Research

Publications

Below you can find a list of our published research.

6205 results

Cited 243 times since 2017 (30.2 per year) source: EuropePMC

Circulation, Volume 135, Issue 24, 12 2 2017, Pages 2373-2388 Causal Associations of Adiposity and Body Fat Distribution With Coronary Heart Disease, Stroke Subtypes, and Type 2 Diabetes Mellitus: A Mendelian Randomization Analysis. Dale CE, Fatemifar G, Palmer TM, White J, Prieto-Merino D, Zabaneh D, Engmann JEL, Shah T, Wong A, Warren HR, McLachlan S, Trompet S, Moldovan M, Morris RW, Sofat R, Kumari M, Hyppönen E, Jefferis BJ, Gaunt TR, Ben-Shlomo Y, Zhou A, Gentry-Maharaj A, Ryan A, UCLEB Consortium; METASTROKE Consortium, Mutsert R, Noordam R, Caulfield MJ, Jukema JW, Worrall BB, Munroe PB, Menon U, Power C, Kuh D, Lawlor DA, Humphries SE, Mook-Kanamori DO, Sattar N, Kivimaki M, Price JF, Davey Smith G, Dudbridge F, Hingorani AD, Holmes MV, Casas JP

Background: The implications of different adiposity measures on cardiovascular disease etiology remain unclear. In this article, we quantify and contrast causal associations of central adiposity (waist-to-hip ratio adjusted for body mass index [WHRadjBMI]) and general adiposity (body mass index [BMI]) with cardiometabolic disease. Methods: Ninety-seven independent single-nucleotide polymorphisms for BMI and 49 single-nucleotide polymorphisms for WHRadjBMI were used to conduct Mendelian randomiza... Abstract

Cited 23 times since 2017 (2.9 per year) source: EuropePMC

The American journal of cardiology, Volume 120, Issue 3, 11 2 2017, Pages 500-504 Prognostic Implications of Left Ventricular Global Longitudinal Strain in Predialysis and Dialysis Patients. Hensen LCR, Goossens K, Delgado V, Rotmans JI, Jukema JW, Bax JJ

Chronic kidney disease (CKD) is a worldwide growing epidemic associated with an increased risk of cardiovascular morbidity and mortality. Left ventricular (LV) global longitudinal strain (GLS) is a measure of LV systolic function associated with prognosis in the general population. However, little is known about the association between LV GLS and survival in patients with CKD. The aim of the present study was to investigate the prognostic implications of LV GLS in predialysis and dialysis patien... Abstract

Cited 1 times since 2017 (0.1 per year) source: EuropePMC

Cardiovascular and interventional radiology, Volume 40, Issue 10, 3 1 2017, Pages 1641-1644 Aortic Aneurysm Rupture After Urokinase Treatment for Acute Limb Ischemia in Two Patients After EVAR. Sudiono DR, Hoencamp R, Ottevanger J, Eefting D, van der Linden E

Endovascular aneurysm repair (EVAR) is first-choice treatment for many patients with abdominal aortic aneurysms. Complications unique to endovascular treatment include endoleak and endotension, which can eventually lead to rupture. We present two cases of late aortic rupture after EVAR, where both patients had recent preceding catheter-directed thrombolysis with urokinase for acute limb ischemia. These cases suggest a relation between thrombolytic therapy and aortic rupture after EVAR, and we sh... Abstract

Cited 13 times since 2017 (1.6 per year) source: EuropePMC

Journal of wound care, Volume 26, Issue 5, 1 1 2017, Pages 218-227 Outcomes after foot surgery in people with a diabetic foot ulcer and a 12-month follow-up. Lenselink E, Holloway S, Eefting D

Objective: The aim of this study was to retrospectively measure the outcomes of foot-sparing surgery at one year follow-up for patients with diabetic foot ulcers (DFUs). We assessed wound healing and the need for further surgery in relation to the variables that influence healing. Method: Data were retrospectively collected by reviewing the electronic files of patients attending the Wound Expert Clinic (WEC). Outcomes of surgical debridement, toe, ray and transmetatarsal amputations were assesse... Abstract

Cited 43 times since 2017 (5.3 per year) source: EuropePMC

The European respiratory journal, Volume 49, Issue 5, 1 1 2017, Pages 1602008 Defining asthma-COPD overlap syndrome: a population-based study. Bonten TN, Kasteleyn MJ, de Mutsert R, Hiemstra PS, Rosendaal FR, Chavannes NH, Slats AM, Taube C

Asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) seems an important clinical phenotype, but multiple definitions have been proposed. This study's objectives were to assess the effect of different ACOS definitions on prevalence, patient characteristics and exacerbations.5675 individuals aged 45-65 years, with 846 asthma/COPD patients, were included in the Netherlands Epidemiology of Obesity study between 2008 and 2012, and followed-up for a median of 1.8 years. ACO... Abstract

Cited 11 times since 2017 (1.4 per year) source: EuropePMC

ASAIO journal (American Society for Artificial Internal Organs : 1992), Volume 63, Issue 3, 1 1 2017, Pages 266-272 Pump Speed Optimization in Stable Patients with a Left Ventricular Assist Device. Couperus LE, Delgado V, Khidir MJH, Vester MPM, Palmen M, Fiocco M, Holman ER, Tops LF, Klautz RJM, Verwey HF, Schalij MJ, Beeres SLMA

Optimal left ventricular assist device (LVAD) functioning and preservation of right ventricular (RV) function are major survival determinants in destination therapy (DT)-LVAD recipients. Currently, the indication for routine pump speed optimization in stable patients and its effect on RV function at follow-up remain underexplored. Hemodynamically stable patients (N = 17, age 61 [interquartile range {IQR} 51-66] years; 13 [77%] male) underwent a routine speed ramp test. Echocardiographic images w... Abstract

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 19, Issue 5, 1 1 2017, Pages 703-704 Death after ablation of atrial flutter: are we doing the right thing? Trines SA

Abstract

Cited 24 times since 2017 (3 per year) source: EuropePMC

Circulation, Volume 135, Issue 20, 1 1 2017, Pages 1956-1976 Stress Testing in Asymptomatic Aortic Stenosis. Redfors B, Pibarot P, Gillam LD, Burkhoff D, Bax JJ, Lindman BR, Bonow RO, O'Gara PT, Leon MB, Généreux P

Aortic stenosis is 1 of the most common heart valve diseases among adults. When symptoms develop, prognosis is poor, and current guidelines recommend prompt aortic valve replacement. Depending of the severity of the aortic stenosis and the presence of concomitant heart disease and medical comorbidities, stress testing represents a reasonable strategy to help better risk stratify asymptomatic patients. The present report provides a comprehensive review of the current available data on stress test... Abstract

Cited 4 times since 2017 (0.5 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 18, Issue 8, 1 1 2017, Pages 849-850 Improved risk stratification with computed tomographic coronary angiography in patients with suspected coronary artery disease. van Rosendael AR, Bax JJ

Abstract

Cited 7 times since 2017 (0.9 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 69, Issue 19, 1 1 2017, Pages 2465-2466 Role of Acquired Cardiovascular Disease in Tetralogy of Fallot Patients >50 Years of Age. Bokma JP, Winter MM, Kuijpers JM, Jongbloed MR, Duijnhouwer AL, Hoendermis ES, Sieswerda GT, Post MC, Mulder BJM, Bouma BJ

Abstract

Cited 75 times since 2017 (9.3 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 69, Issue 19, 1 1 2017, Pages 2383-2392 Prognostic Implications of Moderate Aortic Stenosis in Patients With Left Ventricular Systolic Dysfunction. van Gils L, Clavel MA, Vollema EM, Hahn RT, Spitzer E, Delgado V, Nazif T, De Jaegere PP, Geleijnse ML, Ben-Yehuda O, Bax JJ, Leon MB, Pibarot P, Van Mieghem NM

Background: Left ventricular (LV) systolic dysfunction and moderate aortic stenosis (AS) are more frequent with advancing age and often coexist. Afterload reduction is the mainstay of pharmacological treatment of heart failure (HF). Aortic valve replacement (AVR) is only formally indicated for symptomatic severe AS. Objectives: This study sought to determine the clinical outcome of patients with concomitant moderate AS and LV systolic dysfunction. Methods: Echocardiographic and clinical data of... Abstract

Cited 115 times since 2017 (14.2 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 69, Issue 17, 1 1 2017, Pages 2119-2129 Cardiac Resynchronization Therapy With Wireless Left Ventricular Endocardial Pacing: The SELECT-LV Study. Reddy VY, Miller MA, Neuzil P, Søgaard P, Butter C, Seifert M, Delnoy PP, van Erven L, Schalji M, Boersma LVA, Riahi S

Background: A total of 30% to 40% of patients with congestive heart failure eligible for cardiac resynchronization therapy (CRT) either do not respond to conventional CRT or remain untreated due to an inability or impediment to coronary sinus (CS) lead implantation. The WiSE-CRT system (EBR Systems, Sunnyvale, California) was developed to address this at-risk patient population by performing biventricular pacing via a wireless left ventricular (LV) endocardial pacing electrode. Objectives: The S... Abstract

Cited 4 times since 2017 (0.5 per year) source: EuropePMC

Journal of telemedicine and telecare, Volume 24, Issue 6, 29 5 2017, Pages 404-409 Comparison of the diagnostic accuracy of four smartphone-compatible blood pressure monitors in post-myocardial infarction patients. Treskes RW, Wolterbeek R, van der Velde ET, Eindhoven DC, Schalij MJ

Introduction Smartphone-compatible blood pressure devices may be a good alternative to enable self-measurement of blood pressure by patients. Furthermore, automatic transferral of data to the hospital allows for remote monitoring. To our knowledge, no study has compared four of these smartphone-compatible blood pressure devices. Methods Patients who were followed up for acute myocardial infarction were asked to participate during their outpatient clinic visit. After five minutes of rest, six blo... Abstract

Cited 6 times since 2017 (0.7 per year) source: EuropePMC

Journal of cardiovascular computed tomography, Volume 11, Issue 4, 27 4 2017, Pages 274-280 Coronary computed tomography angiography derived risk score in predicting cardiac events. Uusitalo V, Kamperidis V, de Graaf MA, Maaniitty T, Stenström I, Broersen A, Dijkstra J, Scholte AJ, Saraste A, Bax JJ, Knuuti J

Background: We evaluated the prognostic value of an integrated atherosclerosis risk score combining the markers of coronary plaque burden, location and composition as assessed by computed tomography angiography (CTA). Methods: 922 consecutive patients underwent CTA for suspected coronary artery disease (CAD). Patients without atherosclerosis (n = 261) and in whom quantitative CTA analysis was not feasible due to image quality, step-artefacts or technical factors related to image acquisition or d... Abstract

Cited 10 times since 2017 (1.2 per year) source: EuropePMC

International journal of cardiology, Volume 240, 25 4 2017, Pages 20-24 Long-term mortality in patients with ST-segment elevation myocardial infarction is associated with anti-citrullinated protein antibodies. Hermans MPJ, van der Velden D, Montero Cabezas JM, Putter H, Huizinga TWJ, Kuiper J, Toes REM, Schalij MJ, Wouter Jukema J, van der Woude D

Background: Cardiovascular (CV) mortality is higher in patients with rheumatoid arthritis (RA), in particular when anti-citrullinated protein antibodies (ACPA) are present. Recently, ACPA have also been described in a cohort of patients without RA, but with coronary artery disease (CAD). It is however unknown if ACPA can consistently be found in patients with CAD, and if ACPA are associated with mortality in these patients. The purpose of this study was to assess the relationship between ACPA an... Abstract

Cited 101 times since 2017 (12.5 per year) source: EuropePMC

European journal of pharmacology, Volume 816, 21 3 2017, Pages 107-115 Plaque angiogenesis and intraplaque hemorrhage in atherosclerosis. Parma L, Baganha F, Quax PHA, de Vries MR

Acute cardiovascular events, due to rupture or erosion of an atherosclerotic plaque, represent the major cause of morbidity and mortality in patients. Growing evidence suggests that plaque neovascularization is an important contributor to plaque growth and instability. The vessels' immaturity, with profound structural and functional abnormalities, leads to recurrent intraplaque hemorrhage. This review discusses new insights of atherosclerotic neovascularization, including the effects of lea... Abstract

Cited 223 times since 2017 (27.5 per year) source: EuropePMC

Nature genetics, Volume 49, Issue 6, 17 3 2017, Pages 946-952 Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation. Christophersen IE, Rienstra M, Roselli C, Yin X, Geelhoed B, Barnard J, Lin H, Arking DE, Smith AV, Albert CM, Chaffin M, Tucker NR, Li M, Klarin D, Bihlmeyer NA, Low SK, Weeke PE, Müller-Nurasyid M, Smith JG, Brody JA, Niemeijer MN, Dörr M, Trompet S, Huffman J, Gustafsson S, Schurmann C, Kleber ME, Lyytikäinen LP, Seppälä I, Malik R, Horimoto ARVR, Perez M, Sinisalo J, Aeschbacher S, Thériault S, Yao J, Radmanesh F, Weiss S, Teumer A, Choi SH, Weng LC, Clauss S, Deo R, Rader DJ, Shah SH, Sun A, Hopewell JC, Debette S, Chauhan G, Yang Q, Worrall BB, Paré G, Kamatani Y, Hagemeijer YP, Verweij N, Siland JE, Kubo M, Smith JD, Van Wagoner DR, Bis JC, Perz S, Psaty BM, Ridker PM, Magnani JW, Harris TB, Launer LJ, Shoemaker MB, Padmanabhan S, Haessler J, Bartz TM, Waldenberger M, Lichtner P, Arendt M, Krieger JE, Kähönen M, Risch L, Mansur AJ, Peters A, Smith BH, Lind L, Scott SA, Lu Y, Bottinger EB, Hernesniemi J, Lindgren CM, Wong JA, Huang J, Eskola M, Morris AP, Ford I, Reiner AP, Delgado G, Chen LY, Chen YI,

Atrial fibrillation affects more than 33 million people worldwide and increases the risk of stroke, heart failure, and death. Fourteen genetic loci have been associated with atrial fibrillation in European and Asian ancestry groups. To further define the genetic basis of atrial fibrillation, we performed large-scale, trans-ancestry meta-analyses of common and rare variant association studies. The genome-wide association studies (GWAS) included 17,931 individuals with atrial fibrillation and 115,... Abstract

Cited 25 times since 2017 (3.1 per year) source: EuropePMC

Atherosclerosis, Volume 261, 13 2 2017, Pages 26-36 Inhibition of 14q32 microRNA miR-495 reduces lesion formation, intimal hyperplasia and plasma cholesterol levels in experimental restenosis. Welten SMJ, de Jong RCM, Wezel A, de Vries MR, Boonstra MC, Parma L, Jukema JW, van der Sluis TC, Arens R, Bot I, Agrawal S, Quax PHA, Nossent AY

Background and aims: We aimed at investigating the role of 14q32 microRNAs in intimal hyperplasia and accelerated atherosclerosis; two major contributors to restenosis. Restenosis occurs regularly in patients treated for coronary artery disease and peripheral arterial disease. We have previously shown that inhibition of 14q32 microRNAs leads to increased post-ischemic neovascularization, and microRNA miR-494 also decreased atherosclerosis, while increasing plaque stability. We hypothesized that... Abstract

Cited 22 times since 2017 (2.7 per year) source: EuropePMC

The American journal of cardiology, Volume 120, Issue 1, 12 2 2017, Pages 140-147 Effect of Aging on Left Atrial Compliance and Electromechanical Properties in Subjects Without Structural Heart Disease. Abou R, Leung M, Tonsbeek AM, Podlesnikar T, Maan AC, Schalij MJ, Ajmone Marsan N, Delgado V, Bax JJ

Aging is associated with changes in left atrial (LA) structure and function. The present study aimed at describing the effect of aging on LA properties in a large cohort of subjects without structural heart disease. We divided 386 subjects (mean age 58 years [range 16 to 91]; 188 men [49%]) clinically referred for echocardiography according to age groups. The P-wave dispersion (PWD), reflecting total atrial conduction time, was measured on a 12-lead surface electrocardiogram as the difference be... Abstract

Cited 23 times since 2017 (2.8 per year) source: EuropePMC

PloS one, Volume 12, Issue 4, 6 1 2017, Pages e0174278 Static axial overloading primes lumbar caprine intervertebral discs for posterior herniation. Paul CP, de Graaf M, Bisschop A, Holewijn RM, van de Ven PM, van Royen BJ, Mullender MG, Smit TH, Helder MN

Introduction: Lumbar hernias occur mostly in the posterolateral region of IVDs and mechanical loading is an important risk factor. Studies show that dynamic and static overloading affect the nucleus and annulus of the IVD differently. We hypothesize there is also variance in the effect of overloading on the IVD's anterior, lateral and posterior annulus, which could explain the predilection of herniations in the posterolateral region. We assessed the regional mechanical and cellular response... Abstract