Research

Publications

Below you can find a list of our published research.

6177 results

Cited 42 times since 2000 (1.7 per year) source: EuropePMC

Journal of hypertension, Volume 18, Issue 11, 1 1 2000, Pages 1635-1644 The importance of high-frequency paced breathing in spectral baroreflex sensitivity assessment. Frederiks J, Swenne CA, TenVoorde BJ, Honzíková N, Levert JV, Maan AC, Schalij MJ, Bruschke AV

Objective: Computation of the low-frequency (LF) blood pressure variability (BPV) to heart rate variability (HRV) transfer-index is a common method to assess baroreflex sensitivity (BRS), tacitly assuming that all LF-HRV is caused by baroreflex feedback of LF-BPV. However, respiration may also cause HRV by mechanisms not involving the baroreflex. Application of narrow-band (controlled) high-frequency breathing would keep such non-baroreflex-mediated HRV best out of the LF band. Spontaneous breat... Abstract

Cited 2 times since 2000 (0.1 per year) source: EuropePMC

International journal of cardiac imaging, Volume 16, Issue 5, 1 1 2000, Pages 359-364 Stentless bioprostheses have ideal haemodynamics, even in the small aortic root. Baur LH, Houdas Y, Peels KH, Braun J, van Straten B, Prat A, Kappetein AP, Wolters-Geldoff M, van der Wall EE, Bruschke AV, Huysmans HA

Objective: To determine normal Doppler and 2D gradients and flow characteristics of the Freestyle stentless aortic bioprosthesis related to valve size. Background: The Freestyle stentless aortic bioprosthesis is one of the newer aortic xenografts. Only limited data are available of the echocardiographic flow characteristics during a mid-term follow-up period of this valve. Therefore valve performance related to valve size was measured during a follow-up period of two years. Methods: 175 consecut... Abstract

Echocardiography (Mount Kisco, N.Y.), Volume 17, Issue 7, 1 1 2000, Pages 625-629 Echocardiographic imaging of stentless aortic valve prostheses. Baur LH, Peels K, Braun J, Kappetein AP, Bootsma M, Van Der Ploeg A, Sieders A, Hazekamp M, Van Der Wall EE, Huysmans HA

Unlabelled: Homografts and stentless xenografts are increasingly used in aortic valve surgery. Echocardiography technicians and cardiologists have to know what they will find when performing an echo-Doppler examination in patients who received a stentless valve. We therefore evaluated echocardiographic images of 74 patients who received a Freestyle stentless bioprosthesis with three techniques and a follow-up of 2 years in two high-volume hospitals. Of the patients studied, 81% were operated usi... Abstract

Cited 6 times since 2000 (0.2 per year) source: EuropePMC

The American journal of cardiology, Volume 86, Issue 7, 1 1 2000, Pages 774-6, A6 Effect of simvastatin on restenosis after percutaneous transluminal angioplasty of femoropopliteal arterial obstruction. Hagenaars T, Gussenhoven EJ, van Sambeek MR, Jukema JW, Kranendonk SE, Bom N

This retrospective observational intravascular ultrasound study evaluated whether simvastatin therapy limits lumen area reduction 1-year after percutaneous transluminal angioplasty (PTA) by reducing reactive plaque growth, reducing reactive vasoconstriction, or both. This study showed that plaque growth is a general response 1 year after PTA regardless of the use of simvastatin; simvastatin has the potential to induce positive vascular remodeling, thereby reducing the occurrence of restenosis. Abstract

Cited 30 times since 2000 (1.2 per year) source: EuropePMC

Circulation, Volume 102, Issue 14, 1 1 2000, Pages 1629-1633 Lipoprotein lipase activity is associated with severity of angina pectoris. REGRESS Study Group. Kastelein JJ, Jukema JW, Zwinderman AH, Clee S, van Boven AJ, Jansen H, Rabelink TJ, Peters RJ, Lie KI, Liu G, Bruschke AV, Hayden MR

Background: Raised triglyceride-rich lipoproteins significantly increase the risk for cardiovascular disease. Variation in the activity of the enzyme lipoprotein lipase (LPL), which is crucial in the removal of these lipoproteins, may therefore modulate this risk. Methods and results: Postheparin levels of LPL activity and mass were measured in a large cohort of male coronary artery disease patients participating in the Regression Growth Evaluation Statin Study (REGRESS), a lipid-lowering regres... Abstract

Cited 39 times since 2000 (1.6 per year) source: EuropePMC

The American journal of cardiology, Volume 86, Issue 7, 1 1 2000, Pages 742-746 Pravastatin reduces restenosis two years after percutaneous transluminal coronary angioplasty (REGRESS trial). Mulder HJ, Bal ET, Jukema JW, Zwinderman AH, Schalij MJ, van Boven AJ, Bruschke AV

The Regression Growth Evaluation Statin Study (REGRESS) is a placebo-controlled multicenter study designed to assess the effect of 2-year treatment with pravastatin on the progression and regression of angiographically documented coronary artery disease. One of the secondary end points was the occurrence of 2-year restenosis in the percutaneous transluminal coronary angioplasty (PTCA) block. We randomly assigned eligible patients to receive pravastatin 40 mg once daily or placebo. The end point... Abstract

Cited 5 times since 2000 (0.2 per year) source: EuropePMC

European journal of pharmacology, Volume 403, Issue 1-2, 1 1 2000, Pages 99-109 In vivo evidence that EMD 57033 restores myocardial responsiveness to intracoronary Ca(2+) in stunned myocardium. de Zeeuw S, Trines SA, Krams R, Duncker DJ, Verdouw PD

Despite ample in vitro evidence that myofilament Ca(2+)-responsiveness of stunned myocardium is decreased, in vivo data are inconclusive. Conversely, while Ca(2+)-sensitizing agents increase myofilament Ca(2+)-responsiveness in vitro, it has been questioned whether this also occurs in vivo. We therefore tested in open-chest anesthetized pigs whether EMD 57033 (the (+) enantiomer of 5-[1-(3,4-dimethoxybenzoyl)-1,2,3, 4-tetrahydro-6-quinolyl]-6-methyl-3,6-dihydro-2H-1,3, 4-thiadiazin-2-one) increa... Abstract

Cited 1 times since 2000 (0 per year) source: EuropePMC

American journal of physiology. Heart and circulatory physiology, Volume 279, Issue 3, 1 1 2000, Pages H1264-73 Efficiency of energy transfer, but not external work, is maximized in stunned myocardium. Trines SA, Slager CJ, van der Moer J, Verdouw PD, Krams R

There is no evidence regarding the effect of stunning on maximization of regional myocardial external work (EW) or efficiency of energy transfer (EET) in relation to regional afterload (end-systolic stress, sigma(es)). To that end, we studied these relationships in both the left anterior descending coronary artery (LADCA) and left circumflex coronary artery regions in anesthetized, open-chest pigs before and after LADCA stunning. In normal myocardium, EET vs. sigma(es) was maximal at 75.4 (69.7-... Abstract

Cited 6 times since 2000 (0.2 per year) source: EuropePMC

Thrombosis and haemostasis, Volume 84, Issue 3, 1 1 2000, Pages 460-467 Adenoviral gene transfer of a u-PA receptor-binding plasmin inhibitor and green fluorescent protein: inhibition of migration and visualization of expression. Lamfers ML, Wijnberg MJ, Grimbergen JM, Huisman LG, Aalders MC, Cohen FN, Verheijen JH, van Hinsbergh VW, Quax PH

Smooth muscle cell migration plays a role in the development of intimal hyperplasia. Given the established role of the plasminogen activation system in cell migration, an approach to therapy is to overexpress an inhibitor of plasmin. Therefore, an adenoviral vector was constructed encoding the hybrid protein ATF.BPTI, which contains the active domain of bovine pancreas trypsin inhibitor (BPTI), fused to ATF, the amino terminal fragment or receptor-binding domain of u-PA. Adenoviral vectors expre... Abstract

Cited 57 times since 2000 (2.3 per year) source: EuropePMC

The American journal of cardiology, Volume 86, Issue 4, 1 1 2000, Pages 385-389 Heparin-coated Wiktor stents in human coronary arteries (MENTOR trial). MENTOR Trial Investigators. Vrolix MC, Legrand VM, Reiber JH, Grollier G, Schalij MJ, Brunel P, Martinez-Elbal L, Gomez-Recio M, Bär FW, Bertrand ME, Colombo A, Brachman J

The purpose of this study was to determine the feasibility, safety, and efficacy of elective stenting with heparin-coated Wiktor stents in patients with coronary artery disease. In experimental studies, heparin coating has been shown to prevent subacute thrombosis and restenosis. Recently, a new method of heparin coating was developed, resulting in a more stable and predictable heparin layer on stent devices. This trial constitutes the first in-human use of this coating procedure, applied on the... Abstract

Cited 8 times since 2000 (0.3 per year) source: EuropePMC

Pacing and clinical electrophysiology : PACE, Volume 23, Issue 8, 1 1 2000, Pages 1232-1238 No gender differences in pacemaker selection in patients undergoing their first implantation. Roeters Van Lennep JE, Zwinderman AH, Roeters Van Lennep HW, Van Hemel NM, Schalij MJ, van der Wall EE

Recent studies have indicated that women were less likely to receive sophisticated pacemaker devices than men. These differences could not be fully explained by demographic and clinical variables. The purpose of the present study was to assess whether a gender related difference might exist in pacemaker mode selection in patients undergoing their first implantation in The Netherlands. Records of first implants (n = 39,217) collected from 1988 through 1997 covering 95% of all implantations in The... Abstract

Cited 20 times since 2000 (0.8 per year) source: EuropePMC

American journal of respiratory and critical care medicine, Volume 162, Issue 2 Pt 1, 1 1 2000, Pages 374-379 Right ventricular function in respiratory distress syndrome and subsequent partial liquid ventilation. Homeometric autoregulation in the right ventricle of the newborn animal. Lopes Cardozo RH, Steendijk P, Baan J, Brouwers HA, De Vroomen M, Van Bel F

Infant respiratory distress syndrome (IRDS) and subsequent partial liquid ventilation (PLV) cause increased pulmonary vascular resistance, thus raising afterload. In nine newborn lambs the effects of IRDS and subsequent PLV on right (RV) and left ventricular (LV) contractility and systolic pump function were assessed using indices derived from RV and LV pressure-volume relations, obtained by micromanometric and conductance catheters during transient inferior vena cava occlusion. Pulmonary functi... Abstract

Cited 48 times since 2000 (1.9 per year) source: EuropePMC

Circulation research, Volume 87, Issue 3, 1 1 2000, Pages 248-253 Accelerated atherosclerosis by placement of a perivascular cuff and a cholesterol-rich diet in ApoE*3Leiden transgenic mice. Lardenoye JH, Delsing DJ, de Vries MR, Deckers MM, Princen HM, Havekes LM, van Hinsbergh VW, van Bockel JH, Quax PH

Intimal hyperplasia after vascular injury is usually studied in animal models with healthy, normocholesterolemic animals. Here, we assess the effect of diet-induced hypercholesterolemia on the induction of intimal hyperplasia in ApoE*3Leiden mice. A nonconstrictive polyethylene cuff was placed around the femoral artery of ApoE3*Leiden mice fed a highly cholesterol-rich diet, a mildly cholesterol-rich diet, or a chow diet for 4 weeks. Diets were continued after cuff placement until euthanization.... Abstract

Cited 32 times since 2000 (1.3 per year) source: EuropePMC

Arthritis and rheumatism, Volume 43, Issue 8, 1 1 2000, Pages 1710-1718 Cartilage degradation and invasion by rheumatoid synovial fibroblasts is inhibited by gene transfer of a cell surface-targeted plasmin inhibitor. van der Laan WH, Pap T, Ronday HK, Grimbergen JM, Huisman LG, TeKoppele JM, Breedveld FC, Gay RE, Gay S, Huizinga TW, Verheijen JH, Quax PH

Objective: Joint destruction in rheumatoid arthritis (RA) is a result of degradation and invasion of the articular cartilage by the pannus tissue. The present study was undertaken to examine the role of the plasminogen activation system in cartilage degradation and invasion by synovial fibroblasts and investigate a novel gene therapeutic approach using a cell surface-targeted plasmin inhibitor (ATF.BPTI). Methods: Adenoviral vectors were used for gene transfer. The effects of ATF.BPTI gene trans... Abstract

Cited 22 times since 2000 (0.9 per year) source: EuropePMC

The Journal of thoracic and cardiovascular surgery, Volume 120, Issue 1, 1 1 2000, Pages 55-65 Remodeling of the porcine pulmonary autograft wall in the aortic position. Schoof PH, Gittenberger-De Groot AC, De Heer E, Bruijn JA, Hazekamp MG, Huysmans HA

Objective: Dilatation and valve regurgitation are disturbing sequelae of the pulmonary root functioning at systemic pressures. We tried to characterize the histologic mode of adaptation of the neoaortic wall. Methods: We compared routine histologic studies, immunohistochemical staining, and computer-assisted morphometric analysis of aortic, pulmonary autograft, and native pulmonary wall specimens from pigs in which, as a newborn, a valveless pulmonary autograft had been implanted in the aorta. R... Abstract

Cited 17 times since 2000 (0.7 per year) source: EuropePMC

Journal of clinical microbiology, Volume 38, Issue 6, 1 1 2000, Pages 2065-2075 Monoclonal antibodies directed against conserved epitopes on the nucleocapsid protein and the major envelope glycoprotein of equine arteritis virus. Weiland E, Bolz S, Weiland F, Herbst W, Raamsman MJ, Rottier PJ, De Vries AA

We recently developed a highly effective immunization procedure for the generation of monoclonal antibodies (MAbs) directed against the porcine reproductive and respiratory syndrome virus (E. Weiland, M. Wieczorek-Krohmer, D. Kohl, K. K. Conzelmann, and F. Weiland, Vet. Microbiol. 66:171-186, 1999). The same method was used to produce a panel of 16 MAbs specific for the equine arteritis virus (EAV). Ten MAbs were directed against the EAV nucleocapsid (N) protein, and five MAbs recognized the maj... Abstract

Cited 48 times since 2000 (1.9 per year) source: EuropePMC

Herz, Volume 25, Issue 4, 1 1 2000, Pages 356-364 Arrhythmogenic right ventricular dysplasia: MRI findings. van der Wall EE, Kayser HW, Bootsma MM, de Roos A, Schalij MJ

Arrhythmogenic right ventricular dysplasia (ARVD) is a heart muscle disorder of unknown cause that is characterized pathologically by fibrofatty replacement of the right ventricular myocardium. Clinical manifestations include structural and functional malformations of the right ventricle, electrocardiographic abnormalities, and presentation with ventricular tachycardias with left bundle branch pattern or sudden death. The disease is often familial with an autosomal inheritance. In addition to ri... Abstract

Cited 1 times since 2000 (0 per year) source: EuropePMC

International journal of cardiology, Volume 73, Issue 3, 1 1 2000, Pages 209-211 Detecting hibernating myocardium: how and why? Siebelink HJ, Underwood SR, van der Wall EE, Blanksma PK

Abstract

Cited 10 times since 2000 (0.4 per year) source: EuropePMC

Critical care medicine, Volume 28, Issue 5, 1 1 2000, Pages 1599-1606 Evaluation of a new transcardiac conductance method for continuous on-line measurement of left ventricular volume. Steendijk P, Lardenoye JW, van der Velde ET, Schalij MJ, Baan J

Objective: To evaluate a new, less invasive, conductance method to measure continuous on-line left ventricular volume. End-systolic and end-diastolic volumes obtained with this transcardiac conductance method were compared with simultaneous measurements using the conventional intracardiac conductance catheter. Design: Controlled animal study. Setting: Research laboratory in a university hospital. Subjects: Six sheep. Interventions: Anesthetized sheep were instrumented and inotropic condition was... Abstract

Cited 31 times since 2000 (1.2 per year) source: EuropePMC

Annals of surgical oncology, Volume 7, Issue 4, 1 1 2000, Pages 268-275 Systemic toxicity and cytokine/acute phase protein levels in patients after isolated limb perfusion with tumor necrosis factor-alpha complicated by high leakage. Stam TC, Swaak AJ, de Vries MR, ten Hagen TL, Eggermont AM

Background: Since the introduction of high-dose tumor necrosis factor-alpha (TNFalpha) in the setting of isolated limb perfusion (ILP) in the clinic, prevention of leakage to the body of the patient is monitored with great precision for fear of TNF-mediated toxicity. That we observed remarkably little toxicity in patients with and without leakage prompted us to determine patterns of cytokines and acute phase proteins in patients with high leakage and in patients without any leakage. Methods: TNF... Abstract