7971 results
Cited 2 times since 2021 (0.5 per year)
source: EuropePMC
Current health sciences journal,
Volume 47, Issue 3, 1 1 2021, Pages 331-337
An Examination of the Relationship between Fear of Coronavirus (COVID-19) in First Year Nursing Students and Their Attitudes to the Profession.
Yilmaz D, Yilmaz DU
This study was conducted with the aim of determining the fear of coronavirus (COVID-19) and attitudes to the profession in first year nursing students, and examining the relationship between them. The descriptive study was conducted in April and May 2021 with first year students at the Nursing Department of Bursa Uludağ University. The research sample consisted of 156 students who participated voluntarily in the study. A Student Description Form, a Coronavirus (COVID-19) Fear Scale and an Attitu...
Abstract
Cited 113 times since 2021 (28.9 per year)
source: EuropePMC
Cell reports,
Volume 36, Issue 4, 1 1 2021, Pages 109441
The Cancer SENESCopedia: A delineation of cancer cell senescence.
Jochems F, Thijssen B, De Conti G, Jansen R, Pogacar Z, Groot K, Wang L, Schepers A, Wang C, Jin H, Beijersbergen RL, Leite de Oliveira R, Wessels LFA, Bernards R
Cellular senescence is characterized as a stable proliferation arrest that can be triggered by multiple stresses. Most knowledge about senescent cells is obtained from studies in primary cells. However, senescence features may be different in cancer cells, since the pathways that are involved in senescence induction are often deregulated in cancer. We report here a comprehensive analysis of the transcriptome and senolytic responses in a panel of 13 cancer cell lines rendered senescent by two dis...
Abstract
Cited 14 times since 2021 (3.6 per year)
source: EuropePMC
Proceedings of the National Academy of Sciences of the United States of America,
Volume 118, Issue 27, 1 1 2021, Pages e2102026118
Multiscale mechanics and temporal evolution of vimentin intermediate filament networks.
Schepers AV, Lorenz C, Nietmann P, Janshoff A, Klumpp S, Köster S
The cytoskeleton, an intricate network of protein filaments, motor proteins, and cross-linkers, largely determines the mechanical properties of cells. Among the three filamentous components, F-actin, microtubules, and intermediate filaments (IFs), the IF network is by far the most extensible and resilient to stress. We present a multiscale approach to disentangle the three main contributions to vimentin IF network mechanics-single-filament mechanics, filament length, and interactions between fil...
Abstract
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 60, Issue 2, 1 1 2021, Pages 435-436
Prediction is very difficult, especially about the future.
Tomšič A, Klautz RJM
Abstract
Cited 11 times since 2021 (2.8 per year)
source: EuropePMC
BMJ open gastroenterology,
Volume 8, Issue 1, 1 1 2021, Pages e000670
Quality of life in patients with IBD during the COVID-19 pandemic in the Netherlands.
de Bock E, Filipe MD, Meij V, Oldenburg B, van Schaik FDM, Bastian OW, Fidder HF, Vriens MR, Richir MC
Objective: COVID-19 has put a strain on regular healthcare worldwide. For inflammatory bowel disease (IBD), gastrointestinal surgeries were postponed and changes in treatment and diagnostic procedures were made. As abrupt changes in treatment regimens may result in an increased morbidity and consequent well-being of patients with IBD, the aim of this study was to determine the effect of the COVID-19 pandemic on health-related quality of life (HRQoL) in patients with IBD. Design: All patients wit...
Abstract
Cited 2 times since 2021 (0.5 per year)
source: EuropePMC
Cardiovascular research,
Volume 117, Issue 8, 1 1 2021, Pages 1923-1934
Impaired cytoplasmic domain interactions cause co-assembly defect and loss of function in the p.Glu293Lys KNCJ2 variant isolated from an Andersen-Tawil syndrome patient.
Déri S, Borbás J, Hartai T, Hategan L, Csányi B, Visnyovszki Á, Madácsy T, Maléth J, Hegedűs Z, Nagy I, Arora R, Labro AJ, Környei L, Varró A, Sepp R, Ördög B
Aims: Subunit interactions at the cytoplasmic domain interface (CD-I) have recently been shown to control gating in inward rectifier potassium channels. Here we report the novel KCNJ2 variant p.Glu293Lys that has been found in a patient with Andersen-Tawil syndrome type 1 (ATS1), causing amino acid substitution at the CD-I of the inward rectifier potassium channel subunit Kir2.1. Neither has the role of Glu293 in gating control been investigated nor has a pathogenic variant been described at thi...
Abstract
Balkan medical journal,
Volume 38, Issue 4, 1 1 2021, Pages 222-228
Evaluation of COVID-19 Disease and the Effect of Trends in Intervention Measures: The Pediatric Perspective from a Tertiary Care Hospital in Turkey.
Şık N, Duman M, Yılmaz D, Karaoğlu Asrak H, Erbaş İC, Çakıl Güzin A, Özdem Alataş Ş, Appak Ö, Sayıner AA, Belet N
Background: COVID-19 is an emerging disease of global public health concern. Aims: To evaluate the epidemiological, clinical, laboratory, and radiologic findings and the clinical outcomes of children who were diagnosed with SARS-CoV-2 by polymerase chain reaction (PCR), and to evaluate the effect of the trends in intervention measures. Study design: Between April 2, 2020 and January 16, 2021, children aged 0-18 years who had presented at the pediatric emergency department and were diagnosed with...
Abstract
Cited 4 times since 2021 (1 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 60, Issue 1, 1 1 2021, Pages 7-33
Consensus document on optimal management of patients with common arterial trunk.
Hazekamp MG, Barron DJ, Dangel J, Homfray T, Jongbloed MRM, Voges I, ESC Scientific Document Group
Abstract
Cited 1 times since 2021 (0.3 per year)
source: EuropePMC
Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists,
Volume 28, Issue 6, 30 5 2021, Pages 852-859
Functional Performance After Complex Endovascular Aortic Repair: A Single-Center Retrospective Cohort Study.
Warmerdam BWCM, van Holstein Y, Eefting D, van Rijswijk CSP, van der Meer RW, Mooijaart SP, Hamming JF, van der Vorst JR, van Schaik J
Purpose: Complex endovascular aortic repair (EVAR) procedures provide a treatment option for patients with aortic aneurysms involving visceral branches. Good technical results and short-term outcomes have been reported. Whether complex EVAR provides acceptable functional outcomes is not clear. The current study aims to describe postoperative functional outcomes in complex EVAR patients-an older and relatively frail patient group. Materials and methods: A single-center retrospective cohort study...
Abstract
Cited 4 times since 2021 (1 per year)
source: EuropePMC
Journal of cellular and molecular medicine,
Volume 25, Issue 16, 30 5 2021, Pages 7772-7782
Phosphorylcholine antibodies restrict infarct size and left ventricular remodelling by attenuating the unreperfused post-ischaemic inflammatory response.
Pluijmert NJ, de Jong RCM, de Vries MR, Pettersson K, Atsma DE, Jukema JW, Quax PHA
Phosphorylcholine is a pro-inflammatory epitope exposed on apoptotic cells, and phosphorylcholine monoclonal immunoglobulin (Ig)G antibodies (PC-mAb) have anti-inflammatory properties. In this study, we hypothesize that PC-mAb treatment reduces adverse cardiac remodelling and infarct size (IS) following unreperfused transmural myocardial infarction (MI). Unreperfused MI was induced by permanent ligation of the left anterior descending (LAD) coronary artery in hypercholesterolaemic APOE*3-Leiden...
Abstract
Cited 14 times since 2021 (3.6 per year)
source: EuropePMC
Radiology,
Volume 300, Issue 3, 29 5 2021, Pages 549-556
Relationship of Endothelial Shear Stress with Plaque Features with Coronary CT Angiography and Vasodilating Capability with PET.
Kalykakis GE, Antonopoulos AS, Pitsargiotis T, Siogkas P, Exarchos T, Kafouris P, Sakelarios A, Liga R, Tzifa A, Giannopoulos A, Scholte AJHA, Kaufmann PA, Parodi O, Knuuti J, Fotiadis DI, Neglia D, Anagnostopoulos CD
Background Advances in three-dimensional reconstruction techniques and computational fluid dynamics of coronary CT angiography (CCTA) data sets make feasible evaluation of endothelial shear stress (ESS) in the vessel wall. Purpose To investigate the relationship between CCTA-derived computational fluid dynamics metrics, anatomic and morphologic characteristics of coronary lesions, and their comparative performance in predicting impaired coronary vasodilating capability assessed by using PET myoc...
Abstract
Cited 6 times since 2021 (1.5 per year)
source: EuropePMC
Thrombosis journal,
Volume 19, Issue 1, 27 4 2021, Pages 45
Differential effect of statin use on coagulation markers: an active comparative analysis in the NEO study.
Bordbar M, de Mutsert R, Cevval M, Rosendaal FR, Jukema JW, Lijfering WM
Background: Statins are a potential treatment for venous thromboembolism (VTE) prophylaxis complementary to conventional anticoagulants without associated bleeding complications. This study aimed to compare pro-thrombotic activities of different classes of lipid-lowering drugs in an active comparator design and determine whether there is a relation between statin versus fibrate/niacin use and pro-coagulant factor outcomes. Methods: This is a cross-sectional analysis of participants from the Neth...
Abstract
Cited 8 times since 2021 (2 per year)
source: EuropePMC
Journal of neurology,
Volume 269, Issue 2, 26 4 2021, Pages 945-955
Clinical outcome of CIDP one year after start of treatment: a prospective cohort study.
Bus SRM, Broers MC, Lucke IM, Bunschoten C, van Lieverloo GGA, Adrichem ME, van Veen R, Wieske L, Lingsma HF, Goedee HS, van der Pol WL, van Schaik IN, Van Doorn PA, Jacobs BC, Eftimov F, ICOS Consortium
Objective: To assess clinical outcome in treatment-naive patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Methods: We included adult treatment-naive patients participating in the prospective International CIDP Outcome Study (ICOS) that fulfilled the European Federation of Neurological Societies/Peripheral Nerve Society (EFNS/PNS) diagnostic criteria for CIDP. Patients were grouped based on initial treatment with (1) intravenous immunoglobulin (IVIg), (2) corticoste...
Abstract
Cited 3 times since 2021 (0.8 per year)
source: EuropePMC
International journal of cardiology. Heart & vasculature,
Volume 35, 25 4 2021, Pages 100830
Elevated resting heart rate is a marker of subclinical left ventricular dysfunction in hodgkin lymphoma survivors.
Heemelaar JC, Krol ADG, Louwerens M, L M A Beeres S, Holman ER, Schalij MJ, Louisa Antoni M
Background: Thoracic irradiation is one of the cornerstones of Hodgkin lymphoma (HL) treatment, which contributes to high rates of long-term survivorship, but begets a life-long increased risk of heart disease including heart failure. At the cardio-oncology (CO) clinic, persistent sinus tachycardia or elevated resting heart rate (RHR) is frequently observed in these patients. The aim of this study was to evaluate the relation between RHR and left ventricular (LV) dysfunction. Methods: In 75 HL s...
Abstract
Cited 10 times since 2021 (2.5 per year)
source: EuropePMC
Annals of vascular surgery,
Volume 78, 25 4 2021, Pages 281-287
Assessment of Tissue Viability Following Amputation Surgery Using Near-Infrared Fluorescence Imaging With Indocyanine Green.
Van Den Hoven P, Van Den Berg SD, Van Der Valk JP, Van Der Krogt H, Van Doorn LP, Van De Bogt KEA, Van Schaik J, Schepers A, Vahrmeijer AL, Hamming JF, Van Der Vorst JR
Background: Patients with chronic limb threatening ischemia have a risk of undergoing a major amputation within 1 year of nearly 30% with a substantial risk of re-amputation since wound healing is often impaired. Quantitative assessment of regional tissue viability following amputation surgery can identify patients at risk for impaired wound healing. In quantification of regional tissue perfusion, near-infrared (NIR) fluorescence imaging using Indocyanine Green (ICG) seems promising. Methods: Th...
Abstract
Cited 3 times since 2021 (0.8 per year)
source: EuropePMC
Frontiers in cardiovascular medicine,
Volume 8, 24 4 2021, Pages 668503
Computed Tomography Derived Coronary Triangulated Orifice Area-Deduction of a New Parameter for Follow-up After Surgical Correction of Anomalous Aortic Origin of Coronary Arteries and Call for Validation.
Meijer FMM, Kiès P, Verheijen DBH, Vliegen HW, Jongbloed MRM, Hazekamp MG, Lamb HJ, Egorova AD
Introduction: Anomalous aortic origin of a coronary artery (AAOCA) from the opposite sinus of Valsalva is a rare congenital abnormality. Computed tomography angiography (CTA) is primarily used as a diagnostic tool to evaluate the anatomy and identify potentially malignant AAOCA variants. Limited data is available on the role of CTA during postoperative follow-up. We aimed to develop an objective CTA derived parameter for diagnostic evaluation and follow-up after surgical correction of AAOCA and...
Abstract
Cited 2 times since 2021 (0.5 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 37, Issue 11, 23 4 2021, Pages 3313-3322
Quantification of myocardial ischemia and subtended myocardial mass at adenosine stress cardiac computed tomography: a feasibility study.
van Driest FY, van der Geest RJ, Broersen A, Dijkstra J, El Mahdiui M, Jukema JW, Scholte AJHA
Combination of coronary computed tomography angiography (CCTA) and adenosine stress CT myocardial perfusion (CTP) allows for coronary artery lesion assessment as well as myocardial ischemia. However, myocardial ischemia on CTP is nowadays assessed semi-quantitatively by visual analysis. The aim of this study was to fully quantify myocardial ischemia and the subtended myocardial mass on CTP. We included 33 patients referred for a combined CCTA and adenosine stress CTP protocol, with good or excel...
Abstract
Cited 6 times since 2021 (1.5 per year)
source: EuropePMC
The American journal of cardiology,
Volume 153, 22 4 2021, Pages 30-35
Prevalence of Aortic Valve Stenosis in Patients With ST-Segment Elevation Myocardial Infarction and Effect on Long-Term Outcome.
Singh GK, van der Bijl P, Goedemans L, Vollema EM, Abou R, Ajmone Marsan N, Bax JJ, Delgado V
Several studies have shown an association between aortic valve stenosis (AS), atherosclerosis and cardiovascular risk factors. These risk factors are frequently encountered in patients with ST-segment elevation myocardial infarction (STEMI). The aim of this study was to evaluate the prevalence and the prognostic implications of AS in patients presenting with STEMI. A total of 2041 patients (61 ± 12 years old, 76% male) admitted with STEMI and treated with primary percutaneous coronary interventi...
Abstract
Cited 21 times since 2021 (5.3 per year)
source: EuropePMC
BMC medicine,
Volume 19, Issue 1, 22 4 2021, Pages 139
Association of statin use in older people primary prevention group with risk of cardiovascular events and mortality: a systematic review and meta-analysis of observational studies.
Awad K, Mohammed M, Zaki MM, Abushouk AI, Lip GYH, Blaha MJ, Lavie CJ, Toth PP, Jukema JW, Sattar N, Banach M, Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group and the International Lipid Expert Panel (ILEP)
Background: Current evidence from randomized controlled trials on statins for primary prevention of cardiovascular disease (CVD) in older people, especially those aged > 75 years, is still lacking. We conducted a systematic review and meta-analysis of observational studies to extend the current evidence about the association of statin use in older people primary prevention group with risk of CVD and mortality. Methods: PubMed, Scopus, and Embase were searched from inception until March 18, 20...
Abstract
Cited 5 times since 2021 (1.3 per year)
source: EuropePMC
Molecular cancer research : MCR,
Volume 19, Issue 10, 22 4 2021, Pages 1613-1621
Identification of Autophagy-Related Genes as Targets for Senescence Induction Using a Customizable CRISPR-Based Suicide Switch Screen.
Schepers A, Jochems F, Lieftink C, Wang L, Pogacar Z, Leite de Oliveira R, De Conti G, Beijersbergen RL, Bernards R
Pro-senescence therapies are increasingly being considered for the treatment of cancer. Identifying additional targets to induce senescence in cancer cells could further enable such therapies. However, screening for targets whose suppression induces senescence on a genome-wide scale is challenging, as senescent cells become growth arrested, and senescence-associated features can take 1 to 2 weeks to develop. For a screen with a whole-genome CRISPR library, this would result in billions of undesi...
Abstract
