6555 results
Cited 89 times since 2008 (5.2 per year)
source: EuropePMC
Developmental dynamics : an official publication of the American Association of Anatomists,
Volume 237, Issue 3, 1 1 2008, Pages 847-857
Cardiac malformations and myocardial abnormalities in podoplanin knockout mouse embryos: Correlation with abnormal epicardial development.
Mahtab EA, Wijffels MC, Van Den Akker NM, Hahurij ND, Lie-Venema H, Wisse LJ, Deruiter MC, Uhrin P, Zaujec J, Binder BR, Schalij MJ, Poelmann RE, Gittenberger-De Groot AC
Epicardium and epicardium-derived cells have been shown to be necessary for myocardial differentiation. To elucidate the function of podoplanin in epicardial development and myocardial differentiation, we analyzed podoplanin knockout mouse embryos between embryonic day (E) 9.5 and E15.5 using immunohistochemical differentiation markers, morphometry, and three-dimensional reconstructions. Podoplanin null mice have an increased embryonic lethality, possibly of cardiac origin. Our study reveals imp...
Abstract
Cited 54 times since 2008 (3.2 per year)
source: EuropePMC
Diabetic medicine : a journal of the British Diabetic Association,
Volume 25, Issue 3, 1 1 2008, Pages 277-281
Sulphonylurea therapy improves cognition in a patient with the V59M KCNJ11 mutation.
Slingerland AS, Hurkx W, Noordam K, Flanagan SE, Jukema JW, Meiners LC, Bruining GJ, Hattersley AT, Hadders-Algra M
Background: KCNJ11 mutations are a common cause of diabetes diagnosed in the first 6 months of life, and approximately 25% of patients have neurological features. Sulphonylureas have been shown to improve glycaemic control and also motor function, but the impact on cognitive function has not been extensively addressed previously. Methods: The patient had a low birth weight and was found to have diabetes at the age of 2 days. The patient was treated with insulin from diagnosis. The child also had...
Abstract
Cited 23 times since 2008 (1.4 per year)
source: EuropePMC
Pacing and clinical electrophysiology : PACE,
Volume 31, Issue 3, 1 1 2008, Pages 358-374
Ablation of ventricular tachycardia in patients with structural heart disease.
Zeppenfeld K, Stevenson WG
Catheter ablation is an important therapeutic option for controlling recurrent ventricular arrhythmias in patients with heart disease. Although implantable defibrillators are generally first line therapy in this patient population, a substantial number of patients require additional therapy with either antiarrhythmic drugs, ablation, or both. Studies of mapping and ablation have produced further insights into pathophysiologic mechanisms of these arrhythmias, which are now well characterized. The...
Abstract
Cited 314 times since 2008 (18.5 per year)
source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
Volume 21, Issue 3, 1 1 2008, Pages 191-213
Echocardiography for cardiac resynchronization therapy: recommendations for performance and reporting--a report from the American Society of Echocardiography Dyssynchrony Writing Group endorsed by the Heart Rhythm Society.
Gorcsan J, Abraham T, Agler DA, Bax JJ, Derumeaux G, Grimm RA, Martin R, Steinberg JS, Sutton MS, Yu CM, American Society of Echocardiography Dyssynchrony Writing Group, American Society of Echocardiography Dyssynchrony Writing Group, Heart Rhythm Society
Echocardiography plays an evolving and important role in the care of heart failure patients treated with biventricular pacing, or cardiac resynchronization therapy (CRT). Numerous recent published reports have utilized echocardiographic techniques to potentially aide in patient selection for CRT prior to implantation and to optimized device settings afterwards. However, no ideal approach has yet been found. This consensus report evaluates the contemporary applications of echocardiography for CRT...
Abstract
Cited 22 times since 2008 (1.3 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 94, Issue 3, 1 1 2008, Pages 255-257
CT angiography: an alternative to nuclear perfusion imaging?
Schuijf JD, Bax JJ
Abstract
Cited 2 times since 2008 (0.1 per year)
source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 15, Issue 2, 1 1 2008, Pages 218-224
Stroke volume measurements with first-pass dynamic positron emission tomography: comparison with cardiovascular magnetic resonance.
Knaapen P, Lubberink M, Rijzewijk LJ, van der Meer RW, Unger M, Germans T, Bax JJ, Smit JW, Lamb HJ, van Rossum AC, Diamant M, Visser FC, Lammertsma AA
Background: The assessment of forward stroke volume (SV) using dynamic, first-pass cardiac positron emission tomography (PET) was shown to be feasible in a limited number of studies with small numbers of subjects. The aim of this study was to compare first-pass derived SV with cardiovascular magnetic resonance imaging (CMR)-obtained values in a larger population of subjects. Methods and results: Fifty-nine subjects with varying degrees of cardiac function were studied. Stroke volume was assessed...
Abstract
Cited 29 times since 2008 (1.7 per year)
source: EuropePMC
American journal of physiology. Heart and circulatory physiology,
Volume 294, Issue 5, 29 5 2008, Pages H2150-7
Improved ECG detection of presence and severity of right ventricular pressure load validated with cardiac magnetic resonance imaging.
Henkens IR, Mouchaers KT, Vonk-Noordegraaf A, Boonstra A, Swenne CA, Maan AC, Man SC, Twisk JW, van der Wall EE, Schalij MJ, Vliegen HW
The study aimed to assess whether the 12-lead ECG-derived ventricular gradient, a vectorial representation of ventricular action potential duration heterogeneity directed toward the area of shortest action potential duration, can improve ECG diagnosis of chronic right ventricular (RV) pressure load. ECGs from 72 pulmonary arterial hypertension patients recorded 1 with R > 0.5 mV in V1, and QRS axis >90 degrees ) had a sensitivity of 89% and a specificity of 93% for presence of chronic RV...
Abstract
Cited 3 times since 2008 (0.2 per year)
source: EuropePMC
Current medical research and opinion,
Volume 24, Issue 4, 28 4 2008, Pages 1065-1068
Determinants of CRP level in statin-treated patients.
Liem AH, van de Woestijne AP, Zwinderman AH, Visseren FL, Jukema JW
Objective: All factors of the metabolic syndrome (MetS) are reported to be associated with elevated C-reactive protein (CRP) levels. As CRP levels have been found to decrease as a result of statin treatment, the present study was intended to explore the relationship between CRP and the MetS in statin treated patients. Methods: In this study, the relationship between the components of the MetS and CRP level were analysed and factors determining CRP were identified in patients with longstanding in...
Abstract
Cited 78 times since 2008 (4.6 per year)
source: EuropePMC
European heart journal,
Volume 29, Issue 6, 27 4 2008, Pages 757-765
Mechanism of improvement in mitral regurgitation after cardiac resynchronization therapy.
Ypenburg C, Lancellotti P, Tops LF, Boersma E, Bleeker GB, Holman ER, Thomas JD, Schalij MJ, Piérard LA, Bax JJ
Aims: The aim of the current study was to evaluate the relationship between the presence of left ventricular (LV) dyssynchrony at baseline and acute vs. late improvement in mitral regurgitation (MR) after cardiac resynchronization therapy (CRT). Methods and results: Sixty eight patients consecutive (LV ejection fraction 23 +/- 8%) with at least moderate MR (>or=grade 2+) were included. Echocardiography was performed at baseline, 1 day after CRT initiation and at 6 months follow-up. Speckle tr...
Abstract
Cited 46 times since 2008 (2.7 per year)
source: EuropePMC
Brain : a journal of neurology,
Volume 131, Issue Pt 4, 26 4 2008, Pages 1069-1077
Genetic variation in the interleukin-1 beta-converting enzyme associates with cognitive function. The PROSPER study.
Trompet S, de Craen AJ, Slagboom P, Shepherd J, Blauw GJ, Murphy MB, Bollen EL, Buckley BM, Ford I, Gaw A, Macfarlane PW, Packard CJ, Stott DJ, Jukema JW, Westendorp RG, PROSPER Group
Inflammation is thought to play an important role in the development of cognitive decline and dementia in old age. The interleukin-1 signalling pathway may play a prominent role in this process. The gene encoding for interleukin-1 beta-converting enzyme (ICE) is likely to influence IL-1 beta levels. Inhibition of ICE decreases the age-related increase in IL-1 beta levels and may therefore improve memory function. We assessed whether genetic variation in the ICE gene associates with cognitive fun...
Abstract
Cited 32 times since 2008 (1.9 per year)
source: EuropePMC
Differentiation; research in biological diversity,
Volume 76, Issue 7, 21 3 2008, Pages 809-819
Periostin expression by epicardium-derived cells is involved in the development of the atrioventricular valves and fibrous heart skeleton.
Lie-Venema H, Eralp I, Markwald RR, van den Akker NM, Wijffels MC, Kolditz DP, van der Laarse A, Schalij MJ, Poelmann RE, Bogers AJ, Gittenberger-de Groot AC
The epicardium is embryologically formed by outgrowth of proepicardial cells over the naked heart tube. Epicardium-derived cells (EPDCs) migrate into the myocardium, contributing to myocardial architecture, valve development, and the coronary vasculature. Defective EPDC formation causes valve malformations, myocardial thinning, and coronary defects. In the atrioventricular (AV) valves and the fibrous heart skeleton isolating atrial from ventricular myocardium, EPDCs colocalize with periostin, a...
Abstract
Cited 3 times since 2008 (0.2 per year)
source: EuropePMC
International journal of oral and maxillofacial surgery,
Volume 37, Issue 5, 12 2 2008, Pages 448-452
Biomechanical evaluation of the consolidation period of alveolar distraction osteogenesis with three-dimensional finite element analysis.
Veziroglu F, Yilmaz D
In this study, three-dimensional (3D) modeling and finite element analysis were used to determine the optimum consolidation period for implant loading under forces of different directions and amounts after alveolar distraction osteogenesis. A 3D model of an atrophic edentulous alveolar crest was prepared. Distraction osteogenesis with the required bone height was simulated. After a consolidation period of 4, 8, 12 and 16 weeks, horizontal, vertical and oblique forces were applied to the conical...
Abstract
Cited 44 times since 2008 (2.6 per year)
source: EuropePMC
Atherosclerosis,
Volume 200, Issue 1, 8 2 2008, Pages 95-101
Genetic variation at the PCSK9 locus moderately lowers low-density lipoprotein cholesterol levels, but does not significantly lower vascular disease risk in an elderly population.
Polisecki E, Peter I, Robertson M, McMahon AD, Ford I, Packard C, Shepherd J, Jukema JW, Blauw GJ, Westendorp RG, de Craen AJ, Trompet S, Buckley BM, Murphy MB, Ordovas JM, Schaefer EJ, PROSPER Study Group
Caucasian carriers of the T allele at R46L in the proprotein convertase subtilisin/kexin type 9 (PCSK9) locus have been reported to have 15% lower low-density lipoprotein (LDL) cholesterol (C) levels and 47% lower coronary heart disease (CHD) risk. Our objective was to examine two PCSK9 single nucleotide polymorphisms (SNPs), R46L and E670G, in 5783 elderly participants in Prospective Study of Pravastatin in the Elderly at Risk (PROSPER), of whom 43% had a history of vascular disease at baseline...
Abstract
Cited 44 times since 2008 (2.6 per year)
source: EuropePMC
Atherosclerosis,
Volume 200, Issue 1, 7 1 2008, Pages 109-114
Genetic variation at the LDL receptor and HMG-CoA reductase gene loci, lipid levels, statin response, and cardiovascular disease incidence in PROSPER.
Polisecki E, Muallem H, Maeda N, Peter I, Robertson M, McMahon AD, Ford I, Packard C, Shepherd J, Jukema JW, Westendorp RG, de Craen AJ, Buckley BM, Ordovas JM, Schaefer EJ, Prospective Study of Pravastatin in the Elderly at Risk (PROSPER) Investigators
Our purpose was to evaluate associations of single nucleotide polymorphisms (SNPs) at the low density lipoprotein (LDL) receptor (LDLR C44857T, minor allele frequency (MAF) 0.26, and A44964G, MAF 0.25, both in the untranslated region) and HMG-CoA reductase (HMGCR i18 T>G, MAF 0.019) gene loci with baseline lipid values, statin-induced LDL-cholesterol (C) lowering response, and incident coronary heart disease (CHD) and cardiovascular disease (CVD) on trial. Our population consisted of 5804 eld...
Abstract
Cited 38 times since 2008 (2.2 per year)
source: EuropePMC
The American journal of cardiology,
Volume 101, Issue 8, 7 1 2008, Pages 1196-1200
Anemia as an independent predictor of perioperative and long-term cardiovascular outcome in patients scheduled for elective vascular surgery.
Dunkelgrun M, Hoeks SE, Welten GM, Vidakovic R, Winkel TA, Schouten O, van Domburg RT, Bax JJ, Kuijper R, Chonchol M, Verhagen HJ, Poldermans D
Anemia is common in patients scheduled for vascular surgery and is a risk factor for adverse cardiac outcome. However, it is unclear whether this is an independent risk factor or an expression of underlying co-morbidities. In total, 1,211 patients (77% men, 68 +/- 11 years of age) were enrolled. Anemia was defined as serum hemoglobin levels
Abstract
Cited 53 times since 2008 (3.1 per year)
source: EuropePMC
The American journal of cardiology,
Volume 101, Issue 7, 6 1 2008, Pages 1023-1029
Noninvasive imaging of cardiac venous anatomy with 64-slice multi-slice computed tomography and noninvasive assessment of left ventricular dyssynchrony by 3-dimensional tissue synchronization imaging in patients with heart failure scheduled for cardiac resynchronization therapy.
Van de Veire NR, Marsan NA, Schuijf JD, Bleeker GB, Wijffels MC, van Erven L, Holman ER, De Sutter J, van der Wall EE, Schalij MJ, Bax JJ
Objectives of this study were to perform a prospective head-to-head comparison between multi-slice computed tomography (MSCT) venography and invasive venography in cardiac resynchronization therapy (CRT) candidates as well as to evaluate the relation between left ventricular (LV) lead position and effect on LV dyssynchrony and immediate response to CRT. Twenty-one consecutive heart failure patients scheduled for CRT implantation were prospectively enrolled to undergo 64-slice MSCT to visualize t...
Abstract
Cited 90 times since 2008 (5.3 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 51, Issue 6, 1 1 2008, Pages 618-626
Sirolimus-eluting stents versus bare-metal stents in patients with ST-segment elevation myocardial infarction: 9-month angiographic and intravascular ultrasound results and 12-month clinical outcome results from the MISSION! Intervention Study.
van der Hoeven BL, Liem SS, Jukema JW, Suraphakdee N, Putter H, Dijkstra J, Atsma DE, Bootsma M, Zeppenfeld K, Oemrawsingh PV, van der Wall EE, Schalij MJ
Objectives: Our purpose was to evaluate the efficacy and safety of drug-eluting stents in the setting of primary percutaneous coronary intervention for ST-segment elevation myocardial infarction (STEMI). Background: There is inconsistent and limited evidence about the efficacy and safety of drug-eluting stents in STEMI patients. Methods: A single-blind, single-center, randomized study was performed to compare bare-metal stents (BMS) with sirolimus-eluting stents (SES) in 310 STEMI patients. The...
Abstract
Cited 51 times since 2008 (3 per year)
source: EuropePMC
The Journal of cardiovascular surgery,
Volume 49, Issue 1, 1 1 2008, Pages 51-58
Intramuscular or combined intramuscular/intra-arterial administration of bone marrow mononuclear cells: a clinical trial in patients with advanced limb ischemia.
Van Tongeren RB, Hamming JF, Fibbe WE, Van Weel V, Frerichs SJ, Stiggelbout AM, Van Bockel JH, Lindeman JH
Aim: Recent evidence indicates that bone marrow mononuclear cells (BMC) promote collateral vessel formation in patients with severe peripheral arterial disease (PAD). However, aspects concerning optimal administration mode, durability and long-term safety require consideration. Combined intra-arterial (IA) plus intramuscular (IM) BMC delivery may be more effective than exclusive intramuscular injections. The aim of this study was to evaluate feasibility, safety and effect of exclusive IM versus...
Abstract
Cited 2 times since 2008 (0.1 per year)
source: EuropePMC
Clinical nuclear medicine,
Volume 33, Issue 2, 1 1 2008, Pages 89-93
Myocardial perfusion scintigraphy with adenosine: does it impair the left ventricular ejection fraction obtained with gated SPECT?
Brinkman N, Dibbets-Schneider P, Scholte AJ, Stokkel MP
Background: The aim of this study was to assess whether adenosine impairs left ventricular ejection fraction (LVEF) obtained with gated SPECT in patients with a normal myocardial perfusion scintigram. Materials and methods: This prospective study included 160 consecutive patients with a normal myocardial perfusion scintigraphy (MPS), who were stressed with either exercise (n = 64) or with adenosine (n = 96). Student t-test or chi test was used to compare patient's characteristics and functi...
Abstract
Cited 47 times since 2008 (2.8 per year)
source: EuropePMC
International journal of cardiology,
Volume 132, Issue 2, 1 1 2008, Pages 257-262
Coronary collaterals improve prognosis in patients with ischemic heart disease.
Regieli JJ, Jukema JW, Nathoe HM, Zwinderman AH, Ng S, Grobbee DE, van der Graaf Y, Doevendans PA
Background: The recruitment of coronary collateral vessels results from an endogenous adaptation to ischemic heart disease (IHD). Presence of collaterals may exert protection at the time of acute or chronic obstructive coronary disease. The protective role of collaterals in patients with extensive coronary artery disease however, has been disputed. We examined the effects of coronary collateral circulation on cardiovascular outcomes, with an emphasis on clinical prognostic value and on a putativ...
Abstract
