graaf M
Abstract
Health education research,
Volume 40, Issue 2, 1 1 2025, Pages cyaf001
Implementation of a complex eHealth intervention by a public-private partnership in clinical practice: a qualitative multicentre analysis using CFIR.
IJzerman RVH, van der Vaart R, Breeman LD, Kraaijenhagen RA, Evers AWM, Scholte Op Reimer WJM, Janssen VR
Complex eHealth interventions-featuring multiple components within dynamic systems-are used for healthcare improvement. Public-private partnerships (PPPs), combining resources, expertise, and technology, are crucial in this context. Yet, integrating these interventions into practice remains challenging. This study identifies barriers and facilitators affecting implementation of the BENEFIT programme, a complex eHealth intervention targeting cardiovascular disease patients, by PPP within practice...
Abstract
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 67, Issue 2, 1 1 2025, Pages ezae442
Perioperative extracorporeal membrane oxygenation in neonates with transposition of the great arteries: 15 years of experience.
Weeda JA, Van Der Palen RLF, Bunker-Wiersma HE, Koers L, Van Es E, Hazekamp MG, Te Pas AB, Roeleveld PP
Objectives: Extracorporeal membrane oxygenation (ECMO) can act as a bridge to recovery in both pre- and postoperative patients with transposition of the great arteries (TGA). However, literature on its use in these patients is scarce. Methods: Retrospective single-centre cohort study encompassing all TGA patients who received ECMO between January 2009 and March 2024. Results: Twenty-two neonates received ECMO during the study period, with an overall median age and weight at time of ECMO cannulat...
Abstract
Cited 5 times since 2025 (14.5 per year)
source: EuropePMC
Journal of Crohn's & colitis,
Volume 19, Issue 2, 1 1 2025, Pages jjae189
Open Label Vancomycin in Primary Sclerosing Cholangitis-Inflammatory Bowel Disease: Improved Colonic Disease Activity and Associations With Changes in Host-Microbiome-Metabolomic Signatures.
Quraishi MN, Cheesbrough J, Rimmer P, Mullish BH, Sharma N, Efstathiou E, Acharjee A, Gkoutus G, Patel A, Marchesi JR, Camuzeaux S, Chappell K, Valdivia-Garcia MA, Ferguson J, Brookes MJ, Walmsley M, Rossiter AE, van Schaik W, McInnes RS, Cooney R, Trauner M, Beggs AD, Iqbal TH, Trivedi PJ
Background: We conducted a single-arm interventional study, to explore mucosal changes associated with clinical remission under oral vancomycin (OV) treatment, in primary sclerosing cholangitis-associated inflammatory bowel disease (PSC-IBD); NCT05376228. Methods: Fifteen patients with PSC and active colitis (median fecal calprotectin 459 µg/g; median total Mayo score 5) were treated with OV (125 mg QID) for 4 weeks and followed-up for a further 4 weeks of treatment withdrawal (8 weeks, end-of-s...
Abstract
Molecular biology reports,
Volume 52, Issue 1, 31 5 2025, Pages 180
Upregulation of the MAP2K4 gene triggers endothelial-mesenchymal transition in COVID-19.
Yilmaz E, Yilmaz D, Yildiz CG, Cacan E
Background: SARS-CoV-2 infection is marked by an excessive inflammatory response, leading to elevated production of pro-inflammatory cytokines through activation of intracellular pathways like mitogen-activated protein kinase (MAPK). Viruses can use the MAPK signaling pathway to their advantage, but the relationship of this pathway to the severe SARS-CoV-2 period has not been fully elucidated. MAP2K4 is involved in the MAPK signaling pathway and affects cellular processes such as cell-cell junct...
Abstract
Transboundary and emerging diseases,
Volume 2025, 31 5 2025, Pages 7441785
Assessing the Use of Different Surveillance Components to Detect Highly Pathogenic Avian Influenza Outbreaks in Poultry in the Netherlands in Low- and High-Risk Years.
Vredenberg I, van Schaik G, Velkers FC, Fabri T, Spierenburg MAH, Germeraad EA, van der Poel WHM, Stegeman A
Avian influenza (AI) is a highly contagious zoonotic disease primarily affecting birds with clinical manifestation depending on bird species and virus subtype. Globally, outbreaks have had a large socioeconomic impact. Moreover, highly pathogenic AI virus (HPAIv) outbreaks can pose a public health risk. Detection of AIv, particularly HPAIv, mainly relies on passive surveillance, risking underreporting and delayed detection. This study describes and compares the contribution of passive and active...
Abstract
Open heart,
Volume 12, Issue 1, 30 5 2025, Pages e003009
Sacubitril/valsartan is associated with improvements in quality of life in adult congenital heart disease patients with systemic right ventricular failure.
Neijenhuis RML, Nederend M, van Groningen AE, Jongbloed MRM, Vliegen HW, Jukema JW, Kiès P, Egorova AD
Background: Short-term improvements in quality of life (QOL) have been reported in adult congenital heart disease patients with systemic right ventricle (sRV) failure after treatment with sacubitril/valsartan. This study aimed to evaluate the medium-term QOL changes in sRV failure patients treated with sacubitril/valsartan. Methods: In this single-centre, prospective cohort study, patients with symptomatic sRV failure completed the Netherlands Organisation for Applied Scientific Research/Academi...
Abstract
Clinical and translational radiation oncology,
Volume 52, 29 5 2025, Pages 100927
Effect of FLASH proton therapy on primary bronchial epithelial cell organoids.
Kuipers ME, van Liefferinge F, van der Wal E, Rovituso M, Slats AM, Hiemstra PS, Van Doorn-Wink KCJ
Purpose: The effects of conventional (CONV) and FLASH proton therapy on primary bronchial epithelial cell (PBEC) organoids from individuals with chronic obstructive pulmonary disease (COPD) were investigated. The primary objective was to compare the effect of FLASH and CONV on COPD PBEC organoids with a focus on DNA damage, organoid formation, and gene expression. Methods: PBECs were obtained from six COPD donors, cultured as three-dimensional (3D) organoids and exposed to 2 and 8 Gy CONV and FL...
Abstract
Cited 1 times since 2025 (2.8 per year)
source: EuropePMC
Journal of clinical medicine,
Volume 14, Issue 3, 28 4 2025, Pages 859
From Survival to Recovery: Understanding the Life Impact of an Acute Aortic Dissection Through Activity, Sleep, and Quality of Life.
Bacour N, Grewal S, Theijsse RT, Klautz RJM, Grewal N
Background/Objectives: An acute aortic dissection (AAD) is a cardiovascular emergency with high mortality rates if left untreated. Survival has increased due to improvements in diagnosis and therapy. However, during their recovery, survivors frequently encounter major social, psychological, and physical challenges. This study aimed to evaluate the recovery experience of AAD survivors in The Netherlands. Insights on sleep quality, physical activity, and quality of life were collected from a uniqu...
Abstract
Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology,
Volume 53, Issue 3, 28 4 2025, Pages 311-320
Metagenomics education in a modular CURE format positively affects students' scientific discovery perception and data analytical skills.
Morsink MC, van Schaik EN, Bossers K, Duijker DA, Speksnijder AGCL
Targeted metagenomics is a rapidly expanding technology to analyze complex biological samples and genetic monitoring of environmental samples. In this research field, data analytical aspects play a crucial role. In order to teach targeted metagenomics data analysis, we developed a 4-week inquiry-driven modular course-based undergraduate research experience (mCURE) using publicly available Australian coral microbiome DNA sequencing data and associated metadata. Since an enormous amount of metadat...
Abstract
JTCVS techniques,
Volume 30, 28 4 2025, Pages 81-93
Intraoperative assessment of myocardial perfusion using near-infrared fluorescence and indocyanine green: A literature review.
Peul RC, Kharbanda RK, Koning S, Kruiswijk MW, Tange FP, van den Hoven P, Vahrmeijer AL, Klautz RJM, Hamming JF, Hjortnaes J, van der Vorst JR
Background: Coronary artery bypass grafting (CABG) is among the most commonly performed major surgical procedures worldwide. While flow measurements help assess graft patency during surgery, there are limited tools available for surgeons to objectively evaluate myocardial perfusion after graft placement. Near-infrared fluorescence (NIRF) imaging shows promise in this area, offering real-time visualization of flow and perfusion without the need for radiation or nephrotoxic contrast agents. This r...
Abstract
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics,
27 4 2025, Pages e33024
Pharmacogenetic Testing for Predicting Methylphenidate Treatment Outcomes in Childhood Attention Deficit Hyperactivity Disorder in Turkey: Focus on Carboxylesterase 1, Latrophilin-3, and Catechol-O-Methyltransferase.
Suzer Gamli I, Van Veggel A, Karaaslan RS, Kuerec AH, Marzoukah Z, Adak I, Bulut G, Tunc H, Hizel CP, Parlayan C, Ekinci O, Van Schaik R, Akin D
Pharmacogenetic studies involving Carboxylesterase 1 (CES1), Latrophilin-3 (LPHN3), and Catechol-O-methyltransferase (COMT) revealed individual differences regarding therapeutic response in children with attention deficit hyperactivity disorder (ADHD) under methylphenidate (MPH) treatment. This study aimed to evaluate MPH's association with the adverse effect status in children and its relationship with CES1, LPHN3, and COMT in the Turkish population. The study included 102 children and ado...
Abstract
