Research

Publications

Below you can find a list of our published research.

6177 results

Cited 19 times since 2001 (0.8 per year) source: EuropePMC

The Biochemical journal, Volume 356, Issue Pt 3, 1 1 2001, Pages 907-910 Cloning and characterization of human liver cytosolic beta-glycosidase. de Graaf M, van Veen IC, van der Meulen-Muileman IH, Gerritsen WR, Pinedo HM, Haisma HJ

Cytosolic beta-glucosidase (EC 3.2.1.21) from mammalian liver is a member of the family 1 glycoside hydrolases and is known for its ability to hydrolyse a range of beta-D-glycosides, including beta-D-glucoside and beta-D-galactoside. We therefore refer to this enzyme as cytosolic beta-glycosidase. We cloned the cDNA encoding the human cytosolic beta-glycosidase by performing PCR on cDNA prepared from total human liver RNA. Specific primers were based on human expressed sequence tags found in the... Abstract

Cited 31 times since 2001 (1.3 per year) source: EuropePMC

Radiology, Volume 219, Issue 3, 1 1 2001, Pages 637-643 Aortic valve replacement in patients with aortic valve stenosis improves myocardial metabolism and diastolic function. Beyerbacht HP, Lamb HJ, van Der Laarse A, Vliegen HW, Leujes F, Hazekamp MG, de Roos A, van Der Wall EE

Purpose: To evaluate whether functional and metabolic changes recover after aortic valve replacement (AVR). Materials and methods: Eighteen men with aortic valve stenosis (mean pressure gradient +/- SD, 79.9 mm Hg +/- 15.1) underwent magnetic resonance (MR) imaging and phosphorus 31 MR spectroscopy. In nine patients who underwent AVR, MR imaging and spectroscopy were repeated 40 weeks +/- 12 after AVR. Ten age-matched healthy men were control subjects. Results: Before AVR, the myocardial phospho... Abstract

Cited 20 times since 2001 (0.8 per year) source: EuropePMC

Virology, Volume 284, Issue 2, 1 1 2001, Pages 259-276 Recombinant equine arteritis virus as an expression vector. de Vries AA, Glaser AL, Raamsman MJ, Rottier PJ

Equine arteritis virus (EAV) is the prototypic member of the family Arteriviridae, which together with the Corona- and Toroviridae constitutes the order Nidovirales. A common trait of these positive-stranded RNA viruses is the 3'-coterminal nested set of six to eight leader-containing subgenomic mRNAs which are generated by a discontinuous transcription mechanism and from which the viral open reading frames downstream of the polymerase gene are expressed. In this study, we investigated whet... Abstract

Cited 7 times since 2001 (0.3 per year) source: EuropePMC

The British journal of surgery, Volume 88, Issue 6, 1 1 2001, Pages 884-886 Totally extraperitoneal endoscopic repair of recurrent inguinal hernia. van der Hem JA, Hamming JF, Meeuwis JD, Oostvogel HJ

Background: Conventional repair of recurrent inguinal hernia is associated with a re-recurrence rate as high as 35 per cent. Endoscopic mesh repair has promising results regarding both recurrence and complication rates. Methods: In a retrospective review, the results of endoscopic totally extraperitoneal repair were evaluated in 104 patients with 108 recurrent hernias. Follow-up was at least 1 year. Type of recurrence, time of occurrence after previous repair, duration of surgery, complications,... Abstract

Nederlands tijdschrift voor geneeskunde, Volume 145, Issue 25, 1 1 2001, Pages 1214-1218 [Treatment of intra-atrial reentry tachycardia by catheter ablation, using three-dimensional electro-anatomical map of the atrial activation pattern]. de Groot NM, Schalij MJ

A 30-year-old man, who had been treated surgically for tricuspid valve atresia as a boy, suffered from recurrent supraventricular tachycardias. These atrial reentry tachycardias are frequent post-operative complications in patients with congenital heart disease. The reentry circuit in these patients often circulates around areas of scar tissue or surgically created barriers such as incision scars and implanted synthetic material. A possible curative treatment of these arrhythmias is radiofrequen... Abstract

Cited 29 times since 2001 (1.2 per year) source: EuropePMC

Cardiovascular research, Volume 50, Issue 3, 1 1 2001, Pages 516-524 Cardiac remodeling after myocardial infarction is impaired in IGF-1 deficient mice. Palmen M, Daemen MJ, Bronsaer R, Dassen WR, Zandbergen HR, Kockx M, Smits JF, van der Zee R, Doevendans PA

Objective: To obtain more insight in the role of IGF-1 in cardiac remodeling and function after experimental myocardial infarction. We hypothesized that cardiac remodeling is altered in IGF-1 deficient mice, which may affect cardiac function. Methods: A myocardial infarction was induced by surgical coronary artery ligation in heterozygous IGF-1 deficient mice. One week after surgery, left ventricular function was analyzed, and parameters of cardiac remodeling were measured. Results: No significa... Abstract

Cited 13 times since 2001 (0.5 per year) source: EuropePMC

Early human development, Volume 63, Issue 1, 1 1 2001, Pages 9-21 Endothelin-1 plasma concentration increases in the early phase of pulmonary hypertension development during respiratory distress syndrome: a study in newborn lambs. de Vroomen M, Lopes Cardozo RH, Steendijk P, Frölich M, Baan J, van Bel F

Objective: Elevated plasma concentrations of endothelin-1 (ET-1) have been reported with pulmonary hypertension during respiratory distress syndrome (RDS). However, the exact role of ET-1 in the development of pulmonary hypertension during RDS is unclear. The relative time-course of changes in ET-1 concentrations and pulmonary artery pressure (P(ap)) during RDS may give insight in the role of ET-1. Methods: ET-1 and P(ap) changes were studied in an experimental model of RDS, induced by lung lava... Abstract

Cited 49 times since 2001 (2 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 19, Issue 5, 1 1 2001, Pages 667-670 Pulmonary valve insertion late after repair of Fallot's tetralogy. Hazekamp MG, Kurvers MM, Schoof PH, Vliegen HW, Mulder BM, Roest AA, Ottenkamp J, Dion RA

Objectives: To analyze the results of pulmonary valve insertion late after initial repair of Fallot's tetralogy. Pulmonary insufficiency (PI) after correction of Fallot's tetralogy is usually well tolerated in the short term, but is associated with symptomatic right ventricular dilatation and an increased risk of ventricular arrhythmias over longer periods of time. Methods: From 1993 to July 2000, 51 patients were reoperated for PI at a mean age of 25.7+/-11.9 years. The mean age at in... Abstract

Cited 20 times since 2001 (0.8 per year) source: EuropePMC

RNA (New York, N.Y.), Volume 7, Issue 5, 1 1 2001, Pages 741-752 Identification of a novel cis-acting RNA element involved in nuclear export of hY RNAs. Rutjes SA, Lund E, van der Heijden A, Grimm C, van Venrooij WJ, Pruijn GJ

Ro RNPs are small cytoplasmic RNA-protein complexes of unknown function that have been found in all metazoan cells studied so far. In human cells, Ro RNPs consist of one of four small RNA molecules, termed hY RNAs and at least two well-characterized proteins, Ro60 and La. In previous Xenopus laevis oocyte microinjection studies, we showed that an intact Ro60 binding site (Stem-loop 1) is a prerequisite for efficient nuclear export of hY1 RNA, whereas an intact La-binding site promotes nuclear re... Abstract

Cited 1 times since 2001 (0 per year) source: EuropePMC

Circulation, Volume 103, Issue 17, 1 1 2001, Pages E92-3 False aneurysms of an ascending-aorta-to-abdominal-aorta bypass for coarctation of the aorta. Roest AA, Wasser MN, Versteegh MI, de Roos A, van Der Wall EE, Helbing WA, Vliegen HW

Abstract

Cited 35 times since 2001 (1.5 per year) source: EuropePMC

Journal of molecular biology, Volume 308, Issue 4, 1 1 2001, Pages 597-608 Mutational analysis of conserved sequence motifs in the budding yeast Cdc6 protein. Schepers A, Diffley JF

The Cdc6 protein is required to load a complex of Mcm2-7 family members (the MCM complex) into prereplicative complexes at budding yeast origins of DNA replication. Cdc6p is a member of the AAA(+) superfamily of proteins, which includes the prokaryotic and eukaryotic clamp loading proteins. These proteins share a number of conserved regions of homology and a common three-dimensional architecture. Two of the conserved sequence motifs are the Walker A and B motifs that are involved in nucleotide m... Abstract

Cited 90 times since 2001 (3.7 per year) source: EuropePMC

Journal of virology, Volume 75, Issue 7, 1 1 2001, Pages 3335-3342 Improved adenovirus vectors for infection of cardiovascular tissues. Havenga MJ, Lemckert AA, Grimbergen JM, Vogels R, Huisman LG, Valerio D, Bout A, Quax PH

To identify improved adenovirus vectors for cardiovascular gene therapy, a library of adenovirus vectors based on adenovirus serotype 5 (Ad5) but carrying fiber molecules of other human serotypes, was generated. This library was tested for efficiency of infection of human primary vascular endothelial cells (ECs) and smooth muscle cells (SMCs). Based on luciferase, LacZ, or green fluorescent protein (GFP) marker gene expression, several fiber chimeric vectors were identified that displayed improv... Abstract

Cited 18 times since 2001 (0.7 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 85, Issue 4, 1 1 2001, Pages 458-462 Increased risk for ischaemic events is related to combined RAS polymorphism. van Geel PP, Pinto YM, Zwinderman AH, Henning RH, van Boven AJ, Jukema JW, Bruschke AV, Kastelein JJ, van Gilst WH

Objective: To determine whether the angiotensin converting enzyme (ACE) and the angiotensin II type 1 receptor (AT(1)R A1166C) gene polymorphism interact to increase the risk of ischaemic events, and whether this can be explained by the progression of angiographically defined coronary atherosclerosis. Design: Prospective defined substudy of the lipid lowering regression trial (REGRESS). Setting: University hospital. Patients: 885 male patients with stable coronary artery disease. Main outcome me... Abstract

Cited 6 times since 2001 (0.2 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 71, Issue 4, 1 1 2001, Pages 1382-1383 Implantation of cardioverter device in young children: the perirenal approach. Hazekamp MG, Blom NA, Schoof PH, Schalij MJ, Dion RA

Placement of Implantable cardioverter devices in young children is complicated because of the relatively large size and heavy weight of these devices. A technique is described where the device is implanted in the left perirenal space while an endovascular lead is used instead of an epicardial patch electrode. Abstract

Cited 4 times since 2001 (0.2 per year) source: EuropePMC

Thrombosis and haemostasis, Volume 85, Issue 4, 1 1 2001, Pages 746-747 Factor VII polymorphisms and myocardial infarction: what is special in Italians? REGRESS study group. Regression Growth Evaluation Statin Study. Nederhand RJ, de Maat MP, Jukema JW, Regression Growth Evaluation Statin Study group

Abstract

Cited 76 times since 2001 (3.2 per year) source: EuropePMC

Circulation, Volume 103, Issue 13, 1 1 2001, Pages 1778-1786 Acyl-CoA:cholesterol acyltransferase inhibitor avasimibe reduces atherosclerosis in addition to its cholesterol-lowering effect in ApoE*3-Leiden mice. Delsing DJ, Offerman EH, van Duyvenvoorde W, van Der Boom H, de Wit EC, Gijbels MJ, van Der Laarse A, Jukema JW, Havekes LM, Princen HM

Background: The present study investigated whether the ACAT inhibitor avasimibe can reduce atherogenesis independently of its cholesterol-lowering effect in ApoE*3-Leiden mice. Methods and results: Two groups of 15 female ApoE*3-Leiden mice were put on a high-cholesterol (HC) diet; 1 group received 0.01% (wt/wt) avasimibe mixed into the diet. The HC diet resulted in a plasma cholesterol concentration of 18.7+/-2.6 mmol/L. Addition of avasimibe lowered plasma cholesterol by 56% to 8.1+/-1.2 mmol/... Abstract

Cited 22 times since 2001 (0.9 per year) source: EuropePMC

Gene therapy, Volume 8, Issue 7, 1 1 2001, Pages 534-541 In vivo suppression of restenosis in balloon-injured rat carotid artery by adenovirus-mediated gene transfer of the cell surface-directed plasmin inhibitor ATF.BPTI. Lamfers ML, Lardenoye JH, de Vries MR, Aalders MC, Engelse MA, Grimbergen JM, van Hinsbergh VW, Quax PH

Injury-induced neointimal development results from migration and proliferation of vascular smooth muscle cells (SMC). Cell migration requires controlled proteolytic degradation of extracellular matrix surrounding the cell. Plasmin is a major contributor to this process by degrading various matrix proteins directly, or indirectly by activating matrix metalloproteinases. This makes it an attractive target for inhibition by gene transfer. An adenoviral vector, Ad.ATF.BPTI, was constructed encoding... Abstract

Cited 178 times since 2001 (7.4 per year) source: EuropePMC

Circulation, Volume 103, Issue 9, 1 1 2001, Pages 1198-1205 Common genetic variation in ABCA1 is associated with altered lipoprotein levels and a modified risk for coronary artery disease. Clee SM, Zwinderman AH, Engert JC, Zwarts KY, Molhuizen HO, Roomp K, Jukema JW, van Wijland M, van Dam M, Hudson TJ, Brooks-Wilson A, Genest J, Kastelein JJ, Hayden MR

Background: Low plasma HDL cholesterol (HDL-C) is associated with an increased risk of coronary artery disease (CAD). We recently identified the ATP-binding cassette transporter 1 (ABCA1) as the major gene underlying the HDL deficiency associated with reduced cholesterol efflux. Mutations within the ABCA1 gene are associated with decreased HDL-C, increased triglycerides, and an increased risk of CAD. However, the extent to which common variation within this gene influences plasma lipid levels an... Abstract

Cited 18 times since 2001 (0.7 per year) source: EuropePMC

The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), Volume 45, Issue 1, 1 1 2001, Pages 108-114 Perfusion and functional abnormalities outside the septal region in patients with left bundle branch block assessed with gated SPECT. Bavelaar-Croon CD, Wahba FF, Van Hecke MV, Atsma DE, Stokkel MP, Pauwels EK, Van der Wall EE

Background: The presence of a left bundle branch block (LBBB) pattern on the electrocardiogram may frequently lead to perfusion defects in the septum not necessarily due to ischemic heart disease, but probably due to abnormal septal wall motion. The introduction of gated single photon emission computed tomography (SPECT) allows the evaluation of myocardial perfusion and function in one study. Accordingly, we analysed perfusion and function and the relation between perfusion and regional function... Abstract

Cited 13 times since 2001 (0.5 per year) source: EuropePMC

Analytical biochemistry, Volume 290, Issue 2, 1 1 2001, Pages 283-291 Simultaneous detection of NOS-3 protein expression and nitric oxide production using a flow cytometer. Havenga MJ, van Dam B, Groot BS, Grimbergen JM, Valerio D, Bout A, Quax PH

Nitric oxide (NO) is involved in the regulation of SMC proliferation during intimal hyperplasia as has been shown by the inhibitory effect on intimal hyperplasia of adenovirus-mediated ceNOS overexpression in injured arteries in pig. Good assays to quantify the NO-producing enzymes, i.e., NO synthases (NOS), are essential to analyze the mechanism of action of NO in this process. We have developed novel flow cytometric assays for the simultaneous detection of NOS-3 protein, using NOS-3 specific a... Abstract