Research

Publications

Below you can find a list of our published research.

6131 results

Cited 17 times since 2012 (1.3 per year) source: EuropePMC

The American journal of cardiology, Volume 109, Issue 2, 1 1 2012, Pages 187-194 Cardiovascular mortality and heart failure risk score for patients after ST-segment elevation acute myocardial infarction treated with primary percutaneous coronary intervention (Data from the Leiden MISSION! Infarct Registry). Antoni ML, Hoogslag GE, Boden H, Liem SS, Boersma E, Fox K, Schalij MJ, Bax JJ, Delgado V

The risk scores developed for the prediction of an adverse outcome in patients after ST-segment elevation myocardial infarction (STEMI) have mostly addressed patients treated with thrombolysis and evaluated solely all-cause mortality as the primary end point. Primary percutaneous coronary intervention in patients with STEMI has improved the outcome significantly and might have changed the relative contribution of different risk factors. Our patient population included 1,484 consecutive patients... Abstract

Nederlands tijdschrift voor geneeskunde, Volume 156, Issue 41, 1 1 2012, Pages A3604 [Surgery in patients with centrally-situated non-small cell lung carcinoma: lung-parenchymal sparing procedure versus pneumonectomy]. Versteegh M, Smeenk HG, Annema J, Wijers O, Tjon A, Wolterbeek R, van Kralingen K, Klautz R, Braun J

Objective: To examine if lung-parenchymal sparing resection ('sleeve' resection) is a safe and oncologically responsible alternative to pneumonectomy in patients with central tumours. Further, to evaluate in how far this technique is being used in the Netherlands. Design: Retrospective cohort study. Method: Patients undergoing either lung-parenchymal sparing procedure or pneumonectomy for centrally situated non-small cell lung carcinoma (NSCLC) between January 1995 and January 2010 wer... Abstract

Cited 6 times since 2012 (0.5 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 41, Issue 1, 1 1 2012, Pages 74-80; discussion 80-1 Management of mitral regurgitation during left ventricular reconstruction for ischemic heart failure. Klein P, Braun J, Holman ER, Versteegh MI, Verwey HF, Dion RA, Bax JJ, Klautz RJ

Objective: Remodeling of the left ventricle (LV) in ischemic cardiomyopathy frequently leads to functional mitral regurgitation (MR). The indication for correcting MR in patients undergoing LV reconstruction (LVR) is unclear. In this study, we evaluated our strategy of correcting MR≥grade 2+ by restrictive mitral annuloplasty (RMA) during LVR. Methods: We studied 92 consecutive patients (76 men, mean age 61±10 years) who underwent LVR for ischemic heart failure (IHF). RMA was performed in all pa... Abstract

Cited 1 times since 2012 (0.1 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 59, Issue 5, 1 1 2012, Pages 503-537 Highlights of the Year in JACC 2011. Demaria AN, Bax JJ, Ben-Yehuda O, Feld GK, Greenberg BH, Hall J, Hlatky M, Lew WY, Lima JA, Maisel AS, Narayan SM, Nissen S, Sahn DJ, Tsimikas S

Abstract

Cited 19 times since 2012 (1.4 per year) source: EuropePMC

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Volume 7, Issue 9, 1 1 2012, Pages 1021-1029 Five-year clinical follow-up from the MISSION! Intervention Study: sirolimus-eluting stent versus bare metal stent implantation in patients with ST-segment elevation myocardial infarction, a randomised controlled trial. Boden H, van der Hoeven BL, Liem SS, Atary JZ, Cannegieter SC, Atsma DE, Bootsma M, Jukema JW, Zeppenfeld K, Oemrawsingh PV, van der Wall EE, Schalij MJ

Aims: To evaluate the clinical outcomes of sirolimus-eluting stent (SES) versus bare metal stent (BMS) implantation in patients with ST-segment elevation myocardial infarction (STEMI) at long-term follow-up. Methods and results: After five years, 310 STEMI patients randomly assigned to implantation of either SES or BMS, were compared. Survival rates were comparable between groups (SES 94.3% vs. BMS 92.8%, p=0.57), as were the rates of reinfarction (10.6% vs. 13.7%, p=0.40), freedom of death/re-M... Abstract

Cited 14 times since 2012 (1.1 per year) source: EuropePMC

Asian Pacific journal of cancer prevention : APJCP, Volume 13, Issue 10, 1 1 2012, Pages 4993-4998 Genotoxic and anti-genotoxic effects of vanillic acid against mitomycin C-induced genomic damage in human lymphocytes in vitro. Erdem MG, Cinkilic N, Vatan O, Yilmaz D, Bagdas D, Bilaloglu R

Vanillic acid, a vegetable phenolic compound, is a strong antioxidant. The aim of the present study was to determine its effects on mitomycin C-induced DNA damage in human blood lymphocyte cultures in vitro, both alone and in combination with mitomycin C (MMC). The cytokinesis block micronucleus test and alkaline comet assay were used to determine genotoxic damage and anti-genotoxic effects of vanillic acid at the DNA and chromosome levels. MMC induced genotoxicity at a dose of 0.25 μg/ml. Vanil... Abstract

Cited 11 times since 2012 (0.8 per year) source: EuropePMC

Current problems in cardiology, Volume 37, Issue 1, 1 1 2012, Pages 7-33 Imaging for atrial fibrillation. Leong DP, Delgado V, Bax JJ

Atrial fibrillation (AF) is the most common clinically significant arrhythmia and is associated with considerable increase in morbidity and mortality. Its appropriate evaluation and management are therefore of paramount importance. Cardiac imaging plays a crucial role in this regard. Imaging permits the identification of cardiovascular conditions that predispose to the development and perpetuation of AF. Furthermore, imaging provides important information to refine strategies to prevent thromboe... Abstract

Cited 1 times since 2012 (0.1 per year) source: EuropePMC

Bratislavske lekarske listy, Volume 113, Issue 4, 1 1 2012, Pages 211-213 The evaluation of effects of lornoxicam on blood flow and erythrocyte deformability in comparison with iv paracetamol in rats. Arslan M, Comu FM, Isik B, Atac MS, Yilmaz D

Background: Lornoxicam and iv paracetamol are commonly preferred to be used for postoperative analgesia. Although Aspirin is a well known non-steroid anti-inflammatory drug that decreases the erythrocyte deformability, there is no study comparing lornoxicam and iv paracetamol regarding their effects on erythrocyte deformability recorded in literature. The aim of this study was to compare the effects of lornoxicam and IV paracetamol on blood perfusion and erythrocyte deformability on rats. Method... Abstract

Cited 27 times since 2012 (2 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 5, Issue 1, 1 1 2012, Pages 46-55 Molecular imaging of bone marrow mononuclear cell survival and homing in murine peripheral artery disease. van der Bogt KE, Hellingman AA, Lijkwan MA, Bos EJ, de Vries MR, van Rappard JR, Fischbein MP, Quax PH, Robbins RC, Hamming JF, Wu JC

Objectives: This study aims to provide insight into cellular kinetics using molecular imaging after different transplantation methods of bone marrow-derived mononuclear cells (MNCs) in a mouse model of peripheral artery disease (PAD). Background: MNC therapy is a promising treatment for PAD. Although clinical translation has already been established, there is a lack of knowledge about cell behavior after transplantation and about the mechanism whereby MNC therapy might ameliorate complaints of P... Abstract

Cited 2 times since 2012 (0.2 per year) source: EuropePMC

Nederlands tijdschrift voor geneeskunde, Volume 156, Issue 17, 1 1 2012, Pages A3767 [Many adults with congenital heart disease are lost to follow up]. Vis JC, Schuuring MJ, van der Velde ET, Engelfriet-Rijk LC, Harms IM, Mantels S, Bouma BJ, Mulder BJ

Objective: Identification of adults with congenital heart disease (CHD) who were lost to cardiological follow-up. Design: Cross-sectional study. Method: Adults with CHD and not under cardiological follow-up were asked via a nationwide publicity campaign to contact the CONCOR (CONgenital CORvitia) project group. Results: A total of 593 patients with mild (85%) to moderate-severe (15%) CHD were registered via the nationwide campaign. Of these patients, 66% were examined within 1 year by a cardiolo... Abstract

Cited 20 times since 2012 (1.5 per year) source: EuropePMC

Journal of hypertension, Volume 30, Issue 1, 1 1 2012, Pages 107-116 Aliskiren inhibits atherosclerosis development and improves plaque stability in APOE*3Leiden.CETP transgenic mice with or without treatment with atorvastatin. Kühnast S, van der Hoorn JW, van den Hoek AM, Havekes LM, Liau G, Jukema JW, Princen HM

Objective: Aliskiren is the first commercially available, orally active, direct renin inhibitor approved to treat hypertension. The renin-angiotensin system has been shown to be a significant contributor to the development of hypercholesterolemia-induced atherosclerosis. The aim of this study was to evaluate the antiatherosclerotic and plaque stabilization effects of aliskiren alone and in combination with atorvastatin. Methods: APOE*3Leiden.CETP mice (n = 14-17/group) were fed a western-type di... Abstract

Cited 38 times since 2012 (2.9 per year) source: EuropePMC

International journal for parasitology, Volume 42, Issue 3, 1 1 2012, Pages 269-277 Specific glycan elements determine differential binding of individual egg glycoproteins of the human parasite Schistosoma mansoni by host C-type lectin receptors. Meevissen MH, Driessen NN, Smits HH, Versteegh R, van Vliet SJ, van Kooyk Y, Schramm G, Deelder AM, Haas H, Yazdanbakhsh M, Hokke CH

During infection with the blood fluke Schistosoma mansoni, glycan motifs present on glycoproteins of the parasite’s eggs mediate immunomodulatory effects on the host. The recognition of these glycan motifs is primarily mediated by C-type lectin receptors on dendritic cells and other cells of the immune system. However, it is not yet known which individual glycoproteins interact with the different C-type lectin receptors, and which structural components are involved. Here we investigated the stru... Abstract

Cited 33 times since 2011 (2.5 per year) source: EuropePMC

Cardiovascular research, Volume 93, Issue 3, 22 4 2011, Pages 434-444 Connexin43 silencing in myofibroblasts prevents arrhythmias in myocardial cultures: role of maximal diastolic potential. Askar SF, Bingen BO, Swildens J, Ypey DL, van der Laarse A, Atsma DE, Zeppenfeld K, Schalij MJ, de Vries AA, Pijnappels DA

Aims: Arrhythmogenesis in cardiac fibrosis remains incompletely understood. Therefore, this study aims to investigate how heterocellular coupling between cardiomyocytes (CMCs) and myofibroblasts (MFBs) affects arrhythmogeneity of fibrotic myocardial cultures. Potentially, this may lead to the identification of novel anti-arrhythmic strategies. Methods and results: Co-cultures of neonatal rat CMCs and MFBs in a 1:1 ratio were used as a model of cardiac fibrosis, with purified CMC cultures as cont... Abstract

Cited 12 times since 2011 (0.9 per year) source: EuropePMC

Nucleic acids research, Volume 40, Issue 8, 20 3 2011, Pages 3443-3455 Concerted nicking of donor and chromosomal acceptor DNA promotes homology-directed gene targeting in human cells. Gonçalves MA, van Nierop GP, Holkers M, de Vries AA

The exchange of genetic information between donor and acceptor DNA molecules by homologous recombination (HR) depends on the cleavage of phosphodiester bonds. Although double-stranded and single-stranded DNA breaks (SSBs) have both been invoked as triggers of HR, until very recently the focus has been primarily on the former type of DNA lesions mainly due to the paucity of SSB-based recombination models. Here, to investigate the role of nicked DNA molecules as HR-initiating substrates in human s... Abstract

Cited 47 times since 2011 (3.5 per year) source: EuropePMC

Differentiation; research in biological diversity, Volume 83, Issue 2, 9 2 2011, Pages S56-61 Primary cilia as biomechanical sensors in regulating endothelial function. Egorova AD, van der Heiden K, Poelmann RE, Hierck BP

Depending on the pattern of blood flow to which they are exposed and their proliferative status, vascular endothelial cells can present a primary cilium into the flow compartment of a blood vessel. The cilium modifies the response of endothelial cells to biomechanical forces. Shear stress, which is the drag force exerted by blood flow, is best studied in this respect. Here we review the structural composition of the endothelial cilia and the current status of knowledge about the relation between... Abstract

Cited 21 times since 2011 (1.6 per year) source: EuropePMC

Atherosclerosis, Volume 220, Issue 2, 7 1 2011, Pages 456-462 KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly. Akao H, Polisecki E, Kajinami K, Trompet S, Robertson M, Ford I, Jukema JW, de Craen AJ, Westendorp RG, Shepherd J, Packard C, Buckley BM, Schaefer EJ

Single nucleotide polymorphisms (SNPs) at the KIF6 (kinesin like protein 6, rs20455 or 719Arg), LPA (lipoprotein(a), rs3798220), TAS2R50 (taste receptor type 2, member 50, rs1376251) and VAMP8 (vesicle-associated membrane protein 8, rs1010) have previously been associated with low density lipoprotein cholesterol (LDL-C) lowering response to statins, coronary heart disease (CHD) at baseline, or CHD events on trial. We examined SNPs at the KIF6 (rs20455 or 719Arg), LPA (rs3798220), TAS2R50 (rs1376... Abstract

Cited 18 times since 2011 (1.4 per year) source: EuropePMC

PloS one, Volume 6, Issue 12, 6 1 2011, Pages e28638 Upregulation of the cell-cycle regulator RGC-32 in Epstein-Barr virus-immortalized cells. Schlick SN, Wood CD, Gunnell A, Webb HM, Khasnis S, Schepers A, West MJ

Epstein-Barr virus (EBV) is implicated in the pathogenesis of multiple human tumours of lymphoid and epithelial origin. The virus infects and immortalizes B cells establishing a persistent latent infection characterized by varying patterns of EBV latent gene expression (latency 0, I, II and III). The CDK1 activator, Response Gene to Complement-32 (RGC-32, C13ORF15), is overexpressed in colon, breast and ovarian cancer tissues and we have detected selective high-level RGC-32 protein expression in... Abstract

Coronary artery disease, Volume 22, Issue 8, 1 1 2011, Pages 559-564 Prognostic significance of baseline ST-T-wave abnormalities in diagnostic stress echocardiography. Pedone C, Elhendy A, van Domburg RT, Nelwan SP, Biagini E, Di Pasquale G, Bax JJ, Poldermans D

Objective: The aim of this study was to determine whether resting ST-T wave abnormalities (ST-Ta) provide incremental prognostic information in patients with no history of coronary artery disease undergoing dobutamine stress echocardiography (DSE). Methods: We evaluated 1308 consecutive patients without previous myocardial infarction (MI) or revascularization who underwent DSE. Ischemia was defined as new or worsening wall motion abnormalities. End points during follow-up were all-cause death an... Abstract

Cited 11 times since 2011 (0.8 per year) source: EuropePMC

Coronary artery disease, Volume 22, Issue 8, 1 1 2011, Pages 533-536 Distribution of culprit lesions in patients with ST-segment elevation acute myocardial infarction treated with primary percutaneous coronary intervention. Antoni ML, Yiu KH, Atary JZ, Delgado V, Holman ER, van der Wall EE, Schuijf JD, Bax JJ, Schalij MJ

Objectives: Data regarding the distribution of vulnerable lesions in the coronary arteries are scarce. The aim was to evaluate the frequency and distribution of culprit lesions in patients with ST-segment elevation acute myocardial infarction. In addition, the location of culprit lesions was related to infarct size. Methods: Consecutive patients (N=1533, mean age 61±12 years) were evaluated. All patients were treated with primary percutaneous coronary intervention and underwent two-dimensional e... Abstract

Cited 1 times since 2011 (0.1 per year) source: EuropePMC

World journal of surgery, Volume 35, Issue 12, 1 1 2011, Pages 2829-30; author reply 2831 Re: Risk factors for stroke during surgery for carotid body tumors. van der Bogt KE, van Baalen JM, Hamming JF

Abstract