6882 results
Cited 21 times since 2021 (5.7 per year)
source: EuropePMC
Journal of neurology,
Volume 269, Issue 3, 3 1 2021, Pages 1375-1385
The natural history of primary progressive aphasia: beyond aphasia.
Ulugut H, Stek S, Wagemans LEE, Jutten RJ, Keulen MA, Bouwman FH, Prins ND, Lemstra AW, Krudop W, Teunissen CE, van Berckel BNM, Ossenkoppele R, Barkhof F, van der Flier WM, Scheltens P, Pijnenburg YAL
Introduction: Primary progressive aphasia (PPA) is divided into three prototypical subtypes that are all characterized by their single core symptom of aphasia. Although later in their course, other cognitive, behavioral, and motor domains may become involved, little is known about the progression profile of each subtype relative to the other subtypes. Methods: In this longitudinal retrospective cohort study, based on the recent biomarker-supported diagnostic criteria, 24 subjects diagnosed with...
Abstract
Cited 2 times since 2021 (0.5 per year)
source: EuropePMC
Current health sciences journal,
Volume 47, Issue 3, 1 1 2021, Pages 331-337
An Examination of the Relationship between Fear of Coronavirus (COVID-19) in First Year Nursing Students and Their Attitudes to the Profession.
Yilmaz D, Yilmaz DU
This study was conducted with the aim of determining the fear of coronavirus (COVID-19) and attitudes to the profession in first year nursing students, and examining the relationship between them. The descriptive study was conducted in April and May 2021 with first year students at the Nursing Department of Bursa Uludağ University. The research sample consisted of 156 students who participated voluntarily in the study. A Student Description Form, a Coronavirus (COVID-19) Fear Scale and an Attitu...
Abstract
Cited 84 times since 2021 (22.8 per year)
source: EuropePMC
Cell reports,
Volume 36, Issue 4, 1 1 2021, Pages 109441
The Cancer SENESCopedia: A delineation of cancer cell senescence.
Jochems F, Thijssen B, De Conti G, Jansen R, Pogacar Z, Groot K, Wang L, Schepers A, Wang C, Jin H, Beijersbergen RL, Leite de Oliveira R, Wessels LFA, Bernards R
Cellular senescence is characterized as a stable proliferation arrest that can be triggered by multiple stresses. Most knowledge about senescent cells is obtained from studies in primary cells. However, senescence features may be different in cancer cells, since the pathways that are involved in senescence induction are often deregulated in cancer. We report here a comprehensive analysis of the transcriptome and senolytic responses in a panel of 13 cancer cell lines rendered senescent by two dis...
Abstract
Cited 380 times since 2021 (103.3 per year)
source: EuropePMC
European heart journal,
Volume 42, Issue 25, 1 1 2021, Pages 2439-2454
SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe.
SCORE2 working group and ESC Cardiovascular risk collaboration
Aims: The aim of this study was to develop, validate, and illustrate an updated prediction model (SCORE2) to estimate 10-year fatal and non-fatal cardiovascular disease (CVD) risk in individuals without previous CVD or diabetes aged 40-69 years in Europe. Methods and results: We derived risk prediction models using individual-participant data from 45 cohorts in 13 countries (677 684 individuals, 30 121 CVD events). We used sex-specific and competing risk-adjusted models, including age, smoking s...
Abstract
Cited 9 times since 2021 (2.4 per year)
source: EuropePMC
Proceedings of the National Academy of Sciences of the United States of America,
Volume 118, Issue 27, 1 1 2021, Pages e2102026118
Multiscale mechanics and temporal evolution of vimentin intermediate filament networks.
Schepers AV, Lorenz C, Nietmann P, Janshoff A, Klumpp S, Köster S
The cytoskeleton, an intricate network of protein filaments, motor proteins, and cross-linkers, largely determines the mechanical properties of cells. Among the three filamentous components, F-actin, microtubules, and intermediate filaments (IFs), the IF network is by far the most extensible and resilient to stress. We present a multiscale approach to disentangle the three main contributions to vimentin IF network mechanics-single-filament mechanics, filament length, and interactions between fil...
Abstract
Cited 2 times since 2021 (0.5 per year)
source: EuropePMC
Cardiovascular research,
Volume 117, Issue 8, 1 1 2021, Pages 1923-1934
Impaired cytoplasmic domain interactions cause co-assembly defect and loss of function in the p.Glu293Lys KNCJ2 variant isolated from an Andersen-Tawil syndrome patient.
Déri S, Borbás J, Hartai T, Hategan L, Csányi B, Visnyovszki Á, Madácsy T, Maléth J, Hegedűs Z, Nagy I, Arora R, Labro AJ, Környei L, Varró A, Sepp R, Ördög B
Aims: Subunit interactions at the cytoplasmic domain interface (CD-I) have recently been shown to control gating in inward rectifier potassium channels. Here we report the novel KCNJ2 variant p.Glu293Lys that has been found in a patient with Andersen-Tawil syndrome type 1 (ATS1), causing amino acid substitution at the CD-I of the inward rectifier potassium channel subunit Kir2.1. Neither has the role of Glu293 in gating control been investigated nor has a pathogenic variant been described at thi...
Abstract
Cited 3 times since 2021 (0.8 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 60, Issue 1, 1 1 2021, Pages 7-33
Consensus document on optimal management of patients with common arterial trunk.
Hazekamp MG, Barron DJ, Dangel J, Homfray T, Jongbloed MRM, Voges I, ESC Scientific Document Group
Abstract
Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists,
Volume 28, Issue 6, 30 5 2021, Pages 852-859
Functional Performance After Complex Endovascular Aortic Repair: A Single-Center Retrospective Cohort Study.
Warmerdam BWCM, van Holstein Y, Eefting D, van Rijswijk CSP, van der Meer RW, Mooijaart SP, Hamming JF, van der Vorst JR, van Schaik J
Purpose: Complex endovascular aortic repair (EVAR) procedures provide a treatment option for patients with aortic aneurysms involving visceral branches. Good technical results and short-term outcomes have been reported. Whether complex EVAR provides acceptable functional outcomes is not clear. The current study aims to describe postoperative functional outcomes in complex EVAR patients-an older and relatively frail patient group. Materials and methods: A single-center retrospective cohort study...
Abstract
Cited 4 times since 2021 (1.1 per year)
source: EuropePMC
Journal of cellular and molecular medicine,
Volume 25, Issue 16, 30 5 2021, Pages 7772-7782
Phosphorylcholine antibodies restrict infarct size and left ventricular remodelling by attenuating the unreperfused post-ischaemic inflammatory response.
Pluijmert NJ, de Jong RCM, de Vries MR, Pettersson K, Atsma DE, Jukema JW, Quax PHA
Phosphorylcholine is a pro-inflammatory epitope exposed on apoptotic cells, and phosphorylcholine monoclonal immunoglobulin (Ig)G antibodies (PC-mAb) have anti-inflammatory properties. In this study, we hypothesize that PC-mAb treatment reduces adverse cardiac remodelling and infarct size (IS) following unreperfused transmural myocardial infarction (MI). Unreperfused MI was induced by permanent ligation of the left anterior descending (LAD) coronary artery in hypercholesterolaemic APOE*3-Leiden...
Abstract
Cited 12 times since 2021 (3.3 per year)
source: EuropePMC
Radiology,
Volume 300, Issue 3, 29 5 2021, Pages 549-556
Relationship of Endothelial Shear Stress with Plaque Features with Coronary CT Angiography and Vasodilating Capability with PET.
Kalykakis GE, Antonopoulos AS, Pitsargiotis T, Siogkas P, Exarchos T, Kafouris P, Sakelarios A, Liga R, Tzifa A, Giannopoulos A, Scholte AJHA, Kaufmann PA, Parodi O, Knuuti J, Fotiadis DI, Neglia D, Anagnostopoulos CD
Background Advances in three-dimensional reconstruction techniques and computational fluid dynamics of coronary CT angiography (CCTA) data sets make feasible evaluation of endothelial shear stress (ESS) in the vessel wall. Purpose To investigate the relationship between CCTA-derived computational fluid dynamics metrics, anatomic and morphologic characteristics of coronary lesions, and their comparative performance in predicting impaired coronary vasodilating capability assessed by using PET myoc...
Abstract
Cited 5 times since 2021 (1.4 per year)
source: EuropePMC
Thrombosis journal,
Volume 19, Issue 1, 27 4 2021, Pages 45
Differential effect of statin use on coagulation markers: an active comparative analysis in the NEO study.
Bordbar M, de Mutsert R, Cevval M, Rosendaal FR, Jukema JW, Lijfering WM
Background: Statins are a potential treatment for venous thromboembolism (VTE) prophylaxis complementary to conventional anticoagulants without associated bleeding complications. This study aimed to compare pro-thrombotic activities of different classes of lipid-lowering drugs in an active comparator design and determine whether there is a relation between statin versus fibrate/niacin use and pro-coagulant factor outcomes. Methods: This is a cross-sectional analysis of participants from the Neth...
Abstract
Cited 3 times since 2021 (0.8 per year)
source: EuropePMC
International journal of cardiology. Heart & vasculature,
Volume 35, 25 4 2021, Pages 100830
Elevated resting heart rate is a marker of subclinical left ventricular dysfunction in hodgkin lymphoma survivors.
Heemelaar JC, Krol ADG, Louwerens M, L M A Beeres S, Holman ER, Schalij MJ, Louisa Antoni M
Background: Thoracic irradiation is one of the cornerstones of Hodgkin lymphoma (HL) treatment, which contributes to high rates of long-term survivorship, but begets a life-long increased risk of heart disease including heart failure. At the cardio-oncology (CO) clinic, persistent sinus tachycardia or elevated resting heart rate (RHR) is frequently observed in these patients. The aim of this study was to evaluate the relation between RHR and left ventricular (LV) dysfunction. Methods: In 75 HL s...
Abstract
Cited 7 times since 2021 (1.9 per year)
source: EuropePMC
Annals of vascular surgery,
Volume 78, 25 4 2021, Pages 281-287
Assessment of Tissue Viability Following Amputation Surgery Using Near-Infrared Fluorescence Imaging With Indocyanine Green.
Van Den Hoven P, Van Den Berg SD, Van Der Valk JP, Van Der Krogt H, Van Doorn LP, Van De Bogt KEA, Van Schaik J, Schepers A, Vahrmeijer AL, Hamming JF, Van Der Vorst JR
Background: Patients with chronic limb threatening ischemia have a risk of undergoing a major amputation within 1 year of nearly 30% with a substantial risk of re-amputation since wound healing is often impaired. Quantitative assessment of regional tissue viability following amputation surgery can identify patients at risk for impaired wound healing. In quantification of regional tissue perfusion, near-infrared (NIR) fluorescence imaging using Indocyanine Green (ICG) seems promising. Methods: Th...
Abstract
Cited 3 times since 2021 (0.8 per year)
source: EuropePMC
Frontiers in cardiovascular medicine,
Volume 8, 24 4 2021, Pages 668503
Computed Tomography Derived Coronary Triangulated Orifice Area-Deduction of a New Parameter for Follow-up After Surgical Correction of Anomalous Aortic Origin of Coronary Arteries and Call for Validation.
Meijer FMM, Kiès P, Verheijen DBH, Vliegen HW, Jongbloed MRM, Hazekamp MG, Lamb HJ, Egorova AD
Introduction: Anomalous aortic origin of a coronary artery (AAOCA) from the opposite sinus of Valsalva is a rare congenital abnormality. Computed tomography angiography (CTA) is primarily used as a diagnostic tool to evaluate the anatomy and identify potentially malignant AAOCA variants. Limited data is available on the role of CTA during postoperative follow-up. We aimed to develop an objective CTA derived parameter for diagnostic evaluation and follow-up after surgical correction of AAOCA and...
Abstract
Cited 2 times since 2021 (0.5 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 37, Issue 11, 23 4 2021, Pages 3313-3322
Quantification of myocardial ischemia and subtended myocardial mass at adenosine stress cardiac computed tomography: a feasibility study.
van Driest FY, van der Geest RJ, Broersen A, Dijkstra J, El Mahdiui M, Jukema JW, Scholte AJHA
Combination of coronary computed tomography angiography (CCTA) and adenosine stress CT myocardial perfusion (CTP) allows for coronary artery lesion assessment as well as myocardial ischemia. However, myocardial ischemia on CTP is nowadays assessed semi-quantitatively by visual analysis. The aim of this study was to fully quantify myocardial ischemia and the subtended myocardial mass on CTP. We included 33 patients referred for a combined CCTA and adenosine stress CTP protocol, with good or excel...
Abstract
Cited 5 times since 2021 (1.4 per year)
source: EuropePMC
The American journal of cardiology,
Volume 153, 22 4 2021, Pages 30-35
Prevalence of Aortic Valve Stenosis in Patients With ST-Segment Elevation Myocardial Infarction and Effect on Long-Term Outcome.
Singh GK, van der Bijl P, Goedemans L, Vollema EM, Abou R, Ajmone Marsan N, Bax JJ, Delgado V
Several studies have shown an association between aortic valve stenosis (AS), atherosclerosis and cardiovascular risk factors. These risk factors are frequently encountered in patients with ST-segment elevation myocardial infarction (STEMI). The aim of this study was to evaluate the prevalence and the prognostic implications of AS in patients presenting with STEMI. A total of 2041 patients (61 ± 12 years old, 76% male) admitted with STEMI and treated with primary percutaneous coronary interventi...
Abstract
Cited 16 times since 2021 (4.3 per year)
source: EuropePMC
BMC medicine,
Volume 19, Issue 1, 22 4 2021, Pages 139
Association of statin use in older people primary prevention group with risk of cardiovascular events and mortality: a systematic review and meta-analysis of observational studies.
Awad K, Mohammed M, Zaki MM, Abushouk AI, Lip GYH, Blaha MJ, Lavie CJ, Toth PP, Jukema JW, Sattar N, Banach M, Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group and the International Lipid Expert Panel (ILEP)
Background: Current evidence from randomized controlled trials on statins for primary prevention of cardiovascular disease (CVD) in older people, especially those aged > 75 years, is still lacking. We conducted a systematic review and meta-analysis of observational studies to extend the current evidence about the association of statin use in older people primary prevention group with risk of CVD and mortality. Methods: PubMed, Scopus, and Embase were searched from inception until March 18, 20...
Abstract
Cited 5 times since 2021 (1.4 per year)
source: EuropePMC
Molecular cancer research : MCR,
Volume 19, Issue 10, 22 4 2021, Pages 1613-1621
Identification of Autophagy-Related Genes as Targets for Senescence Induction Using a Customizable CRISPR-Based Suicide Switch Screen.
Schepers A, Jochems F, Lieftink C, Wang L, Pogacar Z, Leite de Oliveira R, De Conti G, Beijersbergen RL, Bernards R
Pro-senescence therapies are increasingly being considered for the treatment of cancer. Identifying additional targets to induce senescence in cancer cells could further enable such therapies. However, screening for targets whose suppression induces senescence on a genome-wide scale is challenging, as senescent cells become growth arrested, and senescence-associated features can take 1 to 2 weeks to develop. For a screen with a whole-genome CRISPR library, this would result in billions of undesi...
Abstract
Cited 7 times since 2021 (1.9 per year)
source: EuropePMC
ESC heart failure,
Volume 8, Issue 5, 22 4 2021, Pages 3512-3520
Identification of sex-specific biomarkers predicting new-onset heart failure.
Raafs A, Verdonschot J, Ferreira JP, Wang P, Collier T, Henkens M, Björkman J, Boccanelli A, Clark AL, Delles C, Diez J, González A, Girerd N, Jukema JW, Pinet F, Rossignol P, Thum T, Vodovar N, de Boer RA, van Empel V, Staessen JA, Hazebroek M, Cleland J, Zannad F, Heymans S
Aims: Heart failure (HF) is common in both men and women, yet disease pathophysiology, presentation, and progression differ between sexes. Studies addressing whether biomarkers predict new onset HF sex-specifically are scarce. This study therefore aims to test the sex-specificity of 252 protein biomarkers for new-onset HF. Methods and results: A matched case-control design in patients selected from cohorts within the HOMAGE consortium was used. Cases (new-onset HF, n = 562) and controls (n = 780...
Abstract
Cited 3 times since 2021 (0.8 per year)
source: EuropePMC
The Journal of dermatological treatment,
Volume 33, Issue 4, 21 3 2021, Pages 1986-1989
Eczema control and treatment satisfaction in atopic dermatitis patients treated with dupilumab - a cross-sectional study from the BioDay registry.
Oosterhaven JAF, Spekhorst LS, Zhang J, Voorberg AN, Romeijn GLE, Boesjes CM, de Graaf M, de Bruin-Weller MS, Schuttelaar MLA
Background: Eczema control is a new construct to be measured in atopic dermatitis (AD). Objectives: Measuring patient-perceived eczema control and treatment satisfaction in AD patients, treated with dupilumab between 16 and 52 weeks. Methods: Cross-sectional questionnaire study. Patients from the Dutch BioDay registry completed the Atopic Dermatitis Control Test (ADCT), Recap of Atopic Eczema (RECAP) and Treatment Satisfaction Questionnaire for Medication, Version II (TSQM v. II), along with oth...
Abstract
