8551 results
Cited 16 times since 2016 (1.6 per year)
source: EuropePMC
European journal of nuclear medicine and molecular imaging,
Volume 43, Issue 8, 18 3 2016, Pages 1522-1529
Segmental quantitative myocardial perfusion with PET for the detection of significant coronary artery disease in patients with stable angina.
Berti V, Sciagrà R, Neglia D, Pietilä M, Scholte AJ, Nekolla S, Rouzet F, Pupi A, Knuuti J
Purpose: The goal of this study is to determine the technical accuracy of segmental perfusion parameters assessed with quantitative cardiac PET imaging in the evaluation of coronary artery disease (CAD) in patients with stable angina. Methods: A cohort of patients who participated in the EVINCI protocol underwent an evaluation of coronary anatomy by invasive coronary angiography (ICA) and/or coronary computed tomography angiography (CCTA) and PET myocardial perfusion imaging with H2 (15)O, (13)N...
Abstract
Cited 62 times since 2016 (6.3 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 17, Issue 9, 18 3 2016, Pages 951-960
Multicentre multi-device hybrid imaging study of coronary artery disease: results from the EValuation of INtegrated Cardiac Imaging for the Detection and Characterization of Ischaemic Heart Disease (EVINCI) hybrid imaging population.
Liga R, Vontobel J, Rovai D, Marinelli M, Caselli C, Pietila M, Teresinska A, Aguadé-Bruix S, Pizzi MN, Todiere G, Gimelli A, Chiappino D, Marraccini P, Schroeder S, Drosch T, Poddighe R, Casolo G, Anagnostopoulos C, Pugliese F, Rouzet F, Le Guludec D, Cappelli F, Valente S, Gensini GF, Zawaideh C, Capitanio S, Sambuceti G, Marsico F, Filardi PP, Fernández-Golfín C, Rincón LM, Graner FP, de Graaf MA, Stehli J, Reyes E, Nkomo S, Mäki M, Lorenzoni V, Turchetti G, Carpeggiani C, Puzzuoli S, Mangione M, Marcheschi P, Giannessi D, Nekolla S, Lombardi M, Sicari R, Scholte AJ, Zamorano JL, Underwood SR, Knuuti J, Kaufmann PA, Neglia D, Gaemperli O, EVINCI Study Investigators
Aims: Hybrid imaging provides a non-invasive assessment of coronary anatomy and myocardial perfusion. We sought to evaluate the added clinical value of hybrid imaging in a multi-centre multi-vendor setting. Methods and results: Fourteen centres enrolled 252 patients with stable angina and intermediate (20-90%) pre-test likelihood of coronary artery disease (CAD) who underwent myocardial perfusion scintigraphy (MPS), CT coronary angiography (CTCA), and quantitative coronary angiography (QCA) with...
Abstract
Cited 38 times since 2016 (3.9 per year)
source: EuropePMC
BMJ open,
Volume 6, Issue 3, 17 3 2016, Pages e009971
Epidemic potential of Escherichia coli ST131 and Klebsiella pneumoniae ST258: a systematic review and meta-analysis.
Dautzenberg MJ, Haverkate MR, Bonten MJ, Bootsma MC
Objectives: Observational studies have suggested that Escherichia coli sequence type (ST) 131 and Klebsiella pneumoniae ST258 have hyperendemic properties. This would be obvious from continuously high incidence and/or prevalence of carriage or infection with these bacteria in specific patient populations. Hyperendemicity could result from increased transmissibility, longer duration of infectiousness, and/or higher pathogenic potential as compared with other lineages of the same species. The aim...
Abstract
Cited 65 times since 2016 (6.6 per year)
source: EuropePMC
Journal of molecular and cellular cardiology,
Volume 94, 17 3 2016, Pages 13-20
Simulation of early calcific aortic valve disease in a 3D platform: A role for myofibroblast differentiation.
Hjortnaes J, Goettsch C, Hutcheson JD, Camci-Unal G, Lax L, Scherer K, Body S, Schoen FJ, Kluin J, Khademhosseini A, Khademhosseini A, Aikawa E
Purpose: Calcific aortic valve disease (CAVD) is the most prevalent valve disease in the Western world. Recent difficulty in translating experimental results on statins to beneficial clinical effects warrants the need for understanding the role of valvular interstitial cells (VICs) in CAVD. In two-dimensional culture conditions, VICs undergo spontaneous activation similar to pathological differentiation, which intrinsically limits the use of in vitro models to study CAVD. Here, we hypothesized t...
Abstract
Cited 34 times since 2016 (3.5 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 50, Issue 3, 16 3 2016, Pages 456-463
Follow-up after tricuspid valve surgery in adult patients with systemic right ventricles.
Koolbergen DR, Ahmed Y, Bouma BJ, Scherptong RW, Bruggemans EF, Vliegen HW, Holman ER, Mulder BJ, Hazekamp MG
Objectives: In patients with congenitally corrected transposition of the great arteries (ccTGA) or after atrial (Mustard or Senning) correction for transposition of the great arteries (acTGA), the right ventricle (RV) supports the systemic circulation. The tricuspid valve (TV) (systemic atrioventricular valve) is prone to regurgitation in these patients and this is associated with impending RV failure and decreased survival. This study evaluates mid-term functional improvements, echocardiographi...
Abstract
Cited 41 times since 2016 (4.2 per year)
source: EuropePMC
RMD open,
Volume 2, Issue 1, 15 3 2016, Pages e000159
Therapeutic and diagnostic outcomes of a standardised, comprehensive care pathway for patients with systemic sclerosis.
Meijs J, Schouffoer AA, Ajmone Marsan N, Kroft LJ, Stijnen T, Ninaber MK, Huizinga TW, Vliet Vlieland TP, de Vries-Bouwstra JK
Objectives: To determine the outcomes, including number of medical interventions and initiation of immunosuppressive treatment of a standardised, comprehensive, diagnostic care pathway for patients with systemic sclerosis (SSc). Patient characteristics associated with need for medical interventions and with need for immunosuppressive treatment were determined. Methods: Data were routinely gathered in connection with a 2-day care pathway combining multidisciplinary care and complete diagnostic wo...
Abstract
Cited 2 times since 2016 (0.2 per year)
source: EuropePMC
European journal of pharmacology,
Volume 779, 9 2 2016, Pages 91-101
Role of the dysfunctional ryanodine receptor - Na(+)-Ca(2+)exchanger axis in progression of cardiovascular diseases: What we can learn from pharmacological studies?
Acsai K, Ördög B, Varró A, Nánási PP
Abnormal Ca(2+)homeostasis is often associated with chronic cardiovascular diseases, such as hypertension, heart failure or cardiac arrhythmias, and typically contributes to the basic ethiology of the disease. Pharmacological targeting of cardiac Ca(2+)handling has great therapeutic potential offering invaluable options for the prevention, slowing down the progression or suppression of the harmful outcomes like life threatening cardiac arrhythmias. In this review we outline the existing knowledg...
Abstract
Cited 10 times since 2016 (1 per year)
source: EuropePMC
Journal of applied clinical medical physics,
Volume 17, Issue 2, 8 2 2016, Pages 291-303
Diamond detector in absorbed dose measurements in high-energy linear accelerator photon and electron beams.
Ravichandran R, Binukumar JP, Al Amri I, Davis CA
Diamond detectors (DD) are preferred in small field dosimetry of radiation beams because of small dose profile penumbras, better spatial resolution, and tissue-equivalent properties. We investigated a commercially available 'microdiamond' detector in realizing absorbed dose from first principles. A microdiamond detector, type TM 60019 with tandem electrometer is used to measure absorbed doses in water, nylon, and PMMA phantoms. With sensitive volume 0.004 mm3, radius 1.1mm, thickness 1...
Abstract
Cited 1 times since 2016 (0.1 per year)
source: EuropePMC
Clinical and experimental rheumatology,
Volume 34, Issue 3 Suppl 97, 7 1 2016, Pages S146
Azathioprine-induced eosinophilic myocarditis in a patient with ANCA-associated vasculitis.
Berden AE, Beeres SL, Crobach S, Schalij MJ, Rabelink TJ, Teng YK
Abstract
Cited 62 times since 2016 (6.3 per year)
source: EuropePMC
PloS one,
Volume 11, Issue 3, 7 1 2016, Pages e0144997
Genome-Wide Association Study for Incident Myocardial Infarction and Coronary Heart Disease in Prospective Cohort Studies: The CHARGE Consortium.
Dehghan A, Bis JC, White CC, Smith AV, Morrison AC, Cupples LA, Trompet S, Chasman DI, Lumley T, Völker U, Buckley BM, Ding J, Jensen MK, Folsom AR, Kritchevsky SB, Girman CJ, Ford I, Dörr M, Salomaa V, Uitterlinden AG, Eiriksdottir G, Vasan RS, Franceschini N, Carty CL, Virtamo J, Demissie S, Amouyel P, Arveiler D, Heckbert SR, Ferrières J, Ducimetière P, Smith NL, Wang YA, Siscovick DS, Rice KM, Wiklund PG, Taylor KD, Evans A, Kee F, Rotter JI, Karvanen J, Kuulasmaa K, Heiss G, Kraft P, Launer LJ, Hofman A, Markus MR, Rose LM, Silander K, Wagner P, Benjamin EJ, Lohman K, Stott DJ, Rivadeneira F, Harris TB, Levy D, Liu Y, Rimm EB, Jukema JW, Völzke H, Ridker PM, Blankenberg S, Franco OH, Gudnason V, Psaty BM, Boerwinkle E, O'Donnell CJ
Background: Data are limited on genome-wide association studies (GWAS) for incident coronary heart disease (CHD). Moreover, it is not known whether genetic variants identified to date also associate with risk of CHD in a prospective setting. Methods: We performed a two-stage GWAS analysis of incident myocardial infarction (MI) and CHD in a total of 64,297 individuals (including 3898 MI cases, 5465 CHD cases). SNPs that passed an arbitrary threshold of 5×10-6 in Stage I were taken to Stage II for...
Abstract
Cited 18 times since 2016 (1.8 per year)
source: EuropePMC
The Journal of steroid biochemistry and molecular biology,
Volume 165, Issue Pt A, 5 1 2016, Pages 57-63
Novel and prevalent CYP11B1 gene mutations in Turkish patients with 11-β hydroxylase deficiency.
Kandemir N, Yilmaz DY, Gonc EN, Ozon A, Alikasifoglu A, Dursun A, Ozgul RK
11β-Hydroxylase deficiency is the second most frequent type of congenital adrenal hyperplasia and is more common in those of Turkish descent than in other populations. The purpose of this study is to examine the spectrum of CYP11B1 gene mutations in Turkish patients with 11β-hydroxylase deficiency. Twenty-eight patients from 24 families, ages ranging from 0.1 to 7 years, were included in the study. Clinical diagnosis was based on virilization and high levels of 11-deoxycortisol. Twenty-six cases...
Abstract
Cited 54 times since 2016 (5.5 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 18, Issue 11, 3 1 2016, Pages 1740-1747
Combined leadless pacemaker and subcutaneous implantable defibrillator therapy: feasibility, safety, and performance.
Tjong FV, Brouwer TF, Smeding L, Kooiman KM, de Groot JR, Ligon D, Sanghera R, Schalij MJ, Wilde AA, Knops RE
Aims: The subcutaneous implantable cardioverter-defibrillator (S-ICD) and leadless pacemaker (LP) are evolving technologies that do not require intracardiac leads. However, interactions between these two devices are unexplored. We investigated the feasibility, safety, and performance of combined LP and S-ICD therapy, considering (i) simultaneous device-programmer communication, (ii) S-ICD rhythm discrimination during LP communication and pacing, and (iii) post-shock LP performance. Methods and r...
Abstract
Cited 41 times since 2016 (4.2 per year)
source: EuropePMC
European heart journal. Cardiovascular pharmacotherapy,
Volume 2, Issue 4, 2 1 2016, Pages 229-243
P2Y12 receptor inhibitors in patients with non-ST-elevation acute coronary syndrome in the real world: use, patient selection, and outcomes from contemporary European registries.
Zeymer U, Widimsky P, Danchin N, Lettino M, Bardaji A, Barrabes JA, Cequier A, Claeys MJ, De Luca L, Dörler J, Erlinge D, Erne P, Goldstein P, Koul SM, Lemesle G, Lüscher TF, Matter CM, Montalescot G, Radovanovic D, Sendón JL, Tousek P, Weidinger F, Weston CF, Zaman A, Andell P, Li J, Jukema JW, PIRAEUS group
Aims: Non-ST-elevation acute coronary syndrome (NSTE-ACS) is present in about 60-70% of patients admitted with acute coronary syndromes in clinical practice. This study provides a 'real-life' overview of NSTE-ACS patient characteristics, dual antiplatelet therapy clinical practice, and outcomes at both the time of discharge from hospital and up to 1-year post-discharge. Methods and results: A total of 10 registries (documenting 84 054 NSTE-ACS patients) provided data in a systematic ma...
Abstract
Cited 391 times since 2016 (39.8 per year)
source: EuropePMC
The New England journal of medicine,
Volume 374, Issue 12, 2 1 2016, Pages 1134-1144
Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease.
Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators, Stitziel NO, Stirrups KE, Masca NG, Erdmann J, Ferrario PG, König IR, Weeke PE, Webb TR, Auer PL, Schick UM, Lu Y, Zhang H, Dube MP, Goel A, Farrall M, Peloso GM, Won HH, Do R, van Iperen E, Kanoni S, Kruppa J, Mahajan A, Scott RA, Willenberg C, Braund PS, van Capelleveen JC, Doney AS, Donnelly LA, Asselta R, Merlini PA, Duga S, Marziliano N, Denny JC, Shaffer CM, El-Mokhtari NE, Franke A, Gottesman O, Heilmann S, Hengstenberg C, Hoffman P, Holmen OL, Hveem K, Jansson JH, Jöckel KH, Kessler T, Kriebel J, Laugwitz KL, Marouli E, Martinelli N, McCarthy MI, Van Zuydam NR, Meisinger C, Esko T, Mihailov E, Escher SA, Alver M, Moebus S, Morris AD, Müller-Nurasyid M, Nikpay M, Olivieri O, Lemieux Perreault LP, AlQarawi A, Robertson NR, Akinsanya KO, Reilly DF, Vogt TF, Yin W, Asselbergs FW, Kooperberg C, Jackson RD, Stahl E, Strauch K, Varga TV, Waldenberger M, Zeng L, Kraja AT, Liu C, Ehret GB, Newton-Cheh C, Chasman DI, Chowdhury R, Ferra
Background: The discovery of low-frequency coding variants affecting the risk of coronary artery disease has facilitated the identification of therapeutic targets. Methods: Through DNA genotyping, we tested 54,003 coding-sequence variants covering 13,715 human genes in up to 72,868 patients with coronary artery disease and 120,770 controls who did not have coronary artery disease. Through DNA sequencing, we studied the effects of loss-of-function mutations in selected genes. Results: We confirme...
Abstract
Cited 116 times since 2016 (11.8 per year)
source: EuropePMC
European heart journal,
Volume 37, Issue 37, 2 1 2016, Pages 2823-2829
Happy heart syndrome: role of positive emotional stress in takotsubo syndrome.
Ghadri JR, Sarcon A, Diekmann J, Bataiosu DR, Cammann VL, Jurisic S, Napp LC, Jaguszewski M, Scherff F, Brugger P, Jäncke L, Seifert B, Bax JJ, Ruschitzka F, Lüscher TF, Templin C, InterTAK Co-investigators:
Aims: Takotsubo syndrome (TTS) is typically provoked by negative stressors such as grief, anger, or fear leading to the popular term 'broken heart syndrome'. However, the role of positive emotions triggering TTS remains unclear. The aim of the present study was to analyse the prevalence and characteristics of patients with TTS following pleasant events, which are distinct from the stressful or undesirable episodes commonly triggering TTS. Methods and results: Takotsubo syndrome patient...
Abstract
Cited 11 times since 2016 (1.1 per year)
source: EuropePMC
Saudi medical journal,
Volume 37, Issue 3, 1 1 2016, Pages 304-308
The effect of air-lock technique on pain at the site of intramuscular injection.
Yılmaz DK, Dikmen Y, Köktürk F, Dedeoğlu Y
Objectives: To investigate the effects of air-lock technique (ALT) on pain of intramuscular (IM) injection delivered to the ventrogluteal and dorsogluteal site (DS). Methods: A randomized controlled trial design was used to assess the pain intensity associated with IM injections administered using 2 different methods and injection sites. Recruitment of patients was carried out between April and August 2013 at the Department of Brain Surgery, Cekirge State Hospital, Bursa, Turkey. The sample comp...
Abstract
The Journal of craniofacial surgery,
Volume 27, Issue 2, 1 1 2016, Pages e175-6
Atypical Carcinoid Tumor and Chondroid and Glandular Hamartoma of the Arythenoid Region.
Sarioglu S, Akturk G, Aslier NG, Yilmaz DB, Dogan E
Neuroendocrine tumors of the head and neck are rare. Laryngeal hamartomas are even rarer especially in adult patients. Here in a 69-year-old male patient is presented who had atypical carcinoid tumor and chondroid and glandular hamartoma of the medial mucosa of the left arythenoid. To the best of our knowledge, this is the first case presenting the association of these 2 rare lesions.
Abstract
Cited 19 times since 2016 (1.9 per year)
source: EuropePMC
Critical care medicine,
Volume 44, Issue 3, 1 1 2016, Pages e158-67
Inotropic Effects of Experimental Hyperthermia and Hypothermia on Left Ventricular Function in Pigs-Comparison With Dobutamine.
Alogna A, Manninger M, Schwarzl M, Zirngast B, Steendijk P, Verderber J, Zweiker D, Maechler H, Pieske BM, Post H
Objectives: The results from the recent Targeted Temperature Management trial raised the question whether cooling or merely the avoidance of fever mediates better neurologic outcome in resuscitated patients. As temperature per se is a major determinant of cardiac function, we characterized the effects of hyperthermia (40.5°C), normothermia (38.0°C), and mild hypothermia (33.0°C) on left ventricular contractile function in healthy pigs and compared them with dobutamine infusion. Design: Animal st...
Abstract
Annals of surgery,
Volume 263, Issue 3, 1 1 2016, Pages e41
Comment on "Trainee Participation Is Associated With Adverse Outcomes in Emergency General Surgery: An Analysis of the National Surgical Quality Improvement Program Database".
Graat LJ, Roukema JA, Hamming JF
Abstract
Cited 19 times since 2016 (1.9 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 67, Issue 9, 1 1 2016, Pages 1123-1124
Pulmonary Valve Replacement After Repair of Pulmonary Stenosis Compared With Tetralogy of Fallot.
Bokma JP, Winter MM, Oosterhof T, Vliegen HW, van Dijk AP, Pieper PG, Meijboom FJ, Groenink M, Mulder BJM, Bouma BJ
Abstract
