7401 results
Cited 156 times since 2021 (35.4 per year)
source: EuropePMC
Emerging infectious diseases,
Volume 27, Issue 5, 1 1 2021, Pages 1405-1415
Monitoring SARS-CoV-2 Circulation and Diversity through Community Wastewater Sequencing, the Netherlands and Belgium.
Izquierdo-Lara R, Elsinga G, Heijnen L, Munnink BBO, Schapendonk CME, Nieuwenhuijse D, Kon M, Lu L, Aarestrup FM, Lycett S, Medema G, Koopmans MPG, de Graaf M
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly become a major global health problem, and public health surveillance is crucial to monitor and prevent virus spread. Wastewater-based epidemiology has been proposed as an addition to disease-based surveillance because virus is shed in the feces of ≈40% of infected persons. We used next-generation sequencing of sewage samples to evaluate the diversity of SARS-CoV-2 at the community level in the Netherlands and Belgium. Phylo...
Abstract
Cited 2 times since 2021 (0.5 per year)
source: EuropePMC
BJS open,
Volume 5, Issue 3, 1 1 2021, Pages zraa065
Effects of hospital preference for endovascular repair on postoperative mortality after elective abdominal aortic aneurysm repair: analysis of the Dutch Surgical Aneurysm Audit.
Lijftogt N, Vahl AC, Karthaus EG, van der Willik EM, Amodio S, van Zwet EW, Hamming JF, Dutch Society of Vascular Surgery, the Steering Committee of the Dutch Surgical Aneurysm Audit, and the Dutch Institute for Clinical Auditing
Background: Increased use of endovascular aneurysm repair (EVAR) and reduced open surgical repair (OSR), has decreased postoperative mortality after elective repair of abdominal aortic aneurysms (AAAs). The choice between EVAR or OSR depends on aneurysm anatomy, and the experience and preference of the vascular surgeon, and therefore differs between hospitals. The aim of this study was to investigate the current mortality risk difference (RD) between EVAR and OSR, and the effect of hospital pref...
Abstract
Cited 6 times since 2021 (1.4 per year)
source: EuropePMC
Lupus science & medicine,
Volume 8, Issue 1, 1 1 2021, Pages e000472
Effectiveness of a multidisciplinary clinical pathway for women with systemic lupus erythematosus and/or antiphospholipid syndrome.
Wind M, Hendriks M, van Brussel BTJ, Eikenboom J, Allaart CF, Lamb HJ, Siebelink HJ, Ninaber MK, van Geloven N, van Lith JMM, Huizinga TWJ, Rabelink TJ, Sueters M, Teng YKO
Objectives: SLE and/or antiphospholipid syndrome (SLE/APS) are complex and rare systemic autoimmune diseases that predominantly affect women of childbearing age. Women with SLE/APS are at high risk of developing complications during pregnancy. Therefore, clinical practice guidelines recommend that patients with SLE/APS should receive multidisciplinary counselling before getting pregnant. We investigated the clinical effectiveness of implementing a multidisciplinary clinical pathway including pre...
Abstract
Cited 61 times since 2021 (13.9 per year)
source: EuropePMC
European heart journal,
Volume 42, Issue 18, 1 1 2021, Pages 1742-1756
Genetically determined NLRP3 inflammasome activation associates with systemic inflammation and cardiovascular mortality.
Schunk SJ, Kleber ME, März W, Pang S, Zewinger S, Triem S, Ege P, Reichert MC, Krawczyk M, Weber SN, Jaumann I, Schmit D, Sarakpi T, Wagenpfeil S, Kramann R, Boerwinkle E, Ballantyne CM, Grove ML, Tragante V, Pilbrow AP, Richards AM, Cameron VA, Doughty RN, Dubé MP, Tardif JC, Feroz-Zada Y, Sun M, Liu C, Ko YA, Quyyumi AA, Hartiala JA, Tang WHW, Hazen SL, Allayee H, McDonough CW, Gong Y, Cooper-DeHoff RM, Johnson JA, Scholz M, Teren A, Burkhardt R, Martinsson A, Smith JG, Wallentin L, James SK, Eriksson N, White H, Held C, Waterworth D, Trompet S, Jukema JW, Ford I, Stott DJ, Sattar N, Cresci S, Spertus JA, Campbell H, Tierling S, Walter J, Ampofo E, Niemeyer BA, Lipp P, Schunkert H, Böhm M, Koenig W, Fliser D, Laufs U, Speer T, eQTLGen consortium, BIOS consortium
Aims: Inflammation plays an important role in cardiovascular disease (CVD) development. The NOD-like receptor protein-3 (NLRP3) inflammasome contributes to the development of atherosclerosis in animal models. Components of the NLRP3 inflammasome pathway such as interleukin-1β can therapeutically be targeted. Associations of genetically determined inflammasome-mediated systemic inflammation with CVD and mortality in humans are unknown. Methods and results: We explored the association of genetic N...
Abstract
Nature genetics,
Volume 53, Issue 5, 1 1 2021, Pages 762
Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.
Surendran P, Feofanova EV, Lahrouchi N, Ntalla I, Karthikeyan S, Cook J, Chen L, Mifsud B, Yao C, Kraja AT, Cartwright JH, Hellwege JN, Giri A, Tragante V, Thorleifsson G, Liu DJ, Prins BP, Stewart ID, Cabrera CP, Eales JM, Akbarov A, Auer PL, Bielak LF, Bis JC, Braithwaite VS, Brody JA, Daw EW, Warren HR, Drenos F, Nielsen SF, Faul JD, Fauman EB, Fava C, Ferreira T, Foley CN, Franceschini N, Gao H, Giannakopoulou O, Giulianini F, Gudbjartsson DF, Guo X, Harris SE, Havulinna AS, Helgadottir A, Huffman JE, Hwang SJ, Kanoni S, Kontto J, Larson MG, Li-Gao R, Lindström J, Lotta LA, Lu Y, Luan J, Mahajan A, Malerba G, Masca NGD, Mei H, Menni C, Mook-Kanamori DO, Mosen-Ansorena D, Müller-Nurasyid M, Paré G, Paul DS, Perola M, Poveda A, Rauramaa R, Richard M, Richardson TG, Sepúlveda N, Sim X, Smith AV, Smith JA, Staley JR, Stanáková A, Sulem P, Thériault S, Thorsteinsdottir U, Trompet S, Varga TV, Velez Edwards DR, Veronesi G, Weiss S, Willems SM, Yao J, Young R, Yu B, Zhang W, Zhao JH, Zhao W, Zhao W, Evangelou E,
Abstract
Cited 6 times since 2021 (1.4 per year)
source: EuropePMC
Ultrastructural pathology,
Volume 45, Issue 3, 1 1 2021, Pages 167-181
Effects of Theranekron and alpha-lipoic acid combined treatment on GAP-43 and Krox-20 gene expressions and inflammation markers in peripheral nerve injury.
Sencar L, Coşkun G, Şaker D, Sapmaz T, Kara S, Çelenk A, Polat S, Yılmaz DM, Dağlıoğlu YK, Polat S
Peripheral nerve injury (PNI) is a major health problem that results in loss of motor and sensory functions. In treatment of PNI, various methods such as anastomosis, nerve grafts, nonneural tissue grafts, and nerve conduits are applied. In the present study, it was aimed to investigate the effects of Theranekron and Alpha-lipoic acid (ALA) combined treatment on nerve healing in experimental PNI by using histomorphometric, electron microscopic, immunohistochemical and molecular biological method...
Abstract
Cited 15 times since 2021 (3.4 per year)
source: EuropePMC
International journal of molecular sciences,
Volume 22, Issue 9, 30 5 2021, Pages 4804
Endoglin/CD105-Based Imaging of Cancer and Cardiovascular Diseases: A Systematic Review.
Sier VQ, van der Vorst JR, Quax PHA, de Vries MR, Zonoobi E, Vahrmeijer AL, Dekkers IA, de Geus-Oei LF, Smits AM, Cai W, Sier CFM, Goumans MJTH, Hawinkels LJAC
Molecular imaging of pathologic lesions can improve efficient detection of cancer and cardiovascular diseases. A shared pathophysiological feature is angiogenesis, the formation of new blood vessels. Endoglin (CD105) is a coreceptor for ligands of the Transforming Growth Factor-β (TGF-β) family and is highly expressed on angiogenic endothelial cells. Therefore, endoglin-based imaging has been explored to visualize lesions of the aforementioned diseases. This systematic review highlights the prog...
Abstract
Cited 41 times since 2021 (9.3 per year)
source: EuropePMC
Frontiers in cardiovascular medicine,
Volume 8, 28 4 2021, Pages 647785
Post-ischemic Myocardial Inflammatory Response: A Complex and Dynamic Process Susceptible to Immunomodulatory Therapies.
Pluijmert NJ, Atsma DE, Quax PHA
Following acute occlusion of a coronary artery causing myocardial ischemia and implementing first-line treatment involving rapid reperfusion, a dynamic and balanced inflammatory response is initiated to repair and remove damaged cells. Paradoxically, restoration of myocardial blood flow exacerbates cell damage as a result of myocardial ischemia-reperfusion (MI-R) injury, which eventually provokes accelerated apoptosis. In the end, the infarct size still corresponds to the subsequent risk of deve...
Abstract
Cited 13 times since 2021 (2.9 per year)
source: EuropePMC
JMIR mHealth and uHealth,
Volume 9, Issue 4, 28 4 2021, Pages e26161
Impact of Mobile Health Devices for the Detection of Atrial Fibrillation: Systematic Review.
Biersteker TE, Schalij MJ, Treskes RW
Background: Atrial fibrillation (AF) is the most common arrhythmia, and its prevalence is increasing. Early diagnosis is important to reduce the risk of stroke. Mobile health (mHealth) devices, such as single-lead electrocardiogram (ECG) devices, have been introduced to the worldwide consumer market over the past decade. Recent studies have assessed the usability of these devices for detection of AF, but it remains unclear if the use of mHealth devices leads to a higher AF detection rate. Object...
Abstract
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine,
Volume 174, 28 4 2021, Pages 109756
Albedo factors of some boron compounds at 59.54 keV.
Yılmaz D, Akkuş T
In this study, the albedo factors (number, energy, and dose) of some boron compounds were investigated at a scattering angle of 180°. Eight boron compounds were tested in the mean atomic number range of 4.571 ≤ Z‾ ≤ 19.00. The samples were irradiated by gamma rays emitted at 59.54 keV from an Am-241-point source with an activity of 0.43 MBq. The scattered gamma rays were counted by an ultra-low energy germanium detector with a resolution of 140 eV at 5.9 keV. The results showed that the albedo f...
Abstract
Cited 9 times since 2021 (2 per year)
source: EuropePMC
International journal of colorectal disease,
Volume 36, Issue 7, 27 4 2021, Pages 1507-1513
Normal inflammatory markers and acute appendicitis: a national multicentre prospective cohort analysis.
de Jonge J, Scheijmans JCG, van Rossem CC, van Geloven AAW, Boermeester MA, Bemelman WA, Snapshot Appendicitis Collaborative Study group
Purpose: For the diagnosis of acute appendicitis, the combination of clinical and laboratory variables achieves high diagnostic accuracy. Nevertheless, appendicitis can present with normal laboratory tests of inflammation. The aim of this study was to investigate the incidence of normal inflammatory markers in patients operated for acute appendicitis. Methods: This is an analysis of data from a prospective, multicentre SNAPSHOT cohort study of patients with suspected acute appendicitis. Only pat...
Abstract
Cited 16 times since 2021 (3.6 per year)
source: EuropePMC
Diabetologia,
Volume 64, Issue 7, 27 4 2021, Pages 1550-1562
Prognostic models for predicting the risk of foot ulcer or amputation in people with type 2 diabetes: a systematic review and external validation study.
Beulens JWJ, Yauw JS, Elders PJM, Feenstra T, Herings R, Slieker RC, Moons KGM, Nijpels G, van der Heijden AA
Aims/hypothesis: Approximately 25% of people with type 2 diabetes experience a foot ulcer and their risk of amputation is 10-20 times higher than that of people without type 2 diabetes. Prognostic models can aid in targeted monitoring but an overview of their performance is lacking. This study aimed to systematically review prognostic models for the risk of foot ulcer or amputation and quantify their predictive performance in an independent cohort. Methods: A systematic review identified studies...
Abstract
Cited 2 times since 2021 (0.5 per year)
source: EuropePMC
Journal of cardiovascular development and disease,
Volume 8, Issue 5, 26 4 2021, Pages 47
The Role of Cell Tracing and Fate Mapping Experiments in Cardiac Outflow Tract Development, New Opportunities through Emerging Technologies.
Peterson JC, Kelder TP, Goumans MJTH, Jongbloed MRM, DeRuiter MC
Whilst knowledge regarding the pathophysiology of congenital heart disease (CHDs) has advanced greatly in recent years, the underlying developmental processes affecting the cardiac outflow tract (OFT) such as bicuspid aortic valve, tetralogy of Fallot and transposition of the great arteries remain poorly understood. Common among CHDs affecting the OFT, is a large variation in disease phenotypes. Even though the different cell lineages contributing to OFT development have been studied for many de...
Abstract
Cited 1 times since 2021 (0.2 per year)
source: EuropePMC
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology,
Volume 47, Issue 8, 26 4 2021, Pages 1811-1812
Assessing the complexity of a carotid body tumor resection.
Hamming JF, Schepers A
Abstract
Cited 1 times since 2021 (0.2 per year)
source: EuropePMC
BMC nephrology,
Volume 22, Issue 1, 23 4 2021, Pages 150
Practice variation in the treatment of patients with renal hyperparathyroidism: a survey-based study in the Netherlands.
Zhang JLH, Appelman-Dijkstra NM, Fu EL, Rotmans JI, Schepers A
Background: Renal hyperparathyroidism is a disease entity that is complex and poorly understood. Although there are guidelines regarding how to manage this patient group, evidence is scarce. Therefore, this survey-based study aims to map the physicians' attitude in terms of preference for management of renal hyperparathyroidism and the influence of patient and respondent factors. Methods: A survey was sent to Dutch societies of nephrology, endocrinology, and surgeons with interest in endocr...
Abstract
Cited 11 times since 2021 (2.5 per year)
source: EuropePMC
Circulation. Genomic and precision medicine,
Volume 14, Issue 3, 22 4 2021, Pages e003231
Genetically Determined Serum Calcium Levels and Markers of Ventricular Repolarization: A Mendelian Randomization Study in the UK Biobank.
Young WJ, Warren HR, Mook-Kanamori DO, Ramírez J, van Duijvenboden S, Orini M, Tinker A, van Heemst D, Lambiase PD, Jukema JW, Munroe PB, Noordam R
Background: ECG markers of ventricular depolarization and repolarization are associated with an increased risk of arrhythmia and sudden cardiac death. Our prior work indicated lower serum calcium concentrations are associated with longer QT and JT intervals in the general population. Here, we investigate whether serum calcium is a causal risk factor for changes in ECG measures using Mendelian randomization (MR). Methods: Independent lead variants from a newly performed genome-wide association st...
Abstract
Cited 5 times since 2021 (1.1 per year)
source: EuropePMC
Transplant infectious disease : an official journal of the Transplantation Society,
Volume 23, Issue 4, 20 3 2021, Pages e13612
Utility of methicillin-resistant Staphylococcus aureus (MRSA) nasal screening in patients with acute myeloid leukemia (AML).
Talagtag M, Patel TS, Scappaticci GB, Perissinotti AJ, Schepers AJ, Petty LA, Pettit KM, Burke PW, Bixby DL, Marini BL
Background: Current literature has demonstrated the utility of the MRSA nasal screen as a de-escalation tool to decrease unnecessary anti-MRSA antibiotic therapy. However, data on the applicability of this test in patients with hematologic malignancy is lacking. Methods: This is a single-center, retrospective cohort study of patients with acute myeloid leukemia (AML) with or without a history of hematopoietic cell transplant (HCT), with pneumonia and MRSA nasal screening with respiratory culture...
Abstract
Cited 4 times since 2021 (0.9 per year)
source: EuropePMC
BMC musculoskeletal disorders,
Volume 22, Issue 1, 20 3 2021, Pages 370
The CAST study protocol: a cluster randomized trial assessing the effect of circumferential casting versus plaster splinting on fracture redisplacement in reduced distal radius fractures in adults.
Barvelink B, Reijman M, Schep NWL, Brown V, Kraan GA, Gosens T, Polinder S, Ista E, Verhaar JAN, Colaris JW, CAST study group
Background: There is no consensus concerning the optimal casting technique for displaced distal radius fractures (DRFs) following closed reduction. This study evaluates whether a splint or a circumferential cast is most optimal to prevent fracture redisplacement in adult patients with a reduced DRF. Additionally, the cost-effectiveness of both cast types will be calculated. Methods/design: This multicenter cluster randomized controlled trial will compare initial immobilization with a circumferen...
Abstract
Cited 4 times since 2021 (0.9 per year)
source: EuropePMC
International journal of cardiology,
Volume 334, 20 3 2021, Pages 10-17
Clopidogrel in noncarriers of CYP2C19 loss-of-function alleles versus ticagrelor in elderly patients with acute coronary syndrome: A pre-specified sub analysis from the POPular Genetics and POPular Age trials CYP2C19 alleles in elderly patients.
Claassens DMF, Gimbel ME, Bergmeijer TO, Vos GJA, Hermanides RS, van der Harst P, Barbato E, Morisco C, Tjon Joe Gin RM, de Vrey EA, Heestermans TACM, Jukema JW, von Birgelen C, Waalewijn RA, Hofma SH, den Hartog FR, Voskuil M, Van't Hof AWJ, Asselbergs FW, Mosterd A, Herrman JR, Dewilde W, Mahmoodi BK, Deneer VHM, Ten Berg JM
Background: Patients with acute coronary syndrome (ACS) who are carrying CYP2C19 loss-of-function alleles derive less benefit from clopidogrel treatment. Despite this, in elderly patients, clopidogrel might be preferred over more potent P2Y12 inhibitors due to a lower bleeding risk. Whether CYP2C19 genotype-guided antiplatelet treatment in the elderly could be of benefit has not been studied specifically. Methods: Patients aged 70 years and older with known CYP2C19*2 and *3 genotype were identif...
Abstract
Cited 628 times since 2021 (141.6 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 77, Issue 21, 19 3 2021, Pages 2717-2746
Valve Academic Research Consortium 3: Updated Endpoint Definitions for Aortic Valve Clinical Research.
VARC-3 WRITING COMMITTEE:, Généreux P, Piazza N, Alu MC, Nazif T, Hahn RT, Pibarot P, Bax JJ, Leipsic JA, Blanke P, Blackstone EH, Finn MT, Kapadia S, Linke A, Mack MJ, Makkar R, Mehran R, Popma JJ, Reardon M, Rodes-Cabau J, Van Mieghem NM, Webb JG, Cohen DJ, Leon MB
Aims: The Valve Academic Research Consortium (VARC), founded in 2010, was intended to (i) identify appropriate clinical endpoints and (ii) standardize definitions of these endpoints for transcatheter and surgical aortic valve clinical trials. Rapid evolution of the field, including the emergence of new complications, expanding clinical indications, and novel therapy strategies have mandated further refinement and expansion of these definitions to ensure clinical relevance. This document provides...
Abstract
