Research

Publications

Below you can find a list of our published research.

6139 results

Cited 24 times since 2011 (1.7 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 91, Issue 1, 1 1 2011, Pages 113-121 Three-dimensional echocardiography for the preoperative assessment of patients with left ventricular aneurysm. Marsan NA, Westenberg JJ, Roes SD, van Bommel RJ, Delgado V, van der Geest RJ, de Roos A, Klautz RJ, Reiber JC, Bax JJ

Background: Surgical ventricular reconstruction has been proposed as a treatment option in heart failure patients with left ventricular (LV) aneurysm. The feasibility of this procedure has some limitations, and extensive preoperative evaluation is necessary to give the correct indication. For this purpose, magnetic resonance imaging (MRI) is currently considered the gold standard, providing accurate quantification of LV shape, size, and global and regional function together with the assessment o... Abstract

Cited 105 times since 2011 (7.4 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 57, Issue 3, 1 1 2011, Pages 324-331 Left atrial strain predicts reverse remodeling after catheter ablation for atrial fibrillation. Tops LF, Delgado V, Bertini M, Marsan NA, Den Uijl DW, Trines SA, Zeppenfeld K, Holman E, Schalij MJ, Bax JJ

Objectives: The purpose of this study was to assess left atrial (LA) strain during long-term follow-up after catheter ablation for atrial fibrillation and to find predictors for LA reverse remodeling. Background: The association between LA reverse remodeling and improvement in LA strain after catheter ablation has not been investigated thus far. Methods: In 148 patients undergoing catheter ablation for atrial fibrillation, LA volumes and LA strain were assessed with echocardiography at baseline... Abstract

Cited 31 times since 2011 (2.2 per year) source: EuropePMC

American heart journal, Volume 161, Issue 1, 1 1 2011, Pages 197-203 Natriuretic peptide levels predict recurrence of atrial fibrillation after radiofrequency catheter ablation. den Uijl DW, Delgado V, Tops LF, Ng AC, Boersma E, Trines SA, Zeppenfeld K, Schalij MJ, van der Laarse A, Bax JJ

Background: the presence of atrial fibrillation (AF) is related to increased levels of natriuretic peptides. In addition, increased natriuretic peptide levels are predictive of the development of AF. However, the role of natriuretic peptides to predict recurrence of AF after radiofrequency catheter ablation (RFCA) is controversial. Objective: the study aimed to investigate the role of natriuretic peptides in the prediction of AF recurrence after RFCA for AF. Methods: pre-procedural amino-termina... Abstract

Cited 20 times since 2011 (1.4 per year) source: EuropePMC

International review of cell and molecular biology, Volume 290, 1 1 2011, Pages 87-119 Role for primary cilia as flow detectors in the cardiovascular system. Van der Heiden K, Egorova AD, Poelmann RE, Wentzel JJ, Hierck BP

The cardiovascular system is exposed to biochemical and biomechanical signals. Various sensors for these signals have been described and they contribute to cardiovascular development, maintenance of vessel integrity during adult life, and to pathogenesis. In the past 10years, primary cilia, membrane-covered, rod-like cellular protrusions, were discovered on multiple cell types of the cardiovascular system. Primary cilia are sensory organelles involved in several key (developmental) signaling pat... Abstract

Cited 1 times since 2011 (0.1 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 57, Issue 4, 1 1 2011, Pages 480-514 Highlights of the year in JACC 2010. DeMaria AN, Bax JJ, Ben-Yehuda O, Feld GK, Greenberg BH, Hall J, Hlatky M, Lew WY, Lima JA, Maisel AS, Narayan SM, Nissen S, Sahn DJ, Tsimikas S

Abstract

Cited 1 times since 2011 (0.1 per year) source: EuropePMC

Cardiology journal, Volume 18, Issue 3, 1 1 2011, Pages 289-296 Interventional creation of an atrial septal defect and its impact on right ventricular function: an animal study with the pressure-volume conductance system. Uebing A, Fischer G, Schlangen J, Hansen T, Grabitz RG, Becker K, Steendijk P, Kramer HH

Background: The aim of our study was to assess the suitability of different interventional techniques to create an atrial septal defect (ASD) and to evaluate the short-term effects of right ventricular (RV) volume overload on RV contractility in the growing swine. Methods: Thirteen ASD and six control animals were studied. An ASD was created by balloon dilatation (BD) of the fossa ovalis (n = 4) or by implantation of a multi-perforated Amplatzer Septal Occluder (n = 4) or a patch-less nitinol de... Abstract

Cited 1 times since 2011 (0.1 per year) source: EuropePMC

Nederlands tijdschrift voor geneeskunde, Volume 155, 1 1 2011, Pages A3158 [Summary of the practice guideline 'Venous leg ulcer' from the Dutch College of General Practitioners]. van Rijn-van Kortenhof NM, Wiersma T, van Hof N, Balak FS, Goudswaard LA

The practice guideline 'Venous leg ulcer' from the Dutch College of General Practitioners provides recommendations for the diagnosis and treatment of venous leg ulcer by the general practitioner. When counseling the patient it is important to make clear that the healing process can take a long time. Compression therapy remains the most important treatment for venous leg ulcer; it also reduces recurrence rates. The choice of wound dressing is dependent on the wound phase, the degree of... Abstract

Cited 6 times since 2011 (0.4 per year) source: EuropePMC

Disease markers, Volume 30, Issue 5, 1 1 2011, Pages 245-252 Asymmetric dimethylarginine (ADMA) levels display a morning peak in patients with acute myocardial infarction. Bergheanu SC, van der Laarse A, van der Bom JG, van der Hoeven BL, le Cessie S, de Jong MG, Liem SS, Schalij MJ, Jukema JW

High Asymmetric Dimethylarginine (ADMA) levels are associated with increased platelet activity, elevated blood pressure, vasoconstriction and impaired vascular relaxation. We hypothesized that the myocardial infarction morning peak of occurrence is closely related to a morning peak of ADMA levels. We performed a cross-sectional study among patients with documented myocardial infarction who had been enrolled in the prospective MISSION! Intervention Study. In total, serum ADMA levels were measured... Abstract

Cited 52 times since 2011 (3.7 per year) source: EuropePMC

Current pharmaceutical design, Volume 17, Issue 19, 1 1 2011, Pages 1890-1910 Clinical applications of the urokinase receptor (uPAR) for cancer patients. Boonstra MC, Verspaget HW, Ganesh S, Kubben FJ, Vahrmeijer AL, van de Velde CJ, Kuppen PJ, Quax PH, Sier CF

Since decades the urokinase plasminogen activator (uPA) system has been associated with the invasion of malignant cells. The receptor of urokinase (uPAR) is one of the key players in this proteolytic cascade, because it focuses uPA's proteolytic activity to the cell surface and in addition functions as a signaling receptor. uPAR is highly expressed in virtually all human cancers, suggesting possible clinical applications as diagnostic marker, predictive tool of survival or clinical response... Abstract

Cited 12 times since 2010 (0.8 per year) source: EuropePMC

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, Volume 41, Issue 3, 30 5 2011, Pages 418-428 T-cell-pre-stimulated monocytes promote neovascularisation in a murine hind limb ischaemia model. Hellingman AA, Zwaginga JJ, van Beem RT, TeRM/Smart Mix Consortium, Hamming JF, Fibbe WE, Quax PH, Geutskens SB

Aim: Monocytes play a significant role in neovascularisation. The stimuli that differentiate monocytes along a pro-angio-/arteriogenic-supporting pathway are currently unclear. We investigated whether pre-stimulation of human monocytes with soluble T-cell-derived factors improves revascularisation in murine hind limb ischaemia as a new option for therapeutic angio- and arteriogenesis. Design: Human monocytes were cultured with or without soluble T-cell-derived factors. Unstimulated and pre-stimu... Abstract

Cited 9 times since 2010 (0.6 per year) source: EuropePMC

Foot (Edinburgh, Scotland), Volume 21, Issue 3, 23 4 2010, Pages 124-128 Foot and ankle fractures at the supination line. Schepers T, van Schie-van der Weert EM, de Vries MR, van der Elst M

Background: The supination line is a fictive line along the foot and ankle, on which over twenty fracture types and approximately ten different ligamentous sprain-injuries have been identified. Objective: The current study was conducted to evaluate the incidence of different types of supination line injuries visible at the initial radiographs at the Emergency Department and to determine the type and percentage of misdiagnosed injuries. Method: Retrospective study of consecutive patients who visi... Abstract

Cited 18 times since 2010 (1.3 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 19, Issue 1, 22 4 2010, Pages 24-30 Improvements in 25 Years of Implantable Cardioverter Defibrillator Therapy. van Welsenes GH, Borleffs CJ, van Rees JB, Atary JZ, Thijssen J, van der Wall EE, Schalij MJ

In 1980, Dr. Michel Mirowski and his team inserted the first implantable cardioverter defibrillator (ICD) in a patient. Initially, ICD therapy was not widely accepted, and many physicians actually considered this therapy unethical. Large secondary and primary prevention trials, demonstrating a beneficial effect of ICD therapy in selected patients not only on arrhythmic death but also on all-cause mortality, stimulated a rapid growth in the number of implants and increased patient's and phys... Abstract

Cited 16 times since 2010 (1.1 per year) source: EuropePMC

The American journal of cardiology, Volume 107, Issue 4, 22 4 2010, Pages 609-614 Usefulness of repeated N-terminal pro-B-type natriuretic peptide measurements as incremental predictor for long-term cardiovascular outcome after vascular surgery. Goei D, van Kuijk JP, Flu WJ, Hoeks SE, Chonchol M, Verhagen HJ, Bax JJ, Poldermans D

Plasma N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) levels improve preoperative cardiac risk stratification in vascular surgery patients. However, single preoperative measurements of NT-pro-BNP cannot take into account the hemodynamic stress caused by anesthesia and surgery. Therefore, the aim of the present study was to assess the incremental predictive value of changes in NT-pro-BNP during the perioperative period for long-term cardiac mortality. Detailed cardiac histories, rest left... Abstract

Cited 7 times since 2010 (0.5 per year) source: EuropePMC

The American journal of cardiology, Volume 107, Issue 5, 22 4 2010, Pages 736-740 Value of the surface electrocardiogram in detecting right ventricular dilatation in the presence of left bundle branch block. Van Bommel RJ, Marsan NA, Delgado V, van Rijnsoever EP, Schalij MJ, Bax JJ, Wellens HJ

Approximately 20% of patients with heart failure have left bundle branch block (LBBB) on surface electrocardiogram (ECG). In this group of patients, detection of right ventricular (RV) dilatation on standard ECG can be of clinical relevance because RV enlargement is an important prognostic marker. Consequently, the aim of this study was to evaluate diagnostic accuracy for several electrocardiographic criteria in determining significant RV dilatation in these patients. Standard 12-lead ECGs were... Abstract

Cited 170 times since 2010 (11.9 per year) source: EuropePMC

Circulation, Volume 123, Issue 1, 20 3 2010, Pages 70-78 Relative merits of left ventricular dyssynchrony, left ventricular lead position, and myocardial scar to predict long-term survival of ischemic heart failure patients undergoing cardiac resynchronization therapy. Delgado V, van Bommel RJ, Bertini M, Borleffs CJ, Marsan NA, Arnold CT, Nucifora G, van de Veire NR, Ypenburg C, Boersma E, Holman ER, Schalij MJ, Bax JJ

Background: The relative merits of left ventricular (LV) dyssynchrony, LV lead position, and myocardial scar to predict long-term outcome after cardiac resynchronization therapy remain unknown and were evaluated in the present study. Methods and results: In 397 ischemic heart failure patients, 2-dimensional speckle tracking imaging was performed, with comprehensive assessment of LV radial dyssynchrony, identification of the segment with latest mechanical activation, and detection of myocardial s... Abstract

The international journal of cardiovascular imaging, Volume 27, Issue 7, 18 3 2010, Pages 1089-1093 Functional analysis by 64-slice CT scanning: prediction of left ventricular dysfunction together with reduction in radiation exposure? van der Wall EE, de Graaf FR, van Velzen JE, Jukema JW, Schuijf JD, Bax JJ

Abstract

Cited 1 times since 2010 (0.1 per year) source: EuropePMC

Case reports in oncology, Volume 4, Issue 2, 17 3 2010, Pages 323-326 Imatinib treatment alone in Philadelphia-positive acute lymphoblastic leukemia: is it enough? Ay Y, Yilmaz D, Balkan C, Karapinar B, Karadas N, Kavakli K

BCR-ABL fusion gene t(9;22)(q34;q11) occurs in only 3% of pediatric acute lymphoblastic leukemia (ALL) cases. Previously, less than 40% of Philadelphia-positive ALL patients were cured with intensive chemotherapy. The use of imatinib (340 mg/m(2)/day) added to an intensive chemotherapy regimen has improved the outcome in this population at 3 years to an event-free survival of 80%. Imatinib treatment alone was administered after remission induction chemotherapy to a patient with Philadelphia-posi... Abstract

Cited 16 times since 2010 (1.1 per year) source: EuropePMC

Journal of the American Society of Nephrology : JASN, Volume 22, Issue 3, 16 3 2010, Pages 508-517 γ-Adducin stimulates the thiazide-sensitive NaCl cotransporter. Dimke H, San-Cristobal P, de Graaf M, Lenders JW, Deinum J, Hoenderop JG, Bindels RJ

The thiazide-sensitive NaCl cotransporter (NCC) plays a key role in renal salt reabsorption and the determination of systemic BP, but the molecular mechanisms governing the regulation of NCC are not completely understood. Here, through pull-down experiments coupled to mass spectrometry, we found that γ-adducin interacts with the NCC transporter. γ-Adducin colocalized with NCC to the distal convoluted tubule. (22)Na(+) uptake experiments in the Xenopus laevis oocyte showed that γ-adducin stimulat... Abstract

Cited 1 times since 2010 (0.1 per year) source: EuropePMC

BMC bioinformatics, Volume 11, 14 2 2010, Pages 598 Initial steps towards a production platform for DNA sequence analysis on the grid. Luyf AC, van Schaik BD, de Vries M, Baas F, van Kampen AH, Olabarriaga SD

Background: Bioinformatics is confronted with a new data explosion due to the availability of high throughput DNA sequencers. Data storage and analysis becomes a problem on local servers, and therefore it is needed to switch to other IT infrastructures. Grid and workflow technology can help to handle the data more efficiently, as well as facilitate collaborations. However, interfaces to grids are often unfriendly to novice users. Results: In this study we reused a platform that was developed in... Abstract

Cited 2 times since 2010 (0.1 per year) source: EuropePMC

International journal of clinical oncology, Volume 16, Issue 5, 8 2 2010, Pages 574-576 Blue toe syndrome and sunitinib. Postema PG, Regeer MV, van der Valk PR, Stroes ES, Richel DJ

We present a patient with metastatic renal cell carcinoma treated with sunitinib, a multitargeted tyrosine kinase inhibitor. The patient experienced bilateral blue toe syndrome which we related to sunitinib use. Discontinuation of sunitinib to lower the patient's prothrombotic state and increase the ability to form collaterals, together with the addition of low-molecular-weight heparin to treat the occluding thrombi, resulted in waning of the blue toe syndrome. This case adds to the accumul... Abstract