6177 results
Cited 83 times since 2004 (3.9 per year)
source: EuropePMC
Journal of cardiovascular electrophysiology,
Volume 15, Issue 3, 1 1 2004, Pages 349-355
Embryonic conduction tissue: a spatial correlation with adult arrhythmogenic areas.
Jongbloed MR, Schalij MJ, Poelmann RE, Blom NA, Fekkes ML, Wang Z, Fishman GI, Gittenberger-De Groot AC
Introduction: The occurrence of arrhythmias in adult patients may arise preferentially in anatomic regions derived from the specialized cardiac conduction system. To examine this hypothesis, we performed a detailed analysis of the developing cardiac conduction system using the recently described CCS-lacZ transgenic mouse strain. Methods and results: Transgenic embryos (E9.5-15.5) were stained for beta-galactosidase activity and co-stained with the myocardial marker HHF35. Results were reconstruc...
Abstract
Cited 298 times since 2004 (14 per year)
source: EuropePMC
Arthritis research & therapy,
Volume 6, Issue 2, 5 1 2004, Pages R142-50
Rheumatoid arthritis specific anti-Sa antibodies target citrullinated vimentin.
Vossenaar ER, Després N, Lapointe E, van der Heijden A, Lora M, Senshu T, van Venrooij WJ, Ménard HA
Antibodies directed to the Sa antigen are highly specific for rheumatoid arthritis (RA) and can be detected in approximately 40% of RA sera. The antigen, a doublet of protein bands of about 50 kDa, is present in placenta and in RA synovial tissue. Although it has been stated that the Sa antigen is citrullinated vimentin, experimental proof for this claim has never been published. In this study, we investigated the precise nature of the antigen. Peptide sequences that were obtained from highly pu...
Abstract
Cited 6 times since 2004 (0.3 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 20, Issue 1, 1 1 2004, Pages 53-60
Six-months of recombinant human GH therapy in patients with ischemic cardiac failure.
van Thiel SW, Smit JW, de Roos A, Bax JJ, van der Wall EE, Biermasz NR, Viergever E, Vliegen HW, Romijn JA, Roelfsema F, Lamb HJ
Growth hormone therapy in patients with idiopathic dilated cardiomyopathy and ischemic cardiac failure has revealed varying effects on systolic function, probably related to the response in serum insulin-like growth factor I (IGF-I) levels. As diastolic function has not been studied thoroughly, we studied the effects of 6 months of recombinant human growth hormone (rh GH) treatment on systolic and diastolic function in patients with ischemic cardiac failure, using cardiovascular magnetic resonan...
Abstract
Cited 3 times since 2004 (0.1 per year)
source: EuropePMC
Circulation,
Volume 109, Issue 4, 1 1 2004, Pages e25-6
Images in cardiovascular medicine. Dynamic multislice computed tomography of left ventricular function.
Dirksen MS, Bax JJ, de Roos A, Jukema JW, van der Geest RJ, Geleijns J, van der Wall EE, Lamb HJ
Abstract
Cited 1 times since 2004 (0 per year)
source: EuropePMC
The Annals of thoracic surgery,
Volume 77, Issue 2, 1 1 2004, Pages 725
Elective surgery for fibroelastoma of the aortic valve.
Koolbergen DR, Voigt P, Kolowca M, Smit VT, Somer ST, Dion RA
Abstract
Cited 28 times since 2004 (1.3 per year)
source: EuropePMC
Expert opinion on pharmacotherapy,
Volume 5, Issue 2, 1 1 2004, Pages 459-468
Amlodipine and atorvastatin in atherosclerosis: a review of the potential of combination therapy.
Jukema JW, van der Hoorn JW
Hypertension and hyperlipidaemia are major risk factors for the development of atherosclerosis. Calcium channel blockers (CCBs) have been used for decades and have established antihypertensive effects. Statins have been extensively used because of their potent lipid lowering properties. Amongst other factors, inflammation and oxidation are involved in enhanced progression of atherosclerosis and new lesion development. Therefore, research has been initiated focusing on the antioxidant and anti-in...
Abstract
Cited 5 times since 2004 (0.2 per year)
source: EuropePMC
Clinical science (London, England : 1979),
Volume 106, Issue 2, 1 1 2004, Pages 173-181
Dobutamine induces ineffective work in regional ischaemic myocardium: an experimental strain rate imaging study.
Weidemann F, Broscheit J, Eberbach N, Steendijk P, Voelker W, Greim C, Ertl G, Roewer N, Strotmann JM
In the present study, we sought to investigate the effects of differing inotropic conditions on regional myocardial function in ischaemic segments. In an experimental pig model ( n =11), the regional deformation parameters peak systolic strain rate [SR(SYS) (peak velocity of thickening)], systolic strain [epsilon(SYS) (systolic wall thickening)] and post-systolic strain [epsilon(PST) (ongoing wall thickening after end of systole)] were measured during normal perfusion and regional ischaemia of t...
Abstract
Cited 13 times since 2004 (0.6 per year)
source: EuropePMC
Journal of magnetic resonance imaging : JMRI,
Volume 19, Issue 2, 1 1 2004, Pages 176-181
MR flow mapping of dobutamine-induced changes in diastolic heart function.
Paelinck BP, Lamb HJ, Bax JJ, van der Wall EE, de Roos A
Purpose: To evaluate the ability of MR flow mapping to measure changes in left ventricular filling during beta-adrenergic stimulation. Materials and methods: Mitral flow was measured in 10 healthy volunteers using conventional free breathing fast-field echo (FFE) with a spatial resolution of 2.7 x 2.2 mm and a temporal resolution of 22 msec. The sequence was repeated during dobutamine infusion (20 microg/kg/minute). Results: Stroke volume increased from a median of 99 mL (range: 68-142 mL) (Note...
Abstract
Cited 50 times since 2004 (2.4 per year)
source: EuropePMC
The Journal of thoracic and cardiovascular surgery,
Volume 127, Issue 2, 1 1 2004, Pages 385-390
Why do patients with ischemic cardiomyopathy and a substantial amount of viable myocardium not always recover in function after revascularization?
Schinkel AF, Poldermans D, Rizzello V, Vanoverschelde JL, Elhendy A, Boersma E, Roelandt JR, Bax JJ
Objective: In patients with ischemic cardiomyopathy and a substantial amount of dysfunctional but viable myocardium, myocardial revascularization may improve left ventricular ejection fraction. The aim of this study was to evaluate why not all patients with a substantial amount of viable tissue recover in function after revascularization. Methods: A total of 118 consecutive patients with a depressed left ventricular ejection fraction (on average 29% +/- 6%) due to chronic coronary artery disease...
Abstract
Cited 1 times since 2004 (0 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 20, Issue 1, 1 1 2004, Pages 67-69
Multi-slice spiral computed tomography: useful for non-invasive coronary angiography?
Schroeder S, Bax JJ
Abstract
Cited 8 times since 2004 (0.4 per year)
source: EuropePMC
The American journal of cardiology,
Volume 93, Issue 4, 1 1 2004, Pages 450-452
Prediction of all-cause mortality in women with known or suspected coronary artery disease by stress technetium-99m tetrofosmin myocardial perfusion imaging.
Elhendy A, Schinkel AF, van Domburg RT, Bax JJ, Valkema R, Poldermans D
We studied the incremental value of stress technetium-99m tetrofosmin imaging for predicting all-cause mortality in 503 women (aged 58 +/- 12 years) with known or suspected coronary artery disease. The annual mortality rate was 1.4% with normal perfusion and 4% with abnormal perfusion (p
Abstract
Cited 1 times since 2004 (0 per year)
source: EuropePMC
Pacing and clinical electrophysiology : PACE,
Volume 27, Issue 2, 1 1 2004, Pages 249-251
Cyclic appropriate mode switching and inappropriate back switching of a biventricular pacemaker during atrial tachyarrhythmia.
van Erven L, Molhoek SG, van der Wall EE, Schalij MJ
In patients with resynchronization devices and intact intrinsic AV conduction, atrial tachyarrhythmias may give rise to high ventricular rates, resulting in inhibition of (bi)ventricular pacing and concomitant lack of therapeutic effects of the device. This report presents a patient with atrial arrhythmias in whom mode switching and back switching of the biventricular pacemaker occurred, due to special timing of the atrial and ventricular deflections. This case report stresses the importance of...
Abstract
Cited 30 times since 2004 (1.4 per year)
source: EuropePMC
Blood,
Volume 103, Issue 10, 22 4 2004, Pages 3777-3782
Hepatic low-density lipoprotein receptor-related protein deficiency in mice increases atherosclerosis independent of plasma cholesterol.
Espirito Santo SM, Pires NM, Boesten LS, Gerritsen G, Bovenschen N, van Dijk KW, Jukema JW, Princen HM, Bensadoun A, Li WP, Herz J, Havekes LM, van Vlijmen BJ
The low-density lipoprotein (LDL) receptor-related protein (LRP) has a well-established role in the hepatic removal of atherogenic apolipoprotein E (APOE)-rich remnant lipoproteins from plasma. In addition, LRP recognizes multiple distinct pro- and antiatherogenic ligands in vitro. Here, we investigated the role of hepatic LRP in atherogenesis independent of its role in removal of APOE-rich remnant lipoproteins. Mice that allow inducible inactivation of hepatic LRP were combined with LDL recepto...
Abstract
Cited 20 times since 2004 (0.9 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 90, Issue 1, 1 1 2004, Pages 97-98
Atrial and brain natriuretic peptides as markers of response to resynchronisation therapy.
Molhoek SG, Bax JJ, van Erven L, Bootsma M, Steendijk P, Lentjes E, Boersma E, van der Laarse A, van der Wall EE, Schalij MJ
Abstract
Cited 66 times since 2004 (3.1 per year)
source: EuropePMC
European journal of clinical investigation,
Volume 34, Issue 1, 1 1 2004, Pages 21-28
Cholesteryl ester transfer protein concentration is associated with progression of atherosclerosis and response to pravastatin in men with coronary artery disease (REGRESS).
Klerkx AH, de Grooth GJ, Zwinderman AH, Jukema JW, Kuivenhoven JA, Kastelein JJ
Background: The TaqIB polymorphism in the cholesteryl ester transfer protein (CETP) gene is associated with HDL-C, progression of coronary artery disease (CAD) and response to pravastatin treatment in men with angiographically proven CAD (REGRESS). We hypothesized that differences in CETP concentration could explain these associations and now investigated whether CETP concentration is an independent determinant of these parameters. Materials and methods: Plasma CETP concentrations at baseline an...
Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 12, Issue 1, 1 1 2004, Pages 13-17
Genetic programme of cardiogenesis: implications for therapeutic application.
van Tuyn J, de Vries AA, van der Laarse A, Schalij MJ, van der Wall EE, Atsma DE
It has become accepted that new cardiomyocytes can be derived from stem cells. Although the potential for therapeutic application is evident, the reported efficiency of differentiation varies greatly from 0.02 to 54%. To obtain clinically relevant numbers of newly differentiated cardiac cells, stem cell differentiation should be as efficient as possible. A plausible way to increase the efficiency of differentiation of stem cells into cardiomyocytes is through the introduction of cardiac specific...
Abstract
Cited 13 times since 2004 (0.6 per year)
source: EuropePMC
American heart journal,
Volume 147, Issue 1, 1 1 2004, Pages 181-186
Interaction between a genetic variant of the platelet fibrinogen receptor and fibrinogen levels in determining the risk of cardiovascular events.
Boekholdt SM, Peters RJ, de Maat MP, Zwinderman AH, van Der Wall EE, Reitsma PH, Jukema JW, Kastelein JJ
Background: The PlA1A2 polymorphism of glycoprotein IIIa (GPIIIa), which affects postoccupancy signaling by the platelet fibrinogen receptor IIbIIIa, has been investigated as a potential genetic risk factor for cardiovascular events in numerous studies, without consistent results. We investigated whether the effect of this genetic variant of the platelet fibrinogen receptor on the risk of cardiovascular events is affected by fibrinogen plasma levels. Methods: The GPIIIa PlA1A2 polymorphism and f...
Abstract
Cited 57 times since 2004 (2.7 per year)
source: EuropePMC
Archives of internal medicine,
Volume 164, Issue 1, 1 1 2004, Pages 40-44
Additive benefits of pravastatin and aspirin to decrease risks of cardiovascular disease: randomized and observational comparisons of secondary prevention trials and their meta-analyses.
Hennekens CH, Sacks FM, Tonkin A, Jukema JW, Byington RP, Pitt B, Berry DA, Berry SM, Ford NF, Walker AJ, Natarajan K, Sheng-Lin C, Fiedorek FT, Belder R
Background: In randomized trials of secondary prevention, pravastatin sodium and aspirin reduce risks of cardiovascular disease. Pravastatin has a predominantly delayed antiatherogenic effect, and aspirin has an immediate antiplatelet effect, raising the possibility of additive clinical benefits. Methods: In 5 randomized trials of secondary prevention with pravastatin (40 mg/d), comprising 73 900 patient-years of observation, aspirin use was also prescribed in varying frequencies, and data were...
Abstract
Cited 25 times since 2004 (1.2 per year)
source: EuropePMC
European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology,
Volume 5, Issue 1, 1 1 2004, Pages 34-40
Radiofrequency catheter ablation of ventricular tachycardia guided by intracardiac echocardiography.
Jongbloed MR, Bax JJ, van der Burg AE, Van der Wall EE, Schalij MJ
Aims: Ventricular tachycardia (VT) frequently has an anatomical substrate. Identification of areas prone to arrhythmogenicity facilitates radiofrequency catheter ablation (RFCA). Furthermore, direct monitoring of complications potentially increases safety of RFCA. The aim of this study was to evaluate the feasibility of guiding RFCA of VT with intracardiac echocardiography (ICE), in order to improve outcome and procedural safety. Methods and results: Eleven patients (age 59 +/- 15 years) with dr...
Abstract
Cited 9 times since 2004 (0.4 per year)
source: EuropePMC
Pediatric hematology and oncology,
Volume 21, Issue 1, 1 1 2004, Pages 1-8
A single institutional experience: is epoetin alpha effective in anemic children with cancer?
Yilmaz D, Cetingül N, Kantar M, Oniz H, Kansoy S, Kavakli K
The authors aimed to investigate the efficacy of epoetin-alpha on hemoglobin levels and red cell transfusion requirement in children with both hematologic malignancy (HM, n = 27) and solid tumors (ST, n = 14). Epoetin-alpha was given (150 U/kg or 250 U/kg, thrice weekly) for 12 weeks. Epoetin alpha significantly increased the hemoglobin levels at the 2nd and 3rd months of therapy (p
Abstract
