6125 results
Cited 1 times since 2023 (0.5 per year)
source: EuropePMC
Clinical and translational allergy,
Volume 13, Issue 1, 1 1 2023, Pages e12219
The positive effect of dupilumab on comorbid asthma in patients with atopic dermatitis.
Spekhorst LS, de Graaf M, van der Rijst LP, Zuithoff NPA, Schweizer RC, Kamsteeg M, Haeck I, van Lynden-van Nes AMT, van Lumig P, Romeijn GLE, Schuttelaar ML, de Bruin-Weller MS
Abstract
Cited 8 times since 2022 (3.7 per year)
source: EuropePMC
Circulation. Genomic and precision medicine,
Volume 16, Issue 1, 29 5 2022, Pages e003672
Variant Location Is a Novel Risk Factor for Individuals With Arrhythmogenic Cardiomyopathy Due to a Desmoplakin (<i>DSP</i>) Truncating Variant.
Hoorntje ET, Burns C, Marsili L, Corden B, Parikh VN, Te Meerman GJ, Gray B, Adiyaman A, Bagnall RD, Barge-Schaapveld DQCM, van den Berg MP, Bootsma M, Bosman LP, Correnti G, Duflou J, Eppinga RN, Fatkin D, Fietz M, Haan E, Jongbloed JDH, Hauer AD, Lam L, van Lint FHM, Lota A, Marcelis C, McCarthy HJ, van Mil AM, Oldenburg RA, Pachter N, Planken RN, Reuter C, Semsarian C, van der Smagt JJ, Thompson T, Vohra J, Volders PGA, van Waning JI, Whiffin N, van den Wijngaard A, Amin AS, Wilde AAM, van Woerden G, Yeates L, Zentner D, Ashley EA, Wheeler MT, Ware JS, van Tintelen JP, Ingles J
Background: Truncating variants in desmoplakin (DSPtv) are an important cause of arrhythmogenic cardiomyopathy; however the genetic architecture and genotype-specific risk factors are incompletely understood. We evaluated phenotype, risk factors for ventricular arrhythmias, and underlying genetics of DSPtv cardiomyopathy. Methods: Individuals with DSPtv and any cardiac phenotype, and their gene-positive family members were included from multiple international centers. Clinical data and family hi...
Abstract
Cited 4 times since 2022 (1.8 per year)
source: EuropePMC
Journal of clinical medicine,
Volume 12, Issue 1, 29 5 2022, Pages 272
Are Thoracic Aortic Aneurysm Patients at Increased Risk for Cardiovascular Diseases?
Dolmaci OB, El Mathari S, Driessen AHG, Klautz RJM, Poelmann RE, Lindeman JHN, Grewal N
Objectives: Abdominal aortic aneurysms are associated with a sharply increased cardiovascular risk. Cardiovascular risk management is therefore recommended in prevailing guidelines for abdominal aneurysm patients. It has been hypothesized that associated risk relates to loss of aortic compliance. If this hypothesis is correct, observations for abdominal aneurysms would also apply to thoracic aortic aneurysms. The objective of this study is to test whether thoracic aneurysms are also associated w...
Abstract
Cited 10 times since 2022 (4.6 per year)
source: EuropePMC
JACC. Cardiovascular interventions,
Volume 16, Issue 2, 28 4 2022, Pages 140-151
Staging Heart Failure Patients With Secondary Mitral Regurgitation Undergoing Transcatheter Edge-to-Edge Repair.
Stolz L, Doldi PM, Orban M, Karam N, Puscas T, Wild MG, Popescu A, von Bardeleben RS, Iliadis C, Baldus S, Adamo M, Thiele H, Besler C, Unterhuber M, Ruf T, Pfister R, Higuchi S, Koell B, Giannini C, Petronio A, Kassar M, Weckbach LT, Butter C, Stocker TJ, Neuss M, Melica B, Braun D, Windecker S, Massberg S, Praz F, Näbauer M, Kalbacher D, Lurz P, Metra M, Bax JJ, Hausleiter J, EuroSMR Investigators
Background: Secondary mitral regurgitation (SMR) is a progressive disease with characteristic pathophysiological changes that may influence prognosis. Although the staging of SMR patients suffering from heart failure with reduced ejection fraction (HFrEF) according to extramitral cardiac involvement has prognostic value in medically treated patients, such data are so far lacking for edge-to-edge mitral valve repair (M-TEER). Objectives: This study sought to classify M-TEER patients into disease...
Abstract
Cited 5 times since 2022 (2.3 per year)
source: EuropePMC
International journal of cardiology,
Volume 374, 28 4 2022, Pages 79-82
Right ventricular strain in Fabry disease: Prognostic implications.
Meucci MC, Lillo R, Mango F, Lombardo A, Lanza GA, Parisi V, Grandinetti M, Massetti M, Ajmone Marsan N, Crea F, Graziani F
Introduction: Left ventricular (LV) hypertrophy is the main feature of cardiac involvement in Anderson-Fabry disease (FD), but the right ventricle (RV) is also frequently affected. Previous studies failed to demonstrate an independent association between conventional parameters of RV performance and outcomes in FD. Nevertheless, if RV free wall strain (RV-FWS), assessed by 2D speckle tracking analysis, may provide a better prognostication is currently unknown. Methods: We retrospectively evaluat...
Abstract
Cited 1 times since 2022 (0.5 per year)
source: EuropePMC
Circulation,
Volume 147, Issue 10, 27 4 2022, Pages 798-811
The MIDA-Q Mortality Risk Score: A Quantitative Prognostic Tool for the Mitral Valve Prolapse Spectrum.
Essayagh B, Benfari G, Antoine C, Grigioni F, Le Tourneau T, Roussel JC, Bax JJ, Delgado V, Ajmone Marsan N, van Wijngaarden A, Tribouilloy C, Rusinaru D, Hochstadt A, Topilsky Y, Topilsky Y, Thapa P, Michelena HI, Enriquez-Sarano M
Background: Mitral valve prolapse (MVP) is responsible for a considerable disease burden but is widely heterogeneous. The lack of a comprehensive prognostic instrument covering the entire MVP spectrum, encompassing the quantified consequent degenerative mitral regurgitation (DMR), hinders clinical management and therapeutic trials. Methods: The new Mitral Regurgitation International Database Quantitative (MIDA-Q) registry enrolled 8187 consecutive patients (ages 63±16 years, 47% women, follow-up...
Abstract
Cited 3 times since 2022 (1.4 per year)
source: EuropePMC
Molecular imaging and biology,
Volume 25, Issue 1, 27 4 2022, Pages 228-239
Data-Driven Identification of Targets for Fluorescence-Guided Surgery in Non-Small Cell Lung Cancer.
Meijer RPJ, Neijenhuis LKA, Zeilstra AP, Roerink SF, Bhairosingh SS, Hilling DE, Mieog JSD, Kuppen PJK, Sier CFM, Braun J, Burggraaf J, Vahrmeijer AL, Cohen D, Hutteman M
Purpose: Intraoperative identification of lung tumors can be challenging. Tumor-targeted fluorescence-guided surgery can provide surgeons with a tool for real-time intraoperative tumor detection. This study evaluated cell surface biomarkers, partially selected via data-driven selection software, as potential targets for fluorescence-guided surgery in non-small cell lung cancers: adenocarcinomas (ADC), adenocarcinomas in situ (AIS), and squamous cell carcinomas (SCC). Procedures: Formalin-fixed p...
Abstract
Cited 27 times since 2022 (12.5 per year)
source: EuropePMC
Genome biology,
Volume 23, Issue 1, 27 4 2022, Pages 268
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.
Kanoni S, Graham SE, Wang Y, Surakka I, Ramdas S, Zhu X, Clarke SL, Bhatti KF, Vedantam S, Winkler TW, Locke AE, Marouli E, Zajac GJM, Wu KH, Ntalla I, Hui Q, Klarin D, Hilliard AT, Wang Z, Xue C, Thorleifsson G, Helgadottir A, Gudbjartsson DF, Holm H, Olafsson I, Hwang MY, Han S, Akiyama M, Sakaue S, Terao C, Kanai M, Zhou W, Brumpton BM, Rasheed H, Havulinna AS, Veturi Y, Pacheco JA, Rosenthal EA, Lingren T, Feng Q, Kullo IJ, Narita A, Takayama J, Martin HC, Hunt KA, Trivedi B, Haessler J, Giulianini F, Bradford Y, Miller JE, Campbell A, Lin K, Millwood IY, Rasheed A, Hindy G, Faul JD, Zhao W, Weir DR, Turman C, Huang H, Graff M, Choudhury A, Sengupta D, Mahajan A, Brown MR, Zhang W, Yu K, Schmidt EM, Pandit A, Gustafsson S, Yin X, Luan J, Zhao JH, Matsuda F, Jang HM, Yoon K, Medina-Gomez C, Pitsillides A, Hottenga JJ, Wood AR, Ji Y, Gao Z, Haworth S, Yousri NA, Mitchell RE, Chai JF, Aadahl M, Bjerregaard AA, Yao J, Manichaikul A, Hwu CM, Hung YJ, Warren HR, Ramirez J, Bork-Jensen J, Kårhus LL, Goel A, Saba
Background: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. Results: To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,65...
Abstract
Cited 17 times since 2022 (7.8 per year)
source: EuropePMC
The Science of the total environment,
Volume 865, 26 4 2022, Pages 161196
Normalisation of SARS-CoV-2 concentrations in wastewater: The use of flow, electrical conductivity and crAssphage.
Langeveld J, Schilperoort R, Heijnen L, Elsinga G, Schapendonk CEM, Fanoy E, de Schepper EIT, Koopmans MPG, de Graaf M, Medema G
Over the course of the Corona Virus Disease-19 (COVID-19) pandemic in 2020-2022, monitoring of the severe acute respiratory syndrome coronavirus 2 ribonucleic acid (SARS-CoV-2 RNA) in wastewater has rapidly evolved into a supplementary surveillance instrument for public health. Short term trends (2 weeks) are used as a basis for policy and decision making on measures for dealing with the pandemic. Normalisation is required to account for the dilution rate of the domestic wastewater that can stro...
Abstract
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 30, Issue 4, 24 4 2022, Pages 1396-1398
More evidence for prognostic value of quantification of myocardial perfusion.
Saraste A, Knuuti J, Bax JJ
Abstract
BMC primary care,
Volume 23, Issue 1, 22 4 2022, Pages 336
Non-acute chest pain in primary care; referral rates, communication and guideline adherence: a cohort study using routinely collected health data.
van den Bulk S, Spoelman WA, van Dijkman PRM, Numans ME, Bonten TN, Leiden University Medical Center(LUMC)
Background: The prevalence of coronary artery disease is increasing due to the aging population and increasing prevalence of cardiovascular risk factors. Non-acute chest pain often is the first symptom of stable coronary artery disease. To optimise care for patients with non-acute chest pain and make efficient use of available resources, we need to know more about the current incidence, referral rate and management of these patients. Methods: We used routinely collected health data from the STIZ...
Abstract
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology,
Volume 53, Issue 2, 22 4 2022, Pages 239-243
Biomarkers in tear fluid of dupilumab-treated moderate-to-severe atopic dermatitis patients.
Achten R, Thijs J, van Luijk C, Knol E, Delemarre E, de Graaf M, Bakker D, de Boer J, van Wijk F, de Bruin-Weller M
Abstract
Frontiers in cardiovascular medicine,
Volume 9, 22 4 2022, Pages 1012147
A percutaneous treatment strategy of an adult patient with a bicuspid aortic valve, coarctation of the aorta, and an exceptionally large aneurysm of a collateral artery: Case report and literature overview.
Verheijen DBH, Stöger JL, van der Kley F, Schalij MJ, Jongbloed MRM, Vliegen HW, Kiès P, Egorova AD
Coarctation of the aorta (CoA) is a congenital heart defect that is associated with a bicuspid aortic valve (BAV), ascending aorta dilatation, intracerebral aneurysms, and premature atherosclerotic disease. The first presentation during late adulthood is rare and is frequently driven by late sequelae. Hypertrophic collateral arteries can develop aneurysms which are at risk for spontaneous rupture, however, treatment recommendations for these aneurysms are scarce. Here, we describe the clinical c...
Abstract
The American journal of cardiology,
Volume 190, 20 3 2022, Pages 41-47
Association Between Chronic Obstructive Pulmonary Disease and All-Cause Mortality After Aortic Valve Replacement for Aortic Stenosis.
Myagmardorj R, Nabeta T, Hirasawa K, Singh GK, van der Kley F, de Weger A, Ajmone Marsan N, Bax JJ, Delgado V
Chronic obstructive pulmonary disease (COPD) and aortic stenosis (AS) are the most common diseases in which age plays a major role in the increase of their prevalence and when they co-exist, the outcomes prognosis worsens significantly. The aim of the present study was to evaluate the association between pulmonary functional parameters and all-cause mortality after aortic valve replacement (transcatheter or surgical). A total of 400 patients with severe AS and preoperative pulmonary functional t...
Abstract
Cited 4 times since 2022 (1.8 per year)
source: EuropePMC
Journal of the American Heart Association,
Volume 11, Issue 24, 19 3 2022, Pages e027260
Performance of the American Heart Association/American College of Cardiology Guideline-Recommended Pretest Probability Model for the Diagnosis of Obstructive Coronary Artery Disease.
Winther S, Murphy T, Schmidt SE, Bax JJ, Wijns W, Knuuti J, Bøttcher M
Background Substantial differences exist between different guideline-recommended pretest probability (PTP) models for the detection of obstructive coronary artery disease (CAD). This study was performed to study the performance of the 2021 American Heart Association/American College of Cardiology (AHA/ACC) guideline-recommended PTP (AHA/ACC-PTP) model in assessing the likelihood of obstructive CAD compared with previously proposed models. Methods and Results Symptomatic patients (N=50 561) refer...
Abstract
Cited 2 times since 2022 (0.9 per year)
source: EuropePMC
Pharmaceutics,
Volume 14, Issue 12, 18 3 2022, Pages 2840
Predicting the Temperature Evolution during Nanomilling of Drug Suspensions via a Semi-Theoretical Lumped-Parameter Model.
Guner G, Yilmaz D, Yao HF, Clancy DJ, Bilgili E
Although temperature can significantly affect the stability and degradation of drug nanosuspensions, temperature evolution during the production of drug nanoparticles via wet stirred media milling, also known as nanomilling, has not been studied extensively. This study aims to establish both descriptive and predictive capabilities of a semi-theoretical lumped parameter model (LPM) for temperature evolution. In the experiments, the mill was operated at various stirrer speeds, bead loadings, and b...
Abstract
Frontiers in cardiovascular medicine,
Volume 9, 16 3 2022, Pages 1094094
Editorial: Inflammation and immunomodulation in cardiovascular remodeling.
Ewing M, Karper JC, de Vries MR, Quax PHA
Abstract
Cited 6 times since 2022 (2.7 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 16, Issue 4, 14 2 2022, Pages 495-504
Clinical and Coronary Plaque Predictors of Atherosclerotic Nonresponse to Statin Therapy.
van Rosendael SE, van den Hoogen IJ, Lin FY, Andreini D, Al-Mallah MH, Budoff MJ, Cademartiri F, Chinnaiyan K, Choi JH, Conte E, Marques H, de Araújo Gonçalves P, Gottlieb I, Hadamitzky M, Leipsic JA, Maffei E, Pontone G, Raff GL, Shin S, Kim YJ, Lee BK, Chun EJ, Sung JM, Lee SE, Virmani R, Samady H, Stone PH, Min JK, Narula J, Shaw LJ, Chang HJ, van Rosendael AR, Bax JJ
Background: Statins reduce the incidence of major cardiovascular events, but residual risk remains. The study examined the determinants of atherosclerotic statin nonresponse. Objectives: This study aimed to investigate factors associated with statin nonresponse-defined atherosclerosis progression in patients treated with statins. Methods: The multicenter PARADIGM (Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging) registry included patients who underwen...
Abstract
Cited 2 times since 2022 (0.9 per year)
source: EuropePMC
Ecology and evolution,
Volume 12, Issue 12, 14 2 2022, Pages e9591
A new GTSeq resource to facilitate multijurisdictional research and management of walleye <i>Sander vitreus</i>.
Euclide PT, Larson WA, Bootsma M, Miller LM, Scribner KT, Stott W, Wilson CC, Latch EK
Conservation and management professionals often work across jurisdictional boundaries to identify broad ecological patterns. These collaborations help to protect populations whose distributions span political borders. One common limitation to multijurisdictional collaboration is consistency in data recording and reporting. This limitation can impact genetic research, which relies on data about specific markers in an organism's genome. Incomplete overlap of markers between separate studies c...
Abstract
Cited 10 times since 2022 (4.5 per year)
source: EuropePMC
The American journal of medicine,
Volume 136, Issue 3, 10 2 2022, Pages 260-269.e7
Integrating Coronary Atherosclerosis Burden and Progression with Coronary Artery Disease Risk Factors to Guide Therapeutic Decision Making.
Freeman AM, Raman SV, Aggarwal M, Maron DJ, Bhatt DL, Parwani P, Osborne J, Earls JP, Min JK, Bax JJ, Shapiro MD
Importance: Although atherosclerosis represents the primary driver of coronary artery disease, evaluation and treatment approaches have historically relied upon indirect markers of atherosclerosis that include surrogates (cholesterol), signs (angina), and sequelae (ischemia) of atherosclerosis. Direct quantification and characterization of atherosclerosis may encourage a precision heart care paradigm that improves diagnosis, risk stratification, therapeutic decision-making, and longitudinal dise...
Abstract
