9607 results
Cited 16 times since 2015 (1.6 per year)
source: EuropePMC
Stroke,
Volume 46, Issue 11, 8 2 2015, Pages 3048-3057
White Matter Lesion Progression: Genome-Wide Search for Genetic Influences.
Hofer E, Cavalieri M, Bis JC, DeCarli C, Fornage M, Sigurdsson S, Srikanth V, Trompet S, Verhaaren BF, Wolf C, Yang Q, Adams HH, Amouyel P, Beiser A, Buckley BM, Callisaya M, Chauhan G, de Craen AJ, Dufouil C, van Duijn CM, Ford I, Freudenberger P, Gottesman RF, Gudnason V, Heiss G, Hofman A, Lumley T, Martinez O, Mazoyer B, Moran C, Niessen WJ, Phan T, Psaty BM, Satizabal CL, Sattar N, Schilling S, Shibata DK, Slagboom PE, Smith A, Stott DJ, Taylor KD, Thomson R, Töglhofer AM, Tzourio C, van Buchem M, Wang J, Westendorp RG, Windham BG, Vernooij MW, Zijdenbos A, Beare R, Debette S, Ikram MA, Jukema JW, Launer LJ, Longstreth WT, Mosley TH, Seshadri S, Schmidt H, Schmidt R, Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium
Background and purpose: White matter lesion (WML) progression on magnetic resonance imaging is related to cognitive decline and stroke, but its determinants besides baseline WML burden are largely unknown. Here, we estimated heritability of WML progression, and sought common genetic variants associated with WML progression in elderly participants from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Methods: Heritability of WML progression was calculated in t...
Abstract
Cited 17 times since 2015 (1.7 per year)
source: EuropePMC
PloS one,
Volume 10, Issue 10, 7 1 2015, Pages e0139909
Sex Differences in Object Manipulation in Wild Immature Chimpanzees (Pan troglodytes schweinfurthii) and Bonobos (Pan paniscus): Preparation for Tool Use?
Koops K, Furuichi T, Hashimoto C, van Schaik CP
Sex differences in immatures predict behavioural differences in adulthood in many mammal species. Because most studies have focused on sex differences in social interactions, little is known about possible sex differences in 'preparation' for adult life with regards to tool use skills. We investigated sex and age differences in object manipulation in immature apes. Chimpanzees use a variety of tools across numerous contexts, whereas bonobos use few tools and none in foraging. In both s...
Abstract
Cited 9 times since 2015 (0.9 per year)
source: EuropePMC
Journal of periodontology,
Volume 87, Issue 2, 2 1 2015, Pages 193-202
Analyses of Gingival Adhesion Molecules in Periodontitis: Theoretical In Silico, Comparative In Vivo, and Explanatory In Vitro Models.
Gürsoy UK, Zeidán-Chuliá F, Yilmaz D, Özdemir V, Mäki-Petäys J, Neves de Oliveira BH, Firatli Y, Güncü GN, Caglayan F, Könönen E
Background: A deeper understanding of periodontitis pathophysiology is central to future development of novel biomarkers and therapeutics. The following is reported here: 1) an in silico network model of interactions among cell adhesion molecules and a network-focused microarray analysis of the corresponding genes in periodontitis; 2) analysis of secretions of adhesion molecules in gingival tissue samples from patients with periodontitis and healthy controls; and 3) effect of the human neutrophi...
Abstract
Cited 282 times since 2015 (28.8 per year)
source: EuropePMC
PLoS genetics,
Volume 11, Issue 10, 1 1 2015, Pages e1005378
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.
Winkler TW, Justice AE, Graff M, Barata L, Feitosa MF, Chu S, Czajkowski J, Esko T, Fall T, Kilpeläinen TO, Lu Y, Mägi R, Mihailov E, Pers TH, Rüeger S, Teumer A, Ehret GB, Ferreira T, Heard-Costa NL, Karjalainen J, Lagou V, Mahajan A, Neinast MD, Prokopenko I, Simino J, Teslovich TM, Jansen R, Westra HJ, White CC, Absher D, Ahluwalia TS, Ahmad S, Albrecht E, Alves AC, Bragg-Gresham JL, de Craen AJ, Bis JC, Bonnefond A, Boucher G, Cadby G, Cheng YC, Chiang CW, Delgado G, Demirkan A, Dueker N, Eklund N, Eiriksdottir G, Eriksson J, Feenstra B, Fischer K, Frau F, Galesloot TE, Geller F, Goel A, Gorski M, Grammer TB, Gustafsson S, Haitjema S, Hottenga JJ, Huffman JE, Jackson AU, Jacobs KB, Johansson Å, Kaakinen M, Kleber ME, Lahti J, Mateo Leach I, Lehne B, Liu Y, Lo KS, Lorentzon M, Luan J, Madden PA, Mangino M, McKnight B, Medina-Gomez C, Monda KL, Montasser ME, Müller G, Müller-Nurasyid M, Nolte IM, Panoutsopoulou K, Pascoe L, Paternoster L, Rayner NW, Renström F, Rizzi F, Rose LM, Ryan KA, Salo P, Sanna S, Sc
Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of Europ...
Abstract
Cited 3 times since 2015 (0.3 per year)
source: EuropePMC
Thrombosis and haemostasis,
Volume 115, Issue 2, 1 1 2015, Pages 353-360
Platelet density per monocyte predicts adverse events in patients after percutaneous coronary intervention.
Rutten B, Roest M, McClellan EA, Sels JW, Stubbs A, Jukema JW, Doevendans PA, Waltenberger J, van Zonneveld AJ, Pasterkamp G, De Groot PG, Hoefer IE
Monocyte recruitment to damaged endothelium is enhanced by platelet binding to monocytes and contributes to vascular repair. Therefore, we studied whether the number of platelets per monocyte affects the recurrence of adverse events in patients after percutaneous coronary intervention (PCI). Platelet-monocytes complexes with high and low median fluorescence intensities (MFI) of the platelet marker CD42b were isolated using cell sorting. Microscopic analysis revealed that a high platelet marker M...
Abstract
Cited 11 times since 2015 (1.1 per year)
source: EuropePMC
Journal of hypertension,
Volume 33, Issue 10, 1 1 2015, Pages 2091-2098
Real-world evidence of suboptimal blood pressure control in patients with type 2 diabetes.
Walraven I, Mast MR, Hoekstra T, Jansen AP, Rauh SP, Rutters FR, van der Heijden AA, Elders PJ, Moll AC, Polak BC, Dekker JM, Nijpels G
Aims: In order to eventually improve blood pressure (BP) management, the aim of this study was to identify subgroups of type 2 diabetes mellitus (T2DM) patients with distinct trajectories of SBP levels. Identifying subgroups with distinct SBP trajectories helps to better understand the course of SBP levels in T2DM patients and its associated consequences. Subgroup characteristics were determined and the prevalence of complications and mortality rates over time in the different subgroups was inve...
Abstract
Cited 1 times since 2015 (0.1 per year)
source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 22, Issue 5, 1 1 2015, Pages 866-873
Highlights of the 12th International Conference on Nuclear Cardiology and Cardiac CT.
Kitsiou A, Dorbala S, Scholte AJ
Abstract
Cited 39 times since 2015 (4 per year)
source: EuropePMC
Expert opinion on therapeutic targets,
Volume 20, Issue 2, 30 5 2015, Pages 223-239
Targeting danger-associated molecular patterns after myocardial infarction.
van Hout GP, Arslan F, Pasterkamp G, Hoefer IE
Introduction: Myocardial infarction (MI) provokes an intense inflammatory response that can lead to left ventricular adverse remodeling and heart failure (HF). The prognosis of HF patients is poor and related to a decreased quality of life and considerable health care costs. Hence, targeting the early inflammatory response after MI provides an interesting target to attenuate left ventricular remodeling and prevent HF. Areas covered: In the current review, we discuss the theory that our immune sy...
Abstract
Cited 5 times since 2015 (0.5 per year)
source: EuropePMC
International journal of cardiology,
Volume 202, 28 4 2015, Pages 571-572
Reduction of healthcare utilization after bone marrow cell therapy for refractory angina pectoris.
Rodrigo SF, Mann I, van Ramshorst J, Beeres SL, Zwaginga JJ, Fibbe WE, Bax JJ, Schalij MJ, Atsma DE
Abstract
Cited 8 times since 2015 (0.8 per year)
source: EuropePMC
Clinics and practice,
Volume 5, Issue 3, 28 4 2015, Pages 780
Cognitive Impairment and Electroconvulsive Therapy in Geriatric Depression, What Could be the Role of Rivastigmine? A Case Series.
van Schaik AM, Rhebergen D, Henstra MJ, Kadouch DJ, van Exel E, Stek ML
Electroconvulsive therapy (ECT), albeit highly effective in treating depression, is frequently associated with cognitive impairment, either temporary or more persistent. Especially in older patients, who generally respond even better, serious cognitive impairment during the course of ECT may lead to premature termination of ECT. Treatment of this cognitive impairment is of utmost importance. In this case series report, we present the effect of rivastigmine, an acetylcholinesterase inhibitor, on...
Abstract
Cited 3 times since 2015 (0.3 per year)
source: EuropePMC
Revista espanola de cardiologia (English ed.),
Volume 68, Issue 11, 26 4 2015, Pages 1043
The "De Winter Pattern" Can Progress to ST-segment Elevation Acute Coronary Syndrome. Response.
Montero-Cabezas JM, van der Kley F, Karalis I, Schalij MJ
Abstract
Cited 31 times since 2015 (3.2 per year)
source: EuropePMC
General and comparative endocrinology,
Volume 223, 26 4 2015, Pages 9-15
Effects of body region and time on hair cortisol concentrations in chimpanzees (Pan troglodytes).
Carlitz EH, Kirschbaum C, Miller R, Rukundo J, van Schaik CP
Hair cortisol concentrations (HCC) are increasingly recognized as an integrated measure of the systemic cortisol secretion. Yet, we still know very little about confounding effects on HCC in animals. The present study therefore used hair from semi-wild and zoo living chimpanzees to investigate (1) intra-individual variability of HCC (body-region effect), and (2) the stability of HCC along the hair shaft (traditionally called the washout effect). Our results indicate that absolute HCC varied subs...
Abstract
Cited 39 times since 2015 (4 per year)
source: EuropePMC
International journal of cardiology,
Volume 202, 26 4 2015, Pages 784-795
Atrioventricular septal defect: From embryonic development to long-term follow-up.
Calkoen EE, Hazekamp MG, Blom NA, Elders BB, Gittenberger-de Groot AC, Haak MC, Bartelings MM, Roest AA, Jongbloed MR
Atrioventricular septal defect (AVSD) covers a spectrum of heart anomalies with a common atrioventricular connection and has an incidence of 4-5.3 per 10.000 live births. About half of the AVSDs occur in patient with Down syndrome. This review provides a bench to bedside overview of AVSD. Developmental aspects, nomenclature, anatomy, and classification of AVSD are discussed. Furthermore an overview of genetic and maternal risk factors for AVSD is provided, and available literature on (fetal) dia...
Abstract
Cited 3 times since 2015 (0.3 per year)
source: EuropePMC
Journal of electrocardiology,
Volume 49, Issue 1, 26 4 2015, Pages 60-68
Electrocardiographic detection of pulmonary hypertension in patients with systemic sclerosis using the ventricular gradient.
Couperus LE, Vliegen HW, Henkens IR, Maan AC, Treskes RW, de Vries JK, Schouffoer AA, Swenne CA, Schalij MJ, Scherptong RW
Background: Pulmonary hypertension (PH) is a leading cause of death in systemic sclerosis (SSc) patients. The current study assessed the ability of the ECG-derived ventricular gradient (VG-RVPO) to detect PH and predict all-cause mortality in PH patients with subtypes of SSc differing in the extent of multi-organ involvement. Methods: ECGs were obtained from 196 patients with limited and 77 patients with diffuse SSc included from our screening programme on cardiac complications. The association...
Abstract
Cited 11 times since 2015 (1.1 per year)
source: EuropePMC
Clinical journal of the American Society of Nephrology : CJASN,
Volume 10, Issue 10, 25 4 2015, Pages 1740-1748
Cardiac Resynchronization Therapy in CKD Stage 4 Patients.
Höke U, Khidir MJ, van der Velde ET, Schalij MJ, Bax JJ, Delgado V, Marsan NA
Background and objectives: Cardiac resynchronization therapy (CRT) is a well established heart failure treatment that has shown to improve renal function. However, landmark CRT trials excluded patients with severe renal dysfunction. Therefore, this study evaluated the effect of CRT on renal function and long-term prognosis in patients with stage 4 CKD. Design, setting, participants, & measurements: This study evaluated 73 consecutive CRT patients (71±10 years) with stage 4 CKD who underwent...
Abstract
Cited 2 times since 2015 (0.2 per year)
source: EuropePMC
Pharmacogenomics,
Volume 16, Issue 14, 24 4 2015, Pages 1527-1539
Systems medicine, personalized health and therapy.
Siest G, Auffray C, Taniguchi N, Ingelman-Sundberg M, Murray H, Visvikis-Siest S, Ansari M, Marc J, Jacobs P, Meyer U, Van Schaik RH, Müller MM, Wevers RA, Simmaco M, Kussmann M, Manolopoulos VG, Alizadeh BZ, Beastall G, Németh G
The 7th Santorini Conference was held in Santorini, Greece, and brought together 200 participants from 40 countries in several continents, including Europe, USA but also Japan, Korea, Brazil and South Africa. The attendees had the opportunity to: listen to 60 oral presentations; participate in two lunch symposia; look at 103 posters, which were divided in two groups ('systems medicine and environment' and 'pharmacogenomics and cancer') and attend a dedicated exhibition with s...
Abstract
Cited 236 times since 2015 (24 per year)
source: EuropePMC
Nature genetics,
Volume 47, Issue 11, 21 3 2015, Pages 1282-1293
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.
Kato N, Loh M, Takeuchi F, Verweij N, Wang X, Zhang W, Kelly TN, Saleheen D, Lehne B, Leach IM, Drong AW, Abbott J, Wahl S, Tan ST, Scott WR, Campanella G, Chadeau-Hyam M, Afzal U, Ahluwalia TS, Bonder MJ, Chen P, Dehghan A, Edwards TL, Esko T, Go MJ, Harris SE, Hartiala J, Kasela S, Kasturiratne A, Khor CC, Kleber ME, Li H, Yu Mok Z, Nakatochi M, Sapari NS, Saxena R, Stewart AFR, Stolk L, Tabara Y, Teh AL, Wu Y, Wu JY, Zhang Y, Aits I, Da Silva Couto Alves A, Das S, Dorajoo R, Hopewell JC, Kim YK, Koivula RW, Luan J, Lyytikäinen LP, Nguyen QN, Pereira MA, Postmus I, Raitakari OT, Scannell Bryan M, Scott RA, Sorice R, Tragante V, Traglia M, White J, Yamamoto K, Zhang Y, Adair LS, Ahmed A, Akiyama K, Asif R, Aung T, Barroso I, Bjonnes A, Braun TR, Cai H, Chang LC, Chen CH, Cheng CY, Chong YS, Collins R, Courtney R, Davies G, Delgado G, Do LD, Doevendans PA, Gansevoort RT, Gao YT, Grammer TB, Grarup N, Grewal J, Gu D, Wander GS, Hartikainen AL, Hazen SL, He J, Heng CK, Hixson JE, Hofman A, Hsu C, Huang W, Husem
We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10(-11) to 5.0 × 10(-21)). The sentinel blood pressure SNPs are enriched for association with DNA methylation at multiple nearby CpG sites, suggesting that, at some of the loci identified, DNA methylation may lie on the reg...
Abstract
Cited 17 times since 2015 (1.7 per year)
source: EuropePMC
PloS one,
Volume 10, Issue 9, 21 3 2015, Pages e0136025
Regional differences in WT-1 and Tcf21 expression during ventricular development: implications for myocardial compaction.
Vicente-Steijn R, Scherptong RW, Kruithof BP, Duim SN, Goumans MJ, Wisse LJ, Zhou B, Pu WT, Poelmann RE, Schalij MJ, Tallquist MD, Gittenberger-de Groot AC, Jongbloed MR
Background: Morphological and functional differences of the right and left ventricle are apparent in the adult human heart. A differential contribution of cardiac fibroblasts and smooth muscle cells (populations of epicardium-derived cells) to each ventricle may account for part of the morphological-functional disparity. Here we studied the relation between epicardial derivatives and the development of compact ventricular myocardium. Results: Wildtype and Wt1CreERT2/+ reporter mice were used to...
Abstract
Cited 9 times since 2015 (0.9 per year)
source: EuropePMC
Journal of fish biology,
Volume 87, Issue 5, 19 3 2015, Pages 1191-1208
Shallow genetic divergence and species delineations in the endemic Labeobarbus species flock of Lake Tana, Ethiopia.
Nagelkerke LA, Leon-Kloosterziel KM, Megens HJ, De Graaf M, Diekmann OE, Sibbing FA
To assess whether the species distinctions of Lake Tana's Labeobarbus spp. are supported by genetic information, microsatellite markers were used. A total of 376 Labeobarbus spp., belonging to 24 populations of 11 species from three regions of the lake (north, south and east), were sampled. Eight microsatellite markers were analysed. In general, differences between conspecific populations were smaller than differences between populations of different species. For six species, conspecific po...
Abstract
Cited 16 times since 2015 (1.6 per year)
source: EuropePMC
Circulation. Arrhythmia and electrophysiology,
Volume 8, Issue 6, 18 3 2015, Pages 1452-1459
Fatigue as Presenting Symptom and a High Burden of Premature Ventricular Contractions Are Independently Associated With Increased Ventricular Wall Stress in Patients With Normal Left Ventricular Function.
van Huls van Taxis CF, Piers SR, de Riva Silva M, Dekkers OM, Pijnappels DA, Schalij MJ, Wijnmaalen AP, Zeppenfeld K
Background: High idiopathic premature ventricular contractions (PVC) burden has been associated with PVC-induced cardiomyopathy. Patients may be symptomatic before left ventricular (LV) dysfunction develops. N-terminal pro-B-type natriuretic peptide (NT-proBNP) and circumferential end-systolic wall stress (cESS) on echocardiography are markers for increased ventricular wall stress. This study aimed to evaluate the relation between presenting symptoms, PVC burden, and increased ventricular wall s...
Abstract
