Research

Publications

Below you can find a list of our published research.

6190 results

Cited 371 times since 2016 (40 per year) source: EuropePMC

Nature communications, Volume 7, 21 3 2016, Pages 10023 Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. Pattaro C, Teumer A, Gorski M, Chu AY, Li M, Mijatovic V, Garnaas M, Tin A, Sorice R, Li Y, Taliun D, Olden M, Foster M, Yang Q, Chen MH, Pers TH, Johnson AD, Ko YA, Fuchsberger C, Tayo B, Nalls M, Feitosa MF, Isaacs A, Dehghan A, d'Adamo P, Adeyemo A, Dieffenbach AK, Zonderman AB, Nolte IM, van der Most PJ, Wright AF, Shuldiner AR, Morrison AC, Hofman A, Smith AV, Dreisbach AW, Franke A, Uitterlinden AG, Metspalu A, Tonjes A, Lupo A, Robino A, Johansson Å, Demirkan A, Kollerits B, Freedman BI, Ponte B, Oostra BA, Paulweber B, Krämer BK, Mitchell BD, Buckley BM, Peralta CA, Hayward C, Helmer C, Rotimi CN, Shaffer CM, Müller C, Sala C, van Duijn CM, Saint-Pierre A, Ackermann D, Shriner D, Ruggiero D, Toniolo D, Lu Y, Cusi D, Czamara D, Ellinghaus D, Siscovick DS, Ruderfer D, Gieger C, Grallert H, Rochtchina E, Atkinson EJ, Holliday EG, Boerwinkle E, Salvi E, Bottinger EP, Murgia F, Rivadeneira F, Ernst F, Kronenberg F, Hu FB, Navis GJ, Curhan GC, Ehret GB, Homuth G, Coassin S, Thun GA, Pistis G, Gambaro G, Mal

Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that... Abstract

Cited 3 times since 2016 (0.3 per year) source: EuropePMC

Atherosclerosis, Volume 246, 19 3 2016, Pages 267-273 Serum CETP concentration is not associated with measures of body fat: The NEO study. Blauw LL, de Mutsert R, Lamb HJ, de Roos A, Rosendaal FR, Jukema JW, Wang Y, van Dijk KW, Rensen PC

Introduction: Adipose tissue has been postulated to contribute substantially to the serum cholesteryl ester transfer protein (CETP) pool. However, in a recent large cohort study waist circumference was not associated with plasma CETP. The aim of the present study was to further examine associations of accurate measures of body fat and body fat distribution with serum CETP concentration. Methods: In this cross-sectional analysis of the Netherlands Epidemiology of Obesity study, we examined in 660... Abstract

Cited 21 times since 2016 (2.3 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 49, Issue 6, 19 3 2016, Pages 1699-1704 Stentless bioprostheses: a versatile and durable solution in extensive aortic valve endocarditis. Schneider AW, Hazekamp MG, Versteegh MI, Bruggemans EF, Holman ER, Klautz RJ, Braun J

Objectives: Infective endocarditis of the aortic valve with local aortic root destruction requires radical resection of infected tissues and subsequent reconstruction of periannular structures and the left ventricular outflow tract (LVOT). Homografts or stentless bioprostheses are recommended for use in this specific patient group. The Freestyle stentless bioprosthesis is a porcine aortic root prosthesis, which approaches the surgical versatility of the homograft, but has the advantage of ready... Abstract

Cited 4 times since 2016 (0.4 per year) source: EuropePMC

European heart journal, Volume 37, Issue 28, 18 3 2016, Pages 2272-2275 Does computed tomography detect bioprosthetic aortic valve thrombosis? New findings, new questions? Bax JJ, Delgado V, Prendergast B

Abstract

Cited 75 times since 2016 (8.1 per year) source: EuropePMC

European heart journal, Volume 37, Issue 43, 18 3 2016, Pages 3285-3290 Genotype impacts survival in Marfan syndrome. Franken R, Groenink M, de Waard V, Feenstra HM, Scholte AJ, van den Berg MP, Pals G, Zwinderman AH, Timmermans J, Mulder BJ

Aims: The aorta in Marfan syndrome (MFS) patients is variably affected. We investigated the assumed genotype-effect on protein production as a risk factor for a severe aortic phenotype in adult MFS patients. Methods and results: We collected clinical and genetic data from all 570 adults with MFS who had been included in the Dutch CONgenital CORvitia registry since the start in 2001. Mean age was 36.5 ± 13.5 years (51.2% male, 28.9% prior aortic surgery, 8.2% prior aortic dissection). Patients we... Abstract

Cited 2 times since 2016 (0.2 per year) source: EuropePMC

Journal of electrocardiology, Volume 49, Issue 3, 13 2 2016, Pages 316-322 Subtraction electrocardiography: Detection of ischemia-induced ST displacement without the need to identify the J point. Ter Haar CC, Man SC, Maan AC, Schalij MJ, Swenne CA

Background: When triaging a patient with acute chest pain at first medical contact, an electrocardiogram (ECG) is routinely made and inspected for signs of myocardial ischemia. The guidelines recommend comparison of the acute and an earlier-made ECG, when available. No concrete recommendations for this comparison exist, neither is known how to handle J-point identification difficulties. Here we present a J-point independent method for such a comparison. Methods: After conversion to vectorcardiog... Abstract

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 49, Issue 5, 5 1 2016, Pages 1426-1427 Down-sizing of cryopreserved homografts is a valuable technique, but do not make them too small. Koolbergen DR

Abstract

Cited 18 times since 2016 (1.9 per year) source: EuropePMC

European journal of heart failure, Volume 18, Issue 5, 4 1 2016, Pages 469-481 Diagnosis and management of aortic valve stenosis in patients with heart failure. Kamperidis V, Delgado V, van Mieghem NM, Kappetein AP, Leon MB, Bax JJ

Aortic stenosis (AS) is the most frequent degenerative valvular heart disease in Western countries and its prevalence increases in parallel with the ageing process of the population. Heart failure (HF), defined by the presence of reduced left ventricular ejection fraction, may be present in up to a quarter of patients with severe AS, posing diagnostic and management challenges. The present article reviews the prevalence of HF in severe AS patients, discusses the diagnostic challenges and the adv... Abstract

Cited 3 times since 2016 (0.3 per year) source: EuropePMC

European heart journal, Volume 37, Issue 8, 3 1 2016, Pages 667-675 The year in cardiology 2015: imaging. Gaemperli O, Delgado V, Habib G, Kaufmann PA, Bax JJ

Abstract

Cited 11 times since 2016 (1.2 per year) source: EuropePMC

Methods in molecular biology (Clifton, N.J.), Volume 1408, 1 1 2016, Pages 319-331 Optogenetic Engineering of Atrial Cardiomyocytes. Feola I, Teplenin A, de Vries AA, Pijnappels DA

Optogenetics is emerging in the cardiology field as a new strategy to explore biological functions through the use of light-sensitive proteins and dedicated light sources. For example, this technology allows modification of the electrophysiological properties of cardiac muscle cells with superb spatiotemporal resolution and quantitative control. In this chapter, the optogenetic modification of atrial cardiomyocytes (aCMCs) from 2-day-old Wistar rats using lentiviral vector (LV) technology and th... Abstract

Cited 68 times since 2016 (7.3 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 67, Issue 3, 1 1 2016, Pages 275-287 Myocardial Infarction Alters Adaptation of the Tethered Mitral Valve. Dal-Bianco JP, Aikawa E, Bischoff J, Guerrero JL, Hjortnaes J, Beaudoin J, Szymanski C, Bartko PE, Seybolt MM, Handschumacher MD, Sullivan S, Garcia ML, Mauskapf A, Titus JS, Wylie-Sears J, Irvin WS, Chaput M, Messas E, Hagège AA, Carpentier A, Levine RA, Leducq Transatlantic Mitral Network

Background: In patients with myocardial infarction (MI), leaflet tethering by displaced papillary muscles induces mitral regurgitation (MR), which doubles mortality. Mitral valves (MVs) are larger in such patients but fibrosis sets in counterproductively. The investigators previously reported that experimental tethering alone increases mitral valve area in association with endothelial-to-mesenchymal transition. Objectives: The aim of this study was to explore the clinically relevant situation of... Abstract

Nederlands tijdschrift voor geneeskunde, Volume 160, 1 1 2016, Pages A9290 [Preference for endovascular aortic aneurysm repair: results of RCTs versus nationwide audits]. Geelkerken RH, Hamming JF

This short comment puts into perspective the value of randomised controlled clinical trials in comparison with nationwide audits in the field of aortic aneurysm treatment. RCTs represent greater scientific value but nationwide audits represent daily practices and seem to be more appropriate for shared decision-making. Abstract

Cited 7 times since 2016 (0.7 per year) source: Scopus

Journal of geriatric cardiology : JGC, Volume 13, Issue 1, 1 1 2016, Pages 31-36 Impact of age on transcatheter aortic valve implantation outcomes: a comparison of patients aged ≤ 80 years versus patients > 80 years. van der Kley F, van Rosendael PJ, Katsanos S, Kamperidis V, Marsan NA, Karalis I, de Weger A, Palmen M, Bax JJ, Schalij MJ, Delgado V

Objective: To investigate the procedural outcomes and the long-term survival of patients undergoing transcatheter aortic valve implantation (TAVI) and compare study results of patients ≤ 80 years and patients > 80 years old. Methods: A total of 240 patients treated with TAVI were divided into two groups according to age ≤ 80 years (n = 105; 43.8%) and > 80 years (n = 135; 56.2%). The baseline characteristics and the procedural outcomes were compared between these two groups of patients. Re... Abstract

Cited 2 times since 2016 (0.2 per year) source: EuropePMC

World journal of emergency medicine, Volume 7, Issue 1, 1 1 2016, Pages 30-34 Comparison of intravenous pantoprazole and ranitidine in patients with dyspepsia presented to the emergency department: a randomized, double blind, controlled trial. Senay E, Eken C, Yildiz M, Yilmaz D, Alkan E, Akin M, Serinken M

Background: This study aimed to compare pantoprazole, a proton-pomp inhibitors (PPIs), and ranitidine, a H2 receptor antagonists (H2RA), in ceasing dyspeptic symptoms in the emergency department (ED). Methods: This randomized, double-blinded study compared the effectiveness of 50 mg ranitidine (Ulcuran(®)) and 40 mg pantoprazole (Pantpas(®)), given in a 100 mL saline solution by an intravenous rapid infusion within 2-4 minutes in patients with dyspepsia presented to the ED. Pain intensity was me... Abstract

Cited 11 times since 2016 (1.2 per year) source: EuropePMC

Journal of applied oral science : revista FOB, Volume 24, Issue 1, 1 1 2016, Pages 67-75 Lactobacillus rhamnosus could inhibit Porphyromonas gingivalis derived CXCL8 attenuation. Mendi A, Köse S, Uçkan D, Akca G, Yilmaz D, Aral L, Gültekin SE, Eroğlu T, Kiliç E, Uçkan S

Unlabelled: An increasing body of evidence suggests that the use of probiotic bacteria is a promising intervention approach for the treatment of inflammatory diseases with a polymicrobial etiology. P. gingivalis has been noted to have a different way of interacting with the innate immune response of the host compared to other pathogenic bacteria, which is a recognized feature that inhibits CXCL8 expression. Objective: The aim of the study was to determine if P. gingivalis infection modulates the... Abstract

Cited 9 times since 2015 (1 per year) source: EuropePMC

The American journal of cardiology, Volume 117, Issue 6, 30 5 2016, Pages 887-893 Value of Coronary Computed Tomography Angiography in Tailoring Aspirin Therapy for Primary Prevention of Atherosclerotic Events in Patients at High Risk With Diabetes Mellitus. Dimitriu-Leen AC, Scholte AJ, van Rosendael AR, van den Hoogen IJ, Kharagjitsingh AV, Wolterbeek R, Knuuti J, Kroft LJ, Delgado V, Jukema JW, de Graaf MA, Bax JJ

Aspirin use for primary prevention in patients at high risk with diabetes mellitus (DM) is often recommended under the assumption that most patients with DM have coronary artery disease (CAD). However, not all patients may have CAD. The present study evaluated, in 425 patients at high risk with DM (without chest pain syndrome or a history of cardiac disease), the prevalence of CAD on coronary computed tomography angiography (CTA). Moreover, the association between the presence and number of trad... Abstract

Cited 8 times since 2015 (0.9 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 49, Issue 6, 30 5 2016, Pages 1564-1570 Twenty-year experience with the Ross-Konno procedure. Schneider AW, Bökenkamp R, Bruggemans EF, Hazekamp MG

Objectives: The Ross-Konno procedure is a last resort for patients with complex multilevel left ventricular outflow tract obstruction (LVOTO) often having other cardiovascular anomalies. It is typically preceded by multiple surgeries. Literature is scarce on long-term follow-up series. Therefore, we have reviewed our 20-year experience with this procedure in order to provide insights in patients' outcomes and to optimize patient selection. Methods: Between January 1995 and December 2014, 48... Abstract

Cited 68 times since 2015 (7.3 per year) source: EuropePMC

Journal of thrombosis and haemostasis : JTH, Volume 14, Issue 1, 29 5 2016, Pages 121-128 Derivation of a clinical prediction score for chronic thromboembolic pulmonary hypertension after acute pulmonary embolism. Klok FA, Dzikowska-Diduch O, Kostrubiec M, Vliegen HW, Pruszczyk P, Hasenfuß G, Huisman MV, Konstantinides S, Lankeit M

Unlabelled: Essentials Predicting chronic thromboembolic pulmonary hypertension (CTEPH) after pulmonary embolism is hard. We studied 772 patients with pulmonary embolism who were followed for CTEPH (incidence 2.8%). Logistic regression analysis revealed 7 easily collectable clinical variables that combined predict CTEPH. Our score identifies patients at low (0.38%) or higher (10%) risk of CTEPH. Summary: Introduction Validated risk factors for the diagnosis of chronic thromboembolic pulmonary hy... Abstract

Cited 30 times since 2015 (3.2 per year) source: EuropePMC

Frontiers in cellular and infection microbiology, Volume 5, 24 4 2015, Pages 99 Salivary Antimicrobial Peptides in Early Detection of Periodontitis. Güncü GN, Yilmaz D, Könönen E, Gürsoy UK

In the pathogenesis of periodontitis, an infection-induced inflammatory disease of the tooth-supporting tissues, there is a complex interaction between the subgingival microbiota and host tissues. A periodontal diagnostic tool for detecting the initiation and progression of the disease, monitoring the response to therapy, or measuring the degree of susceptibility to future disease progression has been of interest for a long time. The value of various enzymes, proteins, and immunoglobulins, which... Abstract

Cited 3 times since 2015 (0.3 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 17, Issue 3, 20 3 2015, Pages 353 Four-dimensional flow cardiovascular magnetic resonance for the evaluation of the atrial baffle after Mustard repair. van der Palen RL, Westenberg JJ, Hazekamp MG, Kuipers IM, Roest AA

Abstract