9562 results
Annals of surgical oncology,
23 4 2025
Accuracy of Predicting Residual Disease and Disease Progression During Active Surveillance for Esophageal Cancer.
Gangaram Panday SSG, van Klaveren D, Lagarde SM, Lingsma HF, Mostert B, Coene PLO, Dekker JWT, Hartgrink HH, Heisterkamp J, Hutteman M, Kouwenhoven EA, Nieuwenhuijzen GAP, Pierie JP, van Sandick JW, Sosef MN, van der Zaag ES, van Lanschot JJB, Wijnhoven BPL, SANO Study Group
Background: To date, active surveillance has been non-inferior to standard surgery for patients with esophageal cancer, achieving a clinical complete response (CCR) after neoadjuvant chemoradiotherapy (nCRT). However, two thirds of patients have residual disease detected 12 weeks after nCRT and undergo surgery. At 12 weeks, nearly half of the patients with CCR will experience locoregional regrowth. This study aimed to identify routine predictive factors for achieving (sustained) CCR to improve p...
Abstract
The American journal of cardiology,
Volume 258, 22 4 2025, Pages 261-267
Clinical and Technical Predictors of Adverse Cardiovascular Events Following Coronary Lithotripsy in the BENELUX-IVL Registry.
van Oort MJH, Phagu AAS, Oliveri F, Bingen BO, Mincione G, Paradies V, Claessen BEPM, Dimitriu-Leen AC, Vossenberg TN, Kefer J, Mandurino-Mirizzi A, van der Kley F, Jukema JW, Amri IA, Montero-Cabezas JM
Intravascular lithotripsy (IVL) has emerged as a viable treatment option for calcified coronary lesions. This study aimed to identify clinical and procedural factors associated with major adverse cardiovascular events (MACE) following IVL. This retrospective analysis included 583 patients (72.9 ± 9 years, 74% male) treated with IVL for 612 lesions from the multicenter BENELUX-IVL registry (May 2019-December 2024). Kaplan-Meier analysis was performed to evaluate survival probability. Binary logis...
Abstract
Heart (British Cardiac Society),
20 3 2025, Pages heartjnl-2025-326395
Ventricular arrhythmias during exercise in patients with mitral valve prolapse.
van Wijngaarden AL, de Riva M, Sabbag A, El-Am E, Essayagh B, Michelena HI, Rahme SJ, Medina Inojosa J, Enriquez-Sarano M, Bax JJ, Ajmone Marsan N
Background: Mitral valve prolapse (MVP) can be associated with ventricular arrhythmias (VA), but little is known about the relationship between VA and exercise in these patients. The aim of this study was to assess the occurrence and severity of VA during exercise tests in patients with MVP, and to explore the association between VA during exercise and the occurrence of arrhythmic events during follow-up. Methods: In this multicentre study, 375 patients with MVP (58 (48-69) years, 53% male) who...
Abstract
European heart journal,
17 3 2025, Pages ehaf791
Outcomes of moderate mixed aortic valve stenosis and regurgitation.
Lopez Santi P, Bernard J, Chua A, Laenens D, Powers A, Abdoun K, Velders BJJ, Sarrazyn C, Springhetti P, Zhang J, Amanullah MR, Ewe SH, Yiu KH, Palmen M, Hjortnaes J, Pibarot P, Clavel MA, Bax JJ, Ajmone Marsan N
Background and aims: There are limited data on mortality in patients with moderate mixed aortic valve disease (MAVD), defined as the combination of moderate aortic stenosis (AS) and moderate aortic regurgitation (AR). Consequently, current guidelines lack specific recommendations for aortic valve replacement (AVR) in this population. This study aims to compare survival between moderate MAVD and isolated severe AS or severe AR, and to evaluate the impact of symptoms or left ventricular ejection f...
Abstract
Revista da Associacao Medica Brasileira (1992),
Volume 71, Issue 9, 17 3 2025, Pages e20250355
Comparison of tension-free transvaginal tape and transobturator tape in terms of urinary incontinence and quality of life among Turkish women.
Karkin PÖ, Sezer G, Pişkin N, Yilmaz D
Objective: Urinary incontinence is more common in women than men; additionally, prevalence rises in elderly women. This study was conducted to compare the 10-year results of tension-free transvaginal tape and transobturator tape operations in terms of urinary incontinence and quality of life in women. Methods: Women who underwent transvaginal tape and transobturator tape operations in the urogynecology department at Istanbul Kanuni Sultan Süleyman Training and Research Hospital between January a...
Abstract
Surgery in practice and science,
Volume 23, 17 3 2025, Pages 100316
Nationwide survey of Indian cardiac surgeons on the management of acute type A aortic dissection.
Idhrees M, Grewal N, Ayyub M, Nilofer J, Velayudhan B
Objective: Acute Type A aortic dissection (ATAAD) is associated with high morbidity and mortality, and management strategies vary widely among surgeons. This study aimes to evaluate practice patterns and decision-making among Indian cardiac surgeons regarding ATAAD, with focus on differences related to surgical experience and institutional case volume. Methods: A 23-item electronic questionnaire covering preoperative, intraoperative and postoperative management of ATAAD was distributed to all me...
Abstract
Intensive & critical care nursing,
Volume 92, 15 3 2025, Pages 104253
Important and feasible patient- and family-centered intensive care interventions: A Delphi study with stakeholders.
Tilburgs B, Bakker-Crommentuijn C, de Graaf M, van den Boogaard M
Background: Intensive care unit (ICU) admissions can be stressful for patients and family members. Patients may face discomfort, pain, delirium, immobility, and uncertainty about recovery, while family members often experience emotional strain, uncertainty and fatigue. Patient- and family-centered care (PFCC) is a guideline recommended approach to reduce ICU-burden for both patient and family members. However, which interventions are important and feasible for PFCC in the ICU is unknown. Objecti...
Abstract
Frontiers in medicine,
Volume 12, 14 2 2025, Pages 1704188
Editorial: Distributed training and rural health professions education.
Strasser RP, Wright J, Abdalla ME, Van Schaik L, Muller JV
Abstract
Cited 1 times since 2025 (7.9 per year)
source: EuropePMC
European journal of preventive cardiology,
14 2 2025, Pages zwaf661
Future myocardial infarction after an acute coronary syndrome and pharmacogenetic response to dalcetrapib.
Tardif JC, Pfeffer MA, Kouz S, Koenig W, Maggioni AP, McMurray JJV, Waters DD, Jukema JW, White HD, Heinonen T, Kallend D, Laghrissi-Thode F, Muroke V, Fortier A, Guertin MC, Dubé MP
Background: Acute coronary syndrome (ACS) survivors have heightened risk for subsequent cardiovascular events. Methods: All baseline characteristics collected in both the Dal-Outcomes and Dal-GenE trials were considered as potential risk markers. A prediction index for subsequent fatal and non-fatal myocardial infarction (MI) following ACS was developed using Cox proportional hazards modeling on data from Dal-Outcomes placebo patients (n=7086). This prediction index was then applied in all Dal-G...
Abstract
European journal of heart failure,
14 2 2025
Multimodality imaging in advanced heart failure. A clinical consensus statement of the Heart Failure Association of the ESC. Part 1: Multimodality imaging for the evaluation of patients with advanced heart failure.
Aimo A, Tops LF, Adamopoulos S, Bonios M, Çelik A, Chioncel O, Cikes M, Crespo-Leiro MG, Damman K, Di Nora C, Dreyfus J, Gustafsson F, Hashmani S, Masetti M, Mordi I, Nalbantgil S, van Laake LW, von Bardeleben RS, Metra M, Gal TB, Moura B
Heart failure (HF) represents a significant global health burden, with approximately 10% of patients progressing to advanced stages characterized by severe symptoms and recurrent hospitalizations despite conventional treatments such as guideline-directed medical therapy, devices, and surgery. This clinical consensus statement from the Heart Failure Association of the European Society of Cardiology discusses the applications of imaging modalities in patients with advanced HF. Transthoracic echoca...
Abstract
European journal of heart failure,
14 2 2025
Multimodality imaging in advanced heart failure. A clinical consensus statement of the Heart Failure Association of the ESC. Part 2: Mechanical circulatory support and heart transplantation.
Tops LF, Aimo A, Adamopoulos S, Bonios M, Çelik A, Chioncel O, Cikes M, Crespo-Leiro MG, Damman K, Di Nora C, Dreyfus J, Gustafsson F, Hashmani S, Masetti M, Mordi I, Nalbantgil S, van Laake LW, von Bardeleben RS, Metra M, Moura B, Ben Gal T
This clinical consensus statement outlines the vital role of multimodality imaging in managing patients with advanced heart failure (HF), particularly those receiving mechanical circulatory support (MCS) and heart transplantation (HT). For both temporary and durable MCS, multimodality imaging, primarily echocardiography, is crucial for selecting candidates, ensuring proper device placement, and monitoring in the post-implantation period. Preoperatively, it helps to identify HF phenotypes, assess...
Abstract
Nature communications,
Volume 16, Issue 1, 14 2 2025, Pages 9122
Analysis of cfDNA fragmentomics metrics and commercial targeted sequencing panels.
Helzer KT, Sharifi MN, Sperger JM, Chrostek MR, Bootsma ML, Reese SR, Taylor A, Kaufmann KR, Krause H, Schehr J, Sethakorn N, Kosoff D, Kyriakopoulos CE, Bassetti M, Blitzer G, Floberg J, Sjöström M, Armstrong AJ, Beltran H, McKay RR, Feng FY, O'Regan R, Wisinski KB, Emamekhoo H, Wyatt AW, Lang JM, Zhao SG
Fragmentomics based analysis of cell-free DNA (cfDNA) has recently emerged as a method to infer epigenetic and transcriptional data. Many of these reports analyze whole genome sequencing (WGS) which is not readily available clinically. Targeted exon panels are used for clinical cfDNA variant calling. In this report, we conduct an investigation of multiple published fragmentomics methods for WGS, but on cancer exon panels. We find that strategies utilizing normalized depth metrics, as well as all...
Abstract
Irish journal of medical science,
14 2 2025
Enhancing educator preparedness for type 1 diabetes: a theory-based intervention targeting knowledge and Self-efficacy in low-resource schools.
Yılmaz DA, Dege G, Atasoy M
Background: Type 1 diabetes mellitus (T1DM) is an increasing concern among school-aged children, with more than 1.2 million affected globally. In low- and middle-income countries (LMICs), teachers often act as first responders to diabetes-related emergencies despite limited preparation. Structured education programs informed by behavioral theory may help strengthen both knowledge and applied competence among school staff. Aim: This study examined the short-term effects of a Bandura-based diabete...
Abstract
Environmental pollution (Barking, Essex : 1987),
13 2 2025, Pages 127266
Assessment of microplastic transport and distribution in the urban environment of Coimbra municipality.
Leitão IA, van Schaik L, Ferreira AJD, Geissen V
Microplastics (MPs) largely originate from terrestrial environments, especially urban areas, where controlling their spread is difficult. This is concerning due to MPs' impacts on ecosystems and human health. To develop mitigation strategies, understanding how MPs move and spread is essential. This study examined MP transport and distribution in Coimbra municipality, Portugal, at a small watershed scale. Samples were collected from dry and wet atmospheric deposition, runoff, and streams, bo...
Abstract
Trends in cardiovascular medicine,
13 2 2025, Pages S1050-1738(25)00135-5
Controversies in valvular heart disease: insights from cardiac imaging.
van der Bijl P, Ajmone Marsan N, Bax JJ
Numerous controversies still exist in the diagnosis and management of valvular heart disease, for example, the benefit of treating moderate aortic stenosis (AS) or asymptomatic, severe AS and the appropriate selection criteria for transcatheter edge-to-edge mitral valve repair. While numerous imaging parameters have been linked to the risk of sudden cardiac death in mitral valve prolapse, their relative merits are unknown and this is a challenging population to risk-stratify. No large, randomize...
Abstract
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions,
12 2 2025
Modification Procedures for Chronic Total Occlusion Percutaneous Coronary Intervention: Insights From the PROGRESS-CTO Registry.
Kladou E, Strepkos D, Alexandrou M, Mutlu D, Carvalho PEP, Sara JDS, Ser OS, Alaswad K, Basir MB, Khelimskii D, Jaffer FA, Rafeh NA, Chandwaney R, Cevik C, Ahmad Y, Mastrodemos O, Rangan BV, Jalli S, Voudris K, Sandoval Y, Nicholas Burke M, Brilakis ES, PROGRESS‐CTO Investigators
Background: CTO-ARC (Chronic Total Occlusion Academic Research Consortium) defines CTO modification procedures (previously called investment procedures) as intentional balloon dilatation (diameter ≥ 2.0 mm) of the entire CTO, including the proximal and distal caps and the CTO body. Aims: The aim of this study is to compare the outcomes of repeat CTO PCI between patients who underwent lesion modification during the initial failed procedure and those who did not. Methods: We analyzed the associati...
Abstract
Journal of cardiovascular development and disease,
Volume 12, Issue 10, 11 2 2025, Pages 403
Trends in Conventional Heart Failure Therapy in a Real-World Multinational ATTR-CA Cohort.
van der Geest EH, Ajmone Marsan N, Laenens D, Debonnaire PJMR, Claeys M, Pinto F, Brito D, Donal E, Droogmans S, Van de Veire N, Bertrand P, Nabeta T, Graziani F, Regeer MV
Background: Conventional HF treatment in transthyretin cardiac amyloidosis (ATTR-CA) resulting in restrictive cardiomyopathy is debated due to absent trial evidence in this specific sub-population of heart failure (HF) patients. Current European Society of Cardiology guidelines recommend the use of diuretics and mineralocorticoid receptor antagonists (MRAs). However, beta-blockers (BBs) and angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers (ACEi/ARBs) are often discontinu...
Abstract
JMIR medical informatics,
Volume 13, 10 2 2025, Pages e71994
Evaluation of Machine Learning Model Performance in Diabetic Foot Ulcer: Retrospective Cohort Study.
van Velze VY, Burger HL, van der Steenhoven TJ, Al-Ers H, Goncalves LN, Eefting D, de Jong WJ, Smeets HJ, Welleweerd JCS, van der Vorst JR, Uchtmann S, Rissmann R, Hamming JF, Stergioulas L, van der Bogt KE
Background: Machine learning (ML) has shown great potential in recognizing complex disease patterns and supporting clinical decision-making. Diabetic foot ulcers (DFUs) represent a significant multifactorial medical problem with high incidence and severe outcomes, providing an ideal example for a comprehensive framework that encompasses all essential steps for implementing ML in a clinically relevant fashion. Objective: This paper aims to provide a framework for the proper use of ML algorithms t...
Abstract
American journal of physiology. Heart and circulatory physiology,
Volume 329, Issue 5, 10 2 2025, Pages H1414-H1421
Bone morphogenetic protein 10: clinical correlates and risk of incident atrial fibrillation.
Suthahar N, Yap SC, de Vries AAF, Damman K, Fabritz L, Bakker SJL, Gansevoort RT, Kirchhof P, Rienstra M, de Boer RA
Bone morphogenetic protein-10 (BMP10), a protein predominantly secreted by atrial cardiomyocytes, has emerged as a promising biomarker in patients with atrial fibrillation (AF) and as a marker of atrial stress in patients with heart failure. Its clinical correlates in community-dwelling adults and its association with incident AF remain unexplored. BMP10 was measured in 5,883 participants from the Prevention of Renal and Vascular End-stage Disease (PREVEND) community-based cohort (mean age 53.6...
Abstract
Journal of clinical microbiology,
Volume 63, Issue 11, 9 2 2025, Pages e0027225
<i>In vitro</i> activity of antibiotic monotherapy and combination therapy with bacteriophages against <i>Staphylococcus aureus</i> LVAD-driveline infections.
Molendijk MM, Verkaik NJ, de Vogel CP, Lemmens-den Toom N, Knight GM, Caliskan K, Bode LGM, Verbon A, Koopmans MPG, de Graaf M, van Wamel WJB
Left-ventricular assist devices (LVADs) are increasingly used as a bridge to heart transplantation and destination therapy. These devices, especially the driveline, are susceptible to difficult-to-treat infections, associated with high morbidity and mortality rates. Staphylococcus aureus (S. aureus) is a major causative pathogen of LVAD infections. Antibiotic resistance and biofilm formation can complicate the treatment of these infections. A novel in vitro assay was developed to study the antib...
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