Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
7155 results
Cited 6 times since 2020 (1.2 per year) source: EuropePMC
JACC. Cardiovascular imaging, Volume 13, Issue 8, 15 3 2020, Pages 1852-1854 Regional Left Ventricular Myocardial Work Indices and Response to Cardiac Resynchronization Therapy. Kostyukevich MV, van der Bijl P, Vo NM, Lustosa RP, Pio SM, Bootsma M, Ajmone Marsan N, Delgado V, Bax JJ
Cited 7 times since 2020 (1.4 per year) source: EuropePMC
Journal of cardiovascular computed tomography, Volume 14, Issue 6, 11 2 2020, Pages 520-523 4D MDCT in the assessment of the tricuspid valve and its spatial relationship with the right coronary artery: A customized tool based on computed tomography for the planning of percutaneous procedures. Pappalardo OA, Votta E, Selmi M, Luciani GB, Redaelli A, Delgado V, Bax JJ, Ajmone Marsan N
Multidetector computed tomography (MDCT) is currently the imaging technique of choice for the assessment of tricuspid valve (TV) annulus geometry and relationship with the right coronary artery (RCA). However, standardized protocols with a full 3D analysis are still lacking to plan percutaneous procedures for functional tricuspid regurgitation (FTR). A novel customized 4-dimensional tool based on MDCT data was developed and provided accurate information on TV annulus morphology (3D-perimeter, 2D... Abstract
Cited 14 times since 2020 (2.8 per year) source: EuropePMC
Journal of medical genetics, Volume 57, Issue 12, 10 2 2020, Pages 843-850 Identification of known and unknown genes associated with mitral valve prolapse using an exome slice methodology. van Wijngaarden AL, Hiemstra YL, Koopmann TT, Ruivenkamp CAL, Aten E, Schalij MJ, Bax JJ, Delgado V, Barge-Schaapveld DQCM, Ajmone Marsan N
Purpose: Although a familial distribution has been documented, the genetic aetiology of mitral valve prolapse (MVP) is largely unknown, with only four genes identified so far: FLNA, DCHS1, DZIP1 and PLD1. The aim of this study was to evaluate the genetic yield in known causative genes and to identify possible novel genes associated with MVP using a heart gene panel based on exome sequencing. Methods: Patients with MVP were referred for genetic counselling when a positive family history for MVP w... Abstract
Cited 1 times since 2020 (0.2 per year) source: EuropePMC
Stem cell research, Volume 45, 8 2 2020, Pages 101764 Generation of two human induced pluripotent stem cell lines, LUMCi020-A and LUMCi021-A, from two patients with Catecholaminergic Polymorphic Ventricular Tachycardia carrying heterozygous mutations in the RYR2 gene. Meraviglia V, Arendzen CH, Freund C, Atsma DE, Mummery CL, Bellin M
Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) is a malignant channelopathy associated with exercise- and stress-induced cardiac sudden death. The autosomal dominant form of CPVT is due to mutations in the ryanodine receptor 2 (RYR2) gene. We generated induced pluripotent stem cells (hiPSCs) from skin fibroblasts of two patients carrying the c.12441 G>T and c.14885 A>G RYR2 missense mutations, respectively, using non-integrating Sendai virus. These lines show the typical morp... Abstract
Cited 3 times since 2020 (0.6 per year) source: EuropePMC
JMIR human factors, Volume 7, Issue 2, 8 2 2020, Pages e17131 Teamwork and Safety Attitudes in Complex Aortic Surgery at a Dutch Hospital: Cross-Sectional Survey Study. Hilt AD, Kaptein AA, Schalij MJ, van Schaik J
Background: Improving teamwork in surgery is a complex goal and difficult to achieve. Human factors questionnaires, such as the Safety Attitudes Questionnaire (SAQ), can help us understand medical teamwork and may assist in achieving this goal. Objective: This paper aimed to assess local team and safety culture in a cardiovascular surgery setting to understand how purposeful teamwork improvements can be reached. Methods: Two cardiovascular surgical teams performing complex aortic treatments were... Abstract
Cited 7 times since 2020 (1.4 per year) source: EuropePMC
Journal of molecular and cellular cardiology, Volume 143, 8 2 2020, Pages 26-37 Human epicardium-derived cells reinforce cardiac sympathetic innervation. Ge Y, Smits AM, van Munsteren JC, Gittenberger-de Groot AC, Poelmann RE, van Brakel TJ, Schalij MJ, Goumans MJ, DeRuiter MC, Jongbloed MRM
Rationale: After cardiac damage, excessive neurite outgrowth (sympathetic hyperinnervation) can occur, which is related to ventricular arrhythmias/sudden cardiac death. Post-damage reactivation of epicardium causes epicardium-derived cells (EPDCs) to acquire a mesenchymal character, contributing to cardiac regeneration. Whether EPDCs also contribute to cardiac re/hyperinnervation, is unknown. Aim: To investigate whether mesenchymal EPDCs influence cardiac sympathetic innervation. Methods and res... Abstract
Cited 29 times since 2020 (5.9 per year) source: EuropePMC
Circulation research, Volume 127, Issue 2, 6 1 2020, Pages 229-243 Identification of Functional Variant Enhancers Associated With Atrial Fibrillation. van Ouwerkerk AF, Bosada FM, Liu J, Zhang J, van Duijvenboden K, Chaffin M, Tucker NR, Pijnappels D, Ellinor PT, Barnett P, de Vries AAF, Christoffels VM
Rationale: Genome-wide association studies have identified a large number of common variants (single-nucleotide polymorphisms) associated with atrial fibrillation (AF). These variants are located mainly in noncoding regions of the genome and likely include variants that modulate the function of transcriptional regulatory elements (REs) such as enhancers. However, the actual REs modulated by variants and the target genes of such REs remain to be identified. Thus, the biological mechanisms by whic... Abstract
Cited 20 times since 2020 (4.1 per year) source: EuropePMC
Atherosclerosis, Volume 301, 6 1 2020, Pages 37-43 The relation between healthy lifestyle changes and decrease in systemic inflammation in patients with stable cardiovascular disease. van 't Klooster CC, van der Graaf Y, Ridker PM, Westerink J, Hjortnaes J, Sluijs I, Asselbergs FW, Bots ML, Kappelle LJ, Visseren FLJ, UCC-SMART study group
Background and aims: Pharmacological lowering of inflammation has proven effective in reducing recurrent cardiovascular event rates. Aim of the current study is to evaluate lifestyle changes (smoking cessation, weight loss, physical activity level increase, alcohol moderation, and a summary lifestyle improvement score) in relation to change in plasma C-reactive protein (CRP) concentration in patients with established cardiovascular disease. Methods: In total, 1794 patients from the UCC-SMART coh... Abstract
Heart and vessels, Volume 35, Issue 9, 4 1 2020, Pages 1290-1298 Influence of long-standing pulmonary arterial hypertension and its severity on pulmonary artery aneurysm development. Nuche J, Montero-Cabezas JM, Lareo A, Huertas S, Jiménez López-Guarch C, Velázquez Martín M, Alonso Charterina S, Revilla Ostolaza Y, Delgado JF, Arribas Ynsaurriaga F, Escribano Subías P
Pulmonary artery aneurysm (PAA) is a common finding in patients with long-term pulmonary arterial hypertension (PAH). The influence of PAH severity in the development of PAA remains unclear. We sought to determine whether PAA development is related to PAH severity and whether treatment optimization based on risk profile estimation is effective to stop pulmonary artery (PA) enlargement. This is a retrospective study of 125 PAH patients who underwent an imaging test (computed tomography or magneti... Abstract
Cited 3 times since 2020 (0.6 per year) source: EuropePMC
Journal of cardiology, Volume 76, Issue 3, 4 1 2020, Pages 287-294 Blood biomarkers in patients with bicuspid aortic valve disease. Bons LR, Geenen LW, van den Hoven AT, Dik WA, van den Bosch AE, Duijnhouwer AL, Siebelink HJ, Budde RPJ, Boersma E, Wessels MW, van de Laar IMBH, DeRuiter MC, Goumans MJ, Loeys BL, Roos-Hesselink JW
Background: Patients with a bicuspid aortic valve (BAV) are at risk of developing valve deterioration and aortic dilatation. We aimed to investigate whether blood biomarkers are associated with disease stage in patients with BAV. Methods: Serum levels of high sensitivity C-reactive protein (hsCRP), high sensitivity troponin T (hsTnT), N-terminal pro-B-type natriuretic peptide (NT-proBNP), and total transforming growth factor-beta 1 (TGF-ß1) were measured in adult BAV patients with valve dysfunct... Abstract
Cited 7 times since 2020 (1.4 per year) source: EuropePMC
Japan journal of nursing science : JJNS, Volume 17, Issue 4, 2 1 2020, Pages e12338 Effects of three different methods used during heel lance procedures on pain level in term neonates. Yilmaz D, Inal S
Aim: This study aims to experimentally determine effects of three different methods (swaddling; swaddling and holding; swaddling, holding and breastfeeding) used during heel lancing on pain levels in healthy term neonates. Methods: This study was a prospective, randomized controlled trial. The sample of newborns (n = 160) were allocated to the groups (group 1, control; group 2, swaddling; group 3, swaddling and holding; group 4, swaddling, holding and breastfeeding) by blocked randomization. The... Abstract
Cited 22 times since 2020 (4.5 per year) source: EuropePMC
JAMA internal medicine, Volume 180, Issue 4, 1 1 2020, Pages 533-541 Effect of No Prehydration vs Sodium Bicarbonate Prehydration Prior to Contrast-Enhanced Computed Tomography in the Prevention of Postcontrast Acute Kidney Injury in Adults With Chronic Kidney Disease: The Kompas Randomized Clinical Trial. Timal RJ, Kooiman J, Sijpkens YWJ, de Vries JPM, Verberk-Jonkers IJAM, Brulez HFH, van Buren M, van der Molen AJ, Cannegieter SC, Putter H, van den Hout WB, Jukema JW, Rabelink TJ, Huisman MV
Importance: Prevention of postcontrast acute kidney injury in patients with stage 3 chronic kidney disease (CKD) by means of prehydration has been standard care for years. However, evidence for the need for prehydration in this group is limited. Objective: To assess the renal safety of omitting prophylactic prehydration prior to iodine-based contrast media administration in patients with stage 3 CKD. Design, setting, and participants: The Kompas trial was a multicenter, noninferiority, randomize... Abstract
Cited 4 times since 2020 (0.8 per year) source: EuropePMC
Medicine, Volume 99, Issue 17, 1 1 2020, Pages e19851 Pain acceptance levels of patients with chronic pain. Çinar HG, Yilmaz D, Akin E
This study was conducted with the aim of determining pain acceptance levels in patients with chronic pain attending an algology outpatients' department.The research was conducted as a descriptive and cross-sectional study. The population of the study consisted of 97 patients with chronic pain who attended the Algology Outpatients' Department of the Health Implementation and Research Center of Bursa Uludağ University. A Patient Description Form and a Chronic Pain Acceptance Questionnair... Abstract
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 57, Issue 4, 1 1 2020, Pages 815 Concomitant aortic root enlargement is perhaps safe, but is it also effective? Vriesendorp MD, de Lind van Wijngaarden RAF, Klautz RJM
Cited 14 times since 2020 (2.8 per year) source: EuropePMC
European heart journal. Cardiovascular Imaging, Volume 21, Issue 4, 1 1 2020, Pages 357-362 The evaluation of aortic stenosis, how the new guidelines are implemented across Europe: a survey by EACVI. Michalski B, Dweck MR, Marsan NA, Cameli M, D'Andrea A, Carvalho RF, Holte E, Podlesnikar T, Manka R, Haugaa KH
Aortic stenosis (AS) is the most prevalent valvular disease in developed countries, with a prevalence that is set to expand further with an ageing population. The most recent guidelines on valvular heart disease published by the European Society of Cardiology and the European Association for Cardio-Thoracic Surgery, aim to standardize the diagnosis and management of valvular heart diseases. The imaging criteria of the current guidelines are mostly based on EACVI Recommendations, with an appropri... Abstract
Cited 33 times since 2020 (6.7 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 75, Issue 16, 1 1 2020, Pages 1869-1877 Age-Related Variations in Takotsubo Syndrome. Cammann VL, Szawan KA, Stähli BE, Kato K, Budnik M, Wischnewsky M, Dreiding S, Levinson RA, Di Vece D, Gili S, Citro R, Bossone E, Neuhaus M, Franke J, Meder B, Jaguszewski M, Noutsias M, Knorr M, Heiner S, D'Ascenzo F, Dichtl W, Burgdorf C, Kherad B, Tschöpe C, Sarcon A, Shinbane J, Rajan L, Michels G, Pfister R, Cuneo A, Jacobshagen C, Karakas M, Koenig W, Pott A, Meyer P, Roffi M, Banning A, Wolfrum M, Cuculi F, Kobza R, Fischer TA, Vasankari T, Airaksinen KEJ, Napp LC, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Chan C, Bridgman P, Beug D, Delmas C, Lairez O, Gilyarova E, Shilova A, Gilyarov M, El-Battrawy I, Akin I, Poledniková K, Toušek P, Winchester DE, Galuszka J, Ukena C, Poglajen G, Carrilho-Ferreira P, Hauck C, Paolini C, Bilato C, Kobayashi Y, Shoji T, Ishibashi I, Takahara M, Himi T, Din J, Al-Shammari A, Prasad A, Rihal CS, Liu K, Schulze PC, Bianco M, Jörg L, Rickli H, Pestana G, Nguyen TH, Böhm M, Maier LS, Pinto FJ, Widimský P, Felix SB, Braun-Dullaeus RC, Rottbauer W, Hasenfu
Background: Takotsubo syndrome (TTS) occurs predominantly in post-menopausal women but is also found in younger patients. Objectives: This study aimed to investigate age-related differences in TTS. Methods: Patients diagnosed with TTS and enrolled in the International Takotsubo Registry between January 2011 and February 2017 were included in this analysis and were stratified by age (younger: ≤50 years, middle-age: 51 to 74 years, elderly: ≥75 years). Baseline characteristics, hospital course, as... Abstract
Cited 17 times since 2020 (3.4 per year) source: EuropePMC
European heart journal. Cardiovascular Imaging, Volume 21, Issue 4, 1 1 2020, Pages 363-374 Increased long-term mortality in women with high left ventricular ejection fraction: data from the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter) long-term registry. Gebhard C, Maredziak M, Messerli M, Buechel RR, Lin F, Gransar H, Achenbach S, Al-Mallah MH, Andreini D, Bax JJ, Berman DS, Budoff MJ, Cademartiri F, Callister TQ, Chang HJ, Chinnaiyan K, Chow BJW, Cury RC, DeLago A, Feuchtner G, Hadamitzky M, Hausleiter J, Kim YJ, Leipsic J, Maffei E, Marques H, Gonçalves PA, Pontone G, Raff GL, Rubinshtein R, Shaw LJ, Villines TC, Lu Y, Jones EC, Peña JM, Min JK, Kaufmann PA
Aims: There are significant sex-specific differences in left ventricular ejection fraction (LVEF), with a higher LVEF being observed in women. We sought to assess the clinical relevance of an increased LVEF in women and men. Methods and results: A total of 4632 patients from the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter) registry (44.8% women; mean age 58.7 ± 13.2 years in men and 59.5 ± 13.3 years in women, P = 0.05), in whom LVEF was measur... Abstract
JACC. Cardiovascular imaging, Volume 13, Issue 4, 1 1 2020, Pages 1099 The Authors Reply: Computed Tomography Angiography-Based Risk Discrimination: An Established Bright Future for Prognostication. van Rosendael AR, Min JK, Shaw LJ, Bax JJ
Cited 2 times since 2020 (0.4 per year) source: EuropePMC
Annals of surgery, Volume 271, Issue 4, 1 1 2020, Pages 781-789 Variation in Surgical Treatment of Abdominal Aortic Aneurysms With Small Aortic Diameters in the Netherlands. Karthaus EG, Vahl A, van der Werf LR, Elsman BHP, Van Herwaarden JA, Wouters MWJM, Hamming JF
Objective: To evaluate reasons to deviate from aneurysm diameter thresholds, and focus on the difference in how Dutch vascular surgical units (VSUs) perceive their deviation and their actual deviation. Background: Guidelines recommend surgical treatment for asymptomatic abdominal aortic aneurysms (AAAs) with a diameter of at least 55 mm for men and 50 mm for women. We evaluate reasons to deviate from these guidelines, and focus on the difference in how Dutch vascular surgical units (VSUs) percei... Abstract
Cited 51 times since 2020 (10.3 per year) source: EuropePMC
JAMA network open, Volume 3, Issue 4, 1 1 2020, Pages e202165 Effect of Smartphone-Enabled Health Monitoring Devices vs Regular Follow-up on Blood Pressure Control Among Patients After Myocardial Infarction: A Randomized Clinical Trial. Treskes RW, van Winden LAM, van Keulen N, van der Velde ET, Beeres SLMA, Atsma DE, Schalij MJ
Importance: Smart technology via smartphone-compatible devices might improve blood pressure (BP) regulation in patients after myocardial infarction. Objectives: To investigate whether smart technology in clinical practice can improve BP regulation and to evaluate the feasibility of such an intervention. Design, setting, and participants: This study was an investigator-initiated, single-center, nonblinded, feasibility, randomized clinical trial conducted at the Department of Cardiology of the Lei... Abstract