Research

Publications

Below you can find a list of our published research.

6196 results

Cited 53 times since 2008 (3.2 per year) source: EuropePMC

American journal of physiology. Endocrinology and metabolism, Volume 295, Issue 3, 15 3 2008, Pages E714-8 Short-term flexibility of myocardial triglycerides and diastolic function in patients with type 2 diabetes mellitus. Hammer S, van der Meer RW, Lamb HJ, de Boer HH, Bax JJ, de Roos A, Romijn JA, Smit JW

Short-term caloric restriction increases plasma levels of nonesterified fatty acids (NEFAs) and is associated with increased myocardial triglyceride (TG) content and decreased myocardial function in healthy subjects. Whether this flexibility of myocardial TG stores and myocardial function is also present in patients with type 2 diabetes mellitus (T2DM) is yet unknown. Myocardial TG content and left ventricular (LV) ratio between the early (E) and atrial (A) diastolic filling phase (E/A) were det... Abstract

Cited 36 times since 2008 (2.1 per year) source: EuropePMC

The American journal of cardiology, Volume 102, Issue 7, 9 2 2008, Pages 921-926 Usefulness of hypertensive blood pressure response during a single-stage exercise test to predict long-term outcome in patients with peripheral arterial disease. de Liefde II, Hoeks SE, van Gestel YR, Bax JJ, Klein J, van Domburg RT, Poldermans D

The prognostic value of a hypertensive blood pressure (BP) response is still unclear. Therefore, the prognostic value of a hypertensive BP response in patients during single-stage exercise testing for peripheral arterial disease (PAD) on long-term mortality and major adverse cerebrovascular and cardiac events (MACCEs) was investigated. In addition, effects of statin, beta-blocker, and aspirin use in patients with known or suspected PAD were studied. A total of 2,109 patients were enrolled in an... Abstract

Cited 42 times since 2008 (2.5 per year) source: EuropePMC

Diabetologia, Volume 51, Issue 9, 8 2 2008, Pages 1581-1593 Non-invasive cardiac imaging techniques and vascular tools for the assessment of cardiovascular disease in type 2 diabetes mellitus. Djaberi R, Beishuizen ED, Pereira AM, Rabelink TJ, Smit JW, Tamsma JT, Huisman MV, Jukema JW

Cardiovascular disease is the major cause of mortality in type 2 diabetes mellitus. The criteria for the selection of those asymptomatic patients with type 2 diabetes who should undergo cardiac screening and the therapeutic consequences of screening remain controversial. Non-invasive techniques as markers of atherosclerosis and myocardial ischaemia may aid risk stratification and the implementation of tailored therapy for the patient with type 2 diabetes. In the present article we review the lit... Abstract

Circulation, Volume 118, Issue 3, 1 1 2008, Pages e65-8 The difficulty of adequate risk stratification for patients with asymptomatic diabetes. Scholte AJ, Schuijf JD, Stokkel MP, de Roos A, Bax JJ

Abstract

Cited 113 times since 2008 (6.7 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 52, Issue 3, 1 1 2008, Pages 216-222 Noninvasive evaluation with multislice computed tomography in suspected acute coronary syndrome: plaque morphology on multislice computed tomography versus coronary calcium score. Henneman MM, Schuijf JD, Pundziute G, van Werkhoven JM, van der Wall EE, Jukema JW, Bax JJ

Objectives: Our aim was to evaluate the atherosclerotic plaque burden and morphology as determined by 64-slice multislice computed tomography (MSCT) coronary angiography in relation to the calcium score in patients presenting with suspected acute coronary syndrome (ACS). Background: The absence of coronary calcium during coronary calcium scoring has been proposed to rule out significant coronary artery disease (CAD). However, data in patients presenting with suspected ACS are scarce. Methods: In... Abstract

Cited 24 times since 2008 (1.4 per year) source: EuropePMC

The Journal of general virology, Volume 89, Issue Pt 7, 1 1 2008, Pages 1553-1562 Generation of temperature-sensitive human metapneumovirus strains that provide protective immunity in hamsters. Herfst S, de Graaf M, Schrauwen EJA, Sprong L, Hussain K, van den Hoogen BG, Osterhaus ADME, Fouchier RAM

Human metapneumovirus (HMPV) causes acute respiratory tract illness primarily in young children, immunocompromised individuals and the elderly. Vaccines would be desirable to prevent severe illnesses in these risk groups. Here, we describe the generation and evaluation of cold-passage (cp) temperature-sensitive (ts) HMPV strains as vaccine candidates. Repeated passage of HMPV at low temperatures in Vero cells resulted in the accumulation of mutations in the viral genome. Introduction of these mu... Abstract

Cited 12 times since 2008 (0.7 per year) source: EuropePMC

Congenital heart disease, Volume 3, Issue 4, 1 1 2008, Pages 277-283 Menstrual cycle and its disorders in women with congenital heart disease. Drenthen W, Hoendermis ES, Moons P, Heida KY, Roos-Hesselink JW, Mulder BJ, Van Dijk AP, Vliegen HW, Sollie KM, Berger RM, Lely AT, Canobbio MM, Pieper PG

Objectives: To investigate the age at menarche, the prevalence of menstrual cycle (interval) disorders, and determinants in women with congenital heart disease (CHD). Design: Using two CHD registries, 1802 (82%) of the 2196 women with CHD contacted (aged 18-58 years) provided written informed consent. After exclusion of patients with genetic disorders known to be associated with menstrual cycle disorders, 1593 eligible patients remained. Interviews by telephone and reviews of medical records wer... Abstract

Mikrobiyoloji bulteni, Volume 42, Issue 3, 1 1 2008, Pages 421-428 [Investigation of herpes simplex virus in viral meningoencephalitis suspected cases using molecular and serological methods]. Akçali A, Ozkaya E, Yilmaz D, Uyar Y, Oncül O

Herpes simplex virus (HSV) meningoencephalitis has a high mortality rate if proper antiviral therapy is not applied. Thus rapid diagnosis is of peculiar importance in such cases. In this study we aimed to evaluate the use of polymerase chain reaction (PCR) and detection of intrathecally synthesized antibodies by serological methods in viral meningoencephalitis suspected cases to determine HSV as the causative agent. Seventeen cases with cerebrospinal fluid (CSF) samples with microscopical and bi... Abstract

Cited 8 times since 2008 (0.5 per year) source: EuropePMC

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], Volume 34, Issue 10, 27 4 2008, Pages 1333-1339 A prospective study of incidence of saphenous nerve injury after total great saphenous vein stripping. Flu HC, Breslau PJ, Hamming JF, Lardenoye JW

Background and objectives: Total stripping of the great saphenous vein (GSV) is a validated surgical strategy of treating patients with primary varicose veins (PVV). An often cited, but not well documented and studied, complication of total stripping is postoperative damage of the saphenous nerve (SN). Objective: The objective was to evaluate the incidence of SN damage and to assess the therapeutic efficacy after total stripping of the GSV. Materials and methods: Patients undergoing total stripp... Abstract

Cited 25 times since 2008 (1.5 per year) source: EuropePMC

Journal of vascular surgery, Volume 48, Issue 3, 24 4 2008, Pages 659-668 The effect of implementation of an optimized care protocol on the outcome of arteriovenous hemodialysis access surgery. Flu H, Breslau PJ, Krol-van Straaten JM, Hamming JF, Lardenoye JW

Background: The long-term patency of arteriovenous fistulas (AVFs) and arteriovenous grafts (AVGs) suffers from a high incidence of primary failure due to early thrombosis, myointimal hyperplasia at the venous access site, or failure to mature. A multidisciplinary meeting in vascular access surgery was initiated to optimize the timing, indication, type of intervention, and the logistics of AVFs/AVGs during the preoperative and postoperative period. This study evaluated the influence of the new o... Abstract

Cited 21 times since 2008 (1.2 per year) source: EuropePMC

European heart journal, Volume 29, Issue 16, 23 4 2008, Pages 2006-2013 Multi-slice computed tomography coronary angiography for ruling out suspected coronary artery disease: what is the prevalence of a normal study in a general clinical population? Henneman MM, Schuijf JD, van Werkhoven JM, Pundziute G, van der Wall EE, Jukema JW, Bax JJ

Aims: To assess the prevalence of a normal multi-slice computed tomography (MSCT) in patients with suspected coronary artery disease (CAD) and to relate these observations to clinical presentation and pre-test likelihood of CAD. Methods and results: In total, 340 consecutive patients (182 men, 55 +/- 12 years) without a history of CAD who were referred for MSCT angiography were included in the study. Based on patient characteristics and the referral reason for MSCT angiography, patients were cla... Abstract

Cited 43 times since 2008 (2.5 per year) source: EuropePMC

Journal of molecular and cellular cardiology, Volume 45, Issue 3, 21 3 2008, Pages 446-452 CCL3 (MIP-1 alpha) levels are elevated during acute coronary syndromes and show strong prognostic power for future ischemic events. de Jager SC, Kraaijeveld AO, Grauss RW, de Jager W, Liem SS, van der Hoeven BL, Prakken BJ, Putter H, van Berkel TJ, Atsma DE, Schalij MJ, Jukema JW, Biessen EA

As chemokines are considered instrumental in thrombotic plaque rupture and erosion as well as in ischemia-reperfusion injury processes, we aimed to identify previously unknown chemokines associated with acute coronary syndromes. Plasma of 44 patients with acute myocardial infarction (AMI) and 22 controls were profiled for a panel of chemokines by multiplex analysis. Levels of CCL3 were prospectively verified in 54 patients with unstable angina pectoris (UAP). An AMI mouse model was used to asses... Abstract

Cited 7 times since 2008 (0.4 per year) source: EuropePMC

Nucleic acids research, Volume 36, Issue 13, 19 3 2008, Pages e83 Conditional gene vectors regulated in cis. Pich D, Humme S, Spindler MP, Schepers A, Hammerschmidt W

Non-integrating gene vectors, which are stably and extrachromosomally maintained in transduced cells would be perfect tools to support long-term expression of therapeutic genes but preserve the genomic integrity of the cellular host. Small extrachromosomal plasmids share some of these ideal characteristics but are primarily based on virus blueprints. These plasmids are dependent on viral trans-acting factors but they can replicate their DNA molecules in synchrony with the chromosome of the cellu... Abstract

Cited 76 times since 2008 (4.5 per year) source: EuropePMC

American journal of respiratory and critical care medicine, Volume 178, Issue 7, 19 3 2008, Pages 695-700 Impact of cardioselective beta-blockers on mortality in patients with chronic obstructive pulmonary disease and atherosclerosis. van Gestel YR, Hoeks SE, Sin DD, Welten GM, Schouten O, Witteveen HJ, Simsek C, Stam H, Mertens FW, Bax JJ, van Domburg RT, Poldermans D

Rationale: beta-Blocker use is associated with improved health outcomes in patients with cardiovascular disease. There is a general reluctance to prescribe beta-blockers in patients with chronic obstructive pulmonary disease (COPD) because they may worsen symptoms. Objectives: We investigated the relationship between cardioselective beta-blockers and mortality in patients with COPD undergoing major vascular surgery. Methods: We evaluated 3,371 consecutive patients who underwent major vascular su... Abstract

Cited 7 times since 2008 (0.4 per year) source: EuropePMC

The American journal of cardiology, Volume 102, Issue 6, 18 3 2008, Pages 718-721 Effects of interruption of long-term cardiac resynchronization therapy on left ventricular function and dyssynchrony. Ypenburg C, Van Bommel RJ, Marsan NA, Delgado V, Bleeker GB, van der Wall EE, Schalij MJ, Bax JJ

Interruption of short-term cardiac resynchronization therapy (CRT) has been shown to acutely worsen left ventricular (LV) function, mitral regurgitation, and LV dyssynchrony. The present study aims to assess whether LV reverse remodeling influences interruption of CRT, and, more practically, whether long-term continuous pacing is necessary in patients with reverse LV remodeling. A total of 135 recipients of CRT were selected after showing LV reverse remodeling defined as a decrease in LV end-sys... Abstract

Cited 1 times since 2008 (0.1 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 24, Issue 7, 18 3 2008, Pages 761-762 Characterization of carotid plaques with a new CT technique. van der Laarse A, Bax JJ, van der Wall EE

Abstract

Cited 73 times since 2008 (4.3 per year) source: EuropePMC

The Journal of clinical endocrinology and metabolism, Volume 93, Issue 9, 17 3 2008, Pages 3348-3356 Aortic valve calcification and mild tricuspid regurgitation but no clinical heart disease after 8 years of dopamine agonist therapy for prolactinoma. Kars M, Delgado V, Holman ER, Feelders RA, Smit JW, Romijn JA, Bax JJ, Pereira AM

Objective: Treatment with ergot-derived dopamine agonists, pergolide, and cabergoline has been associated with an increased frequency of valvular heart disease in Parkinson's disease. The aim of the present study was to assess the prevalence of valvular heart disease in patients treated with dopamine agonists for prolactinomas. Design: This was a cross-sectional study. Patients: We performed two-dimensional and Doppler echocardiography in 78 consecutive patients with prolactinoma (mean age... Abstract

Cited 35 times since 2008 (2.1 per year) source: EuropePMC

Current medical research and opinion, Volume 24, Issue 8, 17 3 2008, Pages 2151-2157 Prevention of sudden cardiac death: rationale and design of the Implantable Cardioverter Defibrillators in Dialysis patients (ICD2) Trial--a prospective pilot study. de Bie MK, Lekkerkerker JC, van Dam B, Gaasbeek A, van Buren M, Putter H, van Erven L, Bax JJ, Schalij MJ, Rabelink TJ, Jukema JW

Objective: Sudden cardiac (arrhythmic) death (SCD) is the single largest cause of death in dialysis patients. Prophylactic Implantable Cardioverter Defibrillator (ICD) therapy reduces SCD and reduces all-cause mortality in several groups of patients at high risk for arrhythmic death. Whether this also applies to dialysis patients is unknown. Research design and methods: The Implantable Cardioverter Defibrillator in Dialysis patients (ICD2) trial is a prospective randomised controlled study. It h... Abstract

Cited 73 times since 2008 (4.3 per year) source: EuropePMC

Circulation, Volume 118, Issue 1, 16 3 2008, Pages 26-32 Gender and outcome in adult congenital heart disease. Verheugt CL, Uiterwaal CS, van der Velde ET, Meijboom FJ, Pieper PG, Vliegen HW, van Dijk AP, Bouma BJ, Grobbee DE, Mulder BJ

Background: Gender differences in prognosis have frequently been reported in cardiovascular disease but less so in congenital heart disease. We investigated whether gender is associated with outcome in adult patients with congenital heart disease. Methods and results: From the CONgenital CORvitia (CONCOR) national registry for adults with congenital heart disease, 7414 patients were identified. All outcomes before entry into the registry and during subsequent follow-up were recorded, and differe... Abstract

Cited 15 times since 2008 (0.9 per year) source: EuropePMC

American journal of physiology. Heart and circulatory physiology, Volume 295, Issue 2, 13 2 2008, Pages H755-60 Biventricular pacing in chronic heart failure acutely facilitates the arterial baroreflex. Gademan MG, van Bommel RJ, Ypenburg C, Haest JC, Schalij MJ, van der Wall EE, Bax JJ, Swenne CA

Metabolic and mechanical stress in the failing heart activates the cardiac sympathetic afferent reflex (CSAR). It has been demonstrated that cardiac resynchronization therapy (CRT) acutely reduces MSNA in clinical responders. Mechanistically, this beneficial effect might be explained by acute deactivation of the CSAR. In addition to sympathoexcitation, CSAR inhibits the arterial baroreflex at the level of the nucleus tractus solitarii. Hence, in responders, CRT is likely to remove/reduce this in... Abstract