Research

Publications

Below you can find a list of our published research.

6161 results

Cited 189 times since 2007 (10.6 per year) source: EuropePMC

Current problems in cardiology, Volume 32, Issue 7, 1 1 2007, Pages 375-410 Hibernating myocardium: diagnosis and patient outcomes. Schinkel AF, Bax JJ, Poldermans D, Elhendy A, Ferrari R, Rahimtoola SH

Approximately 50% of the patients with chronic obstructive coronary artery disease resulting in chronic contractile dysfunction have hibernating myocardium and may benefit from revascularization. This pooled analysis describes the relative merits of dobutamine echocardiography, thallium-201 and technetium-99m scintigraphy, positron emission tomography, and magnetic resonance imaging, for the diagnosis of hibernating myocardium and prediction of patient outcomes. Abstract

Cited 61 times since 2007 (3.4 per year) source: EuropePMC

Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, Volume 9, Issue 4, 1 1 2007, Pages 645-651 Magnetic resonance assessment of aortic pulse wave velocity, aortic distensibility, and cardiac function in uncomplicated type 2 diabetes mellitus. van der Meer RW, Diamant M, Westenberg JJ, Doornbos J, Bax JJ, de Roos A, Lamb HJ

Background: Type 2 diabetes mellitus (DM2) may augment arterial stiffening and thereby modulates left ventricular (LV) function. Cardiovascular magnetic resonance (CMR) is well suited to assess aortic pulse wave velocity (PWV) and aortic distensibility, both markers of arterial stiffness, without the use of geometric assumptions. Furthermore, CMR is a reliable method for assessing left ventricular (LV) function. The purpose of this study was to assess LV function, PWV, and aortic distensibility... Abstract

Cited 83 times since 2007 (4.7 per year) source: EuropePMC

European heart journal, Volume 28, Issue 18, 29 5 2007, Pages 2223-2230 Impaired myocardial perfusion and perfusion reserve associated with increased coronary resistance in persistent idiopathic atrial fibrillation. Range FT, Schäfers M, Acil T, Schäfers KP, Kies P, Paul M, Hermann S, Brisse B, Breithardt G, Schober O, Wichter T

Aims: Patients with atrial fibrillation (AF) present with symptoms of myocardial ischaemia despite exclusion of coronary artery disease. A small vessel disease has been suggested. We quantified myocardial perfusion, perfusion reserve, and coronary vascular resistance (CVR) in AF patients using positron emission tomography (PET). Methods and results: Twenty-five male patients (age: 58 +/- 13 years) with persistent idiopathic AF were compared with 13 age- and risk-matched male controls (age: 56 +/... Abstract

Cited 59 times since 2007 (3.3 per year) source: EuropePMC

Arteriosclerosis, thrombosis, and vascular biology, Volume 27, Issue 9, 28 4 2007, Pages 2050-2057 Vaccination against VEGFR2 attenuates initiation and progression of atherosclerosis. Hauer AD, van Puijvelde GH, Peterse N, de Vos P, van Weel V, van Wanrooij EJ, Biessen EA, Quax PH, Niethammer AG, Reisfeld RA, van Berkel TJ, Kuiper J

Objective: Vascular endothelial growth factor receptor 2 (VEGFR2)-overexpressing cells may form an interesting target for the treatment of atherosclerosis because of their involvement in processes that contribute to this disease, such as angiogenesis. Methods and results: We vaccinated mice against VEGFR2 by an orally administered DNA vaccine, comprising a plasmid, encoding murine VEGFR2, carried by live attenuated Salmonella typhimurium. This vaccine induces cellular immunity against cells that... Abstract

Cited 43 times since 2007 (2.4 per year) source: EuropePMC

European journal of heart failure, Volume 9, Issue 8, 22 4 2007, Pages 808-813 Importance of the echocardiographic evaluation of right ventricular function in patients with AL amyloidosis. Ghio S, Perlini S, Palladini G, Marsan NA, Faggiano G, Vezzoli M, Klersy C, Campana C, Merlini G, Tavazzi L

Background: Patients with AL amyloidosis often present with signs of congestive heart failure. Aim: This study was prospectively designed to assess the significance of RV dysfunction in AL amyloidosis. Methods and results: Seventy-four patients with biopsy proven AL amyloidosis underwent a thorough echocardiographic evaluation. A tricuspid annular plane systolic excursion (TAPSE) Abstract

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, Volume 34, Issue 3, 19 3 2007, Pages 378 The Oslo Balloon Angioplasty versus Conservative Treatment Study (OBACT) - The 2-years results of a single centre, prospective, randomised study in patients with intermittent claudication. Breek JC, De Vries J, Hamming JF

Abstract

Cited 29 times since 2007 (1.6 per year) source: EuropePMC

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Volume 21, Issue 12, 19 3 2007, Pages 3369-3379 Fibroblasts from human postmyocardial infarction scars acquire properties of cardiomyocytes after transduction with a recombinant myocardin gene. van Tuyn J, Pijnappels DA, de Vries AA, de Vries I, van der Velde-van Dijke I, Knaän-Shanzer S, van der Laarse A, Schalij MJ, Atsma DE

Myocardial scar formation impairs heart function by inducing cardiac remodeling, decreasing myocardial compliance, and compromising normal electrical conduction. Conversion of myocardial scar fibroblasts (MSFs) into (functional) cardiomyocytes may be an effective alternative treatment to limit loss of cardiac performance after myocardial injury. In this study, we investigated whether the phenotype of MSFs can be modified by gene transfer into cells with properties of cardiomyocytes. To this end,... Abstract

Cited 194 times since 2007 (10.9 per year) source: EuropePMC

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Volume 48, Issue 7, 15 3 2007, Pages 1104-1111 Can LV dyssynchrony as assessed with phase analysis on gated myocardial perfusion SPECT predict response to CRT? Henneman MM, Chen J, Dibbets-Schneider P, Stokkel MP, Bleeker GB, Ypenburg C, van der Wall EE, Schalij MJ, Garcia EV, Bax JJ

Unlabelled: Cardiac resynchronization therapy (CRT) is now a well-recognized therapeutic option for patients with end-stage heart failure. However, not all patients respond to CRT, and, therefore, preimplantation identification of responders is desirable. The aim of the present study was to investigate whether the degree of left ventricular (LV) dyssynchrony, as assessed with phase analysis from gated myocardial perfusion SPECT (GMPS), can predict which patients will respond to CRT. Methods: For... Abstract

Cited 70 times since 2007 (3.9 per year) source: EuropePMC

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Volume 48, Issue 7, 15 3 2007, Pages 1135-1146 Assessment of myocardial viability in patients with heart failure. Schinkel AF, Poldermans D, Elhendy A, Bax JJ

The prognosis for patients with chronic ischemic left ventricular dysfunction is poor, despite advances in different therapies. Noninvasive assessment of myocardial viability may guide patient management. Multiple imaging techniques have been developed to assess viable and nonviable myocardium by evaluating perfusion, cell membrane integrity, mitochondria, glucose metabolism, scar tissue, and contractile reserve. PET, (201)Tl and (99m)Tc scintigraphy, and dobutamine stress echocardiography have... Abstract

Cited 17 times since 2007 (1 per year) source: EuropePMC

The American journal of cardiology, Volume 100, Issue 3, 14 2 2007, Pages 476-482 Usefulness of triplane tissue Doppler imaging to predict acute response to cardiac resynchronization therapy. Van de Veire NR, Bleeker GB, Ypenburg C, De Sutter J, Ajmone Marsan N, Holman ER, van der Wall EE, Schalij MJ, Bax JJ

This study evaluated the value of triplane tissue Doppler imaging (TDI) to predict acute response after cardiac resynchronization therapy (CRT). Forty-nine patients scheduled for CRT underwent triplane echocardiography with simultaneous TDI acquisition before and 48 hours after implantation. A 3-dimensional left ventricular (LV) volume was generated and LV volumes and ejection fraction were calculated. A parametric imaging technique, tissue synchronization imaging, was applied to portray the are... Abstract

Cited 271 times since 2007 (15.2 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 49, Issue 24, 4 1 2007, Pages 2303-2311 Outcome of pregnancy in women with congenital heart disease: a literature review. Drenthen W, Pieper PG, Roos-Hesselink JW, van Lottum WA, Voors AA, Mulder BJ, van Dijk AP, Vliegen HW, Yap SC, Moons P, Ebels T, van Veldhuisen DJ, ZAHARA Investigators

A search of peer-reviewed literature was conducted to identify reports that provide data on complications associated with pregnancy in women with structural congenital heart disease (CHD). This review describes the outcome of 2,491 pregnancies, including 377 miscarriages (15%) and 114 elective abortions (5%). Important cardiac complications were seen in 11% of the pregnancies. Obstetric complications do not appear to be more prevalent. In complex CHD, premature delivery rates are high, and more... Abstract

Cited 20 times since 2007 (1.1 per year) source: EuropePMC

Proceedings of the National Academy of Sciences of the United States of America, Volume 104, Issue 24, 4 1 2007, Pages 10000-10005 Global distribution of negative cofactor 2 subunit-alpha on human promoters. Albert TK, Grote K, Boeing S, Stelzer G, Schepers A, Meisterernst M

Negative cofactor 2 (NC2) forms a stable complex with TATA-binding protein (TBP) on promoters in vitro. Its association with TBP prevents the binding of TFIIB and leads to inhibition of preinitiation complex formation. Here, we investigate the association of NC2 subunit-alpha with human RNA polymerase II promoter regions by using gene-specific ChIP and genome-wide promoter ChIPchip analyses. We find NC2alpha associated with a large number of human promoters, where it peaks close to the core regi... Abstract

Cited 19 times since 2007 (1.1 per year) source: EuropePMC

Journal of the American Geriatrics Society, Volume 55, Issue 6, 1 1 2007, Pages 872-877 The routine electrocardiogram for cardiovascular risk stratification in old age: the Leiden 85-plus study. de Ruijter W, Westendorp RG, Macfarlane PW, Jukema JW, Assendelft WJ, Gussekloo J

Objectives: To explore the prognostic value of signs of prior myocardial infarction (MI) and atrial fibrillation (AF) on routine electrocardiograms (ECGs) at the age of 85 with respect to mortality and changes in functional status. Design: Observational, prospective cohort study with complete 6-year follow-up. Setting: General population. Participants: A population-based sample of 566 85-year-old participants (377 women, 189 men), without exclusion criteria. Measurements: Annual ECG recording an... Abstract

Cited 4 times since 2007 (0.2 per year) source: EuropePMC

Current opinion in anaesthesiology, Volume 20, Issue 3, 1 1 2007, Pages 254-260 Perioperative medical management of ischemic heart disease in patients undergoing noncardiac surgery. Feringa HH, Bax JJ, Poldermans D

Purpose of review: Cardiovascular disease is the leading cause of death after anesthesia and surgery. The preoperative identification of patients with underlying coronary artery disease is important to initiate appropriate treatment strategies in order to reduce the risk of perioperative complications. The current review will discuss new insights in the field of perioperative medicine that can be applied to clinical practice or stimulate further investigation. Recent findings: Recent findings in... Abstract

Cited 12 times since 2007 (0.7 per year) source: EuropePMC

Current opinion in anaesthesiology, Volume 20, Issue 3, 1 1 2007, Pages 274-278 Management of patients with cardiac stents undergoing noncardiac surgery. Schouten O, Bax JJ, Poldermans D

Purpose of review: Coronary stenting is performed in over 4 million patients annually. Approximately 5% of these patients undergo a noncardiac surgical procedure within 1 year after stenting. Surgery might induce hypercoagulability. This causes increased concern about the effects of previous coronary stenting on postoperative cardiac outcome, particularly in-stent thrombosis. On the other hand, patients with multiple cardiac risk factors are at high risk for postoperative adverse cardiac events... Abstract

Cited 37 times since 2007 (2.1 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 94, Issue 1, 31 5 2007, Pages 48-52 Gender influence on the diagnostic accuracy of 64-slice multislice computed tomography coronary angiography for detection of obstructive coronary artery disease. Pundziute G, Schuijf JD, Jukema JW, van Werkhoven JM, Boersma E, de Roos A, van der Wall EE, Bax JJ

Objective: To compare the diagnostic accuracy of 64-slice multislice computed tomography (MSCT) coronary angiography between female and male patients using conventional coronary angiography as the reference standard. Design: Diagnostic accuracy study. Setting: University hospital. Patients: 103 consecutive patients (51 men, 52 women, mean (SD) age 60 (10) years) with known and suspected coronary artery disease underwent 64-slice MSCT. Main outcome measures: Diagnostic accuracy of 64-slice MSCT t... Abstract

Cited 11 times since 2007 (0.6 per year) source: EuropePMC

Heart rhythm, Volume 4, Issue 9, 24 4 2007, Pages 1144-1148 Does left ventricular dyssynchrony immediately after acute myocardial infarction result in left ventricular dilatation? Mollema SA, Bleeker GB, Liem SS, Boersma E, van der Hoeven BL, Holman ER, van der Wall EE, Schalij MJ, Bax JJ

Background: Reverse remodeling of the left ventricle (LV) is one of the advantageous mechanisms of cardiac resynchronization therapy (CRT). Substantial LV dyssynchrony seems mandatory for echocardiographic response to CRT. Conversely, LV dyssynchrony early after acute myocardial infarction may result in LV dilatation during follow-up. Objective: The purpose of this study was to evaluate the relation between LV dyssynchrony early after acute myocardial infarction and the occurrence of long-term L... Abstract

Cited 68 times since 2007 (3.8 per year) source: EuropePMC

Journal of lipid research, Volume 48, Issue 8, 24 4 2007, Pages 1763-1771 Fenofibrate increases HDL-cholesterol by reducing cholesteryl ester transfer protein expression. van der Hoogt CC, de Haan W, Westerterp M, Hoekstra M, Dallinga-Thie GM, Romijn JA, Princen HM, Jukema JW, Havekes LM, Rensen PC

In addition to efficiently decreasing VLDL-triglycerides (TGs), fenofibrate increases HDL-cholesterol levels in humans. We investigated whether the fenofibrate-induced increase in HDL-cholesterol is dependent on the expression of the cholesteryl ester transfer protein (CETP). To this end, APOE*3-Leiden (E3L) transgenic mice without and with the human CETP transgene, under the control of its natural regulatory flanking regions, were fed a Western-type diet with or without fenofibrate. Fenofibrate... Abstract

Cited 81 times since 2007 (4.5 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 49, Issue 22, 23 4 2007, Pages 2204-2210 Usefulness of 64-slice multislice computed tomography coronary angiography to assess in-stent restenosis. Cademartiri F, Schuijf JD, Pugliese F, Mollet NR, Jukema JW, Maffei E, Kroft LJ, Palumbo A, Ardissino D, Serruys PW, Krestin GP, Van der Wall EE, de Feyter PJ, Bax JJ

Objectives: This study sought to evaluate the diagnostic accuracy of 64-slice multislice computed tomography (MSCT) coronary angiography in the follow-up of patients with previous coronary stent implantation. Background: Recent investigations have shown increased image quality and diagnostic accuracy for noninvasive coronary angiography with 64-slice MSCT as compared with previous-generation MSCT scanners, but data on the evaluation of coronary stents are scarce. Methods: In 182 patients (152 [8... Abstract

Cited 67 times since 2007 (3.7 per year) source: EuropePMC

The American journal of cardiology, Volume 100, Issue 2, 22 4 2007, Pages 316-320 Effect of statin withdrawal on frequency of cardiac events after vascular surgery. Schouten O, Hoeks SE, Welten GM, Davignon J, Kastelein JJ, Vidakovic R, Feringa HH, Dunkelgrun M, van Domburg RT, Bax JJ, Poldermans D

The discontinuation of statin therapy in patients with acute coronary syndromes has been associated with an increase of adverse coronary events. Patients who undergo major surgery frequently are not able to take oral medication shortly after surgery. Because there is no intravenous formula for statins, the interruption of statins in the postoperative period is a serious concern. The objective of this study was to assess the effect of perioperative statin withdrawal on postoperative cardiac outco... Abstract