Research

Publications

Below you can find a list of our published research.

6228 results

Cited 18 times since 1993 (0.6 per year) source: EuropePMC

Nuclear medicine and biology, Volume 20, Issue 7, 1 1 1993, Pages 825-833 The labeling of proteins and LDL with 99mTc: a new direct method employing KBH4 and stannous chloride. Pauwels EK, Welling MM, Feitsma RI, Atsma DE, Nieuwenhuizen W

A new direct labeling technique for proteins with technetium-99m (99mTc) has been developed and makes use of borohydride and stannous chloride. The method is simple and reproducible and gives a high labeling efficiency and high retention of biological activity for proteins, including polyclonal immunoglobulin (Ig), antifibrin monoclonal antibody, tissue type plasminogen activator, fibrinogen and low density lipoprotein (LDL). This method can be used in kit-format and takes about 20 min preparati... Abstract

Cited 93 times since 1993 (2.9 per year) source: EuropePMC

The EMBO journal, Volume 12, Issue 10, 1 1 1993, Pages 3921-3929 A transcription factor with homology to the AP-1 family links RNA transcription and DNA replication in the lytic cycle of Epstein-Barr virus. Schepers A, Pich D, Hammerschmidt W

oriLyt, the lytic origin of DNA replication of Epstein-Barr virus (EBV), ensures viral DNA amplification during the productive or lytic phase of the virus' life cycle. To understand the contribution of cis- and transacting elements involved in DNA replication of oriLyt, a detailed mutational analysis was undertaken which defined BZLF1, a viral transcriptional activator, as an essential replication factor. The BZLF1 protein belongs to the extended fos/jun family of transcription factors and... Abstract

Cited 3 times since 1993 (0.1 per year) source: EuropePMC

Catheterization and cardiovascular diagnosis, Volume 29, Issue 4, 1 1 1993, Pages 283-284 Nineteen years survival after occlusion of the left main coronary artery by virtue of an anomalous septal branch. Vliegen HW, Cats VM

This case presents a patient who survived 19 years with an occluded left main coronary artery as a result of collateral flow to the anterior wall from an anomalous septal branch arising from the right coronary artery. The case illustrates that minor variations in coronary anatomy may have important effects on the prognosis of a patient. Abstract

Cited 21 times since 1993 (0.7 per year) source: EuropePMC

Pediatric research, Volume 34, Issue 2, 1 1 1993, Pages 178-181 The influence of indomethacin on the autoregulatory ability of the cerebral vascular bed in the newborn lamb. van Bel F, Klautz RJ, Steendijk P, Schipper IB, Teitel DF, Baan J

Prevention of hyperperfusion of the brain in the perinatal period has been thought to be an important mechanism by which indomethacin reduces the risk for severe periventricular-intraventricular hemorrhage. The present study investigated whether an indomethacin-induced enhancement of the upper limit of cerebral vascular autoregulatory ability in the neonate contributed to this reduction in cerebral blood flow. In seven anesthetized newborn lambs, we measured temporal blood flow velocity (TMFV) i... Abstract

Cited 6 times since 1993 (0.2 per year) source: EuropePMC

Biological trace element research, Volume 38, Issue 2, 1 1 1993, Pages 107-115 Dietary fructose vs glucose lowers copper solubility in the digesta in the small intestine of rats. Van den Berg GJ, Yu S, Van der Heijden A, Lemmens AG, Beynen AC

The hypothesis was tested that dietary fructose vs glucose lowers copper solubility in the digesta in the small intestine of rats, which in turn causes a decreased copper absorption. Male rats were fed adequate-copper (5 mg Cu/kg) diets containing either fructose or glucose (709.4 g monosaccharide/kg) for a period of 5 wk. Fructose vs glucose significantly lowered copper concentrations in plasma and the liver, but did not alter hepatic copper mass. Fructose feeding resulted in a significantly le... Abstract

Indian heart journal, Volume 45, Issue 4, 1 1 1993, Pages 259-264 Progression and regression of coronary atherosclerosis. Bruschke AV, Jukema JW, Van der Wall EE

Abstract

Cited 62 times since 1993 (1.9 per year) source: EuropePMC

Journal of virology, Volume 67, Issue 7, 1 1 1993, Pages 4237-4245 cis-acting elements in the lytic origin of DNA replication of Epstein-Barr virus. Schepers A, Pich D, Mankertz J, Hammerschmidt W

oriLyt, the cis-acting element of Epstein-Barr virus, mediates viral DNA replication in the lytic phase of the virus's life cycle. Oligonucleotide-directed in vitro mutagenesis of oriLyt plasmids allowed the identification of two noncontiguous components within the complex structure of oriLyt. Both components were indispensable for DNA replication of this origin. The upstream component colocalized with the promoter of the viral BHLF1-encoding gene, and mutants affecting DNA replication affe... Abstract

Cited 52 times since 1993 (1.6 per year) source: EuropePMC

The American journal of physiology, Volume 264, Issue 6 Pt 2, 1 1 1993, Pages H2198-207 Left ventricular stroke volume by single and dual excitation of conductance catheter in dogs. Steendijk P, Van der Velde ET, Baan J

The conductance method employs a multielectrode catheter to measure intracavitary electric conductance from which left ventricular volume is estimated. A dual-excitation method introduced by us uses a more homogeneous electric field and thereby should enable more accurate volume estimation. In six anesthetized open-chest dogs we compared stroke volume obtained from electromagnetic flow probes with the conventional single-excitation method and with the new dual-excitation conductance method. Cava... Abstract

Cited 17 times since 1993 (0.5 per year) source: EuropePMC

Veterinary immunology and immunopathology, Volume 36, Issue 4, 1 1 1993, Pages 369-378 Effects of inoculum route and dose on the immune response of common carp, Cyprinus carpio to the blood parasite, Trypanoplasma borreli. Jones SR, Palmen M, van Muiswinkel WB

Carp were inoculated intramuscularly (im) or intraperitoneally (ip) with different doses of live Trypanoplasma borreli. Prepatent period was shortened by using the im route and by increasing the dose. Haematocrit was reduced following im inoculation with 9.5 x 10(5) parasites. Most fish recovered between 8 and 13 weeks post-inoculation (wpi). Neither parasitaemia nor anaemia was detected in any recovered fish following homologous challenge. An enzyme-linked immunosorbent assay was developed to q... Abstract

Cited 2 times since 1993 (0.1 per year) source: EuropePMC

Nutricion hospitalaria, Volume 8, Issue 5, 1 1 1993, Pages 279-287 [Effect of increasing protein ingestion on the nitrogen balance of mechanically ventilated critically ill patients receiving total parenteral nutrition]. van der Heijden A, Verbeek MJ, Schreurs VV, Akkermans LM, Vos A

The amount of protein recommended to minimise N loss in critically ill patients receiving total parenteral nutrition (TPN) varies in the literature. Therefore, we studied the effect of increased protein intake on the N balance, administering TPN with either 1.2 g protein/kg/day (low N diet) or 1.8 g protein/kg/day (high N diet). Fifteen mechanically ventilated critically ill patients were studied in a surgical intensive care unit. After at least two days of standard TPN, patients were randomly a... Abstract

Cited 58 times since 1993 (1.8 per year) source: EuropePMC

The American journal of cardiology, Volume 71, Issue 12, 1 1 1993, Pages 1036-1040 Comparison of magnetic resonance imaging studies with enzymatic indexes of myocardial necrosis for quantification of myocardial infarct size. Holman ER, van Jonbergen HP, van Dijkman PR, van der Laarse A, de Roos A, van der Wall EE

To evaluate the potential of gadolinium-diethylene triamine pentaacetic acid (DTPA)-enhanced magnetic resonance imaging (MRI) in the quantification of infarct size in patients with a first acute myocardial infarction, 24 patients with a first acute myocardial infarction were studied by electrocardiographic gated MRI at a mean of 4.3 days after the acute event. Multislice, single-phase, T1-weighted, spin-echo MRI in the true short-axis plane was performed 20 minutes after intravenous injection of... Abstract

Cited 84 times since 1993 (2.6 per year) source: EuropePMC

European heart journal, Volume 14, Issue 4, 1 1 1993, Pages 456-463 Quantitation of global and regional left ventricular function by cine magnetic resonance imaging during dobutamine stress in normal human subjects. van Rugge FP, Holman ER, van der Wall EE, de Roos A, van der Laarse A, Bruschke AV

Magnetic resonance imaging (MRI) provides high-resolution images of the heart. However, physical exercise during MRI is difficult due to space restriction and motion artefacts. To evaluate the feasibility of MRI during stress conditions, dobutamine was used as an alternative to exercise. Haemodynamics, ventricular volumes and wall thickening were measured at rest and during peak dobutamine infusion (15 micrograms.kg-1 x min-1) in 23 normal human subjects. To calculate left ventricular volumes, e... Abstract

Cited 2 times since 1993 (0.1 per year) source: EuropePMC

Journal of cardiovascular pharmacology, Volume 21, Issue 4, 1 1 1993, Pages 552-559 Comparison of diltiazem standard formulation and diltiazem controlled release in patients with stable angina pectoris: a randomized, double-blind, cross-over, multicenter study. Vliegen HW, van der Wall EE, Kragten JA, Holwerda NJ, Schenkel WM, Muijs van de Moer WM, ten Kate JB, Mulder PG, Bruschke AV

In a randomized, double-blind, cross-over, multicenter study with a placebo run-in phase, the efficacy and safety of two oral formulations of diltiazem, standard three or four times daily (t.i.d. or q.i.d.) and controlled release twice daily (b.i.d.), were compared in 49 patients with stable angina pectoris. ST-segment depression at maximum exercise 12 h after tablet intake was less frequently observed with diltiazem controlled release than with standard diltiazem (34 of 49, 69% vs. 43 of 49, 88... Abstract

Cited 8 times since 1993 (0.2 per year) source: EuropePMC

Basic research in cardiology, Volume 88, Issue 2, 1 1 1993, Pages 167-178 Effect of coronary occlusion and reperfusion on local electrical resistivity of myocardium in dogs. Steendijk P, van Dijk AD, Mur G, van der Velde ET, Baan J

The effect of coronary occlusion and reperfusion on myocardial electrical resistivity was studied in nine anesthetized open-chest dogs. Anisotropic resistivity was measured on the anterior free wall of the left ventricle (LV) before (control) and during transient occlusion of the left anterior descending (LAD) coronary artery, and during reperfusion. To measure local resistivity longitudinal (RL) and transverse (RT) to epicardial muscle fiber direction, a sensor was developed based on the four e... Abstract

Cited 8 times since 1993 (0.2 per year) source: EuropePMC

Pediatric research, Volume 33, Issue 3, 1 1 1993, Pages 295-301 Myocardial perfusion and performance after indomethacin administration in newborn lambs. Klautz RJ, van Bel F, Teitel DF, Steendijk P, Baan J

Indomethacin is a drug widely used to achieve pharmacologic closure of a patent ductus arteriosus in the premature infant. In several vascular beds (brain, kidney, intestine), indomethacin has been shown to cause vasoconstriction. Possible negative effects on myocardial blood flow and performance could be deleterious in premature infants with limited cardiac reserve. Before, during, and 30 and 60 min after administration of 1 mg.kg-1 of indomethacin in nine newborn lambs, we measured coronary bl... Abstract

Cited 1 times since 1993 (0 per year) source: EuropePMC

Archives francaises de pediatrie, Volume 50, Issue 2, 1 1 1993, Pages 174 [Digestive form of Langerhans cell histiocytosis]. Abadie V, Canioni D, Janssen V, Brugières L, Brousse N

Abstract

Cited 7 times since 1993 (0.2 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 7, Issue 7, 1 1 1993, Pages 356-359 Surgery for membranous subaortic stenosis. Long-term follow-up. Hazekamp MG, Frank M, Hardjowijono R, Quaegebeur JM, Ottenkamp J, Huysmans HA

From 1958 to 1992, 105 patients were operated for discrete (or membranous) subaortic stenosis (DSAS). Our surgical techniques changed during this period. Before 1980 DSAS was removed by a sharp excision leaving the part on the mitral valve untouched (n = 58). After 1980 blunt dissection was used to enucleate DSAS completely (n = 47). The operation for DSAS was combined with aortic valve replacement (AVR) in 7 instances. Follow-up with recent echo-Doppler studies was complete in 100 patients. Rec... Abstract

Cited 15 times since 1993 (0.5 per year) source: EuropePMC

Biology of the neonate, Volume 64, Issue 4, 1 1 1993, Pages 193-200 Cerebral hemodynamics and oxygenation in preterm infants after low-vs. high-dose surfactant replacement therapy. Dorrepaal CA, Benders MJ, Steendijk P, van de Bor M, van Bel F

In thirteen preterm infants receiving surfactant (Curosurf) replacement therapy, changes in cerebral hemodynamics and oxygenation were investigated by near infrared spectroscopy. Surfactant instillation led to an instantaneous increase in cerebral blood volume (CBV) in all infants, which was primarily due to an increase in deoxygenated hemoglobin. Five infants received a low dose (100 mg/kg = 1.25 ml/kg) of surfactant and 8 a high dose (200 mg/kg = 2.50 ml/kg). A significantly larger increase in... Abstract

Cited 19 times since 1993 (0.6 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 7, Issue 10, 1 1 1993, Pages 514-519 The value of the stentless biovalve prosthesis. An experimental study. Hazekamp MG, Goffin YA, Huysmans HA

Clinical use of the stentless bioprosthesis has not yet been accepted world-wide. Experimental studies are scarce. In a study in growing pigs, 23 aortic valve replacements were performed (7 stented bioprostheses (STB), 10 stentless bioprostheses (SLB) and 6 cryopreserved homografts (CAH)). Valves were studied macroscopically and microscopically after explantation. Five animals died between 1.5 and 4 months after implantation. Two STBs showed extreme calcific degeneration. A third STB animal died... Abstract

Cited 15 times since 1993 (0.5 per year) source: EuropePMC

The Anatomical record, Volume 235, Issue 1, 1 1 1993, Pages 74-86 Histological organization of the right and left atrioventricular valves of the chicken heart and their relationship to the atrioventricular Purkinje ring and the middle bundle branch. Lu Y, James TN, Bootsma M, Terasaki F

In the avian heart the right and left atrioventricular (AV) valves not only exhibit their own special anatomical characteristics, but they also are in close proximity to the conduction system. The right AV valve is a single, spiral plane of myocardium, in remarkable contrast to the fibrous structure characteristic of the mammalian tricuspid valve. A ring of Purkinje tissue encircles the avian right AV orifice and connects to the muscular valve. The chicken has no crista supraventricularis, its r... Abstract