7971 results
Cited 10 times since 2021 (2.5 per year)
source: EuropePMC
ESC heart failure,
Volume 8, Issue 5, 22 4 2021, Pages 3512-3520
Identification of sex-specific biomarkers predicting new-onset heart failure.
Raafs A, Verdonschot J, Ferreira JP, Wang P, Collier T, Henkens M, Björkman J, Boccanelli A, Clark AL, Delles C, Diez J, González A, Girerd N, Jukema JW, Pinet F, Rossignol P, Thum T, Vodovar N, de Boer RA, van Empel V, Staessen JA, Hazebroek M, Cleland J, Zannad F, Heymans S
Aims: Heart failure (HF) is common in both men and women, yet disease pathophysiology, presentation, and progression differ between sexes. Studies addressing whether biomarkers predict new onset HF sex-specifically are scarce. This study therefore aims to test the sex-specificity of 252 protein biomarkers for new-onset HF. Methods and results: A matched case-control design in patients selected from cohorts within the HOMAGE consortium was used. Cases (new-onset HF, n = 562) and controls (n = 780...
Abstract
Cited 5 times since 2021 (1.3 per year)
source: EuropePMC
The Journal of dermatological treatment,
Volume 33, Issue 4, 21 3 2021, Pages 1986-1989
Eczema control and treatment satisfaction in atopic dermatitis patients treated with dupilumab - a cross-sectional study from the BioDay registry.
Oosterhaven JAF, Spekhorst LS, Zhang J, Voorberg AN, Romeijn GLE, Boesjes CM, de Graaf M, de Bruin-Weller MS, Schuttelaar MLA
Background: Eczema control is a new construct to be measured in atopic dermatitis (AD). Objectives: Measuring patient-perceived eczema control and treatment satisfaction in AD patients, treated with dupilumab between 16 and 52 weeks. Methods: Cross-sectional questionnaire study. Patients from the Dutch BioDay registry completed the Atopic Dermatitis Control Test (ADCT), Recap of Atopic Eczema (RECAP) and Treatment Satisfaction Questionnaire for Medication, Version II (TSQM v. II), along with oth...
Abstract
Cited 4 times since 2021 (1 per year)
source: EuropePMC
The American journal of cardiology,
Volume 152, 20 3 2021, Pages 11-18
Prognostic Value of Multilayer Left Ventricular Global Longitudinal Strain in Patients with ST-segment Elevation Myocardial Infarction with Mildly Reduced Left Ventricular Ejection Fractions.
Abou R, Goedemans L, Montero-Cabezas JM, Prihadi EA, El Mahdiui M, Schalij MJ, Ajmone Marsan N, Bax JJ, Delgado V
Multilayer (epi-, mid- and endocardium) left ventricular (LV) global longitudinal strain (GLS) reflects the extent of myocardial damage after ST-segment myocardial infarction (STEMI). However, the prognostic implications of multilayer LV GLS remain unclear. We studied the association between multilayer LV GLS and prognosis in patients with mildly reduced or preserved LV ejection fraction (EF) after STEMI. Patients with first STEMI and LVEF>45% were evaluated retrospectively. Baseline multilay...
Abstract
Cited 9 times since 2021 (2.3 per year)
source: EuropePMC
Scientific reports,
Volume 11, Issue 1, 18 3 2021, Pages 12899
Lipid biomarkers in statin users with coronary artery disease annotated by coronary computed tomography angiography.
Michelucci E, Giorgi ND, Finamore F, Smit JM, Scholte AJHA, Signore G, Rocchiccioli S
Molecular markers are suggested to improve the diagnostic and prognostic accuracy in patients with coronary artery disease (CAD) beyond current clinical scores based on age, gender, symptoms and traditional risk factors. In this context, plasma lipids are emerging as predictors of both plaque composition and risk of future events. We aim to identify plasma lipid biomarkers associated to CAD indexes of stenosis severity, plaque lipid content and a comprensive score of CAD extent and its risk. We...
Abstract
Cited 51 times since 2021 (12.9 per year)
source: EuropePMC
Nature communications,
Volume 12, Issue 1, 18 3 2021, Pages 3799
Vimentin intermediate filaments stabilize dynamic microtubules by direct interactions.
Schaedel L, Lorenz C, Schepers AV, Klumpp S, Köster S
The cytoskeleton determines cell mechanics and lies at the heart of important cellular functions. Growing evidence suggests that the manifold tasks of the cytoskeleton rely on the interactions between its filamentous components-actin filaments, intermediate filaments, and microtubules. However, the nature of these interactions and their impact on cytoskeletal dynamics are largely unknown. Here, we show in a reconstituted in vitro system that vimentin intermediate filaments stabilize microtubules...
Abstract
Cited 26 times since 2021 (6.6 per year)
source: EuropePMC
Diabetes care,
Volume 44, Issue 8, 18 3 2021, Pages 1757-1765
Serum Magnesium Is Inversely Associated With Heart Failure, Atrial Fibrillation, and Microvascular Complications in Type 2 Diabetes.
Oost LJ, van der Heijden AAWA, Vermeulen EA, Bos C, Elders PJM, Slieker RC, Kurstjens S, van Berkel M, Hoenderop JGJ, Tack CJ, Beulens JWJ, de Baaij JHF
Objective: We investigated whether serum magnesium (Mg2+) was prospectively associated with macro- or microvascular complications and mediated by glycemic control (hemoglobin A1c [HbA1c]), in type 2 diabetes (T2D). Research design and methods: We analyzed in 4,348 participants the association of serum Mg2+ with macrovascular disease and mortality (acute myocardial infarction [AMI], coronary heart disease [CHD], heart failure [HF], cerebrovascular accident [CVA], and peripheral arterial disease [...
Abstract
Cited 1 times since 2021 (0.3 per year)
source: EuropePMC
Journal of dairy science,
Volume 104, Issue 9, 17 3 2021, Pages 10217-10231
The effect of new bovine viral diarrhea virus introduction on somatic cell count, calving interval, culling, and calf mortality of dairy herds in the Dutch bovine viral diarrhea virus-free program.
Yue X, van der Voort M, Steeneveld W, van Schaik G, Vernooij JCM, van Duijn L, Hogeveen H
Bovine viral diarrhea virus (BVDV) infection has a major effect on the health of cows and consequently on herd performance. Many countries have implemented control or eradication programs to mitigate BVDV infection and its negative effects. These negative effects of BVDV infection on dairy herds are well documented, but there is much less information about the effects of new introduction of BVDV on dairy herds already participating in a BVDV control program. The objective of our study was to inv...
Abstract
Cited 2 times since 2021 (0.5 per year)
source: EuropePMC
Antimicrobial agents and chemotherapy,
Volume 65, Issue 7, 17 3 2021, Pages e0075421
Erratum for Janssen et al., "Evolution of Colistin Resistance in the Klebsiella pneumoniae Complex Follows Multiple Evolutionary Trajectories with Variable Effects on Fitness and Virulence Characteristics".
Janssen AB, Doorduijn DJ, Mills G, Rogers MRC, Bonten MJM, Rooijakkers SHM, Willems RJL, Bengoechea JA, van Schaik W
Abstract
Cited 1 times since 2021 (0.3 per year)
source: EuropePMC
ACS omega,
Volume 6, Issue 25, 16 3 2021, Pages 16649-16660
Comparative Study: Impacts of Ca and Mg Salts on Iron Oxygen Carriers in Chemical Looping Combustion of Biomass.
Yilmaz D, Steenari BM, Leion H
Chemical looping combustion (CLC) is one of the most promising methods for carbon capture and storage (CCS). An oxygen carrier, i.e., a mineral that can be oxidized and reduced, is used to convert the fuel in the process. The produced CO2 is inherently separated from the air components that enables easier CCS. The use of biomass-based fuels is desirable since it can lead to negative CO2 emissions. On the other hand, alkali compounds from the biomass may interact with the oxygen carrier causing p...
Abstract
Cited 5 times since 2021 (1.3 per year)
source: EuropePMC
AJR. American journal of roentgenology,
Volume 217, Issue 6, 16 3 2021, Pages 1344-1352
Impact of Dose Reduction Strategies on Image Quality of Coronary CTA in Real-World Clinical Practice: A Subanalysis of PROTECTION VI Registry Data.
Stocker TJ, Nühlen N, Schmermund A, Leipsic J, Grove EL, Deseive S, Bax JJ, Maurovich-Horvat P, Otton J, Hadamitzky M, Chen MY, Naoum C, Andreini D, Rubinshtein R, Massberg S, Hausleiter J
BACKGROUND. Dose reduction strategies for coronary CTA (CCTA) have been underused in clinical practice given concern that the strategies may lower image quality. OBJECTIVE. The purpose of this study was to explore associations between dose reduction strategies and CCTA image quality in real-world clinical practice. METHODS. This subanalysis of the international Prospective Multicenter Registry on Radiation Dose Estimates of Cardiac CT Angiography in Daily Practice in 2017 (PROTECTION VI) study i...
Abstract
Cited 10 times since 2021 (2.5 per year)
source: EuropePMC
Frontiers in public health,
Volume 9, 16 3 2021, Pages 568822
Creating a Social Learning Environment for and by Older Adults in the Use and Adoption of Smartphone Technology to Age in Place.
den Haan M, Brankaert R, Kenning G, Lu Y
Smartphone technologies can support older adults in their daily lives as they age in place at home. However, they may struggle to use these technologies which impacts acceptance, adoption, and sustainable use. Peer to peer community learning has the potential to support older adults to learn using (smartphone) technologies. This paper studies such a learning community approach and how it can support older adults to learn using and adopt the smartphone application GoLivePhone. This technology ass...
Abstract
Cited 2 times since 2021 (0.5 per year)
source: EuropePMC
EJNMMI physics,
Volume 8, Issue 1, 16 3 2021, Pages 48
Experimental validation of absolute SPECT/CT quantification for response monitoring in patients with coronary artery disease.
van de Burgt A, Dibbets-Schneider P, Slump CH, Scholte AJHA, Atsma DE, de Geus-Oei LF, van Velden FHP
Background: Quantitative SPECT enables absolute quantification of uptake in perfusion defects. The aim of this experimental study is to assess quantitative accuracy and precision of a novel iterative reconstruction technique (Evolution; GE Healthcare) for the potential application of response monitoring using 99mTc-tetrofosmin SPECT/CT in patients with coronary artery disease (CAD). Methods: Acquisitions of an anthropomorphic torso phantom with cardiac insert containing defects (with varying siz...
Abstract
JACC. Asia,
Volume 1, Issue 1, 15 3 2021, Pages 49-52
The Multidimensionality of Coronary Artery Disease: Combining, Conflating and Changing.
Min JK, Budoff MJ, Bax JJ
Abstract
Cited 1 times since 2021 (0.3 per year)
source: EuropePMC
International journal of laboratory hematology,
Volume 43, Issue 4, 15 3 2021, Pages 786-794
Is monitoring of antiplatelet therapy by light transmission aggregometry dependent on instrument and reagent used?
Monteyne T, Heireman L, Hemelsoet D, van Schaik RHN, Devreese KMJ
Introduction: Light transmission aggregometry (LTA), used to detect clopidogrel resistance in patients under antiplatelet therapy, is prone to multiple variables potentially influencing results and interpretation. Currently, no attention is given to type of aggregometer or reagent used. The aim of this study was to evaluate the interassay variability between two aggregometers (Chronolog700 and TA-8V), using two different ADP reagents (Chrono-Par® and Agro-Bio ADP) in patients under clopidogrel t...
Abstract
Cited 11 times since 2021 (2.8 per year)
source: EuropePMC
Journal of cardiovascular development and disease,
Volume 8, Issue 6, 13 2 2021, Pages 70
How Cardiac Embryology Translates into Clinical Arrhythmias.
Rivaud MR, Blok M, Jongbloed MRM, Boukens BJ
The electrophysiological signatures of the myocardium in cardiac structures, such as the atrioventricular node, pulmonary veins or the right ventricular outflow tract, are established during development by the spatial and temporal expression of transcription factors that guide expression of specific ion channels. Genome-wide association studies have shown that small variations in genetic regions are key to the expression of these transcription factors and thereby modulate the electrical function...
Abstract
Cited 1 times since 2021 (0.3 per year)
source: EuropePMC
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology,
Volume 17, Issue 2, 11 2 2021, Pages e156-e157
Computed tomography-derived transoesophageal echocardiographic views for preprocedural planning of direct transcatheter mitral valve annuloplasty.
Fortuni F, van der Kley F, Ajmone Marsan N, Delgado V
Abstract
Cited 1 times since 2021 (0.3 per year)
source: EuropePMC
European heart journal. Digital health,
Volume 2, Issue 3, 11 2 2021, Pages 511-520
Development of a patient-oriented Hololens application to illustrate the function of medication after myocardial infarction.
Hilt AD, Hierck BP, Eijkenduijn J, Wesselius FJ, Albayrak A, Melles M, Schalij MJ, Scherptong RWC
Aims: Statin treatment is one of the hallmarks of secondary prevention after myocardial infarction. Adherence to statins tends to be difficult and can be improved by patient education. Novel technologies such as mixed reality (MR) expand the possibilities to support this process. To assess if an MR medication-application supports patient education focused on function of statins after myocardial infarction. Methods and results: A human-centred design-approach was used to develop an MR statin tool...
Abstract
Cited 14 times since 2021 (3.5 per year)
source: EuropePMC
Journal of internal medicine,
Volume 290, Issue 3, 10 2 2021, Pages 715-727
Renal function in patients with significant tricuspid regurgitation: pathophysiological mechanisms and prognostic implications.
Butcher SC, Fortuni F, Dietz MF, Prihadi EA, van der Bijl P, Ajmone Marsan N, Bax JJ, Delgado V
Background: The pathophysiological mechanisms linking tricuspid regurgitation (TR) and chronic kidney disease (CKD) remain unknown. This study aimed to determine which pathophysiological mechanisms related to TR are independently associated with renal dysfunction and to evaluate the impact of renal impairment on long-term prognosis in patients with significant (≥ moderate) secondary TR. Methods: A total of 1234 individuals (72 [IQR 63-78] years, 50% male) with significant secondary TR were follo...
Abstract
Cited 96 times since 2021 (24.2 per year)
source: EuropePMC
The Journal of molecular diagnostics : JMD,
Volume 23, Issue 9, 10 2 2021, Pages 1047-1064
Recommendations for Clinical CYP2D6 Genotyping Allele Selection: A Joint Consensus Recommendation of the Association for Molecular Pathology, College of American Pathologists, Dutch Pharmacogenetics Working Group of the Royal Dutch Pharmacists Association, and the European Society for Pharmacogenomics and Personalized Therapy.
Pratt VM, Cavallari LH, Del Tredici AL, Gaedigk A, Hachad H, Ji Y, Kalman LV, Ly RC, Moyer AM, Scott SA, van Schaik RHN, Whirl-Carrillo M, Weck KE
The goals of the Association for Molecular Pathology Clinical Practice Committee's Pharmacogenomics (PGx) Working Group are to define the key attributes of pharmacogenetic alleles recommended for clinical testing, and to determine a minimal set of variants that should be included in clinical PGx genotyping assays. This document series provides recommendations on a minimal panel of variant alleles (Tier 1) and an extended panel of variant alleles (Tier 2) that will aid clinical laboratories...
Abstract
Metabolomics : Official journal of the Metabolomic Society,
Volume 17, Issue 6, 9 2 2021, Pages 57
Differential insulin sensitivity of NMR-based metabolomic measures in a two-step hyperinsulinemic euglycemic clamp study.
Wang W, van Dijk KW, Wijsman CA, Rozing MP, Mooijaart SP, Beekman M, Slagboom PE, Jukema JW, Noordam R, van Heemst D
Background: Insulin is the key regulator of glucose metabolism, but it is difficult to dissect direct insulin from glucose-induced effects. We aimed to investigate the effects of hyperinsulemia on metabolomic measures under euglycemic conditions in nondiabetic participants. Methods: We assessed concentrations of 151 metabolomic measures throughout a two-step hyperinsulinemic euglycemic clamp procedure. We included 24 participants (50% women, mean age = 62 [s.d. = 4.2] years) and metabolomic meas...
Abstract
