6205 results
Cited 7 times since 2015 (0.7 per year)
source: EuropePMC
Rheumatology (Oxford, England),
Volume 55, Issue 3, 15 3 2015, Pages 504-512
Impact of pulmonary fibrosis and elevated pulmonary pressures on right ventricular function in patients with systemic sclerosis.
Yiu KH, Ninaber MK, Kroft LJ, Schouffoer AA, Stolk J, Scherer HU, Meijs J, de Vries-Bouwstra J, Tse HF, Delgado V, Bax JJ, Huizinga TW, Marsan NA
Objectives: Right ventricular (RV) dysfunction is of great prognostic value in patients with SSc. The aim of the present study was to assess in these patients the relationship between pulmonary fibrosis and elevated pulmonary pressure (PHT) with RV function. Methods: A total of 102 SSc patients who underwent thoracic CT and transthoracic echocardiography were included. Speckle tracking-derived RV free wall strain was used to assess RV function. Results: A total of 51 (50%) SSc patients did not h...
Abstract
Cited 34 times since 2015 (3.5 per year)
source: EuropePMC
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery,
Volume 50, Issue 6, 9 2 2015, Pages 702-713
Editor's Choice - Pharmaceutical Management of Small Abdominal Aortic Aneurysms: A Systematic Review of the Clinical Evidence.
Kokje VB, Hamming JF, Lindeman JH
Background: Management of abdominal aortic aneurysms (AAAs) relies on surgical repair of larger AAAs. Consequently medical interventions inhibiting AAA progression could greatly reduce the need for surgical repair. A spectrum of pharmaceutical strategies has been reported, albeit conclusions often appear contradictory. Given the longstanding interest in pharmaceutical AAA stabilization, a systematic review of the available literature is relevant. Objectives: The aim is to provide an up to date s...
Abstract
Cited 2 times since 2015 (0.2 per year)
source: EuropePMC
Revista espanola de cardiologia (English ed.),
Volume 68, Issue 11, 9 2 2015, Pages 1029-1031
The Descending Septal Artery: Description of This Infrequent Coronary Anatomical Variant in Three Different Clinical Scenarios.
Montero-Cabezas JM, Tohamy AM, Karalis I, Delgado V, Schalij MJ
Abstract
Cited 15 times since 2015 (1.6 per year)
source: EuropePMC
Stroke,
Volume 46, Issue 11, 8 2 2015, Pages 3048-3057
White Matter Lesion Progression: Genome-Wide Search for Genetic Influences.
Hofer E, Cavalieri M, Bis JC, DeCarli C, Fornage M, Sigurdsson S, Srikanth V, Trompet S, Verhaaren BF, Wolf C, Yang Q, Adams HH, Amouyel P, Beiser A, Buckley BM, Callisaya M, Chauhan G, de Craen AJ, Dufouil C, van Duijn CM, Ford I, Freudenberger P, Gottesman RF, Gudnason V, Heiss G, Hofman A, Lumley T, Martinez O, Mazoyer B, Moran C, Niessen WJ, Phan T, Psaty BM, Satizabal CL, Sattar N, Schilling S, Shibata DK, Slagboom PE, Smith A, Stott DJ, Taylor KD, Thomson R, Töglhofer AM, Tzourio C, van Buchem M, Wang J, Westendorp RG, Windham BG, Vernooij MW, Zijdenbos A, Beare R, Debette S, Ikram MA, Jukema JW, Launer LJ, Longstreth WT, Mosley TH, Seshadri S, Schmidt H, Schmidt R, Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium
Background and purpose: White matter lesion (WML) progression on magnetic resonance imaging is related to cognitive decline and stroke, but its determinants besides baseline WML burden are largely unknown. Here, we estimated heritability of WML progression, and sought common genetic variants associated with WML progression in elderly participants from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Methods: Heritability of WML progression was calculated in t...
Abstract
Cited 9 times since 2015 (0.9 per year)
source: EuropePMC
Journal of periodontology,
Volume 87, Issue 2, 2 1 2015, Pages 193-202
Analyses of Gingival Adhesion Molecules in Periodontitis: Theoretical In Silico, Comparative In Vivo, and Explanatory In Vitro Models.
Gürsoy UK, Zeidán-Chuliá F, Yilmaz D, Özdemir V, Mäki-Petäys J, Neves de Oliveira BH, Firatli Y, Güncü GN, Caglayan F, Könönen E
Background: A deeper understanding of periodontitis pathophysiology is central to future development of novel biomarkers and therapeutics. The following is reported here: 1) an in silico network model of interactions among cell adhesion molecules and a network-focused microarray analysis of the corresponding genes in periodontitis; 2) analysis of secretions of adhesion molecules in gingival tissue samples from patients with periodontitis and healthy controls; and 3) effect of the human neutrophi...
Abstract
Cited 269 times since 2015 (27.9 per year)
source: EuropePMC
PLoS genetics,
Volume 11, Issue 10, 1 1 2015, Pages e1005378
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.
Winkler TW, Justice AE, Graff M, Barata L, Feitosa MF, Chu S, Czajkowski J, Esko T, Fall T, Kilpeläinen TO, Lu Y, Mägi R, Mihailov E, Pers TH, Rüeger S, Teumer A, Ehret GB, Ferreira T, Heard-Costa NL, Karjalainen J, Lagou V, Mahajan A, Neinast MD, Prokopenko I, Simino J, Teslovich TM, Jansen R, Westra HJ, White CC, Absher D, Ahluwalia TS, Ahmad S, Albrecht E, Alves AC, Bragg-Gresham JL, de Craen AJ, Bis JC, Bonnefond A, Boucher G, Cadby G, Cheng YC, Chiang CW, Delgado G, Demirkan A, Dueker N, Eklund N, Eiriksdottir G, Eriksson J, Feenstra B, Fischer K, Frau F, Galesloot TE, Geller F, Goel A, Gorski M, Grammer TB, Gustafsson S, Haitjema S, Hottenga JJ, Huffman JE, Jackson AU, Jacobs KB, Johansson Å, Kaakinen M, Kleber ME, Lahti J, Mateo Leach I, Lehne B, Liu Y, Lo KS, Lorentzon M, Luan J, Madden PA, Mangino M, McKnight B, Medina-Gomez C, Monda KL, Montasser ME, Müller G, Müller-Nurasyid M, Nolte IM, Panoutsopoulou K, Pascoe L, Paternoster L, Rayner NW, Renström F, Rizzi F, Rose LM, Ryan KA, Salo P, Sanna S, Sc
Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of Europ...
Abstract
Cited 3 times since 2015 (0.3 per year)
source: EuropePMC
Thrombosis and haemostasis,
Volume 115, Issue 2, 1 1 2015, Pages 353-360
Platelet density per monocyte predicts adverse events in patients after percutaneous coronary intervention.
Rutten B, Roest M, McClellan EA, Sels JW, Stubbs A, Jukema JW, Doevendans PA, Waltenberger J, van Zonneveld AJ, Pasterkamp G, De Groot PG, Hoefer IE
Monocyte recruitment to damaged endothelium is enhanced by platelet binding to monocytes and contributes to vascular repair. Therefore, we studied whether the number of platelets per monocyte affects the recurrence of adverse events in patients after percutaneous coronary intervention (PCI). Platelet-monocytes complexes with high and low median fluorescence intensities (MFI) of the platelet marker CD42b were isolated using cell sorting. Microscopic analysis revealed that a high platelet marker M...
Abstract
Cited 1 times since 2015 (0.1 per year)
source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 22, Issue 5, 1 1 2015, Pages 866-873
Highlights of the 12th International Conference on Nuclear Cardiology and Cardiac CT.
Kitsiou A, Dorbala S, Scholte AJ
Abstract
Cited 38 times since 2015 (3.9 per year)
source: EuropePMC
Expert opinion on therapeutic targets,
Volume 20, Issue 2, 30 5 2015, Pages 223-239
Targeting danger-associated molecular patterns after myocardial infarction.
van Hout GP, Arslan F, Pasterkamp G, Hoefer IE
Introduction: Myocardial infarction (MI) provokes an intense inflammatory response that can lead to left ventricular adverse remodeling and heart failure (HF). The prognosis of HF patients is poor and related to a decreased quality of life and considerable health care costs. Hence, targeting the early inflammatory response after MI provides an interesting target to attenuate left ventricular remodeling and prevent HF. Areas covered: In the current review, we discuss the theory that our immune sy...
Abstract
Cited 4 times since 2015 (0.4 per year)
source: EuropePMC
International journal of cardiology,
Volume 202, 28 4 2015, Pages 571-572
Reduction of healthcare utilization after bone marrow cell therapy for refractory angina pectoris.
Rodrigo SF, Mann I, van Ramshorst J, Beeres SL, Zwaginga JJ, Fibbe WE, Bax JJ, Schalij MJ, Atsma DE
Abstract
Cited 3 times since 2015 (0.3 per year)
source: EuropePMC
Revista espanola de cardiologia (English ed.),
Volume 68, Issue 11, 26 4 2015, Pages 1043
The "De Winter Pattern" Can Progress to ST-segment Elevation Acute Coronary Syndrome. Response.
Montero-Cabezas JM, van der Kley F, Karalis I, Schalij MJ
Abstract
Cited 38 times since 2015 (3.9 per year)
source: EuropePMC
International journal of cardiology,
Volume 202, 26 4 2015, Pages 784-795
Atrioventricular septal defect: From embryonic development to long-term follow-up.
Calkoen EE, Hazekamp MG, Blom NA, Elders BB, Gittenberger-de Groot AC, Haak MC, Bartelings MM, Roest AA, Jongbloed MR
Atrioventricular septal defect (AVSD) covers a spectrum of heart anomalies with a common atrioventricular connection and has an incidence of 4-5.3 per 10.000 live births. About half of the AVSDs occur in patient with Down syndrome. This review provides a bench to bedside overview of AVSD. Developmental aspects, nomenclature, anatomy, and classification of AVSD are discussed. Furthermore an overview of genetic and maternal risk factors for AVSD is provided, and available literature on (fetal) dia...
Abstract
Cited 3 times since 2015 (0.3 per year)
source: EuropePMC
Journal of electrocardiology,
Volume 49, Issue 1, 26 4 2015, Pages 60-68
Electrocardiographic detection of pulmonary hypertension in patients with systemic sclerosis using the ventricular gradient.
Couperus LE, Vliegen HW, Henkens IR, Maan AC, Treskes RW, de Vries JK, Schouffoer AA, Swenne CA, Schalij MJ, Scherptong RW
Background: Pulmonary hypertension (PH) is a leading cause of death in systemic sclerosis (SSc) patients. The current study assessed the ability of the ECG-derived ventricular gradient (VG-RVPO) to detect PH and predict all-cause mortality in PH patients with subtypes of SSc differing in the extent of multi-organ involvement. Methods: ECGs were obtained from 196 patients with limited and 77 patients with diffuse SSc included from our screening programme on cardiac complications. The association...
Abstract
Cited 8 times since 2015 (0.8 per year)
source: EuropePMC
Clinical journal of the American Society of Nephrology : CJASN,
Volume 10, Issue 10, 25 4 2015, Pages 1740-1748
Cardiac Resynchronization Therapy in CKD Stage 4 Patients.
Höke U, Khidir MJ, van der Velde ET, Schalij MJ, Bax JJ, Delgado V, Marsan NA
Background and objectives: Cardiac resynchronization therapy (CRT) is a well established heart failure treatment that has shown to improve renal function. However, landmark CRT trials excluded patients with severe renal dysfunction. Therefore, this study evaluated the effect of CRT on renal function and long-term prognosis in patients with stage 4 CKD. Design, setting, participants, & measurements: This study evaluated 73 consecutive CRT patients (71±10 years) with stage 4 CKD who underwent...
Abstract
Cited 232 times since 2015 (24 per year)
source: EuropePMC
Nature genetics,
Volume 47, Issue 11, 21 3 2015, Pages 1282-1293
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.
Kato N, Loh M, Takeuchi F, Verweij N, Wang X, Zhang W, Kelly TN, Saleheen D, Lehne B, Leach IM, Drong AW, Abbott J, Wahl S, Tan ST, Scott WR, Campanella G, Chadeau-Hyam M, Afzal U, Ahluwalia TS, Bonder MJ, Chen P, Dehghan A, Edwards TL, Esko T, Go MJ, Harris SE, Hartiala J, Kasela S, Kasturiratne A, Khor CC, Kleber ME, Li H, Yu Mok Z, Nakatochi M, Sapari NS, Saxena R, Stewart AFR, Stolk L, Tabara Y, Teh AL, Wu Y, Wu JY, Zhang Y, Aits I, Da Silva Couto Alves A, Das S, Dorajoo R, Hopewell JC, Kim YK, Koivula RW, Luan J, Lyytikäinen LP, Nguyen QN, Pereira MA, Postmus I, Raitakari OT, Scannell Bryan M, Scott RA, Sorice R, Tragante V, Traglia M, White J, Yamamoto K, Zhang Y, Adair LS, Ahmed A, Akiyama K, Asif R, Aung T, Barroso I, Bjonnes A, Braun TR, Cai H, Chang LC, Chen CH, Cheng CY, Chong YS, Collins R, Courtney R, Davies G, Delgado G, Do LD, Doevendans PA, Gansevoort RT, Gao YT, Grammer TB, Grarup N, Grewal J, Gu D, Wander GS, Hartikainen AL, Hazen SL, He J, Heng CK, Hixson JE, Hofman A, Hsu C, Huang W, Husem
We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10(-11) to 5.0 × 10(-21)). The sentinel blood pressure SNPs are enriched for association with DNA methylation at multiple nearby CpG sites, suggesting that, at some of the loci identified, DNA methylation may lie on the reg...
Abstract
Cited 17 times since 2015 (1.8 per year)
source: EuropePMC
PloS one,
Volume 10, Issue 9, 21 3 2015, Pages e0136025
Regional differences in WT-1 and Tcf21 expression during ventricular development: implications for myocardial compaction.
Vicente-Steijn R, Scherptong RW, Kruithof BP, Duim SN, Goumans MJ, Wisse LJ, Zhou B, Pu WT, Poelmann RE, Schalij MJ, Tallquist MD, Gittenberger-de Groot AC, Jongbloed MR
Background: Morphological and functional differences of the right and left ventricle are apparent in the adult human heart. A differential contribution of cardiac fibroblasts and smooth muscle cells (populations of epicardium-derived cells) to each ventricle may account for part of the morphological-functional disparity. Here we studied the relation between epicardial derivatives and the development of compact ventricular myocardium. Results: Wildtype and Wt1CreERT2/+ reporter mice were used to...
Abstract
Cited 7 times since 2015 (0.7 per year)
source: EuropePMC
Journal of fish biology,
Volume 87, Issue 5, 19 3 2015, Pages 1191-1208
Shallow genetic divergence and species delineations in the endemic Labeobarbus species flock of Lake Tana, Ethiopia.
Nagelkerke LA, Leon-Kloosterziel KM, Megens HJ, De Graaf M, Diekmann OE, Sibbing FA
To assess whether the species distinctions of Lake Tana's Labeobarbus spp. are supported by genetic information, microsatellite markers were used. A total of 376 Labeobarbus spp., belonging to 24 populations of 11 species from three regions of the lake (north, south and east), were sampled. Eight microsatellite markers were analysed. In general, differences between conspecific populations were smaller than differences between populations of different species. For six species, conspecific po...
Abstract
Cited 14 times since 2015 (1.4 per year)
source: EuropePMC
Circulation. Arrhythmia and electrophysiology,
Volume 8, Issue 6, 18 3 2015, Pages 1452-1459
Fatigue as Presenting Symptom and a High Burden of Premature Ventricular Contractions Are Independently Associated With Increased Ventricular Wall Stress in Patients With Normal Left Ventricular Function.
van Huls van Taxis CF, Piers SR, de Riva Silva M, Dekkers OM, Pijnappels DA, Schalij MJ, Wijnmaalen AP, Zeppenfeld K
Background: High idiopathic premature ventricular contractions (PVC) burden has been associated with PVC-induced cardiomyopathy. Patients may be symptomatic before left ventricular (LV) dysfunction develops. N-terminal pro-B-type natriuretic peptide (NT-proBNP) and circumferential end-systolic wall stress (cESS) on echocardiography are markers for increased ventricular wall stress. This study aimed to evaluate the relation between presenting symptoms, PVC burden, and increased ventricular wall s...
Abstract
Cited 9 times since 2015 (0.9 per year)
source: EuropePMC
Journal of cardiovascular translational research,
Volume 8, Issue 7, 17 3 2015, Pages 393-403
Autologous Mesenchymal Stem Cells Show More Benefit on Systolic Function Compared to Bone Marrow Mononuclear Cells in a Porcine Model of Chronic Myocardial Infarction.
van der Spoel TI, Gathier WA, Koudstaal S, van Slochteren F, Of Lorkeers SJ, Sluijter JP, Hoefer IE, Steendijk P, Cramer MJ, Doevendans PA, van Belle E, Chamuleau SA
Cardiac cell therapy is a strategy to treat patients with chronic myocardial infarction (MI). No consensus exists regarding the optimal cell type. First, a comparison between autologous bone marrow-derived mononuclear cells (BMMNC) and mesenchymal stem cells (MSC) on therapeutic efficacy after MI was performed. Next, the effect of repetitive, NOGA-guided transendocardial injection was determined via a crossover design. Nineteen pigs were allocated in three groups: (1) placebo (at 4 and 8 weeks),...
Abstract
Cited 28 times since 2015 (2.9 per year)
source: EuropePMC
Lung cancer (Amsterdam, Netherlands),
Volume 90, Issue 2, 15 3 2015, Pages 249-254
Comparison of clinical outcome after first-line platinum-based chemotherapy in different types of KRAS mutated advanced non-small-cell lung cancer.
Mellema WW, Masen-Poos L, Smit EF, Hendriks LE, Aerts JG, Termeer A, Goosens MJ, Smit HJ, van den Heuvel MM, van der Wekken AJ, Herder GJ, Krouwels FH, Stigt JA, van den Borne BE, Haitjema TJ, Staal-Van den Brekel AJ, van Heemst RC, Pouw E, Dingemans AM
Objectives: As suggested by in-vitro data, we hypothesize that subtypes of KRAS mutated non-small cell lung cancer (NSCLC) respond differently to chemotherapy regimens. Methods: Patients with advanced NSCLC and known KRAS mutation, treated with first-line platinum-based chemotherapy, were retrieved from hospital databases. Primary objective: to investigate overall response rate (ORR), progression free survival (PFS) and overall survival (OS) between different types of platinum-based chemotherapy...
Abstract
