7503 results
Cited 9 times since 2022 (2.3 per year)
source: EuropePMC
European radiology,
Volume 32, Issue 5, 8 2 2022, Pages 3408-3422
Utilizing (serial) coronary computed tomography angiography (CCTA) to predict plaque progression and major adverse cardiac events (MACE): results, merits and challenges.
van Driest FY, Bijns CM, van der Geest RJ, Broersen A, Dijkstra J, Scholte AJHA, Jukema JW
Objectives: To present an overview of studies using serial coronary computed tomography angiography (CCTA) as a tool for finding both quantitative (changes) and qualitative plaque characteristics as well as epicardial adipose tissue (EAT) volume changes as predictors of plaque progression and/or major adverse cardiac events (MACE) and outline the challenges and advantages of using a serial non-invasive imaging approach for assessing cardiovascular prognosis. Methods: A literature search was perf...
Abstract
Cited 9 times since 2022 (2.3 per year)
source: EuropePMC
PloS one,
Volume 17, Issue 1, 7 1 2022, Pages e0261826
Association of cognitive function with increased risk of cancer death and all-cause mortality: Longitudinal analysis, systematic review, and meta-analysis of prospective observational studies.
Rostamian S, le Cessie S, Marijt KA, Jukema JW, Mooijaart SP, van Buchem MA, van Hall T, Gussekloo J, Trompet S
Background: Disturbed cognitive function is associated with several causes of mortality; however, the association between cognitive function and the risk of cancer death has not been extensively investigated yet. We aimed to evaluate the association of cognitive function with the risk of cancer death and all-cause mortality in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) and Leiden 85-plus Study. Additionally, a systematic review and meta-analysis of longitudinal studies...
Abstract
Cited 4 times since 2022 (1 per year)
source: EuropePMC
Surgical endoscopy,
Volume 36, Issue 8, 6 1 2022, Pages 6214-6222
Does livestreaming surgical education have the future? Development and participant evaluation of a national COVID-19 livestreaming initiative.
Feenstra TM, van Felius LP, Vriens MR, Stassen LPS, van Acker GJD, van Dijkum EJMN, Schijven MP, Bonjer HJ, NVvH Livestream Collaborative Group
Backgrounds: COVID-19 related reduction of surgical procedures jeopardizes learning on the job of surgical residents. Many educators resorted to digital resources in the search for alternatives. However, these resources are often limited to the extent they offer resident-surgeon interaction like a joint surgical performance does. Here we present a roadmap of livestreaming surgical procedures, and evaluate how surgical livestreams on human cadavers address the unmet educational needs of surgical...
Abstract
Cited 22 times since 2022 (5.6 per year)
source: EuropePMC
Nature biomedical engineering,
Volume 6, Issue 4, 6 1 2022, Pages 389-402
Conditional immortalization of human atrial myocytes for the generation of in vitro models of atrial fibrillation.
Harlaar N, Dekker SO, Zhang J, Snabel RR, Veldkamp MW, Verkerk AO, Fabres CC, Schwach V, Lerink LJS, Rivaud MR, Mulder AA, Corver WE, Goumans MJTH, Dobrev D, Klautz RJM, Schalij MJ, Veenstra GJC, Passier R, van Brakel TJ, Pijnappels DA, de Vries AAF
The lack of a scalable and robust source of well-differentiated human atrial myocytes constrains the development of in vitro models of atrial fibrillation (AF). Here we show that fully functional atrial myocytes can be generated and expanded one-quadrillion-fold via a conditional cell-immortalization method relying on lentiviral vectors and the doxycycline-controlled expression of a recombinant viral oncogene in human foetal atrial myocytes, and that the immortalized cells can be used to generat...
Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 30, Issue 2, 3 1 2022, Pages 76-83
No substantial excess all-cause mortality among cardiac implantable electronic device patients during the first COVID‑19 lockdown in the Leiden area.
Feijen M, Egorova AD, van der Velde ET, Schalij MJ, Beeres SLMA
In the Netherlands, the coronavirus disease 2019 (COVID‑19) pandemic has resulted in excess mortality nationwide. Chronic heart disease patients are at risk for a complicated COVID‑19 course. The current study investigates all-cause mortality among cardiac implantable electronic device (CIED) patients during the first peak of the pandemic and compares the data to the statistics for the corresponding period in the two previous years. Data of adult CIED patients undergoing follow-up at the Leiden...
Abstract
Cited 9 times since 2022 (2.3 per year)
source: EuropePMC
Frontiers in immunology,
Volume 12, 3 1 2022, Pages 802877
Spatial and Temporal Heterogeneity of Tumor-Infiltrating Lymphocytes in Advanced Urothelial Cancer.
van Wilpe S, Gorris MAJ, van der Woude LL, Sultan S, Koornstra RHT, van der Heijden AG, Gerritsen WR, Simons M, de Vries IJM, Mehra N
Checkpoint inhibitors targeting PD-(L)1 induce objective responses in 20% of patients with metastatic urothelial cancer (UC). CD8+ T cell infiltration has been proposed as a putative biomarker for response to checkpoint inhibitors. Nevertheless, data on spatial and temporal heterogeneity of tumor-infiltrating lymphocytes in advanced UC are lacking. The major aims of this study were to explore spatial heterogeneity for lymphocyte infiltration and to investigate how the immune landscape changes du...
Abstract
Cited 18 times since 2022 (4.5 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 23, Issue 2, 1 1 2022, Pages e62-e84
Multimodality imaging approach to left ventricular dysfunction in diabetes: an expert consensus document from the European Association of Cardiovascular Imaging.
Marwick TH, Gimelli A, Plein S, Bax JJ, Charron P, Delgado V, Donal E, Lancellotti P, Levelt E, Maurovich-Horvat P, Neubauer S, Pontone G, Saraste A, Cosyns B, Edvardsen T, Popescu BA, Galderisi M, Derumeaux G, Reviewers: This document was reviewed by members of the 2020–2022 EACVI Scientific Documents Committee, Bäck M, Bertrand PB, Dweck M, Keenan N, Magne J, Neglia D, Stankovic I
Heart failure (HF) is among the most important and frequent complications of diabetes mellitus (DM). The detection of subclinical dysfunction is a marker of HF risk and presents a potential target for reducing incident HF in DM. Left ventricular (LV) dysfunction secondary to DM is heterogeneous, with phenotypes including predominantly systolic, predominantly diastolic, and mixed dysfunction. Indeed, the pathogenesis of HF in this setting is heterogeneous. Effective management of this problem wil...
Abstract
Cited 10 times since 2022 (2.5 per year)
source: EuropePMC
European heart journal. Cardiovascular pharmacotherapy,
Volume 8, Issue 1, 1 1 2022, Pages 77-84
Medication in adults after atrial switch for transposition of the great arteries: clinical practice and recommendations.
Woudstra OI, Kuijpers JM, Jongbloed MRM, van Dijk APJ, Sieswerda GT, Vliegen HW, Egorova AD, Kiès P, Duijnhouwer AL, Robbers-Visser D, Konings TC, Zwinderman AH, Meijboom FJ, Mulder BJM, Bouma BJ
Aims: Heart failure is the main threat to long-term health in adults with transposition of the great arteries (TGA) corrected by an atrial switch operation (AtrSO). Current guidelines refrain from recommending heart failure medication in TGA-AtrSO, as there is insufficient data to support the hypothesis that it is beneficial. Medication is therefore prescribed based on personal judgements. We aimed to evaluate medication use in TGA-AtrSO patients and examine the association of use of renin-angio...
Abstract
Cited 1 times since 2022 (0.3 per year)
source: EuropePMC
Methods in molecular biology (Clifton, N.J.),
Volume 2478, 1 1 2022, Pages 677-700
Mechanics of Single Vimentin Intermediate Filaments Under Load.
Schepers AV, Kraxner J, Lorenz C, Köster S
The eukaryotic cytoskeleton consists of three different types of biopolymers - microtubules, actin filaments, and intermediate filaments - and provides cells with versatile mechanical properties, combining stability and flexibility. The unique molecular structure of intermediate filaments leads to high extensibility and stability under load. With high laser power dual optical tweezers, the mechanical properties of intermediate filaments may be investigated, while monitoring the extension with fl...
Abstract
Cited 1 times since 2022 (0.3 per year)
source: EuropePMC
Journal of chromatographic science,
Volume 60, Issue 1, 1 1 2022, Pages 96-103
Application of Tandem Dispersive Liquid-Liquid Microextraction as an Efficient Method for Preconcentration of Two Antidepressant Drugs in Real Samples Combined with High Performance Liquid Chromatography.
Arabkhani B, Goudarzi N, Bagherian G, Chamjangali MA
In the present work, tandem dispersive liquid-liquid microextraction (TDLLME) coupled with liquid chromatography was used for the determination of the two antidepressant drugs citalopram (CIT) and sertraline (SER) in complicated matrices. Indeed, the present approach was used to improve the suitability and appropriateness of the dispersive liquid-liquid microextraction (DLLME) method in complicated matrices. Firstly, 10 mL of the sample solution containing the two understudied drugs was extracte...
Abstract
Cited 17 times since 2022 (4.3 per year)
source: EuropePMC
The Journal of clinical endocrinology and metabolism,
Volume 107, Issue 2, 1 1 2022, Pages 512-524
The Cortisol Response of Male and Female Choroidal Endothelial Cells: Implications for Central Serous Chorioretinopathy.
Brinks J, van Dijk EHC, Kiełbasa SM, Mei H, van der Veen I, Peters HAB, Sips HCM, Notenboom RGE, Quax PHA, Boon CJF, Meijer OC
Context: Central serous chorioretinopathy (CSC) is a severe ocular disease characterized by fluid accumulation under the retina and abnormalities in the underlying vascular layer, the choroid. CSC has a striking prevalence in males of 80% to 90% of total patients. Corticosteroids are the most pronounced extrinsic risk factor for CSC. Choroidal endothelial cells (CECs) are important for the vascular integrity of the choroid, but the effects of corticosteroid effects in these cells are unknown. Ob...
Abstract
Cited 2 times since 2022 (0.5 per year)
source: EuropePMC
Methods in molecular biology (Clifton, N.J.),
Volume 2478, 1 1 2022, Pages 701-723
Quantifying the Interaction Strength Between Biopolymers.
Lorenz C, Schepers AV, Köster S
The cytoskeleton consists of three types of biopolymers-actin filaments, microtubules, and intermediate filaments-and the interplay between these components is essential for many cellular functions such as cell migration, mitosis, and the mechanical response to external cues. In the cell, the interactions between the filaments are mediated by a myriad of cross-linkers and motor proteins; however, direct forces, mediated by electrostatics or hydrophobicity, may also play an important role. Here,...
Abstract
Cited 3 times since 2022 (0.8 per year)
source: EuropePMC
BJS open,
Volume 6, Issue 1, 1 1 2022, Pages zrab150
Validation of the OAKS prognostic model for acute kidney injury after gastrointestinal surgery.
STARSurg Collaborative and EuroSurg Collaborative
Background: Postoperative acute kidney injury (AKI) is a common complication of major gastrointestinal surgery with an impact on short- and long-term survival. No validated system for risk stratification exists for this patient group. This study aimed to validate externally a prognostic model for AKI after major gastrointestinal surgery in two multicentre cohort studies. Methods: The Outcomes After Kidney injury in Surgery (OAKS) prognostic model was developed to predict risk of AKI in the 7 day...
Abstract
Cited 3 times since 2022 (0.8 per year)
source: EuropePMC
Pediatrics international : official journal of the Japan Pediatric Society,
Volume 64, Issue 1, 1 1 2022, Pages e14858
Early application of non-invasive ventilation for children with pulmonary edema after drowning.
Şık N, Şenol HB, Çağlar A, Yılmaz D, Duman M
Background: The present study aimed to assess the efficacy of non-invasive ventilation (NIV) on the clinical course, oxygenation, need for invasive mechanical ventilation (IMV), and outcomes for children with pulmonary edema after drowning. Methods: We conducted a retrospective chart review. Children who were referred to the pediatric emergency department due to drowning-related pulmonary edema and underwent NIV between May 2014 and October 2020 were included. Demographics, vital signs, clinical...
Abstract
Cited 5 times since 2022 (1.3 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 23, Issue 2, 1 1 2022, Pages 266-274
Associations between dyspnoea, coronary atherosclerosis, and cardiovascular outcomes: results from the long-term follow-up CONFIRM registry.
van Rosendael AR, Bax AM, van den Hoogen IJ, Smit JM, Al'Aref SJ, Achenbach S, Al-Mallah MH, Andreini D, Berman DS, Budoff MJ, Cademartiri F, Callister TQ, Chang HJ, Chinnaiyan K, Chow BJW, Cury RC, DeLago A, Feuchtner G, Hadamitzky M, Hausleiter J, Kaufmann PA, Kim YJ, Leipsic JA, Maffei E, Marques H, de Araújo Gonçalves P, Pontone G, Raff GL, Rubinshtein R, Villines TC, Gransar H, Lu Y, Peña JM, Lin FY, Shaw LJ, Narula J, Min JK, Bax JJ
Aims: The relationship between dyspnoea, coronary artery disease (CAD), and major cardiovascular events (MACE) is poorly understood. This study evaluated (i) the association of dyspnoea with the severity of anatomical CAD by coronary computed tomography angiography (CCTA) and (ii) to which extent CAD explains MACE in patients with dyspnoea. Methods and results: From the international COronary CT Angiography EvaluatioN for Clinical Outcomes: An InteRnational Multicenter (CONFIRM) registry, 4425 p...
Abstract
Cited 4 times since 2021 (1 per year)
source: EuropePMC
Pediatric nephrology (Berlin, Germany),
Volume 37, Issue 8, 31 5 2022, Pages 1867-1875
Impact of coronavirus disease-2019 on pediatric nephrology practice and education: an ESPN survey.
Yazıcıoğlu B, Bakkaloğlu SA, European Society for Pediatric Nephrology
Background: Coronavirus disease-2019 (COVID-19) has been challenging for patients and medical staff. Radical changes have been needed to prevent disruptions in patient care and medical education. Methods: A web-based survey was sent to European Society for Pediatric Nephrology (ESPN) members via the ESPN mailing list to evaluate the effects of the COVID-19 pandemic on delivery of pediatric nephrology (PN) care and educational activities. There were ten questions with subheadings. Results: Sevent...
Abstract
Cited 16 times since 2021 (4 per year)
source: EuropePMC
Micromachines,
Volume 13, Issue 1, 29 5 2022, Pages 49
Rapid Prototyping of Organ-on-a-Chip Devices Using Maskless Photolithography.
Kasi DG, de Graaf MNS, Motreuil-Ragot PA, Frimat JMS, Ferrari MD, Sarro PM, Mastrangeli M, van den Maagdenberg AMJM, Mummery CL, Orlova VV
Organ-on-a-chip (OoC) and microfluidic devices are conventionally produced using microfabrication procedures that require cleanrooms, silicon wafers, and photomasks. The prototyping stage often requires multiple iterations of design steps. A simplified prototyping process could therefore offer major advantages. Here, we describe a rapid and cleanroom-free microfabrication method using maskless photolithography. The approach utilizes a commercial digital micromirror device (DMD)-based setup using...
Abstract
Cited 2 times since 2021 (0.5 per year)
source: EuropePMC
Circulation. Arrhythmia and electrophysiology,
Volume 15, Issue 1, 23 4 2021, Pages e009886
Ultrasound-Guided Optogenetic Gene Delivery for Shock-Free Ventricular Rhythm Restoration.
Nyns ECA, Jin T, Bart CI, Bax WH, Zhang G, Poelma RH, de Vries AAF, Pijnappels DA
Abstract
Cited 14 times since 2021 (3.5 per year)
source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
Volume 35, Issue 5, 23 4 2021, Pages 486-494.e2
Left Atrial Deformation Imaging and Atrial Fibrillation in Patients with Rheumatic Mitral Stenosis.
Stassen J, Butcher SC, Namazi F, Ajmone Marsan N, Bax JJ, Delgado V
Background: Atrial fibrillation (AF) is a frequent complication of rheumatic mitral stenosis (MS) and is associated with worse outcomes. Prediction of new-onset AF by assessing left atrial (LA) mechanics with speckle-tracking echocardiography might be useful for risk stratification and guiding therapeutic strategies. Therefore, the aim of this study was to assess the association of LA reservoir strain (LASr) and strain rate (LASRr) with AF at follow-up in patients with rheumatic MS. Methods: Lef...
Abstract
Cited 101 times since 2021 (25.2 per year)
source: EuropePMC
Nature immunology,
Volume 23, Issue 1, 22 4 2021, Pages 23-32
Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8<sup>+</sup> T cell responses following COVID-19.
Roukens AHE, Pothast CR, König M, Huisman W, Dalebout T, Tak T, Azimi S, Kruize Y, Hagedoorn RS, Zlei M, Staal FJT, de Bie FJ, van Dongen JJM, Arbous SM, Zhang JLH, Verheij M, Prins C, van der Does AM, Hiemstra PS, de Vries JJC, Janse JJ, Roestenberg M, Myeni SK, Kikkert M, Yazdanbakhsh M, Heemskerk MHM, Smits HH, Jochems SP, in collaboration with BEAT-COVID group, in collaboration with COVID-19 LUMC group
Systemic immune cell dynamics during coronavirus disease 2019 (COVID-19) are extensively documented, but these are less well studied in the (upper) respiratory tract, where severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replicates1-6. Here, we characterized nasal and systemic immune cells in individuals with COVID-19 who were hospitalized or convalescent and compared the immune cells to those seen in healthy donors. We observed increased nasal granulocytes, monocytes, CD11c+ natura...
Abstract
