Research

Publications

Below you can find a list of our published research.

6177 results

Cited 59 times since 1999 (2.3 per year) source: EuropePMC

Journal of lipid research, Volume 40, Issue 4, 1 1 1999, Pages 735-743 Lipoprotein lipase activity is decreased in a large cohort of patients with coronary artery disease and is associated with changes in lipids and lipoproteins. Henderson HE, Kastelein JJ, Zwinderman AH, Gagné E, Jukema JW, Reymer PW, Groenemeyer BE, Lie KI, Bruschke AV, Hayden MR, Jansen H

Lipoprotein lipase (LPL) is crucial in the hydrolysis of triglycerides (TG) in TG-rich lipoproteins in the formation of HDL particles. As both these lipoproteins play an important role in the pathogenesis of atherosclerotic vascular disease, we sought to assess the relationship between post-heparin LPL (PH-LPL) activity and lipids and lipoproteins in a large, well-defined cohort of Dutch males with coronary artery disease (CAD). These subjects were drawn from the REGRESS study, totaled 730 in nu... Abstract

Cited 66 times since 1999 (2.5 per year) source: EuropePMC

The American journal of cardiology, Volume 83, Issue 6, 1 1 1999, Pages 852-856 Effect of the stromelysin-1 promoter on efficacy of pravastatin in coronary atherosclerosis and restenosis. de Maat MP, Jukema JW, Ye S, Zwinderman AH, Moghaddam PH, Beekman M, Kastelein JJ, van Boven AJ, Bruschke AV, Humphries SE, Kluft C, Henney AM

It has proved difficult to identify high-risk patients for atherosclerosis and to determine how they might respond to medication. Recently, a common promoter variant of the human stromelysin-1 gene has been reported, which has been shown to affect the transcription. We investigated whether this polymorphism had any impact on the risk of events, especially restenosis and progression of coronary artery disease and whether the effect was modulated by treatment with pravastatin. The stromelysin-1 ge... Abstract

Cited 40 times since 1999 (1.5 per year) source: EuropePMC

The American journal of cardiology, Volume 83, Issue 4, 1 1 1999, Pages 558-562 Postsurgical course of patients with congenitally corrected transposition of the great arteries. Voskuil M, Hazekamp MG, Kroft LJ, Lubbers WJ, Ottenkamp J, van der Wall EE, Zwinderman KH, Mulder BJ

Because congenitally corrected transposition is a rare congenital anomaly, little is known about the prognosis of patients with this syndrome. The present study evaluated the functional status and clinical course of 73 patients (42 male and 31 female) aged 10 days to 73 years. Follow-up was 1 week to 37 years (mean 12.7 years). Particular attention was paid to the systemic right ventricle, considering the current controversies about long-term right ventricular function. Survival of patients with... Abstract

Cited 6 times since 1999 (0.2 per year) source: EuropePMC

Basic research in cardiology, Volume 94, Issue 1, 1 1 1999, Pages 23-30 Pretreatment with allopurinol in cardiac hypoxic-ischemic reperfusion injury in newborn lambs exerts its beneficial effect through afterload reduction. Shadid M, Van Bel F, Steendijk P, Dorrepaal CA, Moison R, Van der Velde ET, Baan J

The aim of this study was to determine whether allopurinol (ALLO) reduces reperfusion injury inflicted upon the heart resulting from excess production of free oxygen radicals after hypoxia and ischemia (HI) in newborn animals. We, therefore, produced severe HI in 13 newborn lambs by low O2-ventilation and blood volume reduction. One hour before HI seven lambs received ALLO (20 mg/kg i.v.), six received a placebo (CONT). Cardiac function and hemodynamic parameters were assessed by sequential meas... Abstract

Cited 112 times since 1999 (4.3 per year) source: EuropePMC

Hepatology (Baltimore, Md.), Volume 29, Issue 2, 1 1 1999, Pages 334-339 Effect of losartan, an angiotensin II receptor antagonist, on portal pressure in cirrhosis. Schneider AW, Kalk JF, Klein CP

Administration of angiotensin II causes an increase in portal pressure, and plasma concentration of angiotensin II is elevated in patients with cirrhosis, suggesting that angiotensin II may be involved in the pathogenesis of portal hypertension in cirrhosis. We evaluated the effect of the orally active angiotensin II receptor antagonist, losartan, on portal pressure in patients with cirrhosis and portal hypertension. Thirty patients with severe (hepatic venous pressure gradient [HVPG] >/= 20... Abstract

Folia medica, Volume 41, Issue 1, 1 1 1999, Pages 101-103 Statistical report from Uludag Poison Information Center--34-month experience. Ozyurt G, Tokyay N, Kucer N, Mutlu L, Onder I, Yilmaz D, Senay O

Management of poisoned patient requires accurate knowledge of intoxication. Uludaŏ Poison Information Center (UPIC), founded in January 1996, provides acquired information 24 hours a day 7 days a week for physicians and consultants. We received 2270 phone calls since January 1996 till October 1998 and evaluated the cases statistically regarding "distribution of age and gender", "calling time after poison exposure", "source of poisoning", "reason for intoxicatio... Abstract

Cited 1 times since 1999 (0 per year) source: EuropePMC

Biology of the neonate, Volume 75, Issue 2, 1 1 1999, Pages 130-136 Effect of exchange transfusion on brain perfusion and electrocortical brain activity in newborn lambs. Benders MJ, Meinesz JH, Dorrepaal CA, Steendijk P, van Bel F, van de Bor M

Changes in brain perfusion (using ultrasonic-determined changes in carotid artery blood flow: Qcar) and electrocortical brain activity (ECBA, obtained by a Lectromed cerebral function monitor) were studied during exchange transfusion using the push-pull method in the newborn lamb. Changes in mean arterial blood pressure (MABP), Qcar, heart rate (HR), and ECBA were observed during all exchange transfusions: MABP, Qcar, and ECBA decreased during the withdrawal period and increased during the infus... Abstract

Cited 5 times since 1999 (0.2 per year) source: EuropePMC

Biology of the neonate, Volume 75, Issue 4, 1 1 1999, Pages 239-249 Effect of deferoxamine on post-hypoxic-ischemic reperfusion injury of the newborn lamb heart. Shadid M, Van Bel F, Steendijk P, Dorrepaal CA, Moison R, Van Der Velde ET, Baan J

Unlabelled: Post-hypoxic-ischemic (HI) reperfusion induces excess production of non-protein-bound iron (NPBI), leading to formation of the highly reactive hydroxyl radical. We investigated whether the iron-chelator deferoxamine (DFO) could reduce reperfusion injury and improve left ventricular (LV) function. We produced severe HI in 14 newborn lambs and measured pre-HI, upon reperfusion, 60 and 120 min after HI the following parameters: mean aortic blood pressure, total peripheral resistance, st... Abstract

Cited 18 times since 1998 (0.7 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 66, Issue 6 Suppl, 1 1 1998, Pages S225-32 Tissue chimerism in human cryopreserved homograft valve explants demonstrated by in situ hybridization. Koolbergen DR, Hazekamp MG, Kurvers M, de Heer E, Cornelisse CJ, Huysmans HA, Bruijn JA

Background: The presence of viable cells may contribute to increased homograft valve durability. These cells may be of infiltrating recipient or persisting donor origin. In this study, in situ hybridization was used to assess the origin of cells in cryopreserved homograft valve explants. Methods: A total of 10 homografts with a donor-recipient gender mismatch were acquired from patients whose graft had been explanted at reoperation or at autopsy. The period of implantation varied from 14 days to... Abstract

Cited 16 times since 1998 (0.6 per year) source: EuropePMC

Development, growth & differentiation, Volume 40, Issue 6, 1 1 1998, Pages 577-582 Hormone-inducible expression of secreted factors in zebrafish embryos. de Graaf M, Zivkovic D, Joore J

The study of gene function at later stages of embryonic development by overexpression experiments is often complicated by genes exerting different functions at multiple stages of development, which renders analysis of stage-specific effects difficult. To address this problem an inducible expression system that supports timed expression of essentially any protein, including secreted proteins was designed. The system is based on a two step mechanism. A glucocorticoid inducible, Gal4-site binding c... Abstract

Cited 44 times since 1998 (1.7 per year) source: EuropePMC

The Journal of biological chemistry, Volume 273, Issue 50, 1 1 1998, Pages 33267-33272 Mitogenic effects of urokinase on melanoma cells are independent of high affinity binding to the urokinase receptor. Koopman JL, Slomp J, de Bart AC, Quax PH, Verheijen JH

The structural and functional properties of the urokinase-type plasminogen activator (u-PA) that are involved in the mitogenic effect of this proteolytic enzyme on human melanoma cells M14 and IF6 and the role of the u-PA receptor (u-PAR) in transducing this signal were analyzed. Native u-PA purified from urine induced a mitogenic response in quiescent IF6 and M14 cells that ranged from 25 to 40% of the mitogenic response obtained by fetal calf serum. The half-maximum response in M14 and IF6 cel... Abstract

Cited 34 times since 1998 (1.3 per year) source: EuropePMC

Circulation, Volume 98, Issue 20, 1 1 1998, Pages 2168-2179 Endocardial activation mapping of ventricular tachycardia in patients : first application of a 32-site bipolar mapping electrode catheter. Schalij MJ, van Rugge FP, Siezenga M, van der Velde ET

Background: Localization of early activated endocardial areas during ventricular tachycardia (VT) is mandatory for performance of surgical or radiofrequency catheter interventions. The use of a multielectrode catheter may shorten the procedure time and increase the accuracy of the procedure compared with single-electrode mapping techniques. This study was performed to evaluate the safety and efficacy of a 32-bipolar-electrode mapping catheter in patients. Methods and results: The basket-shaped m... Abstract

Cited 1 times since 1998 (0 per year) source: EuropePMC

The Journal of heart valve disease, Volume 7, Issue 6, 1 1 1998, Pages 615-619 Short-term follow up of the Ross operation in children. Braun J, Hazekamp MG, Schoof PH, Ottenkamp J, Huysmans HA

Background and aims of the study: Aortic valve disease in the pediatric population poses special problems to surgeons and cardiologists. The pulmonary autograft has proven to be a good alternative for aortic valve replacement and left ventricular outflow tract (LVOT) reconstruction in this special group. Methods: Forty-one children (mean age 10.0 +/- 4.8 (SD) years; range: 35 days to 18.8 years) underwent aortic root replacement with a pulmonary autograft between February 1994 and April 1998. Tw... Abstract

Cited 37 times since 1998 (1.4 per year) source: EuropePMC

The Journal of biological chemistry, Volume 273, Issue 45, 1 1 1998, Pages 29905-29914 Structural requirements for O-glycosylation of the mouse hepatitis virus membrane protein. de Haan CA, Roestenberg P, de Wit M, de Vries AA, Nilsson T, Vennema H, Rottier PJ

The mouse hepatitis virus (MHV) membrane (M) protein contains only O-linked oligosaccharides. We have used this protein as a model to study the structural requirements for O-glycosylation. We show that MHV M is modified by the addition of a single oligosaccharide side chain at the cluster of 4 hydroxylamino acids present at its extreme amino terminus and identified Thr at position 5 as the functional acceptor site. The hydroxylamino acid cluster, which is quite conserved among O-glycosylated cor... Abstract

Cited 39 times since 1998 (1.5 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 32, Issue 3, 1 1 1998, Pages 816-826 Effects of critical coronary stenosis on global systolic left ventricular function quantified by pressure-volume relations during dobutamine stress in the canine heart. Steendijk P, Baan J, Van der Velde ET, Baan J

Objectives: In this study we quantified the effects of a critical coronary stenosis on global systolic function using pressure-volume relations at baseline and during incremental dobutamine stress. Background: The effects of coronary stenosis have previously been analyzed mainly in terms of regional (dys)function. Global hemodynamics are generally considered normal until coronary flow is substantially reduced. However, pressure-volume analysis might reveal mechanisms not fully exposed by potenti... Abstract

Cited 9 times since 1998 (0.3 per year) source: EuropePMC

Developmental medicine and child neurology, Volume 40, Issue 8, 1 1 1998, Pages 563-567 Development of visual function in hemihydranencephaly. Porro G, Wittebol-Post D, de Graaf M, van Nieuwenhuizen O, Schenk-Rootlieb AJ, Treffers WF

This study reports on the findings of longitudinal follow-up of visual function in a 12-year-old girl affected by congenital right hemihydranencephaly. This extremely rare unilateral brain malformation allowed the authors to gather new information on neuronal plasticity and functional compensations of the visual system across a period of 10 years. An extension of the preserved right visual hemifields above the middle line and strategical eye or head positions developed to increase visual functio... Abstract

Cited 11 times since 1998 (0.4 per year) source: EuropePMC

The Journal of heart valve disease, Volume 7, Issue 4, 1 1 1998, Pages 407-409 Autologous pericardium for ventricular septal defect closure. Schoof PH, Hazekamp MG, van Ulzen K, Bartelings MM, Bruyn JA, Helbing W, Huysmans HA

Background and aims of the study: The use of living, untreated autologous pericardium for patch repair in the left ventricular outflow tract was considered attractive in children. Methods: Ventricular septal defect (VSD) closure with an untreated autologous pericardial patch was performed in 102 children of mean age 13.4 months (range: 1 to 73 months). Postoperative transthoracic Doppler echocardiography was performed in all children at a mean of nine weeks (range: one day to 50 weeks) after sur... Abstract

Cited 13 times since 1998 (0.5 per year) source: EuropePMC

European journal of cancer (Oxford, England : 1990), Volume 34, Issue 8, 1 1 1998, Pages 1235-1241 Trends in treatment and long-term survival of thyroid cancer in southeastern Netherlands, 1960-1992. Kuijpens JL, Hansen B, Hamming JF, Ribot JG, Haak HR, Coebergh JW

Thyroid cancer (TC), comprising less than 1% of all cancers in the Netherlands, has a good prognosis in general. Controversy still remains on the extent of surgical treatment and the indication for additional Iodine-131 (131I) therapy in the management of differentiated TC. The aim of this study was to describe (changes in) the treatment of TC and to determine independent prognostic factors for crude and relative survival of differentiated TC diagnosed in general hospitals. This population-based... Abstract

Cited 12 times since 1998 (0.4 per year) source: EuropePMC

Journal of computer assisted tomography, Volume 22, Issue 4, 1 1 1998, Pages 569-576 Differential response of the right and left ventricle to beta-adrenergic stimulation: an echo planar MR study in intact animals. Jerzewski A, Pattynama PM, Steendijk P, Leeuwenburgh BP, de Roos A, Baan J

Purpose: The purpose of this study was to compare the response in contractility of the right (RV) and left (LV) ventricle of the heart to beta-adrenergic stimulation using an echo planar MR technique. Method: In six sheep, RV and LV pressure-volume (P-V) relationships were constructed simultaneously using intraventricular pressures and volumes measured with echo planar MRI at rest and during dobutamine stress. Contractility changes were quantified by assessment of the end-systolic P-V relationsh... Abstract

Cited 26 times since 1998 (1 per year) source: EuropePMC

Pediatric research, Volume 44, Issue 1, 1 1 1998, Pages 119-124 The effect of antioxidative combination therapy on post hypoxic-ischemic perfusion, metabolism, and electrical activity of the newborn brain. Shadid M, Moison R, Steendijk P, Hiltermann L, Berger HM, van Bel F

Reoxygenation and reperfusion after severe hypoxia and ischemia (HI) contribute substantially to birth asphyxia-related brain injury. Excess production of free radicals via metabolization of arachidonic acid, xanthine oxidase, and non-protein-bound iron play an important role. Cerebral reperfusion injury is characterized by a decrease in perfusion, oxygen consumption, and electrical activity of the brain. Reduction of free radical production may attenuate these features. We therefore induced sev... Abstract