Research

Publications

Below you can find a list of our published research.

6131 results

Cited 53 times since 2011 (3.7 per year) source: EuropePMC

Stroke, Volume 42, Issue 3, 13 2 2011, Pages 638-644 Cerebral microbleeds are predictive of mortality in the elderly. Altmann-Schneider I, Trompet S, de Craen AJ, van Es AC, Jukema JW, Stott DJ, Sattar N, Westendorp RG, van Buchem MA, van der Grond J

Background and purpose: To investigate the prognostic value of cerebral microbleeds (CMB) regarding overall, cardiovascular-related, and stroke-related mortality and to investigate possible differences based on a cerebral amyloid angiopathy-type and nonlobar distribution of microbleeds. Methods: We included 435 subjects who were participants from the nested MRI substudy of the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER). Cox proportional hazard models were applied to estima... Abstract

Cited 1 times since 2011 (0.1 per year) source: EuropePMC

Expert opinion on emerging drugs, Volume 16, Issue 2, 13 2 2011, Pages 203-233 Emerging drugs for coronary artery disease. From past achievements and current needs to clinical promises. Ahmed TA, Karalis I, Jukema JW

Introduction: Coronary artery disease (CAD) is one of the major causes of morbidity and mortality worldwide, exerting a huge economic burden. Although drug treatment in the past decades has made large advances, significant residual risk remains. However, in the coming years, there are still a lot of great advances and major breakthroughs expected. Areas covered: New treatments are expected to provide higher efficacy with favorable safety profiles. In this review article, we provide an almost com... Abstract

Cited 26 times since 2011 (1.8 per year) source: EuropePMC

Cardiovascular research, Volume 90, Issue 2, 13 2 2011, Pages 295-304 Antiproliferative treatment of myofibroblasts prevents arrhythmias in vitro by limiting myofibroblast-induced depolarization. Askar SF, Ramkisoensing AA, Schalij MJ, Bingen BO, Swildens J, van der Laarse A, Atsma DE, de Vries AA, Ypey DL, Pijnappels DA

Aims: Cardiac fibrosis is associated with increased incidence of cardiac arrhythmias, but the underlying proarrhythmic mechanisms remain incompletely understood and antiarrhythmic therapies are still suboptimal. This study tests the hypothesis that myofibroblast (MFB) proliferation leads to tachyarrhythmias by altering the excitability of cardiomyocytes (CMCs) and that inhibition of MFB proliferation would thus lower the incidence of such arrhythmias. Methods and results: Endogenous MFBs in neon... Abstract

Cited 43 times since 2011 (3 per year) source: EuropePMC

European heart journal, Volume 32, Issue 15, 8 2 2011, Pages 1926-1934 Turning 18 with congenital heart disease: prediction of infective endocarditis based on a large population. Verheugt CL, Uiterwaal CS, van der Velde ET, Meijboom FJ, Pieper PG, Veen G, Stappers JL, Grobbee DE, Mulder BJ

Aims: The risk of infective endocarditis (IE) in adults with congenital heart disease is known to be increased, yet empirical risk estimates are lacking. We sought to predict the occurrence of IE in patients with congenital heart disease at the transition from childhood into adulthood. Methods and results: We identified patients from the CONCOR national registry for adults with congenital heart disease. Potential predictors included patient characteristics, and complications and interventions in... Abstract

Cited 15 times since 2011 (1.1 per year) source: EuropePMC

Journal of cardiovascular translational research, Volume 4, Issue 2, 7 1 2011, Pages 182-191 Bone marrow cell injection for chronic myocardial ischemia: the past and the future. van Ramshorst J, Rodrigo SF, Schalij MJ, Beeres SL, Bax JJ, Atsma DE

Intramyocardial bone marrow cell injection is currently being investigated as a new therapeutic option for the treatment of chronic myocardial ischemia. Experimental studies and early phase clinical trials established a favorable safety profile of this approach and suggested that bone marrow cell injection was associated with clinical and functional improvements. Recently, a randomized, double-blind, placebo-controlled trial demonstrated that intramyocardial bone marrow cell injection was associ... Abstract

Cited 23 times since 2011 (1.6 per year) source: EuropePMC

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, Volume 37, Issue 3, 6 1 2011, Pages 252-257 Intraoperative near-infrared fluorescence imaging of colorectal metastases targeting integrin α(v)β(3) expression in a syngeneic rat model. Hutteman M, Mieog JS, van der Vorst JR, Dijkstra J, Kuppen PJ, van der Laan AM, Tanke HJ, Kaijzel EL, Que I, van de Velde CJ, Löwik CW, Vahrmeijer AL

Aim: Near-infrared (NIR) fluorescence optical imaging is a promising technique to assess the extent of colorectal metastases during curative-intended surgery. However, NIR fluorescence imaging of liver metastases is highly challenging due to hepatic uptake and clearance of many fluorescent dyes. In the current study, the biodistribution and the ability to demarcate liver and peritoneal metastases were assessed during surgery in a syngeneic rat model of colorectal cancer using an integrin α(v)β(3... Abstract

Cited 25 times since 2011 (1.8 per year) source: EuropePMC

PloS one, Volume 6, Issue 1, 6 1 2011, Pages e14493 Exploitation of herpesvirus immune evasion strategies to modify the immunogenicity of human mesenchymal stem cell transplants. de la Garza-Rodea AS, Verweij MC, Boersma H, van der Velde-van Dijke I, de Vries AA, Hoeben RC, van Bekkum DW, Wiertz EJ, Knaän-Shanzer S

Background: Mesenchymal stem cells (MSCs) are multipotent cells residing in the connective tissue of many organs and holding great potential for tissue repair. In culture, human MSCs (hMSCs) are capable of extensive proliferation without showing chromosomal aberrations. Large numbers of hMSCs can thus be acquired from small samples of easily obtainable tissues like fat and bone marrow. MSCs can contribute to regeneration indirectly by secretion of cytokines or directly by differentiation into sp... Abstract

Cited 12 times since 2011 (0.8 per year) source: EuropePMC

Circulation. Cardiovascular imaging, Volume 4, Issue 2, 5 1 2011, Pages 122-129 Intramyocardial bone marrow-derived mononuclear cell injection for chronic myocardial ischemia: the effect on diastolic function. van Ramshorst J, Antoni ML, Beeres SL, Roes SD, Delgado V, Rodrigo SF, de Roos A, Holman ER, Fibbe WE, Lamb HJ, Zwaginga JJ, Boersma E, van der Wall EE, Schalij MJ, Atsma DE, Bax JJ

Background: The present substudy of a recently published randomized trial aimed to investigate the effect of intramyocardial bone marrow cell injection on diastolic function in patients with chronic myocardial ischemia. Methods and results: In a total of 50 patients, diastolic function was evaluated before and 3 months after bone marrow cell injection using standard echocardiography and strain analysis. In addition, MRI-derived transmitral flow measurements were obtained in a subset of 36 patien... Abstract

Cited 58 times since 2011 (4.1 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 13, Issue 3, 5 1 2011, Pages 389-394 Long-term follow-up of primary and secondary prevention implantable cardioverter defibrillator patients. van Welsenes GH, van Rees JB, Borleffs CJ, Cannegieter SC, Bax JJ, van Erven L, Schalij MJ

Aims: The beneficial effects of implantable cardioverter defibrillators (ICDs) in primary and secondary prevention patients are well established. However, data on potential differences between both groups in mortality and ICD therapy rates during long-term follow-up are scarce. The aim of the study was to assess differences in mortality and ICD therapy between secondary and primary prevention ICD recipients. Methods and results: With the exception of patients with congenital monogenetic cardiac... Abstract

Cited 17 times since 2011 (1.2 per year) source: EuropePMC

Heart rhythm, Volume 8, Issue 5, 4 1 2011, Pages 665-671 Reversed polarity of bipolar electrograms for predicting a successful ablation site in focal idiopathic right ventricular outflow tract arrhythmias. van Huls van Taxis CF, Wijnmaalen AP, den Uijl DW, Gawrysiak M, Putter H, Schalij MJ, Zeppenfeld K

Background: Radiofrequency catheter ablation (RFCA) for idiopathic right ventricular outflow tract (RVOT) arrhythmias is typically guided by local activation time (LAT) mapping and unipolar electrogram morphology (QS configuration). However, LAT mapping is limited by the large variation among patients, and the area demonstrating a QS configuration of the unipolar electrogram may be larger than the focal source. Reversed polarity has been proposed as a criterion for guiding RFCA. Objective: The p... Abstract

Cited 11 times since 2011 (0.8 per year) source: EuropePMC

Current problems in cardiology, Volume 36, Issue 1, 1 1 2011, Pages 9-47 Multimodality imaging in diabetic heart disease. Ng AC, Delgado V, Djaberi R, Schuijf JD, Boogers MJ, Auger D, Bertini M, de Roos A, van der Meer RW, Lamb HJ, Bax JJ

Diabetic heart disease is currently defined as left ventricular dysfunction that occurs independently of coronary artery disease and hypertension. Its underlying etiology is likely to be multifactorial, acting synergistically together to cause myocardial dysfunction. Multimodality cardiac imaging, such as echocardiography, nuclear, computed tomography, and magnetic resonance imaging, can provide invaluable insight into different aspects of the disease process, from imaging at the cellular level... Abstract

Cited 55 times since 2011 (3.9 per year) source: EuropePMC

The American journal of cardiology, Volume 107, Issue 2, 1 1 2011, Pages 243-249 Effect of pulmonary vein anatomy and left atrial dimensions on outcome of circumferential radiofrequency catheter ablation for atrial fibrillation. den Uijl DW, Tops LF, Delgado V, Schuijf JD, Kroft LJ, de Roos A, Boersma E, Trines SA, Zeppenfeld K, Schalij MJ, Bax JJ

Multislice computed tomography (MSCT) is commonly acquired before radiofrequency catheter ablation (RFCA) for atrial fibrillation (AF) to plan and guide the procedure. MSCT allows accurate measurement of the left atrial (LA) and pulmonary vein (PV) dimensions and classification of the PV anatomy. The aim of the present study was to investigate the effect of LA dimensions, PV dimensions, and PV anatomy on the outcome of circumferential RFCA for AF. A total of 100 consecutive patients undergoing R... Abstract

Cited 24 times since 2011 (1.7 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 91, Issue 1, 1 1 2011, Pages 113-121 Three-dimensional echocardiography for the preoperative assessment of patients with left ventricular aneurysm. Marsan NA, Westenberg JJ, Roes SD, van Bommel RJ, Delgado V, van der Geest RJ, de Roos A, Klautz RJ, Reiber JC, Bax JJ

Background: Surgical ventricular reconstruction has been proposed as a treatment option in heart failure patients with left ventricular (LV) aneurysm. The feasibility of this procedure has some limitations, and extensive preoperative evaluation is necessary to give the correct indication. For this purpose, magnetic resonance imaging (MRI) is currently considered the gold standard, providing accurate quantification of LV shape, size, and global and regional function together with the assessment o... Abstract

Cited 105 times since 2011 (7.4 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 57, Issue 3, 1 1 2011, Pages 324-331 Left atrial strain predicts reverse remodeling after catheter ablation for atrial fibrillation. Tops LF, Delgado V, Bertini M, Marsan NA, Den Uijl DW, Trines SA, Zeppenfeld K, Holman E, Schalij MJ, Bax JJ

Objectives: The purpose of this study was to assess left atrial (LA) strain during long-term follow-up after catheter ablation for atrial fibrillation and to find predictors for LA reverse remodeling. Background: The association between LA reverse remodeling and improvement in LA strain after catheter ablation has not been investigated thus far. Methods: In 148 patients undergoing catheter ablation for atrial fibrillation, LA volumes and LA strain were assessed with echocardiography at baseline... Abstract

Cited 31 times since 2011 (2.2 per year) source: EuropePMC

American heart journal, Volume 161, Issue 1, 1 1 2011, Pages 197-203 Natriuretic peptide levels predict recurrence of atrial fibrillation after radiofrequency catheter ablation. den Uijl DW, Delgado V, Tops LF, Ng AC, Boersma E, Trines SA, Zeppenfeld K, Schalij MJ, van der Laarse A, Bax JJ

Background: the presence of atrial fibrillation (AF) is related to increased levels of natriuretic peptides. In addition, increased natriuretic peptide levels are predictive of the development of AF. However, the role of natriuretic peptides to predict recurrence of AF after radiofrequency catheter ablation (RFCA) is controversial. Objective: the study aimed to investigate the role of natriuretic peptides in the prediction of AF recurrence after RFCA for AF. Methods: pre-procedural amino-termina... Abstract

Cited 20 times since 2011 (1.4 per year) source: EuropePMC

International review of cell and molecular biology, Volume 290, 1 1 2011, Pages 87-119 Role for primary cilia as flow detectors in the cardiovascular system. Van der Heiden K, Egorova AD, Poelmann RE, Wentzel JJ, Hierck BP

The cardiovascular system is exposed to biochemical and biomechanical signals. Various sensors for these signals have been described and they contribute to cardiovascular development, maintenance of vessel integrity during adult life, and to pathogenesis. In the past 10years, primary cilia, membrane-covered, rod-like cellular protrusions, were discovered on multiple cell types of the cardiovascular system. Primary cilia are sensory organelles involved in several key (developmental) signaling pat... Abstract

Cited 1 times since 2011 (0.1 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 57, Issue 4, 1 1 2011, Pages 480-514 Highlights of the year in JACC 2010. DeMaria AN, Bax JJ, Ben-Yehuda O, Feld GK, Greenberg BH, Hall J, Hlatky M, Lew WY, Lima JA, Maisel AS, Narayan SM, Nissen S, Sahn DJ, Tsimikas S

Abstract

Cited 1 times since 2011 (0.1 per year) source: EuropePMC

Cardiology journal, Volume 18, Issue 3, 1 1 2011, Pages 289-296 Interventional creation of an atrial septal defect and its impact on right ventricular function: an animal study with the pressure-volume conductance system. Uebing A, Fischer G, Schlangen J, Hansen T, Grabitz RG, Becker K, Steendijk P, Kramer HH

Background: The aim of our study was to assess the suitability of different interventional techniques to create an atrial septal defect (ASD) and to evaluate the short-term effects of right ventricular (RV) volume overload on RV contractility in the growing swine. Methods: Thirteen ASD and six control animals were studied. An ASD was created by balloon dilatation (BD) of the fossa ovalis (n = 4) or by implantation of a multi-perforated Amplatzer Septal Occluder (n = 4) or a patch-less nitinol de... Abstract

Cited 1 times since 2011 (0.1 per year) source: EuropePMC

Nederlands tijdschrift voor geneeskunde, Volume 155, 1 1 2011, Pages A3158 [Summary of the practice guideline 'Venous leg ulcer' from the Dutch College of General Practitioners]. van Rijn-van Kortenhof NM, Wiersma T, van Hof N, Balak FS, Goudswaard LA

The practice guideline 'Venous leg ulcer' from the Dutch College of General Practitioners provides recommendations for the diagnosis and treatment of venous leg ulcer by the general practitioner. When counseling the patient it is important to make clear that the healing process can take a long time. Compression therapy remains the most important treatment for venous leg ulcer; it also reduces recurrence rates. The choice of wound dressing is dependent on the wound phase, the degree of... Abstract

Cited 6 times since 2011 (0.4 per year) source: EuropePMC

Disease markers, Volume 30, Issue 5, 1 1 2011, Pages 245-252 Asymmetric dimethylarginine (ADMA) levels display a morning peak in patients with acute myocardial infarction. Bergheanu SC, van der Laarse A, van der Bom JG, van der Hoeven BL, le Cessie S, de Jong MG, Liem SS, Schalij MJ, Jukema JW

High Asymmetric Dimethylarginine (ADMA) levels are associated with increased platelet activity, elevated blood pressure, vasoconstriction and impaired vascular relaxation. We hypothesized that the myocardial infarction morning peak of occurrence is closely related to a morning peak of ADMA levels. We performed a cross-sectional study among patients with documented myocardial infarction who had been enrolled in the prospective MISSION! Intervention Study. In total, serum ADMA levels were measured... Abstract