9562 results
The Journal of invasive cardiology,
7 1 2025
Vascular access and mortality outcomes: insights from the Percutaneous Coronary Interventions registry from the Netherlands Heart Registration.
Karalis I, Timmermans MJ, Tuccillo A, Jukema JW, Derks L, Verbeek EC, Amoroso G, PCI Registration Committee of the Netherlands Heart Registration (NHR)
Objectives: While the transradial approach (TRA) is associated with fewer bleeding complications than the transfemoral approach (TFA), its effect on mortality outcomes in real-world clinical practice remains unclear. This study examines the relationship between vascular access site and mortality in patients undergoing percutaneous coronary intervention (PCI). Methods: This retrospective cohort study used prospectively collected data from the Netherlands Heart Registration, including 130,813 PCI...
Abstract
Multiple sclerosis (Houndmills, Basingstoke, England),
6 1 2025, Pages 13524585251386217
Epigenetic age and telomere length correlations in pediatric-onset multiple sclerosis.
Yang JH, Race J, Sumowski P, Jacques K, Fardad S, Fair A, Hazlett A, Lin J, Yilmaz D, Aaen G, Abrams A, Benson L, Casper TC, Chitnis T, Gorman M, Lotze T, Krupp L, Mar S, Ness J, Rensel M, Rose J, Schreiner T, Tillema JM, Waldman A, Wheeler Y, Barcellos LF, Waubant E, Graves JS
Background: Age is the strongest factor determining disease expression in multiple sclerosis (MS). We previously demonstrated biological age acceleration in pediatric-onset MS (POMS) compared to controls with both epigenetic clocks (DNAm) and telomere length (TL). It is unknown whether these markers report overlapping or distinct aging-related processes. Objectives: To determine the correlation between DNAm and TL aging markers. Methods: We conducted a cross-sectional case-control study within t...
Abstract
Journal of the American Heart Association,
Volume 14, Issue 22, 6 1 2025, Pages e040726
Prognostic Value of a Coronary Computed Tomography Angiography-Derived Ischemia Algorithm: Comparison Against Hybrid Coronary Computed Tomography Angiography/Positron Emission Tomography Imaging.
Maaniitty T, Bär S, Nabeta T, Bax JJ, Saraste A, Knuuti J
Background: Artificial intelligence-guided quantitative computed tomography ischemia (AI-QCTischemia) is a novel machine-learning method for predicting myocardial ischemia from coronary computed tomography angiography (CCTA). This observational cohort study aimed to compare the long-term prognostic value of AI-QCTischemia with hybrid CCTA/positron emission tomography (PET) myocardial perfusion imaging in suspected coronary artery disease (CAD). Methods: Symptomatic patients with suspected CAD un...
Abstract
Open heart,
Volume 12, Issue 2, 5 1 2025, Pages e003630
Trends and risk factors of stroke and mortality after transcatheter aortic valve implantation in the Netherlands.
van Putten SE, Hegeman RRMJJ, Timmers L, Overduin DC, Nieuwkerk PT, Peper J, Roefs MM, Sonker U, Rensing BJWM, Swaans MJ, Klautz RJM, Ten Berg J, Klein P, THI Registration Committee of the Netherlands Heart Registration
Background: Stroke after transcatheter aortic valve implantation (TAVI) is an infrequent but serious complication with important impact on morbidity and mortality. Contemporary real-world evidence on the risk factors of early stroke after TAVI is scarce. We aimed to evaluate the incidence, temporal trends and predictors of in-hospital stroke after TAVI and to assess its association with mortality. Methods: We conducted a retrospective, observational cohort study using data from the Netherlands H...
Abstract
Journal of manipulative and physiological therapeutics,
5 1 2025, Pages S0161-4754(25)00063-6
Effectiveness of Thoracic Spine Manipulation for Upper Quadrant Musculoskeletal Disorders: A Systematic Review.
Thoomes EJ, Tilborghs G, Heneghan NR, Falla D, De Graaf M
Objective: Thoracic high-velocity low-amplitude thrust (Tx-HVLAT) manipulation is a form of conservative management recommended as an effective treatment option for patients with upper quadrant musculoskeletal disorders (UQMD). This systematic review aimed to update the current evidence on the effectiveness of Tx-HVLAT for patients with UQMD on pain, disability, and performance outcome measures. Methods: Electronic libraries of the Cochrane Controlled Trials Register, MEDLINE, EMBASE, CINAHL, PE...
Abstract
Clinical genitourinary cancer,
Volume 24, Issue 1, 4 1 2025, Pages 102464
Recurrence Patterns in a Large Contemporary Cohort of Patients With Non-Muscle Invasive Bladder Cancer.
Hof JP, Kiemeney LALM, Aben KKH, van der Heijden AG, Vrieling A, Vermeulen SH
Aim: Patients with NMIBC frequently experience recurrences. Yet, the timing and characteristics of subsequent recurrences are understudied. We aim to describe subsequent recurrences in a large, contemporary, population-based cohort. Methods: We included 1915 patients from the UroLife study and the Nijmegen Bladder Cancer Study, diagnosed with primary NMIBC between 2011 and 2021. The conditional 1-, 3- and 5-year risks of first to fourth recurrence were calculated using Kaplan-Meier risks, strati...
Abstract
BMJ open,
Volume 15, Issue 11, 4 1 2025, Pages e105053
Prevention of postamputation pain with targeted muscle reinnervation (PreventPAP trial): protocol for a national, multicentre, randomised, sham-controlled trial.
Tendijck GAH, van Schaik J, Dijkman RR, Niesters M, van Zwet EW, van den Hout WB, Ploeg AJ, van Rijt WG, de Ruiter GCW, Coert JH, Duraku LS, Zuidam JM, van de Water W, Pondaag W, van der Krogt H, Groen JL, PreventPAP consortium
Introduction: In the Netherlands, approximately 2200 major amputations of the lower extremities are performed each year, the majority in vascular patients. Around 61% of these patients will develop postamputation pain (PAP). PAP is a severe, lifelong, disabling condition profoundly affecting quality of life. During amputations, the common practice is to cut the nerves without employing nerve-surgical techniques to prevent chronic pain due to neuroma formation. In recent years, targeted muscle re...
Abstract
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery,
4 1 2025, Pages S1078-5884(25)01046-9
Role of Epidural Anaesthesia in Elective Open Abdominal Aortic Aneurysm Repair: Secondary Analysis of a Randomised Trial.
Steunenberg TAH, Eberl S, Wiersema AM, Roosendaal LC, Hoebink M, Jongkind V, ACTION-1 Investigators
Objective: Using peri-operative epidural anaesthesia (PEA) during elective open abdominal aortic aneurysm (AAA) repair is debated by surgeons and anaesthesiologists. This study aimed to evaluate the clinical benefits and risks of PEA in patients undergoing elective open AAA repair. Methods: This exploratory post hoc analysis of the ACTION-1 trial (NCT04061798), a multicentre, international, single blinded, randomised controlled trial designed to compare heparinisation strategies during elective...
Abstract
Open medicine (Warsaw, Poland),
Volume 20, Issue 1, 4 1 2025, Pages 20251272
Effect of vibration on pain during subcutaneous heparin injection: A randomized, single-blind, placebo-controlled trial.
Yılmaz D, Güney BG
Objectives: The administration of subcutaneous low molecular weight heparin (LMWH) injections frequently causes injection pain, disrupting the comfort of patients. No studies were found evaluating the effect of the application of local vibration in the management of pain relating to subcutaneous LMWH injection. The aim of this study is to examine the effect on injection pain of the local vibration technique applied to the injection site during subcutaneous LMWH injection. Methods: The patients w...
Abstract
Proceedings of the National Academy of Sciences of the United States of America,
Volume 122, Issue 45, 3 1 2025, Pages e2506145122
Parental investment and body temperature explain encephalization in vertebrates.
Song Z, Griesser M, van Schaik CP
The systematic variation in relative brain size among vertebrate classes remains poorly understood. Here, based on the expensive brain hypothesis, we propose that two broad constraints explain much of the variation: 1) the ability to produce large offspring, and so provide them with the energy required for constructing larger brains, and 2) the ability to sustain continuously high body temperatures, because cooler and varying brain temperatures reduce brain performance and thus fitness. We there...
Abstract
American heart journal,
Volume 292, 3 1 2025, Pages 107295
Evolocumab before percutaneous coronary intervention for acute myocardial infarction: Design of the AMUNDSEN trial.
Montalescot G, Bolognese L, Bartus S, Cequier-Fillat A, Thiele H, Mach F, Jukema JW, Ferrari E, Souteyrand G, Bouleti C, Range G, Chioccioli M, Picchi A, Batias-Moreau L, Esposito G, Braik N, Redjimi N, Duband B, Guedeney P, Zeitouni M, Brochard K, Silvain J, Vicaut E, AMUNDSEN investigators of the ACTION Study Group
Rationale: PCSK9 inhibitors are currently recommended as third-line therapy for post-myocardial infarction (MI) patients, added to high-dose statin, ezetimibe, and potentially bempedoic acid when the LDL-C target of
Abstract
Cited 23 times since 2025 (299 per year)
source: EuropePMC
European heart journal,
Volume 46, Issue 44, 1 1 2025, Pages 4635-4736
2025 ESC/EACTS Guidelines for the management of valvular heart disease.
Praz F, Borger MA, Lanz J, Marin-Cuartas M, Abreu A, Adamo M, Ajmone Marsan N, Barili F, Bonaros N, Cosyns B, De Paulis R, Gamra H, Jahangiri M, Jeppsson A, Klautz RJM, Mores B, Pérez-David E, Pöss J, Prendergast BD, Rocca B, Rossello X, Suzuki M, Thiele H, Tribouilloy CM, Wojakowski W, ESC/EACTS Scientific Document Group
Abstract
Journal of Crohn's & colitis,
Volume 19, Issue 10, 1 1 2025, Pages jjaf176
How long is long enough? Timing of pre-conceptional remission predicts relapse risk during pregnancy in IBD.
Bouwknegt DG, Hoekstra B, Donker HC, van Es B, Groen H, Dijkstra G, van Dop WA, Tauber T, van der Woude CJ, Visschedijk MC, Dutch Initiative on Crohn and Colitis (ICC)
Background and aims: Inflammatory bowel disease (IBD) often coincides with pregnancy, and disease activity during pregnancy increases the risk of adverse outcomes. We aimed to determine how disease course before conception influences relapse risk during pregnancy, adjusting for established risk factors. Methods: In this multicenter, retrospective cohort study, we included adult women with IBD who were pregnant during treatment at one of three university hospitals between 2017 and 2022. Using gen...
Abstract
Inflammatory bowel diseases,
Volume 31, Issue 11, 1 1 2025, Pages 3051-3059
Food Compounds Associated With Disease Activity in Inflammatory Bowel Disease.
Meima M, Westerhout J, Meijerink M, Bijlsma S, van Schaik F, Oldenburg B, Houben G
Background: Diet plays a modulatory role in inflammatory bowel disease (IBD), but specific relevant dietary factors have yet to be identified. To advance our understanding, we performed multivariate analyses of food compound intakes using dietary data from an IBD cohort. Methods: We used dietary and disease status data from IBD patients at the University Medical Center Utrecht, The Netherlands. Intake levels for 768 compounds from 135 patients were calculated. Using random forest analyses, we ex...
Abstract
Annals of vascular surgery,
Volume 123, 1 1 2025, Pages 502-513
Rupture Risk of Large Abdominal Aortic Aneurysms: A Scoping Review.
Paping JHM, Bulder RMA, Lancaster E, Chang RW, Putter H, Hamming JF, Lindeman JH
Background: Abdominal aortic aneurysm (AAA) management is currently dictated by the 55 mm intervention threshold. While it has been suggested that this intervention threshold is too conservative, the rupture risk of AAAs larger than 55 mm is discussed differently. This scoping review aims to critically summarize and review the available evidence with respect to the rupture risk of larger AAA. Methods: A quantitative and qualitative evaluation of the available literature on the rupture risk of la...
Abstract
Journal of cellular and molecular medicine,
Volume 29, Issue 21, 1 1 2025, Pages e70933
Breaking (Light) Barriers: Photoacoustics in Atherosclerotic Diseases.
van Dijk K, de Vries MR
Photoacoustic imaging (PAI) is an emerging imaging modality that provides high-resolution, spatiotemporal insights into anatomical structures, functional parameters and molecular characteristics of tissues. By leveraging both endogenous absorbers, such as lipids and collagen, and exogenous contrast agents like nanoparticles and molecular dyes, PAI offers a comprehensive approach to characterising atherosclerosis. This review describes the technical principles underlying various PAI modalities an...
Abstract
Journal of cardiac failure,
Volume 31, Issue 11, 1 1 2025, Pages 1661-1671
Diagnosing HFpEF in Patients With Unexplained Dyspnea by Using Invasive Left Ventricular Pressure-Volume Loops.
Gessner R, Hübner AC, Stöbe S, Rudolph UM, Unger L, Schmeisser A, Steendijk P, Uhe T, Stegmann T, Lavall D, Hagendorff A, Laufs U, Wachter R
Background: Diagnosing heart failure with preserved ejection fraction (HFpEF) remains challenging. Noninvasive diagnostic algorithms have been proposed but not tested against the gold standard, ie, invasive measurement of left ventricular (LV) pressure-volume loops (PVL). This study's aim was to estimate the prevalence of HFpEF in euvolemic patients with unexplained exertional dyspnea by using LV PVL and to validate noninvasive diagnostic algorithms. Methods and results: We included patient...
Abstract
The British journal of surgery,
Volume 112, Issue 11, 1 1 2025, Pages znaf189
Colorectal-vaginal fistula after rectal cancer resection: international comparative cohort study of characteristics and treatment.
van Lieshout ML, Lemmens JMG, Greijdanus NG, Wienholts K, Ubels S, Talboom K, Hannink G, Wolthuis A, de Lacy FB, Lefevre JH, Solomon M, Frasson M, Rotholtz N, Denost Q, Perez RO, Konishi T, Panis Y, Rutegård M, Hompes R, van Workum F, Tanis PJ, de Wilt JHW, TENTACLE–Rectum Collaborative Group
Abstract
Cited 1 times since 2025 (13 per year)
source: EuropePMC
European heart journal,
Volume 46, Issue 43, 1 1 2025, Pages 4462-4568
2025 ESC Guidelines for the management of cardiovascular disease and pregnancy.
De Backer J, Haugaa KH, Hasselberg NE, de Hosson M, Brida M, Castelletti S, Cauldwell M, Cerbai E, Crotti L, de Groot NMS, Estensen ME, Goossens ES, Haring B, Kurpas D, McEniery CM, Peters SAE, Rakisheva A, Sambola A, Schlager O, Schoenhoff FS, Simoncini T, Steinbach F, Sudano I, Swan L, Valente AM, ESC Scientific Document Group
Abstract
The British journal of surgery,
Volume 112, Issue 11, 1 1 2025, Pages znaf177
The science and art of decision-making in surgery.
Bisset CN, Baigrie R, Dames N, Corbett S, Hill S, Macdermid E, Sier VQ, van der Vorst JR, Rehman U, Sarwar MS, Brennan PA, Cleland J, Ellis R, Bryan JE, Ketley A, Morgan JL, Gogalniceanu P, Kaafarani HMA, Liang R, Moug SJ
Abstract
