Research

Publications

Below you can find a list of our published research.

6128 results

Cited 2 times since 2019 (0.4 per year) source: EuropePMC

Clinical case reports, Volume 8, Issue 1, 17 3 2019, Pages 215-216 Caseous calcification of the mitral annulus assessed by multimodality imaging. Sala ML, van Dijkman PRM, Kuijpers D

Physicians may not be familiar with caseous calcification of the mitral annulus. It can therefore easily be mistaken for other conditions including tumors. In the appropriate clinical context, by using multimodality imaging, a correct diagnosis can be made, and patient concern or even unnecessary surgery can be avoided. Abstract

Cited 3 times since 2019 (0.6 per year) source: EuropePMC

The Canadian journal of cardiology, Volume 36, Issue 9, 17 3 2019, Pages 1525-1533 Myocardial Deformation in the Systemic Right Ventricle: Strain Imaging Improves Prediction of the Failing Heart. Woudstra OI, van Dissel AC, van der Bom T, de Bruin-Bon RHACM, van Melle JP, van Dijk APJ, Vliegen HW, Mulder BJM, Tanck MWT, Meijboom FJ, Bouma BJ

Background: Predicting heart failure events in patients with a systemic right ventricle (sRV) due to transposition of the great arteries (TGA) is important for timely intensification of follow-up. This study assessed the value of strain compared with currently used parameters as predictor for heart failure-free survival in patients with sRV. Methods: In participants of a multicentre trial, speckle-tracking echocardiography (STE) was performed to assess global longitudinal strain (GLS), mechanica... Abstract

Cited 30 times since 2019 (5.8 per year) source: EuropePMC

Journal of lipid research, Volume 61, Issue 3, 16 3 2019, Pages 365-375 Alirocumab, evinacumab, and atorvastatin triple therapy regresses plaque lesions and improves lesion composition in mice. Pouwer MG, Pieterman EJ, Worms N, Keijzer N, Jukema JW, Gromada J, Gusarova V, Princen HMG

Atherosclerosis-related CVD causes nearly 20 million deaths annually. Most patients are treated after plaques develop, so therapies must regress existing lesions. Current therapies reduce plaque volume, but targeting all apoB-containing lipoproteins with intensive combinations that include alirocumab or evinacumab, monoclonal antibodies against cholesterol-regulating proprotein convertase subtilisin/kexin type 9 and angiopoietin-like protein 3, may provide more benefit. We investigated the effec... Abstract

Cited 49 times since 2019 (9.4 per year) source: EuropePMC

Arteriosclerosis, thrombosis, and vascular biology, Volume 40, Issue 2, 12 2 2019, Pages 350-364 Shear Stress Regulation of Endothelial Glycocalyx Structure Is Determined by Glucobiosynthesis. Wang G, Kostidis S, Tiemeier GL, Sol WMPJ, de Vries MR, Giera M, Carmeliet P, van den Berg BM, Rabelink TJ

Objective: Endothelial cells exposed to laminar shear stress express a thick glycocalyx on their surface that plays an important role in reducing vascular permeability and endothelial anti-inflammatory, antithrombotic, and antiangiogenic properties. Production and maintenance of this glycocalyx layer is dependent on cellular carbohydrate synthesis, but its regulation is still unknown. Approach and Results: Here, we show that biosynthesis of the major structural component of the endothelial glyco... Abstract

Cited 52 times since 2019 (9.9 per year) source: EuropePMC

JACC. Heart failure, Volume 8, Issue 2, 11 2 2019, Pages 131-140 Left Ventricular Post-Infarct Remodeling: Implications for Systolic Function Improvement and Outcomes in the Modern Era. van der Bijl P, Abou R, Goedemans L, Gersh BJ, Holmes DR, Ajmone Marsan N, Delgado V, Bax JJ

Objectives: This study sought to investigate the impact of post-infarct left ventricular (LV) remodeling on outcomes in the contemporary era. Background: LV remodeling after ST-segment elevation myocardial infarction (STEMI) is associated with heart failure and increased mortality. Pivotal studies have mostly been performed in the era of thrombolysis, whereas the long-term prognostic impact of LV remodeling has not been reinvestigated in the current era of primary percutaneous coronary intervent... Abstract

Cited 1 times since 2019 (0.2 per year) source: EuropePMC

Aging, Volume 11, Issue 23, 11 2 2019, Pages 10791-10792 PCSK9 inhibition in high-risk patients. Zijlstra LE, Mooijaart SP, Jukema JW

Abstract

Cited 69 times since 2019 (13.2 per year) source: EuropePMC

Nature reviews. Cardiology, Volume 17, Issue 5, 9 2 2019, Pages 298-312 Assessment of mitral valve regurgitation by cardiovascular magnetic resonance imaging. Garg P, Swift AJ, Zhong L, Carlhäll CJ, Ebbers T, Westenberg J, Hope MD, Bucciarelli-Ducci C, Bax JJ, Myerson SG

Mitral regurgitation (MR) is a common valvular heart disease and is the second most frequent indication for heart valve surgery in Western countries. Echocardiography is the recommended first-line test for the assessment of valvular heart disease, but cardiovascular magnetic resonance imaging (CMR) provides complementary information, especially for assessing MR severity and to plan the timing of intervention. As new CMR techniques for the assessment of MR have arisen, standardizing CMR protocols... Abstract

Cited 3 times since 2019 (0.6 per year) source: EuropePMC

The pharmacogenomics journal, Volume 20, Issue 3, 6 1 2019, Pages 482-493 Genome-wide meta-analysis of variant-by-diuretic interactions as modulators of lipid traits in persons of European and African ancestry. de las Fuentes L, Sung YJ, Sitlani CM, Avery CL, Bartz TM, Keyser C, Evans DS, Li X, Musani SK, Ruiter R, Smith AV, Sun F, Trompet S, Xu H, Arnett DK, Bis JC, Broeckel U, Busch EL, Chen YI, Correa A, Cummings SR, Floyd JS, Ford I, Guo X, Harris TB, Ikram MA, Lange L, Launer LJ, Reiner AP, Schwander K, Smith NL, Sotoodehnia N, Stewart JD, Stott DJ, Stürmer T, Taylor KD, Uitterlinden A, Vasan RS, Wiggins KL, Cupples LA, Gudnason V, Heckbert SR, Jukema JW, Liu Y, Psaty BM, Rao DC, Rotter JI, Stricker B, Wilson JG, Whitsel EA

Hypertension (HTN) is a significant risk factor for cardiovascular morbidity and mortality. Metabolic abnormalities, including adverse cholesterol and triglycerides (TG) profiles, are frequent comorbid findings with HTN and contribute to cardiovascular disease. Diuretics, which are used to treat HTN and heart failure, have been associated with worsening of fasting lipid concentrations. Genome-wide meta-analyses with 39,710 European-ancestry (EA) individuals and 9925 African-ancestry (AA) individ... Abstract

Cited 10 times since 2019 (1.9 per year) source: EuropePMC

Journal of cardiovascular computed tomography, Volume 14, Issue 3, 5 1 2019, Pages 251-257 Coronary atherosclerosis scoring with semiquantitative CCTA risk scores for prediction of major adverse cardiac events: Propensity score-based analysis of diabetic and non-diabetic patients. van den Hoogen IJ, van Rosendael AR, Lin FY, Lu Y, Dimitriu-Leen AC, Smit JM, Scholte AJHA, Achenbach S, Al-Mallah MH, Andreini D, Berman DS, Budoff MJ, Cademartiri F, Callister TQ, Chang HJ, Chinnaiyan K, Chow BJW, Cury RC, DeLago A, Feuchtner G, Hadamitzky M, Hausleiter J, Kaufmann PA, Kim YJ, Leipsic JA, Maffei E, Marques H, de Araújo Gonçalves P, Pontone G, Raff GL, Rubinshtein R, Villines TC, Gransar H, Jones EC, Peña JM, Shaw LJ, Min JK, Bax JJ

Aims: We aimed to compare semiquantitative coronary computed tomography angiography (CCTA) risk scores - which score presence, extent, composition, stenosis and/or location of coronary artery disease (CAD) - and their prognostic value between patients with and without diabetes mellitus (DM). Risk scores derived from general chest-pain populations are often challenging to apply in DM patients, because of numerous confounders. Methods: Out of a combined cohort from the Leiden University Medical Ce... Abstract

Cited 14 times since 2019 (2.7 per year) source: EuropePMC

The pharmacogenomics journal, Volume 20, Issue 3, 5 1 2019, Pages 462-470 Statin-induced LDL cholesterol response and type 2 diabetes: a bidirectional two-sample Mendelian randomization study. Smit RAJ, Trompet S, Leong A, Goodarzi MO, Postmus I, Warren H, Theusch E, Barnes MR, Arsenault BJ, Li X, Feng Q, Chasman DI, Cupples LA, Hitman GA, Krauss RM, Psaty BM, Rotter JI, Cessie SL, Stein CM, Jukema JW, GIST consortium

It remains unclear whether the increased risk of new-onset type 2 diabetes (T2D) seen in statin users is due to low LDL-C concentrations, or due to the statin-induced proportional change in LDL-C. In addition, genetic instruments have not been proposed before to examine whether liability to T2D might cause greater proportional statin-induced LDL-C lowering. Using summary-level statistics from the Genomic Investigation of Statin Therapy (GIST, nmax = 40,914) and DIAGRAM (nmax = 159,208) consortia... Abstract

Cited 5 times since 2019 (1 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 20, Issue 12, 1 1 2019, Pages 1332-1336 EACVI survey on multimodality training in ESC countries. Cameli M, Marsan NA, D'Andrea A, Dweck MR, Fontes-Carvalho R, Manka R, Michalski B, Podlesnikar T, Sitges M, Popescu BA, Edvardsen T, Fox KF, Haugaa KH

One of the missions of the European Association of Cardiovascular Imaging (EACVI) is 'to promote excellence in clinical diagnosis, research, technical development, and education in cardiovascular imaging'. The future of imaging involves multimodality so each imager should have the incentive and the possibility to improve its knowledge in other cardiovascular techniques. This article presents the results of a 20 questions survey carried out in cardiovascular imaging (CVI) centres across... Abstract

Cited 9 times since 2019 (1.7 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 12, Issue 12, 1 1 2019, Pages 2560-2570 Core Competencies in Echocardiography for Imaging Structural Heart Disease Interventions: An Expert Consensus Statement. Hahn RT, Mahmood F, Kodali S, Lang R, Monaghan M, Gillam LD, Swaminathan M, Bonow RO, von Bardeleben RS, Bax JJ, Grayburn P, Zoghbi WA, Sengupta PP, Chandrashekhar Y, Little SH

Abstract

Journal of the American College of Cardiology, Volume 74, Issue 22, 1 1 2019, Pages 2826 Reply: Staging Cardiac Damage in Aortic Stenosis. Delgado V, Vollema EM, Tastet L, Pibarot P, Bax JJ

Abstract

Cited 7 times since 2019 (1.3 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 27, Issue 12, 1 1 2019, Pages 590-593 Ventricular assist device implantation in patients with a failing systemic right ventricle: a call to expand current practice. Zandstra TE, Palmen M, Hazekamp MG, Meyns B, Beeres SLMA, Holman ER, Kiès P, Jongbloed MRM, Vliegen HW, Egorova AD, Schalij MJ, Tops LF

Ventricular assist device (VAD) implantation is an established treatment modality for patients with end-stage heart failure, and improves symptoms and survival. In the Netherlands, it is not yet routinely considered in patients with congenital heart disease and failing systemic right ventricle (SRV). Recently, a VAD was implanted in 2 SRV patients, one who underwent a Mustard procedure during infancy for transposition of the great arteries (male, 47 years old) and one with a congenitally correct... Abstract

Cited 8 times since 2019 (1.5 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 12, Issue 12, 1 1 2019, Pages 2555-2559 Core Competencies in Cardiac CT for Imaging Structural Heart Disease Interventions: An Expert Consensus Statement. Leipsic J, Nørgaard BL, Khalique O, Cavalcante JL, Wang DD, Jilaihawi H, Delgado V, Bax JJ, Blanke P

Abstract

Cited 18 times since 2019 (3.4 per year) source: EuropePMC

Circulation. Cardiovascular imaging, Volume 12, Issue 1, 1 1 2019, Pages e008122 Interobserver Variability in Applying American Society of Echocardiography/European Association of Cardiovascular Imaging 2016 Guidelines for Estimation of Left Ventricular Filling Pressure. Nagueh SF, Abraham TP, Aurigemma GP, Bax JJ, Beladan C, Browning A, Chamsi-Pasha MA, Delgado V, Derumeaux G, Dolci G, Donal E, Edvardsen T, El Tallawi KC, Ernande L, Esposito R, Flachskampf FA, Galderisi M, Gentry J, Goldstein SA, Harb SC, Hubert A, Hung J, Klein AL, Lancellotti P, Mahmood RZ, Marino P, Popescu BA, Previato M, Sanghai SR, Smiseth OA, Xu J, for Diastolic Function Assessment Collaborators

Background: Assessment of left ventricular (LV) filling pressure is among the important components of a comprehensive echocardiographic report. Previous studies noted wide limits of agreement using 2009 American Society of Echocardiography/European Association of Echocardiography guidelines, but reproducibility of 2016 guidelines update in estimating LV filling pressure is unknown. Methods: Echocardiographic and hemodynamic data were obtained from 50 patients undergoing cardiac catheterization f... Abstract

JACC. Cardiovascular interventions, Volume 12, Issue 24, 1 1 2019, Pages 2473-2475 Mitral Annular Dilation Relative to the Length of the Leaflets and Outcome of MitraClip Implantation. Delgado V, Ajmone Marsan N, Bax JJ

Abstract

Cited 33 times since 2019 (6.3 per year) source: EuropePMC

European heart journal, Volume 40, Issue 48, 1 1 2019, Pages 3901-3909 The relation between systemic inflammation and incident cancer in patients with stable cardiovascular disease: a cohort study. Van't Klooster CC, Ridker PM, Hjortnaes J, van der Graaf Y, Asselbergs FW, Westerink J, Aerts JGJV, Visseren FLJ

Aims: Low-grade inflammation, measured by elevated plasma concentrations of high-sensitive C-reactive protein (CRP), is a risk factor for cardiovascular disease (CVD). There is evidence that low-grade inflammation is also related to a higher risk of cancer. The present prospective cohort study evaluates the relation between low-grade systemic inflammation and risk of cancer in patients with stable CVD. Methods and results: In total, 7178 patients with stable CVD and plasma CRP levels ≤10 mg/L we... Abstract

Cited 22 times since 2019 (4.2 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 20, Issue 12, 1 1 2019, Pages 1388-1394 Prognostic implications of global, left ventricular myocardial work efficiency before cardiac resynchronization therapy. van der Bijl P, Vo NM, Kostyukevich MV, Mertens B, Ajmone Marsan N, Delgado V, Bax JJ

Aims: Cardiac resynchronization therapy (CRT) restores mechanical efficiency to the failing left ventricular (LV) by resynchronization of contraction. Global, LV myocardial work efficiency (GLVMWE) can be quantified non-invasively with echocardiography. The prognostic implication of GLVMWE remains unexplored, and we therefore related GLVMWE before CRT to long-term prognosis. Methods and results: Data were analysed from an ongoing registry of patients with Class I indications for CRT. GLVMWE was... Abstract

Cited 7 times since 2019 (1.3 per year) source: Scopus

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 56, Issue 6, 1 1 2019, Pages 1117-1123 Reinterventions after freestyle stentless aortic valve replacement: an assessment of procedural risks. Schneider AW, Hazekamp MG, Versteegh MIM, de Weger A, Holman ER, Klautz RJM, Bruggemans EF, Braun J

Objectives: Repeat aortic valve interventions after previous stentless aortic valve replacement (AVR) are considered technically challenging with an increased perioperative risk, especially after full-root replacement. We analysed our experience with reinterventions after stentless AVR. Methods: A total of 75 patients with previous AVR using a Freestyle stentless bioprosthesis (31 subcoronary, 15 root-inclusion and 29 full-root replacement) underwent reintervention in our centre from 1993 until... Abstract