7728 results
Cited 47 times since 2016 (5.4 per year)
source: EuropePMC
Circulation,
Volume 134, Issue 3, 1 1 2016, Pages 212-221
Higher Visit-to-Visit Low-Density Lipoprotein Cholesterol Variability Is Associated With Lower Cognitive Performance, Lower Cerebral Blood Flow, and Greater White Matter Hyperintensity Load in Older Subjects.
Smit RA, Trompet S, Sabayan B, le Cessie S, van der Grond J, van Buchem MA, de Craen AJ, Jukema JW
Background: Recently, it was shown that intraindividual variation in low-density lipoprotein cholesterol (LDL-C) predicts both cerebrovascular and cardiovascular events. We aimed to examine whether this extends to cognitive function and examined possible pathways using a magnetic resonance imaging substudy. Methods: We investigated the association between LDL-C variability and 4 cognitive domains at month 30 in 4428 participants of PROSPER (PROspective Study of Pravastatin in the Elderly at Risk...
Abstract
Cited 4 times since 2016 (0.5 per year)
source: EuropePMC
European journal of human genetics : EJHG,
Volume 24, Issue 7, 1 1 2016, Pages 1096
Genome-wide association studies identify genetic loci for low von Willebrand factor levels.
van Loon J, Dehghan A, Weihong T, Trompet S, McArdle WL, Asselbergs FW, Chen MH, Lopez LM, Huffman JE, Leebeek FW, Basu S, Stott DJ, Rumley A, Gansevoort RT, Davies G, Wilson JJ, Witteman JC, Cao X, de Craen AJ, Bakker SJ, Psaty BM, Starr JM, Hofman A, Jukema JW, Deary IJ, Hayward C, van der Harst P, Lowe GD, Folsom AR, Strachan DP, Smith N, de Maat MP, O'Donnell C
Abstract
Cited 4 times since 2016 (0.5 per year)
source: EuropePMC
Archives of medical science : AMS,
Volume 12, Issue 4, 1 1 2016, Pages 697-703
Serum paraoxonase 1 activity in patients with iron deficiency anemia.
Okuturlar Y, Gedikbasi A, Akalin N, Gunaldi M, Yilmaz D, Mert M, Harmankaya O, Soylu A, Karakaya P, Kumbasar A
Introduction: In this study we aimed to detect paraoxonase 1 (PON-1) activity in iron deficiency anemia (IDA) and to compare it with healthy controls by observing the change after iron therapy. Material and methods: In this study, 50 adult patients with IDA and 40 healthy subjects were enrolled. All patients were analyzed at the beginning and after treatment according to laboratory assessments. Results: Mean paraoxonase and arylesterase activities in the iron deficiency anemia group were signifi...
Abstract
Cited 7 times since 2016 (0.8 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 24, Issue 7-8, 1 1 2016, Pages 441-446
Redesigning healthcare: The 2.4 billion euro question? : Connecting smart technology to improve outcome of patients.
Treskes RW, Van Der Velde ET, Atsma DE, Schalij MJ
Although it has been possible to transfer electrocardiograms via a phone line for more than 100 years, use of internet-based patient monitoring and communication systems in daily care is uncommon. Despite the introduction of numerous health-monitoring devices, and despite most patients having internet access, the implementation of individualised healthcare services is still limited. On the other hand, hospitals have invested heavily in massive information systems offering limited value for money...
Abstract
Cited 18 times since 2016 (2.1 per year)
source: EuropePMC
The Journal of general virology,
Volume 97, Issue 9, 30 5 2016, Pages 2255-2264
Comparison of norovirus genogroup I, II and IV seroprevalence among children in the Netherlands, 1963, 1983 and 2006.
van Beek J, de Graaf M, Xia M, Jiang X, Vinjé J, Beersma M, de Bruin E, van de Vijver D, Holwerda M, van Houten M, Buisman AM, van Binnendijk R, Osterhaus ADME, van der Klis F, Vennema H, Koopmans MPG
Noroviruses are a major cause of acute gastroenteritis worldwide and are a genetically diverse group of viruses. Since 2002, an increasing number of norovirus outbreaks have been reported globally, but it is not clear whether this increase has been caused by a higher awareness or reflects the emergence of new genogroup II genotype 4 (GII.4) variants. The hypothesis that norovirus prevalence has increased post-2002 and is related to the emergence of GII.4 is tested in this study. Sera collected f...
Abstract
Cited 9 times since 2016 (1 per year)
source: EuropePMC
PLoS genetics,
Volume 12, Issue 6, 29 5 2016, Pages e1006166
Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.
Winkler TW, Justice AE, Graff M, Barata L, Feitosa MF, Chu S, Czajkowski J, Esko T, Fall T, Kilpeläinen TO, Lu Y, Mägi R, Mihailov E, Pers TH, Rüeger S, Teumer A, Ehret GB, Ferreira T, Heard-Costa NL, Karjalainen J, Lagou V, Mahajan A, Neinast MD, Prokopenko I, Simino J, Teslovich TM, Jansen R, Westra HJ, White CC, Absher D, Ahluwalia TS, Ahmad S, Albrecht E, Alves AC, Bragg-Gresham JL, de Craen AJ, Bis JC, Bonnefond A, Boucher G, Cadby G, Cheng YC, Chiang CW, Delgado G, Demirkan A, Dueker N, Eklund N, Eiriksdottir G, Eriksson J, Feenstra B, Fischer K, Frau F, Galesloot TE, Geller F, Goel A, Gorski M, Grammer TB, Gustafsson S, Haitjema S, Hottenga JJ, Huffman JE, Jackson AU, Jacobs KB, Johansson Å, Kaakinen M, Kleber ME, Lahti J, Mateo Leach I, Lehne B, Liu Y, Lo KS, Lorentzon M, Luan J, Madden PA, Mangino M, McKnight B, Medina-Gomez C, Monda KL, Montasser ME, Müller G, Müller-Nurasyid M, Nolte IM, Panoutsopoulou K, Pascoe L, Paternoster L, Rayner NW, Renström F, Rizzi F, Rose LM, Ryan KA, Salo P, Sanna S, Sc
[This corrects the article DOI: 10.1371/journal.pgen.1005378.].
Abstract
Cited 111 times since 2016 (12.8 per year)
source: EuropePMC
Genome biology,
Volume 17, Issue 1, 27 4 2016, Pages 138
Blood lipids influence DNA methylation in circulating cells.
Dekkers KF, van Iterson M, Slieker RC, Moed MH, Bonder MJ, van Galen M, Mei H, Zhernakova DV, van den Berg LH, Deelen J, van Dongen J, van Heemst D, Hofman A, Hottenga JJ, van der Kallen CJ, Schalkwijk CG, Stehouwer CD, Tigchelaar EF, Uitterlinden AG, Willemsen G, Zhernakova A, Franke L, 't Hoen PA, Jansen R, van Meurs J, Boomsma DI, van Duijn CM, van Greevenbroek MM, Veldink JH, Wijmenga C, BIOS Consortium, van Zwet EW, Slagboom PE, Jukema JW, Heijmans BT
Background: Cells can be primed by external stimuli to obtain a long-term epigenetic memory. We hypothesize that long-term exposure to elevated blood lipids can prime circulating immune cells through changes in DNA methylation, a process that may contribute to the development of atherosclerosis. To interrogate the causal relationship between triglyceride, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels and genome-wide DNA methylation while excludi...
Abstract
Cited 12 times since 2016 (1.4 per year)
source: EuropePMC
Echocardiography (Mount Kisco, N.Y.),
Volume 33, Issue 10, 25 4 2016, Pages 1458-1464
Left ventricular reverse remodeling after aortic valve surgery for acute versus chronic aortic regurgitation.
Regeer MV, Versteegh MI, Ajmone Marsan N, Schalij MJ, Klautz RJ, Bax JJ, Delgado V
Aims: Extent of left ventricular (LV) reverse remodeling after aortic valve repair or replacement (AVR) may differ between patients operated for acute aortic regurgitation (AR) and chronic AR. The aim of this study was to compare changes in LV volumes and function between patients with acute and chronic AR who underwent AVR. Methods and results: A total of 98 patients (54±15 years, 61% men) with acute (n=21) or chronic AR (n=77) were included in the present retrospective evaluation. LV volumes,...
Abstract
Cited 33 times since 2016 (3.8 per year)
source: EuropePMC
ACS biomaterials science & engineering,
Volume 3, Issue 9, 20 3 2016, Pages 1964-1971
Oxygen-Generating Photo-Cross-Linkable Hydrogels Support Cardiac Progenitor Cell Survival by Reducing Hypoxia-Induced Necrosis.
Alemdar N, Leijten J, Camci-Unal G, Hjortnaes J, Ribas J, Paul A, Mostafalu P, Gaharwar AK, Qiu Y, Sonkusale S, Liao R, Khademhosseini A
Oxygen is essential to cell survival and tissue function. Not surprisingly, ischemia resulting from myocardial infarction induces cell death and tissue necrosis. Attempts to regenerate myocardial tissue with cell based therapies exacerbate the hypoxic stress by further increasing the metabolic burden. In consequence, implanted tissue engineered cardiac tissues suffer from hypoxia-induced cell death. Here, we report on the generation of oxygen-generating hydrogels composed of calcium peroxide (CP...
Abstract
Cited 10 times since 2016 (1.1 per year)
source: EuropePMC
American heart journal,
Volume 179, 18 3 2016, Pages 69-76
A randomized, parallel group, double-blind study of ticagrelor compared with aspirin for prevention of vascular events in patients undergoing coronary artery bypass graft operation: Rationale and design of the Ticagrelor in CABG (TiCAB) trial: An Investigator-Initiated trial.
de Waha A, Sandner S, von Scheidt M, Boening A, Koch-Buettner K, Hammel D, Hambrecht R, Danner BC, Schöndube FA, Goerlach G, Fischlein T, Schmoeckel M, Oberhoffer M, Schulz R, Walther T, Ziegelhöffer T, Knosalla C, Schönrath F, Beyersdorf F, Siepe M, Attmann T, Misfeld M, Mohr FW, Sievers HH, Joost A, Putman LM, Laufer G, Hamm C, Zeymer U, Kastrati A, Radke PW, Lange R, Cremer J, Schunkert H
Background: For patients with coronary artery disease undergoing coronary bypass surgery, acetylsalicylic acid (ASA) currently represents the gold standard of antiplatelet treatment. However, adverse cardiovascular event rates in the first year after coronary artery bypass grafting (CABG) still exceed 10%. Graft failure, which is predominantly mediated by platelet aggregation, has been identified as a major contributing factor in this context. Therefore, intensified platelet inhibition is likely...
Abstract
Cited 1 times since 2016 (0.1 per year)
source: EuropePMC
Echocardiography (Mount Kisco, N.Y.),
Volume 33, Issue 10, 16 3 2016, Pages 1532-1538
Assessment of global left ventricular excursion using three-dimensional dobutamine stress echocardiography to identify significant coronary artery disease.
Hoogslag GE, Joyce E, Bax JJ, Ajmone Marsan N, Delgado V
Background: Quantitative three-dimensional (3D) dobutamine stress echocardiography (DSE) for myocardial ischemia detection may be an adjuvant to left ventricular (LV) wall-motion analysis. The aim of the current study was to assess the association between global 3D LV excursion during DSE and the presence of significant coronary artery disease (CAD) on coronary angiography. Methods: Three-dimensional DSE was performed in 40 patients (67±12 years, 68% male) who underwent subsequent coronary angio...
Abstract
Cited 29 times since 2016 (3.3 per year)
source: EuropePMC
Journal of the American Heart Association,
Volume 5, Issue 6, 16 3 2016, Pages e002860
Systematic Evaluation of the Cellular Innate Immune Response During the Process of Human Atherosclerosis.
van Dijk RA, Rijs K, Wezel A, Hamming JF, Kolodgie FD, Virmani R, Schaapherder AF, Lindeman JH
Background: The concept of innate immunity is well recognized within the spectrum of atherosclerosis, which is primarily dictated by macrophages. Although current insights to this process are largely based on murine models, there are fundamental differences in the atherosclerotic microenvironment and associated inflammatory response relative to humans. In this light, we characterized the cellular aspects of innate immune response in normal, nonprogressive, and progressive human atherosclerotic p...
Abstract
Dermatology online journal,
Volume 22, Issue 6, 15 3 2016, Pages 13030/qt4f48g7jc
Unusual location of median raphe cyst presenting as perianal polyp: a case report.
Arer IM, Yilmaz D, Ozek OC, Yabanoglu H, Caliskan K
Median raphe cysts (MRC) are uncommon, benign congenital lesions that may present anywhere in the midline between the urinary meatus and the anus, with the shaft of the penis and the glans penis being the most common sites. We report a 52-year-old man with median raphe cyst unusually located in perianal region and treated by surgical excision.
Abstract
Cited 15 times since 2016 (1.7 per year)
source: EuropePMC
Atherosclerosis,
Volume 251, 11 2 2016, Pages 139-146
IL-6: A Janus-like factor in abdominal aortic aneurysm disease.
Kokje VBC, Gäbel G, Koole D, Northoff BH, Holdt LM, Hamming JF, Lindeman JHN
Background and aims: An abdominal aortic aneurysm (AAA) is part of the atherosclerotic spectrum of diseases. The disease is hallmarked by a comprehensive localized inflammatory response with striking IL-6 hyperexpression. IL-6 is a multifaceted cytokine that, depending on the context, acts as a pro- or anti-inflammatory factor. In this study, we explore a putative role for IL-6 in AAA disease. Methods: ELISA's, Western blot analysis, real time PCR and array analysis were used to investigate...
Abstract
Cited 37 times since 2016 (4.2 per year)
source: EuropePMC
Journal of virology,
Volume 90, Issue 13, 10 2 2016, Pages 5928-5938
Multiple Natural Substitutions in Avian Influenza A Virus PB2 Facilitate Efficient Replication in Human Cells.
Mänz B, de Graaf M, Mögling R, Richard M, Bestebroer TM, Rimmelzwaan GF, Fouchier RAM
Unlabelled: A strong restriction of the avian influenza A virus polymerase in mammalian cells generally limits viral host-range switching. Although substitutions like E627K in the PB2 polymerase subunit can facilitate polymerase activity to allow replication in mammals, many human H5N1 and H7N9 viruses lack this adaptive substitution. Here, several previously unknown, naturally occurring, adaptive substitutions in PB2 were identified by bioinformatics, and their enhancing activity was verified u...
Abstract
Cited 8 times since 2016 (0.9 per year)
source: EuropePMC
Journal of magnetic resonance imaging : JMRI,
Volume 45, Issue 1, 2 1 2016, Pages 215-228
Quantification of common carotid artery and descending aorta vessel wall thickness from MR vessel wall imaging using a fully automated processing pipeline.
Gao S, van 't Klooster R, Brandts A, Roes SD, Alizadeh Dehnavi R, de Roos A, Westenberg JJ, van der Geest RJ
Purpose: To develop and evaluate a method that can fully automatically identify the vessel wall boundaries and quantify the wall thickness for both common carotid artery (CCA) and descending aorta (DAO) from axial magnetic resonance (MR) images. Materials and methods: 3T MRI data acquired with T1 -weighted gradient-echo black-blood imaging sequence from carotid (39 subjects) and aorta (39 subjects) were used to develop and test the algorithm. The vessel wall segmentation was achieved by respecti...
Abstract
Cited 1 times since 2016 (0.1 per year)
source: EuropePMC
European journal of heart failure,
Volume 18, Issue 6, 1 1 2016, Pages 727
Erratum to "Traditional and new composite endpoints in heart failure clinical trials: facilitating comprehensive efficacy assessments and improving trial efficiency" [Eur J Heart Fail 2016;18:482-489].
Anker SD, Schroeder S, Atar D, Bax JJ, Ceconi C, Cowie MR, Crisp A, Dominjon F, Ford I, Ghofrani HA, Gropper S, Hindricks G, Hlatky MA, Holcomb R, Honarpour N, Jukema JW, Kim AM, Kunz M, Lefkowitz M, Floch CL, Landmesser U, McDonagh TA, McMurray JJ, Merkely B, Packer M, Prasad K, Revkin J, Rosano GM, Somaratne R, Stough WG, Voors AA, Ruschitzka F
Abstract
Cited 72 times since 2016 (8.2 per year)
source: EuropePMC
Science translational medicine,
Volume 8, Issue 341, 1 1 2016, Pages 341ra76
A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease.
Scott RA, Freitag DF, Li L, Chu AY, Surendran P, Young R, Grarup N, Stancáková A, Chen Y, Varga TV, Yaghootkar H, Luan J, Zhao JH, Willems SM, Wessel J, Wang S, Maruthur N, Michailidou K, Pirie A, van der Lee SJ, Gillson C, Al Olama AA, Amouyel P, Arriola L, Arveiler D, Aviles-Olmos I, Balkau B, Barricarte A, Barroso I, Garcia SB, Bis JC, Blankenberg S, Boehnke M, Boeing H, Boerwinkle E, Borecki IB, Bork-Jensen J, Bowden S, Caldas C, Caslake M, CVD50 consortium, Cupples LA, Cruchaga C, Czajkowski J, den Hoed M, Dunn JA, Earl HM, Ehret GB, Ferrannini E, Ferrieres J, Foltynie T, Ford I, Forouhi NG, Gianfagna F, Gonzalez C, Grioni S, Hiller L, Jansson JH, Jørgensen ME, Jukema JW, Kaaks R, Kee F, Kerrison ND, Key TJ, Kontto J, Kote-Jarai Z, Kraja AT, Kuulasmaa K, Kuusisto J, Linneberg A, Liu C, Marenne G, Mohlke KL, Morris AP, Muir K, Müller-Nurasyid M, Munroe PB, Navarro C, Nielsen SF, Nilsson PM, Nordestgaard BG, Packard CJ, Palli D, Panico S, Peloso GM, Perola M, Peters A, Poole CJ, Quirós JR, Rolandsson O, Sa
Regulatory authorities have indicated that new drugs to treat type 2 diabetes (T2D) should not be associated with an unacceptable increase in cardiovascular risk. Human genetics may be able to guide development of antidiabetic therapies by predicting cardiovascular and other health endpoints. We therefore investigated the association of variants in six genes that encode drug targets for obesity or T2D with a range of metabolic traits in up to 11,806 individuals by targeted exome sequencing and f...
Abstract
Cited 7 times since 2016 (0.8 per year)
source: EuropePMC
Current opinion in lipidology,
Volume 27, Issue 3, 1 1 2016, Pages 288-294
The multifaceted interplay between lipids and epigenetics.
Dekkers KF, Slagboom PE, Jukema JW, Heijmans BT
Purpose of review: The interplay between lipids and epigenetic mechanisms has recently gained increased interest because of its relevance for common diseases and most notably atherosclerosis. This review discusses recent advances in unravelling this interplay with a particular focus on promising approaches and methods that will be able to establish causal relationships. Recent findings: Complementary approaches uncovered close links between circulating lipids and epigenetic mechanisms at multipl...
Abstract
Cited 16 times since 2016 (1.8 per year)
source: EuropePMC
Journal of vascular surgery,
Volume 63, Issue 6, 1 1 2016, Pages 1451-1457
Experience with the GORE EXCLUDER iliac branch endoprosthesis for common iliac artery aneurysms.
van Sterkenburg SM, Heyligers JM, van Bladel M, Verhagen HJ, Eefting D, van Sambeek MR, Zeebregts CJ, Reijnen MM, Dutch IBE Collaboration
Objective: In this study, we analyzed the procedural success and early outcome of endovascular treatment of a multicenter cohort of patients with common iliac artery (CIA) aneurysms treated with the new GORE EXCLUDER (W. L. Gore & Associates, Flagstaff, Ariz) iliac branch endoprosthesis (IBE). Methods: A retrospective cohort analysis was performed in 13 sites in The Netherlands. Anatomic, demographic, procedural, and follow-up data were assessed from hospital records. Results: From November...
Abstract
